{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T05:36:14Z","timestamp":1792733774086,"version":"4.5.0"},"reference-count":85,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jiac-j.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Infection and Chemotherapy"],"published-print":{"date-parts":[[2012]]},"DOI":"10.1007\/s10156-011-0306-2","type":"journal-article","created":{"date-parts":[[2011,11,2]],"date-time":"2011-11-02T12:14:34Z","timestamp":1320236074000},"page":"1-9","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":52,"title":["Paradoxical roles of alveolar macrophages in the host response to Cryptococcus neoformans"],"prefix":"10.1016","volume":"18","author":[{"given":"Travis J.","family":"McQuiston","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter R.","family":"Williamson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1007\/s10156-011-0306-2_bib0005","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1097\/QAD.0b013e328322ffac","article-title":"Estimation of the current global burden of cryptococcal meningitis among persons living with HIV\/AIDS","volume":"23","author":"Park","year":"2009","journal-title":"AIDS"},{"key":"10.1007\/s10156-011-0306-2_bib0010","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1080\/13693780601009493","article-title":"Fungal diseases: an evolving public health challenge","volume":"44","author":"Warnock","year":"2006","journal-title":"Med Mycol"},{"key":"10.1007\/s10156-011-0306-2_bib0015","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.idc.2006.07.001","article-title":"Cryptococcosis","volume":"20","author":"Chayakulkeeree","year":"2006","journal-title":"Infect Dis Clin N Am"},{"key":"10.1007\/s10156-011-0306-2_bib0020","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1086\/592690","article-title":"Cryptococcosis in solid organ transplant recipients: current state of the science","volume":"47","author":"Singh","year":"2008","journal-title":"Clin Infect Dis"},{"key":"10.1007\/s10156-011-0306-2_bib0025","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1097\/00002030-200205030-00009","article-title":"Cryptococcal infection in a cohort of HIV-1-infected Ugandan adults","volume":"16","author":"French","year":"2002","journal-title":"AIDS"},{"key":"10.1007\/s10156-011-0306-2_bib0030","doi-asserted-by":"crossref","first-page":"e21","DOI":"10.1371\/journal.pmed.0040021","article-title":"Determinants of disease presentation and outcome during cryptococcosis: the CryptoA\/D study","volume":"4","author":"Dromer","year":"2007","journal-title":"PLoS Med"},{"key":"10.1007\/s10156-011-0306-2_bib0035","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1086\/649858","article-title":"Clinical practice guidelines for the management of cryptococcal disease: 2010 update by the Infectious Diseases Society of America","volume":"50","author":"Perfect","year":"2010","journal-title":"Clin Infect Dis"},{"key":"10.1007\/s10156-011-0306-2_bib0040","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1093\/oxfordjournals.aje.a112423","article-title":"Epidemiologic differences among serotypes of Cryptococcus neoformans","volume":"105","author":"Bennett","year":"1977","journal-title":"Am J Epidemiol"},{"key":"10.1007\/s10156-011-0306-2_bib0045","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1128\/JCM.41.1.73-77.2003","article-title":"Serotyping of 467 Cryptococcus neoformans isolates from clinical and environmental sources in Brazil: analysis of host and regional patterns","volume":"41","author":"Nishikawa","year":"2003","journal-title":"J Clin Microbiol"},{"key":"10.1007\/s10156-011-0306-2_bib0050","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1099\/mic.0.2007\/015594-0","article-title":"Long-distance dispersal and recombination in environmental populations of Cryptococcus neoformans var. grubii from India","volume":"154","author":"Hiremath","year":"2008","journal-title":"Microbiology"},{"key":"10.1007\/s10156-011-0306-2_bib0055","doi-asserted-by":"crossref","first-page":"4745","DOI":"10.1128\/IAI.00341-08","article-title":"Enhanced innate immune responsiveness to pulmonary Cryptococcus neoformans infection is associated with resistance to progressive infection","volume":"76","author":"Guillot","year":"2008","journal-title":"Infect Immun"},{"key":"10.1007\/s10156-011-0306-2_bib0060","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1002\/jlb.63.5.521","article-title":"Signal transduction by immunoglobulin Fc receptors","volume":"63","author":"Sanchez-Mejorada","year":"1998","journal-title":"J Leukoc Biol"},{"key":"10.1007\/s10156-011-0306-2_bib0065","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1165\/ajrcmb.11.2.8049074","article-title":"Role of human alveolar macrophages as antigen-presenting cells in Cryptococcus neoformans infection","volume":"11","author":"Vecchiarelli","year":"1994","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1007\/s10156-011-0306-2_bib0070","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/j.1365-2249.1994.tb06128.x","article-title":"Encapsulation of Cryptococcus neoformans regulates fungicidal activity and the antigen presentation process in human alveolar macrophages","volume":"98","author":"Vecchiarelli","year":"1994","journal-title":"Clin Exp Immunol"},{"key":"10.1007\/s10156-011-0306-2_bib0075","doi-asserted-by":"crossref","first-page":"2846","DOI":"10.1128\/iai.64.7.2846-2849.1996","article-title":"Purified capsular polysaccharide of Cryptococcus neoformans induces interleukin-10 secretion by human monocytes","volume":"64","author":"Vecchiarelli","year":"1996","journal-title":"Infect Immun"},{"key":"10.1007\/s10156-011-0306-2_bib0080","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1111\/j.1348-0421.2000.tb02573.x","article-title":"Th1-Th2 cytokine kinetics in the bronchoalveolar lavage fluid of mice infected with Cryptococcus neoformans of different virulences","volume":"44","author":"Abe","year":"2000","journal-title":"Microbiol Immunol"},{"key":"10.1007\/s10156-011-0306-2_bib0085","doi-asserted-by":"crossref","first-page":"6346","DOI":"10.4049\/jimmunol.174.10.6346","article-title":"Role of IFN-gamma in regulating T2 immunity and the development of alternatively activated macrophages during allergic bronchopulmonary mycosis","volume":"174","author":"Arora","year":"2005","journal-title":"J Immunol"},{"key":"10.1007\/s10156-011-0306-2_bib0090","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.4049\/jimmunol.174.2.1027","article-title":"Distinct roles for IL-4 and IL-10 in regulating T2 immunity during allergic bronchopulmonary mycosis","volume":"174","author":"Hernandez","year":"2005","journal-title":"J Immunol"},{"key":"10.1007\/s10156-011-0306-2_bib0095","doi-asserted-by":"crossref","first-page":"2959","DOI":"10.1128\/IAI.70.6.2959-2964.2002","article-title":"Induction of interleukin-12 and gamma interferon requires tumor necrosis factor alpha for protective T1-cell-mediated immunity to pulmonary Cryptococcus neoformans infection","volume":"70","author":"Herring","year":"2002","journal-title":"Infect Immun"},{"key":"10.1007\/s10156-011-0306-2_bib0100","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/jlb.55.1.35","article-title":"The role of CD4+ and CD8+ T cells in the protective inflammatory response to a pulmonary cryptococcal infection","volume":"55","author":"Huffnagle","year":"1994","journal-title":"J Leukoc Biol"},{"key":"10.1007\/s10156-011-0306-2_bib0105","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1034\/j.1398-9995.2000.00429.x","article-title":"Interleukin-4-independent production of Th2 cytokines by nasal lymphocytes and nasal eosinophilia in murine allergic rhinitis","volume":"55","author":"Okano","year":"2000","journal-title":"Allergy"},{"key":"10.1007\/s10156-011-0306-2_bib0110","doi-asserted-by":"crossref","first-page":"6256","DOI":"10.1128\/IAI.69.10.6256-6263.2001","article-title":"Regulatory effects of macrophage inflammatory protein 1alpha\/CCL3 on the development of immunity to Cryptococcus neoformans depend on expression of early inflammatory cytokines","volume":"69","author":"Olszewski","year":"2001","journal-title":"Infect Immun"},{"key":"10.1007\/s10156-011-0306-2_bib0115","doi-asserted-by":"crossref","first-page":"5509","DOI":"10.4049\/jimmunol.177.8.5509","article-title":"In the absence of reactive oxygen species, T cells default to a Th1 phenotype and mediate protection against pulmonary Cryptococcus neoformans infection","volume":"177","author":"Snelgrove","year":"2006","journal-title":"J Immunol"},{"key":"10.1007\/s10156-011-0306-2_bib0120","doi-asserted-by":"crossref","first-page":"3450","DOI":"10.1128\/IAI.00297-09","article-title":"Cytokine signaling regulates the outcome of intracellular macrophage parasitism by Cryptococcus neoformans","volume":"77","author":"Voelz","year":"2009","journal-title":"Infect Immun"},{"key":"10.1007\/s10156-011-0306-2_bib0125","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1084\/jem.175.6.1685","article-title":"CD4+ T cells cause multinucleated giant cells to form around Cryptococcus neoformans and confine the yeast within the primary site of infection in the respiratory tract","volume":"175","author":"Hill","year":"1992","journal-title":"J Exp Med"},{"key":"10.1007\/s10156-011-0306-2_bib0130","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s10156-005-0387-X","article-title":"Granuloma and cryptococcosis","volume":"11","author":"Shibuya","year":"2005","journal-title":"J Infect Chemother"},{"key":"10.1007\/s10156-011-0306-2_bib0135","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.2217\/fmb.10.93","article-title":"Mechanisms of cryptococcal virulence and persistence","volume":"5","author":"Olszewski","year":"2010","journal-title":"Future Microbiol"},{"key":"10.1007\/s10156-011-0306-2_bib0140","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1128\/IAI.01049-09","article-title":"Cryptococcus neoformans variants generated by phenotypic switching differ in virulence through effects on macrophage activation","volume":"78","author":"Guerrero","year":"2010","journal-title":"Infect Immun"},{"key":"10.1007\/s10156-011-0306-2_bib0145","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1086\/593068","article-title":"A gene-dosage effect for interleukin-4 receptor alpha-chain expression has an impact on Th2-mediated allergic inflammation during bronchopulmonary mycosis","volume":"198","author":"Muller","year":"2008","journal-title":"J Infect Dis"},{"key":"10.1007\/s10156-011-0306-2_bib0150","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.2353\/ajpath.2009.090530","article-title":"Robust Th1 and Th17 immunity supports pulmonary clearance but cannot prevent systemic dissemination of highly virulent Cryptococcus neoformans H99","volume":"175","author":"Zhang","year":"2009","journal-title":"Am J Pathol"},{"key":"10.1007\/s10156-011-0306-2_bib0155","doi-asserted-by":"crossref","first-page":"5367","DOI":"10.4049\/jimmunol.179.8.5367","article-title":"IL-13 induces disease-promoting type 2 cytokines, alternatively activated macrophages and allergic inflammation during pulmonary infection of mice with Cryptococcus neoformans","volume":"179","author":"Muller","year":"2007","journal-title":"J Immunol"},{"key":"10.1007\/s10156-011-0306-2_bib0160","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1165\/ajrcmb.13.4.7546779","article-title":"Early cytokine production in pulmonary Cryptococcus neoformans infections distinguishes susceptible and resistant mice","volume":"13","author":"Hoag","year":"1995","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1007\/s10156-011-0306-2_bib0165","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1128\/IAI.00274-06","article-title":"Protection against cryptococcosis by using a murine gamma interferon-producing Cryptococcus neoformans strain","volume":"75","author":"Wormley","year":"2007","journal-title":"Infect Immun"},{"key":"10.1007\/s10156-011-0306-2_bib0170","doi-asserted-by":"crossref","first-page":"3244","DOI":"10.4049\/jimmunol.175.5.3244","article-title":"An innate immune system cell is a major determinant of species-related susceptibility differences to fungal pneumonia","volume":"175","author":"Shao","year":"2005","journal-title":"J Immunol"},{"key":"10.1007\/s10156-011-0306-2_bib0175","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1128\/iai.7.2.231-236.1973","article-title":"Growth of Cryptococcus neoformans within human macrophages in vitro","volume":"7","author":"Diamond","year":"1973","journal-title":"Infect Immun"},{"key":"10.1007\/s10156-011-0306-2_bib0180","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1128\/IAI.68.2.832-838.2000","article-title":"Persistent Cryptococcus neoformans pulmonary infection in the rat is associated with intracellular parasitism, decreased inducible nitric oxide synthase expression, and altered antibody responsiveness to cryptococcal polysaccharide","volume":"68","author":"Goldman","year":"2000","journal-title":"Infect Immun"},{"key":"10.1007\/s10156-011-0306-2_bib0185","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0966-842X(01)02035-2","article-title":"Intracellular parasitism of macrophages by Cryptococcus neoformans","volume":"9","author":"Feldmesser","year":"2001","journal-title":"Trends Microbiol"},{"key":"10.1007\/s10156-011-0306-2_bib0190","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1128\/IAI.67.2.885-890.1999","article-title":"Cryptococcus neoformans resides in an acidic phagolysosome of human macrophages","volume":"67","author":"Levitz","year":"1999","journal-title":"Infect Immun"},{"key":"10.1007\/s10156-011-0306-2_bib0195","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1128\/IAI.01065-08","article-title":"Evidence of a role for monocytes in dissemination and brain invasion by Cryptococcus neoformans","volume":"77","author":"Charlier","year":"2009","journal-title":"Infect Immun"},{"key":"10.1007\/s10156-011-0306-2_bib0200","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1086\/341564","article-title":"Pathogenesis of cerebral Cryptococcus neoformans infection after fungemia","volume":"186","author":"Chretien","year":"2002","journal-title":"J Infect Dis"},{"key":"10.1007\/s10156-011-0306-2_bib0205","doi-asserted-by":"crossref","first-page":"4792","DOI":"10.1128\/IAI.00587-07","article-title":"Depletion of alveolar macrophages decreases the dissemination of a glucosylceramide-deficient mutant of Cryptococcus neoformans in immunodeficient mice","volume":"75","author":"Kechichian","year":"2007","journal-title":"Infect Immun"},{"key":"10.1007\/s10156-011-0306-2_bib0210","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1172\/JCI18309","article-title":"Identification of App1 as a regulator of phagocytosis and virulence of Cryptococcus neoformans","volume":"112","author":"Luberto","year":"2003","journal-title":"J Clin Invest"},{"key":"10.1007\/s10156-011-0306-2_bib0215","doi-asserted-by":"crossref","first-page":"2342","DOI":"10.1128\/IAI.01140-09","article-title":"Role of host sphingosine kinase 1 in the lung response against cryptococcosis","volume":"78","author":"McQuiston","year":"2010","journal-title":"Infect Immun"},{"key":"10.1007\/s10156-011-0306-2_bib0220","doi-asserted-by":"crossref","first-page":"3204","DOI":"10.1128\/JCM.37.10.3204-3209.1999","article-title":"Epidemiological evidence for dormant Cryptococcus neoformans infection","volume":"37","author":"Garcia-Hermoso","year":"1999","journal-title":"J Clin Microbiol"},{"key":"10.1007\/s10156-011-0306-2_bib0225","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1080\/02681219280000511","article-title":"Isolation of Cryptococcus neoformans var. gattii from an Asian patient in France: evidence for dormant infection in healthy subjects","volume":"30","author":"Dromer","year":"1992","journal-title":"J Med Vet Mycol"},{"key":"10.1007\/s10156-011-0306-2_bib0230","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1086\/314953","article-title":"Antibodies reactive with the cryptococcal capsular polysaccharide glucuronoxylomannan are present in sera from children with and without human immunodeficiency virus infection","volume":"180","author":"Abadi","year":"1999","journal-title":"J Infect Dis"},{"key":"10.1007\/s10156-011-0306-2_bib0235","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1086\/515130","article-title":"Cryptococcosis in children with AIDS","volume":"28","author":"Abadi","year":"1999","journal-title":"Clin Infect Dis"},{"key":"10.1007\/s10156-011-0306-2_bib0240","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1097\/INF.0b013e318047e073","article-title":"Serologic evidence for regional differences in pediatric cryptococcal infection","volume":"26","author":"Davis","year":"2007","journal-title":"Pediatr Infect Dis J"},{"key":"10.1007\/s10156-011-0306-2_bib0245","doi-asserted-by":"crossref","first-page":"E66","DOI":"10.1542\/peds.107.5.e66","article-title":"Serologic evidence for Cryptococcus neoformans infection in early childhood","volume":"107","author":"Goldman","year":"2001","journal-title":"Pediatrics"},{"key":"10.1007\/s10156-011-0306-2_bib0250","doi-asserted-by":"crossref","first-page":"2857","DOI":"10.1128\/iai.62.7.2857-2864.1994","article-title":"Occurrences, immunoglobulin classes, and biological activities of antibodies in normal human serum that are reactive with Cryptococcus neoformans glucuronoxylomannan","volume":"62","author":"Houpt","year":"1994","journal-title":"Infect Immun"},{"key":"10.1007\/s10156-011-0306-2_bib0255","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1086\/322044","article-title":"Host\u2013pathogen interactions: the attributes of virulence","volume":"184","author":"Casadevall","year":"2001","journal-title":"J Infect Dis"},{"key":"10.1007\/s10156-011-0306-2_bib0260","doi-asserted-by":"crossref","first-page":"4225","DOI":"10.1128\/IAI.68.7.4225-4237.2000","article-title":"Cryptococcus neoformans is a facultative intracellular pathogen in murine pulmonary infection","volume":"68","author":"Feldmesser","year":"2000","journal-title":"Infect Immun"},{"key":"10.1007\/s10156-011-0306-2_bib0265","doi-asserted-by":"crossref","first-page":"5977","DOI":"10.1128\/IAI.00768-06","article-title":"The cryptococcal enzyme inositol phosphosphingolipid-phospholipase C confers resistance to the antifungal effects of macrophages and promotes fungal dissemination to the central nervous system","volume":"74","author":"Shea","year":"2006","journal-title":"Infect Immun"},{"key":"10.1007\/s10156-011-0306-2_bib0270","doi-asserted-by":"crossref","first-page":"4755","DOI":"10.1128\/iai.62.11.4755-4761.1994","article-title":"Pathogenesis of pulmonary Cryptococcus neoformans infection in the rat","volume":"62","author":"Goldman","year":"1994","journal-title":"Infect Immun"},{"key":"10.1007\/s10156-011-0306-2_bib0275","doi-asserted-by":"crossref","first-page":"2156","DOI":"10.1016\/j.cub.2006.09.032","article-title":"Expulsion of live pathogenic yeast by macrophages","volume":"16","author":"Ma","year":"2006","journal-title":"Curr Biol"},{"key":"10.1007\/s10156-011-0306-2_bib0280","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1016\/j.cub.2006.09.061","article-title":"Phagosome extrusion and host-cell survival after Cryptococcus neoformans phagocytosis by macrophages","volume":"16","author":"Alvarez","year":"2006","journal-title":"Curr Biol"},{"issue":"8","key":"10.1007\/s10156-011-0306-2_bib0285","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1001041","article-title":"The human fungal pathogen Cryptococcus neoformans escapes macrophages by a phagosome emptying mechanism that is inhibited by Arp2\/3 complex-mediated actin polymerisation.","volume":"6","author":"Johnston","year":"2010","journal-title":"PLoS Pathog"},{"key":"10.1007\/s10156-011-0306-2_bib0290","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1172\/JCI119688","article-title":"Chloroquine induces human mononuclear phagocytes to inhibit and kill Cryptococcus neoformans by a mechanism independent of iron deprivation","volume":"100","author":"Levitz","year":"1997","journal-title":"J Clin Invest"},{"key":"10.1007\/s10156-011-0306-2_bib0295","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1128\/iai.63.5.1899-1905.1995","article-title":"Variation in the structure of glucuronoxylomannan in isolates from patients with recurrent cryptococcal meningitis","volume":"63","author":"Cherniak","year":"1995","journal-title":"Infect Immun"},{"key":"10.1007\/s10156-011-0306-2_bib0300","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0065-2164(09)01204-0","article-title":"The capsule of the fungal pathogen Cryptococcus neoformans","volume":"68","author":"Zaragoza","year":"2009","journal-title":"Adv Appl Microbiol"},{"key":"10.1007\/s10156-011-0306-2_bib0305","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1111\/j.1462-5822.2008.01186.x","article-title":"Capsule enlargement in Cryptococcus neoformans confers resistance to oxidative stress suggesting a mechanism for intracellular survival","volume":"10","author":"Zaragoza","year":"2008","journal-title":"Cell Microbiol"},{"key":"10.1007\/s10156-011-0306-2_bib0310","doi-asserted-by":"crossref","first-page":"6034","DOI":"10.1128\/IAI.67.11.6034-6039.1999","article-title":"Laccase protects Cryptococcus neoformans from antifungal activity of alveolar macrophages","volume":"67","author":"Liu","year":"1999","journal-title":"Infect Immun"},{"key":"10.1007\/s10156-011-0306-2_bib0315","doi-asserted-by":"crossref","first-page":"5589","DOI":"10.1128\/IAI.69.9.5589-5596.2001","article-title":"Laccase of Cryptococcus neoformans is a cell wall-associated virulence factor","volume":"69","author":"Zhu","year":"2001","journal-title":"Infect Immun"},{"key":"10.1007\/s10156-011-0306-2_bib0320","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1046\/j.1365-2958.2003.03340.x","article-title":"Copper-mediated reversal of defective laccase in a Deltavph1 avirulent mutant of Cryptococcus neoformans","volume":"47","author":"Zhu","year":"2003","journal-title":"Mol Microbiol"},{"key":"10.1007\/s10156-011-0306-2_bib0325","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.4049\/jimmunol.174.3.1491","article-title":"Elemental analysis of Mycobacterium avium-, Mycobacterium tuberculosis-, and Mycobacterium smegmatis-containing phagosomes indicates pathogen-induced microenvironments within the host cell\u2019s endosomal system","volume":"174","author":"Wagner","year":"2005","journal-title":"J Immunol"},{"key":"10.1007\/s10156-011-0306-2_bib0330","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1111\/j.0300-9475.2004.01482.x","article-title":"The effect of iron on the expression of cytokines in macrophages infected with Mycobacterium tuberculosis","volume":"60","author":"Serafin-Lopez","year":"2004","journal-title":"Scand J Immunol"},{"key":"10.1007\/s10156-011-0306-2_bib0335","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/1471-2180-10-64","article-title":"Modulation of iron homeostasis in macrophages by bacterial intracellular pathogens","volume":"10","author":"Pan","year":"2010","journal-title":"BMC Microbiol"},{"key":"10.1007\/s10156-011-0306-2_bib0340","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1128\/EC.00336-06","article-title":"Cryptococcus neoformans produces authentic prostaglandin E2 without a cyclooxygenase","volume":"6","author":"Erb-Downward","year":"2007","journal-title":"Eukaryot Cell"},{"key":"10.1007\/s10156-011-0306-2_bib0345","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1128\/IAI.71.3.1538-1547.2003","article-title":"Role of PLB1 in pulmonary inflammation and cryptococcal eicosanoid production","volume":"71","author":"Noverr","year":"2003","journal-title":"Infect Immun"},{"key":"10.1007\/s10156-011-0306-2_bib0350","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.1128\/IAI.69.5.2957-2963.2001","article-title":"Pathogenic yeasts Cryptococcus neoformans and Candida albicans produce immunomodulatory prostaglandins","volume":"69","author":"Noverr","year":"2001","journal-title":"Infect Immun"},{"key":"10.1007\/s10156-011-0306-2_bib0355","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1128\/AAC.41.1.156","article-title":"The immunosuppressant FK506 and its nonimmunosuppressive analog L-685, 818 are toxic to Cryptococcus neoformans by inhibition of a common target protein","volume":"41","author":"Odom","year":"1997","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1007\/s10156-011-0306-2_bib0360","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1111\/j.1462-5822.2008.01273.x","article-title":"Signalling pathways in the pathogenesis of Cryptococcus","volume":"11","author":"Kozubowski","year":"2009","journal-title":"Cell Microbiol"},{"key":"10.1007\/s10156-011-0306-2_bib0365","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1111\/j.1567-1364.2006.00078.x","article-title":"Intersection of fungal fitness and virulence in Cryptococcus neoformans","volume":"6","author":"Panepinto","year":"2006","journal-title":"FEMS Yeast Res"},{"key":"10.1007\/s10156-011-0306-2_bib0370","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1128\/EC.4.8.1420-1433.2005","article-title":"Cryptococcus neoformans gene expression during murine macrophage infection","volume":"4","author":"Fan","year":"2005","journal-title":"Eukaryot Cell"},{"key":"10.1007\/s10156-011-0306-2_bib0375","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1146\/annurev.bi.64.070195.000525","article-title":"Superoxide radical and superoxide dismutases","volume":"64","author":"Fridovich","year":"1995","journal-title":"Annu Rev Biochem"},{"key":"10.1007\/s10156-011-0306-2_bib0380","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1128\/IAI.71.1.173-180.2003","article-title":"Superoxide dismutase influences the virulence of Cryptococcus neoformans by affecting growth within macrophages","volume":"71","author":"Cox","year":"2003","journal-title":"Infect Immun"},{"key":"10.1007\/s10156-011-0306-2_bib0385","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1111\/j.1365-2958.2005.04503.x","article-title":"Characterization of Cryptococcus neoformans variety gattii SOD2 reveals distinct roles of the two superoxide dismutases in fungal biology and virulence","volume":"55","author":"Narasipura","year":"2005","journal-title":"Mol Microbiol"},{"key":"10.1007\/s10156-011-0306-2_bib0390","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/msb.2008.17","article-title":"Mathematical modeling of pathogenicity of Cryptococcus neoformans","volume":"4","author":"Garcia","year":"2008","journal-title":"Mol Syst Biol"},{"key":"10.1007\/s10156-011-0306-2_bib0395","doi-asserted-by":"crossref","first-page":"37508","DOI":"10.1074\/jbc.M707913200","article-title":"Cell wall-linked cryptococcal phospholipase B1 is a source of secreted enzyme and a determinant of cell wall integrity","volume":"282","author":"Siafakas","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1007\/s10156-011-0306-2_bib0400","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1128\/EC.5.3.488-498.2006","article-title":"Lipid rafts in Cryptococcus neoformans concentrate the virulence determinants phospholipase B1 and Cu\/Zn superoxide dismutase","volume":"5","author":"Siafakas","year":"2006","journal-title":"Eukaryot Cell"},{"key":"10.1007\/s10156-011-0306-2_bib0405","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1128\/EC.00262-06","article-title":"Cryptococcal lipid metabolism: phospholipase B1 is implicated in transcellular metabolism of macrophage-derived lipids","volume":"6","author":"Wright","year":"2007","journal-title":"Eukaryot Cell"},{"key":"10.1007\/s10156-011-0306-2_bib0410","doi-asserted-by":"crossref","first-page":"e410","DOI":"10.1371\/journal.pbio.0040410","article-title":"Iron regulation of the major virulence factors in the AIDS-associated pathogen Cryptococcus neoformans","volume":"4","author":"Jung","year":"2006","journal-title":"PLoS Biol"},{"key":"10.1007\/s10156-011-0306-2_bib0415","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1128\/EC.00166-09","article-title":"Role of ferroxidases in iron uptake and virulence of Cryptococcus neoformans","volume":"8","author":"Jung","year":"2009","journal-title":"Eukaryot Cell"},{"key":"10.1007\/s10156-011-0306-2_bib0420","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1172\/JCI30006","article-title":"Role of a CUF1\/CTR4 copper regulatory axis in the virulence of Cryptococcus neoformans","volume":"117","author":"Waterman","year":"2007","journal-title":"J Clin Invest"},{"key":"10.1007\/s10156-011-0306-2_bib0425","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1172\/JCI32053","article-title":"PI3K signaling of autophagy is required for starvation tolerance and virulence of Cryptococcus neoformans","volume":"118","author":"Hu","year":"2008","journal-title":"J Clin Invest"}],"container-title":["Journal of Infection and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1341321X12703410?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1341321X12703410?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.springerlink.com\/index\/pdf\/10.1007\/s10156-011-0306-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T18:48:49Z","timestamp":1761158929000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1341321X12703410"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":85,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012]]}},"alternative-id":["S1341321X12703410"],"URL":"https:\/\/doi.org\/10.1007\/s10156-011-0306-2","relation":{},"ISSN":["1341-321X"],"issn-type":[{"value":"1341-321X","type":"print"}],"subject":[],"published":{"date-parts":[[2012]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Paradoxical roles of alveolar macrophages in the host response to Cryptococcus neoformans","name":"articletitle","label":"Article Title"},{"value":"Journal of Infection and Chemotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1007\/s10156-011-0306-2","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Japanese Society of Chemotherapy and the Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}