{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T13:19:45Z","timestamp":1793711985844,"version":"4.6.1"},"reference-count":43,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jiac-j.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Infection and Chemotherapy"],"published-print":{"date-parts":[[2012]]},"DOI":"10.1007\/s10156-012-0379-6","type":"journal-article","created":{"date-parts":[[2012,2,19]],"date-time":"2012-02-19T20:28:49Z","timestamp":1329683329000},"page":"228-240","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":82,"title":["The emerging ST8 methicillin-resistant Staphylococcus aureus clone in the community in Japan: associated infections, genetic diversity, and comparative genomics"],"prefix":"10.1016","volume":"18","author":[{"given":"Yasuhisa","family":"Iwao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomomi","family":"Takano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Chun","family":"Hung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wataru","family":"Higuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirokazu","family":"Isobe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihito","family":"Nishiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Khokhlova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuo","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rumiko","family":"Ishii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mio","family":"Yano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rumiko","family":"Ishii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mio","family":"Yano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Tomita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Shibuya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kikuyo","family":"Ogata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Okubo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pak-Leung","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1007\/s10156-012-0379-6_bib0005","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S1473-3099(05)70112-2","article-title":"Community-acquired meticillin-resistant Staphylococcus aureus: an emerging threat","volume":"5","author":"Zetola","year":"2005","journal-title":"Lancet Infect Dis"},{"key":"10.1007\/s10156-012-0379-6_bib0010","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/S0140-6736(06)68853-3","article-title":"Emergence and resurgence of meticillin-resistant Staphylococcus aureus as a public-health threat","volume":"368","author":"Grundmann","year":"2006","journal-title":"Lancet"},{"key":"10.1007\/s10156-012-0379-6_bib0015","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1128\/JB.01128-07","article-title":"Gene acquisition at the insertion site for SCCmec, the genomic island conferring methicillin resistance in Staphylococcus aureus","volume":"190","author":"Noto","year":"2008","journal-title":"J Bacteriol"},{"key":"10.1007\/s10156-012-0379-6_bib0020","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s10156-010-0045-9","article-title":"Community-acquired methicillin-resistant Staphylococcus aureus: community transmission, pathogenesis, and drug resistance","volume":"16","author":"Yamamoto","year":"2010","journal-title":"J Infect Chemother"},{"key":"10.1007\/s10156-012-0379-6_bib0025","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.tim.2008.05.002","article-title":"The role of virulence determinants in community-associated MRSA pathogenesis","volume":"16","author":"Diep","year":"2008","journal-title":"Trends Microbiol"},{"key":"10.1007\/s10156-012-0379-6_bib0030","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1086\/587907","article-title":"The arginine catabolic mobile element and staphylococcal chromosomal cassette mec linkage: convergence of virulence and resistance in the USA300 clone of methicillin-resistant Staphylococcus aureus","volume":"197","author":"Diep","year":"2008","journal-title":"J Infect Dis"},{"key":"10.1007\/s10156-012-0379-6_bib0035","doi-asserted-by":"crossref","first-page":"978","DOI":"10.3201\/eid0908.030089","article-title":"Community-acquired methicillin-resistant Staphylococcus aureus carrying Panton\u2013Valentine leukocidin genes: worldwide emergence","volume":"9","author":"Vandenesch","year":"2003","journal-title":"Emerg Infect Dis"},{"key":"10.1007\/s10156-012-0379-6_bib0040","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1126\/science.1137165","article-title":"Staphylococcus aureus Panton\u2013Valentine leukocidin causes necrotizing pneumonia","volume":"315","author":"Labandeira-Rey","year":"2007","journal-title":"Science"},{"key":"10.1007\/s10156-012-0379-6_bib0045","doi-asserted-by":"crossref","first-page":"e1000715","DOI":"10.1371\/journal.ppat.1000715","article-title":"Staphylococcus aureus Panton\u2013Valentine leukocidin is a very potent cytotoxic factor for human neutrophils","volume":"6","author":"L\u00f6ffler","year":"2010","journal-title":"PLoS Pathog"},{"key":"10.1007\/s10156-012-0379-6_bib0050","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/S0140-6736(06)68231-7","article-title":"Complete genome sequence of USA300, an epidemic clone of community-acquired meticillin-resistant Staphylococcus aureus","volume":"367","author":"Diep","year":"2006","journal-title":"Lancet"},{"key":"10.1007\/s10156-012-0379-6_bib0055","doi-asserted-by":"crossref","first-page":"3356","DOI":"10.1128\/JCM.43.7.3356-3363.2005","article-title":"A Panton\u2013Valentine leucocidin (PVL)-positive community-acquired methicillin-resistant Staphylococcus aureus (MRSA) strain, another such strain carrying a multiple-drug resistance plasmid, and other more-typical PVL-negative MRSA strains found in Japan","volume":"43","author":"Takizawa","year":"2005","journal-title":"J Clin Microbiol"},{"key":"10.1007\/s10156-012-0379-6_bib0060","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1128\/JCM.01742-10","article-title":"Bullous impetigo in children infected with methicillin-resistant Staphylococcus aureus alone or in combination with methicillin-susceptible S. aureus: analysis of genetic characteristics, including assessment of exfoliative toxin gene carriage","volume":"49","author":"Shi","year":"2011","journal-title":"J Clin Microbiol"},{"key":"10.1007\/s10156-012-0379-6_bib0065","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.diagmicrobio.2006.08.003","article-title":"Molecular epidemiology and household transmission of community-associated methicillin-resistant Staphylococcus aureus in Hong Kong","volume":"57","author":"Ho","year":"2007","journal-title":"Diagn Microbiol Infect Dis"},{"key":"10.1007\/s10156-012-0379-6_bib0070","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1001\/jama.298.15.1763","article-title":"Invasive methicillin-resistant Staphylococcus aureus infections in the United States","volume":"298","author":"Klevens","year":"2007","journal-title":"JAMA"},{"key":"10.1007\/s10156-012-0379-6_bib0075","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/j.1348-0421.2011.00397.x","article-title":"Isolation and molecular characterization of methicillin-resistant Staphylococcus aureus (MRSA) from public transport","volume":"56","author":"Iwao","year":"2012","journal-title":"Microbiol Immunol"},{"key":"10.1007\/s10156-012-0379-6_bib0080","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s10156-008-0640-1","article-title":"Emergence of the community-acquired methicillin-resistant Staphylococcus aureus USA300 clone in Japan","volume":"14","author":"Shibuya","year":"2008","journal-title":"J Infect Chemother"},{"key":"10.1007\/s10156-012-0379-6_bib0085","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1007\/s10156-010-0087-z","article-title":"Spread of the community-acquired methicillin-resistant Staphylococcus aureus USA300 clone among family members in Japan","volume":"16","author":"Yabe","year":"2010","journal-title":"J Infect Chemother"},{"key":"10.1007\/s10156-012-0379-6_bib0090","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1111\/j.1346-8138.2011.01284.x","article-title":"Nosocomial outbreak of multidrug-resistant USA300 methicillin-resistant Staphylococcus aureus causing severe furuncles and carbuncles in Japan","volume":"38","author":"Mine","year":"2011","journal-title":"J Dermatol"},{"key":"10.1007\/s10156-012-0379-6_bib0095","doi-asserted-by":"crossref","DOI":"10.1007\/s10156-011-0316-0","article-title":"Super-sticky familial infections caused by Panton\u2013Valentine leukocidin-positive ST22 community-acquired methicillin-resistant Staphylococcus aureus in Japan","author":"Yamamoto","year":"2012","journal-title":"J Infect Chemother"},{"key":"10.1007\/s10156-012-0379-6_bib0100","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1128\/AAC.01001-07","article-title":"Novel characteristics of community-acquired methicillin-resistant Staphylococcus aureus strains belonging to multilocus sequence type 59 in Taiwan","volume":"52","author":"Takano","year":"2008","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1007\/s10156-012-0379-6_bib0105","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1007\/s10156-010-0029-9","article-title":"Molecular characteristics of the Taiwanese multiple drug-resistant ST59 clone of Panton\u2013Valentine leucocidin-positive community-acquired methicillin-resistant Staphylococcus aureus from pediatric cellulitis","volume":"16","author":"Higuchi","year":"2010","journal-title":"J Infect Chemother"},{"key":"10.1007\/s10156-012-0379-6_bib0110","doi-asserted-by":"crossref","first-page":"4077","DOI":"10.1128\/AAC.00847-06","article-title":"Molecular characteristics and in vitro susceptibility to antimicrobial agents, including the des-fluoro(6) quinolone DX-619, of Panton\u2013Valentine leucocidin-positive methicillin-resistant Staphylococcus aureus isolates from the community and hospitals","volume":"50","author":"Yamamoto","year":"2006","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1007\/s10156-012-0379-6_bib0115","doi-asserted-by":"crossref","first-page":"4961","DOI":"10.1128\/AAC.00579-09","article-title":"Classification of staphylococcal cassette chromosome mec (SCCmec): guidelines for reporting novel SCCmec elements","volume":"53","year":"2009","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1007\/s10156-012-0379-6_bib0120","doi-asserted-by":"crossref","DOI":"10.1007\/s10156-011-0348-5","article-title":"A new staphylococcal cassette chromosome mec IV encoding a novel cell-wall-anchored surface protein in a major ST8 community-acquired methicillin-resistant Staphylococcus aureus clone in Japan","author":"Iwao","year":"2012","journal-title":"J Infect Chemother"},{"key":"10.1007\/s10156-012-0379-6_bib0125","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1086\/657419","article-title":"Comparative analysis of virulence and toxin expression of global community-associated methicillin-resistant Staphylococcus aureus strains","volume":"202","author":"Li","year":"2010","journal-title":"J Infect Dis"},{"key":"10.1007\/s10156-012-0379-6_bib0130","series-title":"Performance standard for antimicrobial susceptibility testing; 21st informational supplement. M100-S21.","year":"2011"},{"key":"10.1007\/s10156-012-0379-6_bib0135","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1128\/CMR.12.2.224","article-title":"Clinical, microbial, and biochemical aspects of the exfoliative toxins causing staphylococcal scalded-skin syndrome","volume":"12","author":"Ladhani","year":"1999","journal-title":"Clin Microbiol Rev"},{"key":"10.1007\/s10156-012-0379-6_bib0140","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1086\/340212","article-title":"Clonal association of Staphylococcus aureus causing bullous impetigo and the emergence of new methicillin-resistant clonal groups in Kansai district in Japan","volume":"185","author":"Yamaguchi","year":"2002","journal-title":"J Infect Dis"},{"key":"10.1007\/s10156-012-0379-6_bib0145","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1055\/s-0029-1214382","article-title":"Methicillin-resistant Staphylococcus aureus (MRSA) in the athlete","volume":"30","author":"Redziniak","year":"2009","journal-title":"Int J Sports Med"},{"key":"10.1007\/s10156-012-0379-6_bib0150","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1007\/BF02782858","article-title":"Toxin involvement in methicillin-resistant Staphylococcus aureus enteritis in gastroenterological surgery","volume":"26","author":"Takesue","year":"1991","journal-title":"Gastroenterol Jpn"},{"key":"10.1007\/s10156-012-0379-6_bib0155","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/S1473-3099(09)70133-1","article-title":"Emergence of community-acquired meticillin-resistant Staphylococcus aureus strain USA300 as a cause of necrotising community-onset pneumonia","volume":"9","author":"Hidron","year":"2009","journal-title":"Lancet Infect Dis"},{"key":"10.1007\/s10156-012-0379-6_bib0160","doi-asserted-by":"crossref","first-page":"3013","DOI":"10.1128\/IAI.69.5.3013-3020.2001","article-title":"Expression of pls, a gene closely associated with the mecA gene of methicillin-resistant Staphylococcus aureus, prevents bacterial adhesion in vitro","volume":"69","author":"Savolainen","year":"2001","journal-title":"Infect Immun"},{"key":"10.1007\/s10156-012-0379-6_bib0165","series-title":"Gram-positive pathogens","first-page":"486","article-title":"Staphylococcal sortase and surface proteins","author":"Dedent","year":"2006"},{"key":"10.1007\/s10156-012-0379-6_bib0170","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/nrmicro2393","article-title":"The phage-related chromosomal islands of gram-positive bacteria","volume":"8","author":"Novick","year":"2010","journal-title":"Nat Rev Microbiol"},{"key":"10.1007\/s10156-012-0379-6_bib0175","first-page":"237","article-title":"Insights on virulence and antibiotic resistance: a review of the accessory genome of Staphylococcus aureus","volume":"19","author":"Shittu","year":"2007","journal-title":"Wounds"},{"key":"10.1007\/s10156-012-0379-6_bib0180","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0147-619X(02)00157-9","article-title":"Mobile genetic elements and bacterial toxinoses: the superantigen-encoding pathogenicity islands of Staphylococcus aureus","volume":"49","author":"Novick","year":"2003","journal-title":"Plasmid"},{"key":"10.1007\/s10156-012-0379-6_bib0185","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S1473-3099(09)70066-0","article-title":"Gram-positive toxic shock syndromes","volume":"9","author":"Lappin","year":"2009","journal-title":"Lancet Infect Dis"},{"key":"10.1007\/s10156-012-0379-6_bib0190","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.1469-0691.2009.02806.x","article-title":"Molecular characterization of methicillin-resistant Staphylococcus aureus from a fatal case of necrotizing fasciitis in an extremely low-birth-weight infant","volume":"16","author":"Orii","year":"2010","journal-title":"Clin Microbiol Infect"},{"key":"10.1007\/s10156-012-0379-6_bib0195","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1038\/nm1656","article-title":"Identification of novel cytolytic peptides as key virulence determinants for community-associated MRSA","volume":"13","author":"Wang","year":"2007","journal-title":"Nat Med"},{"key":"10.1007\/s10156-012-0379-6_bib0200","doi-asserted-by":"crossref","first-page":"e1000964","DOI":"10.1371\/journal.ppat.1000964","article-title":"Staphylococcus aureus host cell invasion and virulence in sepsis is facilitated by the multiple repeats within FnBPA","volume":"6","author":"Edwards","year":"2010","journal-title":"PLoS Pathog"},{"key":"10.1007\/s10156-012-0379-6_bib0205","doi-asserted-by":"crossref","first-page":"21457","DOI":"10.1074\/jbc.270.37.21457","article-title":"Staphylococcus aureus expresses a major histocompatibility complex class II analog","volume":"270","author":"J\u00f6nsson","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1007\/s10156-012-0379-6_bib0210","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.coph.2009.07.009","article-title":"An update on community-associated MRSA virulence","volume":"9","author":"Kobayashi","year":"2009","journal-title":"Curr Opin Pharmacol"},{"key":"10.1007\/s10156-012-0379-6_bib0215","first-page":"3039","article-title":"The aacA-aphD gentamicin and kanamycin resistance determinant of Tn4001 from Staphylococcus aureus: expression and nucleotide sequence analysis","volume":"133","author":"Rouch","year":"1987","journal-title":"J Gen Microbiol"}],"container-title":["Journal of Infection and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1341321X12703318?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1341321X12703318?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.springerlink.com\/index\/pdf\/10.1007\/s10156-012-0379-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T18:49:48Z","timestamp":1761158988000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1341321X12703318"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":43,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012]]}},"alternative-id":["S1341321X12703318"],"URL":"https:\/\/doi.org\/10.1007\/s10156-012-0379-6","relation":{},"ISSN":["1341-321X"],"issn-type":[{"value":"1341-321X","type":"print"}],"subject":[],"published":{"date-parts":[[2012]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The emerging ST8 methicillin-resistant Staphylococcus aureus clone in the community in Japan: associated infections, genetic diversity, and comparative genomics","name":"articletitle","label":"Article Title"},{"value":"Journal of Infection and Chemotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1007\/s10156-012-0379-6","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Japanese Society of Chemotherapy and the Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}