{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T15:30:15Z","timestamp":1767972615166,"version":"3.49.0"},"reference-count":26,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jiac-j.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Infection and Chemotherapy"],"published-print":{"date-parts":[[2012]]},"DOI":"10.1007\/s10156-012-0395-6","type":"journal-article","created":{"date-parts":[[2012,2,27]],"date-time":"2012-02-27T01:15:39Z","timestamp":1330305339000},"page":"683-688","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Antimicrobial and anti-inflammatory effects of clarithromycin on Mycobacterium avium complex replication in cultured human bronchial epithelial cells"],"prefix":"10.1016","volume":"18","author":[{"given":"Yoshitaka","family":"Yamazaki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsuhito","family":"Ushiki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keishi","family":"Kubo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinari","family":"Tanabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sekiya","family":"Koyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1007\/s10156-012-0395-6_bib0005","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1164\/rccm.200604-571ST","article-title":"An official ATS\/IDSA statement: diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases","volume":"175","author":"Griffith","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1007\/s10156-012-0395-6_bib0010","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1056\/NEJM198909283211304","article-title":"Infection with Mycobacterium avium complex in patients without predisposing conditions","volume":"321","author":"Prince","year":"1989","journal-title":"N Engl J Med"},{"key":"10.1007\/s10156-012-0395-6_bib0015","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1164\/ajrccm.160.6.9902019","article-title":"Markers indicating deterioration of pulmonary Mycobacterium avium-intracellulare infection","volume":"160","author":"Yamazaki","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1007\/s10156-012-0395-6_bib0020","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1128\/AAC.48.5.1581-1585.2004","article-title":"Molecular mechanisms of anti-inflammatory action of erythromycin in human bronchial epithelial cells: possible role in the signaling pathway that regulates nuclear factor-kappaB activation","volume":"48","author":"Desaki","year":"2004","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1007\/s10156-012-0395-6_bib0025","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1183\/09031936.99.13353599","article-title":"Pathological and radiological changes in resected lung specimens in Mycobacterium avium intracellulare complex disease","volume":"13","author":"Fujita","year":"1999","journal-title":"Eur Respir J"},{"key":"10.1007\/s10156-012-0395-6_bib0030","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1164\/ajrccm.160.3.9811086","article-title":"Effect of clarithromycin regimen for Mycobacterium avium complex pulmonary disease","volume":"160","author":"Tanaka","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1007\/s10156-012-0395-6_bib0035","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1164\/ajrccm.153.6.8665032","article-title":"Clarithromycin regimens for pulmonary Mycobacterium avium complex. The first 50 patients","volume":"153","author":"Wallace","year":"1996","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1007\/s10156-012-0395-6_bib0040","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1111\/j.1462-5822.2005.00667.x","article-title":"The ability to form biofilm influences Mycobacterium avium invasion and translocation of bronchial epithelial cells","volume":"8","author":"Yamazaki","year":"2006","journal-title":"Cell Microbiol"},{"key":"10.1007\/s10156-012-0395-6_bib0045","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1378\/chest.119.4.1131","article-title":"Plasma and BAL fluid concentrations of antimicrobial peptides in patients with Mycobacterium avium-intracellulare infection","volume":"119","author":"Ashitani","year":"2001","journal-title":"Chest"},{"key":"10.1007\/s10156-012-0395-6_bib0050","first-page":"77","article-title":"Isolation of mononuclear cells and granulocytes from human blood","volume":"97","author":"Boyum","year":"1968","journal-title":"Scand J Clin Lab Invest"},{"key":"10.1007\/s10156-012-0395-6_bib0055","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1034\/j.1399-3003.1999.14c11.x","article-title":"The potential of various lipopolysaccharides to release monocyte chemotactic activity from lung epithelial cell and fibroblasts","volume":"14","author":"Koyama","year":"1999","journal-title":"Eur Respir J"},{"key":"10.1007\/s10156-012-0395-6_bib0060","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/0022-1759(80)90211-2","article-title":"A 48-well micro chemotaxis assembly for rapid and accurate measurement of leukocyte migration","volume":"33","author":"Falk","year":"1980","journal-title":"J Immunol Methods"},{"key":"10.1007\/s10156-012-0395-6_bib0065","doi-asserted-by":"crossref","first-page":"670","DOI":"10.2169\/internalmedicine.42.670","article-title":"The effect of combined therapy according to the guidelines for the treatment of Mycobacterium avium complex pulmonary disease","volume":"42","author":"Kobashi","year":"2003","journal-title":"Intern Med"},{"key":"10.1007\/s10156-012-0395-6_bib0070","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1093\/jac\/24.5.719","article-title":"Penetration of macrolides into human polymorphonuclear leukocytes","volume":"24","author":"Ishiguro","year":"1989","journal-title":"J Antimicrob Chemother"},{"key":"10.1007\/s10156-012-0395-6_bib0075","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1007\/s101560070004","article-title":"Evaluation of the activity of antimicrobial agents against Legionella pneumophila multiplying in a human monocytic cell line, THP-a, and an alveolar epithelial cell line, A549","volume":"6","author":"Kunishima","year":"2000","journal-title":"J Infect Chemother"},{"key":"10.1007\/s10156-012-0395-6_bib0080","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.pupt.2008.11.004","article-title":"Concentrations of clarithromycin and active metabolite in the epithelial lining fluid of patients with Mycobacterium avium complex pulmonary disease","volume":"22","author":"Hasegawa","year":"2009","journal-title":"Pulm Pharmacol Ther"},{"key":"10.1007\/s10156-012-0395-6_bib0085","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1136\/thorax.55.5.388","article-title":"Clinical investigation of pulmonary Mycobacterium avium complex infection in human T lymphotrophic virus type I carriers","volume":"55","author":"Matsuyama","year":"2000","journal-title":"Thorax"},{"key":"10.1007\/s10156-012-0395-6_bib0090","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1183\/09031936.98.11061227","article-title":"Analysis of BAL fluid in M. avium-intracellulare infection in individuals without predisposing lung disease","volume":"11","author":"Yamazaki","year":"1998","journal-title":"Eur Respir J"},{"key":"10.1007\/s10156-012-0395-6_bib0095","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1093\/jac\/dkh309","article-title":"Macrolide activities beyond their antimicrobial effects: macrolides in diffuse panbronchiolitis and cystic fibrosis","volume":"54","author":"Schultz","year":"2004","journal-title":"J Antimicrob Chemother"},{"key":"10.1007\/s10156-012-0395-6_bib0100","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1164\/ajrccm.152.6.8520783","article-title":"Inflammatory cytokines in cystic fibrosis lungs","volume":"152","author":"Bonfield","year":"1995","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1007\/s10156-012-0395-6_bib0105","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1086\/515597","article-title":"Initial (6-month) results of three-times-weekly azithromycin in treatment regimens for Mycobacterium avium complex lung disease in human immunodeficiency virus-negative patients","volume":"178","author":"Griffith","year":"1998","journal-title":"J Infect Dis"},{"key":"10.1007\/s10156-012-0395-6_bib0110","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1128\/AAC.43.4.907","article-title":"Fourteen-member macrolides inhibit interleukin-8 release by human eosinophilus from atopic donors","volume":"43","author":"Kohyama","year":"1999","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1007\/s10156-012-0395-6_bib0115","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1097\/00005537-199712000-00016","article-title":"Inhibitory effect of macrolide on interleukin-8 secretion from cultured human nasal epithelial cells","volume":"107","author":"Suzuki","year":"1997","journal-title":"Laryngoscope"},{"key":"10.1007\/s10156-012-0395-6_bib0120","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1164\/ajrccm.156.1.9612065","article-title":"Erythromycin modulates IL-8 expression in normal and inflamed human bronchial epithelial cells","volume":"156","author":"Takizawa","year":"1997","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1007\/s10156-012-0395-6_bib0125","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/S1097-2765(02)00708-6","article-title":"The neutrophil lipocalin NGAL is a bacteriostatic agent that interferes with siderophore-mediated iron acquisition","volume":"10","author":"Goetz","year":"2002","journal-title":"Mol Cell"},{"key":"10.1007\/s10156-012-0395-6_bib0130","doi-asserted-by":"crossref","first-page":"8521","DOI":"10.4049\/jimmunol.181.12.8521","article-title":"Lipocalin 2-dependent inhibition of mycobacterial growth in alveolar epithelium","volume":"181","author":"Saige","year":"2008","journal-title":"J Immunol"}],"container-title":["Journal of Infection and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1341321X12702441?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1341321X12702441?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.springerlink.com\/index\/pdf\/10.1007\/s10156-012-0395-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T18:49:28Z","timestamp":1761158968000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1341321X12702441"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":26,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012]]}},"alternative-id":["S1341321X12702441"],"URL":"https:\/\/doi.org\/10.1007\/s10156-012-0395-6","relation":{},"ISSN":["1341-321X"],"issn-type":[{"value":"1341-321X","type":"print"}],"subject":[],"published":{"date-parts":[[2012]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antimicrobial and anti-inflammatory effects of clarithromycin on Mycobacterium avium complex replication in cultured human bronchial epithelial cells","name":"articletitle","label":"Article Title"},{"value":"Journal of Infection and Chemotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1007\/s10156-012-0395-6","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Japanese Society of Chemotherapy and the Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}