{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:29:09Z","timestamp":1786980549335,"version":"build-2736575974"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Exp Nephrol"],"published-print":{"date-parts":[[2015,4]]},"DOI":"10.1007\/s10157-014-0962-5","type":"journal-article","created":{"date-parts":[[2014,3,30]],"date-time":"2014-03-30T22:16:36Z","timestamp":1396217796000},"page":"208-215","source":"Crossref","is-referenced-by-count":20,"title":["Assessment of tubular reabsorption of phosphate as a surrogate marker for phosphate regulation in chronic kidney disease"],"prefix":"10.1007","volume":"19","author":[{"given":"Yu Ah","family":"Hong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Hee","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Young","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaeni","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keun Suk","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byung Ha","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sungjin","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bum Soon","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chul Woo","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Soo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoon Sik","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheol Whee","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,4,1]]},"reference":[{"issue":"7","key":"962_CR1","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1038\/ki.2009.246","volume":"76","author":"T Isakova","year":"2009","unstructured":"Isakova T, Gutierrez OM, Wolf M. A blueprint for randomized trials targeting phosphorus metabolism in chronic kidney disease. Kidney Int. 2009;76(7):705\u201316. doi: 10.1038\/ki.2009.246 .","journal-title":"Kidney Int"},{"issue":"7","key":"962_CR2","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1681\/ASN.2005010052","volume":"16","author":"O Gutierrez","year":"2005","unstructured":"Gutierrez O, Isakova T, Rhee E, Shah A, Holmes J, Collerone G, et al. Fibroblast growth factor-23 mitigates hyperphosphatemia but accentuates calcitriol deficiency in chronic kidney disease. J Am Soc Nephrol JASN. 2005;16(7):2205\u201315. doi: 10.1681\/asn.2005010052 .","journal-title":"J Am Soc Nephrol JASN"},{"issue":"2","key":"962_CR3","doi-asserted-by":"crossref","first-page":"440","DOI":"10.2215\/CJN.05130610","volume":"6","author":"KJ Martin","year":"2011","unstructured":"Martin KJ, Gonzalez EA. Prevention and control of phosphate retention\/hyperphosphatemia in CKD-MBD: what is normal, when to start, and how to treat? Clin J Am Soc Nephrol. 2011;6(2):440\u20136. doi: 10.2215\/cjn.05130610 .","journal-title":"Clin J Am Soc Nephrol"},{"issue":"2","key":"962_CR4","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s00424-011-0950-5","volume":"462","author":"CL Huang","year":"2011","unstructured":"Huang CL, Moe OW. Klotho: a novel regulator of calcium and phosphorus homeostasis. Pflugers Arch. 2011;462(2):185\u201393. doi: 10.1007\/s00424-011-0950-5 .","journal-title":"Pflugers Arch"},{"issue":"1","key":"962_CR5","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1681\/ASN.2009121311","volume":"22","author":"MC Hu","year":"2011","unstructured":"Hu MC, Shi M, Zhang J, Quinones H, Griffith C, Kuro-o M, et al. Klotho deficiency causes vascular calcification in chronic kidney disease. J Am Soc Nephrol JASN. 2011;22(1):124\u201336. doi: 10.1681\/asn.2009121311 .","journal-title":"J Am Soc Nephrol JASN"},{"issue":"5","key":"962_CR6","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1007\/s10157-012-0621-7","volume":"16","author":"Y Shimamura","year":"2012","unstructured":"Shimamura Y, Hamada K, Inoue K, Ogata K, Ishihara M, Kagawa T, et al. Serum levels of soluble secreted alpha-Klotho are decreased in the early stages of chronic kidney disease, making it a probable novel biomarker for early diagnosis. Clin Exp Nephrol. 2012;16(5):722\u20139. doi: 10.1007\/s10157-012-0621-7 .","journal-title":"Clin Exp Nephrol"},{"issue":"Pt 2","key":"962_CR7","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1177\/000456329803500203","volume":"35","author":"RB Payne","year":"1998","unstructured":"Payne RB. Renal tubular reabsorption of phosphate (TmP\/GFR): indications and interpretation. Ann Clin Biochem. 1998;35(Pt 2):201\u20136.","journal-title":"Ann Clin Biochem"},{"key":"962_CR8","doi-asserted-by":"crossref","unstructured":"Walton Rj, Fau-Bijvoet OL, Bijvoet OL. Nomogram for derivation of renal threshold phosphate concentration. Lancet. 1975;2(7929):309\u201310.","DOI":"10.1016\/S0140-6736(75)92736-1"},{"issue":"12","key":"962_CR9","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1038\/ki.2011.47","volume":"79","author":"T Isakova","year":"2011","unstructured":"Isakova T, Wahl P, Vargas GS, Gutierrez OM, Scialla J, Xie H, et al. Fibroblast growth factor 23 is elevated before parathyroid hormone and phosphate in chronic kidney disease. Kidney Int. 2011;79(12):1370\u20138. doi: 10.1038\/ki.2011.47 .","journal-title":"Kidney Int"},{"issue":"1","key":"962_CR10","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/sj.ki.5002009","volume":"71","author":"A Levin","year":"2007","unstructured":"Levin A, Bakris GL, Molitch M, Smulders M, Tian J, Williams LA, et al. Prevalence of abnormal serum vitamin D, PTH, calcium, and phosphorus in patients with chronic kidney disease: results of the study to evaluate early kidney disease. Kidney Int. 2007;71(1):31\u20138. doi: 10.1038\/sj.ki.5002009 .","journal-title":"Kidney Int"},{"issue":"2","key":"962_CR11","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1093\/ndt\/gfq419","volume":"26","author":"T Isakova","year":"2011","unstructured":"Isakova T, Gutierrez OM, Smith K, Epstein M, Keating LK, Juppner H, et al. Pilot study of dietary phosphorus restriction and phosphorus binders to target fibroblast growth factor 23 in patients with chronic kidney disease. Nephrol Dial Transplant. 2011;26(2):584\u201391. doi: 10.1093\/ndt\/gfq419 .","journal-title":"Nephrol Dial Transplant"},{"issue":"2","key":"962_CR12","doi-asserted-by":"crossref","first-page":"286","DOI":"10.2215\/CJN.05420709","volume":"5","author":"RB Oliveira","year":"2010","unstructured":"Oliveira RB, Cancela AL, Graciolli FG, Dos Reis LM, Draibe SA, Cuppari L, et al. Early control of PTH and FGF23 in normophosphatemic CKD patients: a new target in CKD-MBD therapy? Clin J Am Soc Nephrol. 2010;5(2):286\u201391. doi: 10.2215\/cjn.05420709 .","journal-title":"Clin J Am Soc Nephrol"},{"issue":"9","key":"962_CR13","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1038\/sj.ki.5001813","volume":"70","author":"IC Forster","year":"2006","unstructured":"Forster IC, Hernando N, Biber J, Murer H. Proximal tubular handling of phosphate: a molecular perspective. Kidney Int. 2006;70(9):1548\u201359. doi: 10.1038\/sj.ki.5001813 .","journal-title":"Kidney Int"},{"issue":"8","key":"962_CR14","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1172\/JCI105877","volume":"47","author":"E Slatopolsky","year":"1968","unstructured":"Slatopolsky E, Robson AM, Elkan I, Bricker NS. Control of phosphate excretion in uremic man. J Clin Invest. 1968;47(8):1865\u201374. doi: 10.1172\/jci105877 .","journal-title":"J Clin Invest"},{"issue":"12","key":"962_CR15","doi-asserted-by":"crossref","first-page":"3820","DOI":"10.1172\/JCI36479","volume":"118","author":"LD Quarles","year":"2008","unstructured":"Quarles LD. Endocrine functions of bone in mineral metabolism regulation. J Clin Invest. 2008;118(12):3820\u20138. doi: 10.1172\/jci36479 .","journal-title":"J Clin Invest"},{"issue":"9","key":"962_CR16","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1016\/j.yexcr.2012.02.027","volume":"318","author":"LD Quarles","year":"2012","unstructured":"Quarles LD. Role of FGF23 in vitamin D and phosphate metabolism: implications in chronic kidney disease. Exp Cell Res. 2012;318(9):1040\u20138. doi: 10.1016\/j.yexcr.2012.02.027 .","journal-title":"Exp Cell Res"},{"key":"962_CR17","author":"OM Kuro","year":"2013","unstructured":"Kuro OM. Klotho, phosphate and FGF-23 in ageing and disturbed mineral metabolism. Nat Rev Nephrol. 2013;. doi: 10.1038\/nrneph.2013.111 .","journal-title":"Nat Rev Nephrol"},{"issue":"5","key":"962_CR18","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1681\/ASN.2005111185","volume":"17","author":"S Liu","year":"2006","unstructured":"Liu S, Tang W, Zhou J, Stubbs JR, Luo Q, Pi M, et al. Fibroblast growth factor 23 is a counter-regulatory phosphaturic hormone for vitamin D. J Am Soc Nephrol JASN. 2006;17(5):1305\u201315. doi: 10.1681\/asn.2005111185 .","journal-title":"J Am Soc Nephrol JASN"},{"issue":"5","key":"962_CR19","doi-asserted-by":"crossref","first-page":"F1088","DOI":"10.1152\/ajprenal.00474.2004","volume":"289","author":"T Shimada","year":"2005","unstructured":"Shimada T, Yamazaki Y, Takahashi M, Hasegawa H, Urakawa I, Oshima T, et al. Vitamin D receptor-independent FGF23 actions in regulating phosphate and vitamin D metabolism. Am J Physiol Renal Physiol. 2005;289(5):F1088\u201395. doi: 10.1152\/ajprenal.00474.2004 .","journal-title":"Am J Physiol Renal Physiol"},{"issue":"Suppl 16","key":"962_CR20","first-page":"S136","volume":"23","author":"MC Hu","year":"2010","unstructured":"Hu MC, Kuro-o M, Moe OW. Klotho and kidney disease. J Nephrol. 2010;23(Suppl 16):S136\u201344.","journal-title":"J Nephrol"},{"issue":"5","key":"962_CR21","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1093\/ndt\/gfr645","volume":"27","author":"H Komaba","year":"2012","unstructured":"Komaba H, Koizumi M, Tanaka H, Takahashi H, Sawada K, Kakuta T, et al. Effects of cinacalcet treatment on serum soluble Klotho levels in haemodialysis patients with secondary hyperparathyroidism. Nephrol Dial Transplant. 2012;27(5):1967\u20139. doi: 10.1093\/ndt\/gfr645 .","journal-title":"Nephrol Dial Transplant"},{"issue":"11","key":"962_CR22","doi-asserted-by":"crossref","first-page":"4393","DOI":"10.1172\/JCI46122","volume":"121","author":"C Faul","year":"2011","unstructured":"Faul C, Amaral AP, Oskouei B, Hu MC, Sloan A, Isakova T, et al. FGF23 induces left ventricular hypertrophy. J Clin Invest. 2011;121(11):4393\u2013408. doi: 10.1172\/jci46122 .","journal-title":"J Clin Invest"},{"key":"962_CR23","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1186\/1471-2369-13-155","volume":"13","author":"T Akimoto","year":"2012","unstructured":"Akimoto T, Yoshizawa H, Watanabe Y, Numata A, Yamazaki T, Takeshima E, et al. Characteristics of urinary and serum soluble Klotho protein in patients with different degrees of chronic kidney disease. BMC Nephrol. 2012;13:155. doi: 10.1186\/1471-2369-13-155 .","journal-title":"BMC Nephrol"},{"issue":"2","key":"962_CR24","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.ijcard.2007.02.029","volume":"123","author":"N Kuwahara","year":"2008","unstructured":"Kuwahara N, Sasaki S, Kobara M, Nakata T, Tatsumi T, Irie H, et al. HMG-CoA reductase inhibition improves anti-aging klotho protein expression and arteriosclerosis in rats with chronic inhibition of nitric oxide synthesis. Int J Cardiol. 2008;123(2):84\u201390. doi: 10.1016\/j.ijcard.2007.02.029 .","journal-title":"Int J Cardiol"},{"key":"962_CR25","author":"SC Lim","year":"2013","unstructured":"Lim SC, Liu JJ, Subramaniam T, Sum CF. Elevated circulating alpha-klotho by angiotensin II receptor blocker losartan is associated with reduction of albuminuria in type 2 diabetic patients. J Renin Angiotensin Aldosterone Syst JRAAS. 2013;. doi: 10.1177\/1470320313475905 .","journal-title":"J Renin Angiotensin Aldosterone Syst JRAAS"}],"container-title":["Clinical and Experimental Nephrology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10157-014-0962-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10157-014-0962-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10157-014-0962-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T06:44:41Z","timestamp":1559112281000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10157-014-0962-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4,1]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["962"],"URL":"https:\/\/doi.org\/10.1007\/s10157-014-0962-5","relation":{},"ISSN":["1342-1751","1437-7799"],"issn-type":[{"value":"1342-1751","type":"print"},{"value":"1437-7799","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4,1]]}}}