{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T12:52:28Z","timestamp":1778849548894,"version":"3.51.4"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2014,9,13]],"date-time":"2014-09-13T00:00:00Z","timestamp":1410566400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Exp Nephrol"],"published-print":{"date-parts":[[2015,8]]},"DOI":"10.1007\/s10157-014-1029-3","type":"journal-article","created":{"date-parts":[[2014,9,12]],"date-time":"2014-09-12T11:26:23Z","timestamp":1410521183000},"page":"567-575","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Deficiency of endothelial nitric oxide signaling pathway exacerbates peritoneal fibrosis in mice"],"prefix":"10.1007","volume":"19","author":[{"given":"Hiroyuki","family":"Kadoya","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minoru","family":"Satoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hajime","family":"Nagasu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamaki","family":"Sasaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Kashihara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,9,13]]},"reference":[{"key":"1029_CR1","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1056\/NEJM199805143382006","volume":"338","author":"S Pastan","year":"1998","unstructured":"Pastan S, Bailey J. Dialysis therapy. N Engl J Med. 1998;338:1428\u201337.","journal-title":"N Engl J Med."},{"key":"1029_CR2","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/S0140-6736(98)09410-0","volume":"353","author":"R Gokal","year":"1999","unstructured":"Gokal R, Mallick NP. Peritoneal dialysis. Lancet. 1999;353:823\u20138.","journal-title":"Lancet."},{"key":"1029_CR3","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1681\/ASN.V132470","volume":"13","author":"JD Williams","year":"2002","unstructured":"Williams JD, Craig KJ, Topley N, Von Ruhland C, Fallon M, Newman GR, Mackenzie RK, Williams GT. Morphologic changes in the peritoneal membrane of patients with renal disease. J Am Soc Nephrol. 2002;13:470\u20139.","journal-title":"J Am Soc Nephrol."},{"key":"1029_CR4","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1161\/01.ATV.0000051384.43104.FC","volume":"23","author":"PO Bonetti","year":"2003","unstructured":"Bonetti PO, Lerman LO, Lerman A. Endothelial dysfunction: a marker of atherosclerotic risk. Arterioscler Thromb Vasc Biol. 2003;23:168\u201375.","journal-title":"Arterioscler Thromb Vasc Biol."},{"key":"1029_CR5","doi-asserted-by":"crossref","first-page":"3877","DOI":"10.4049\/jimmunol.144.10.3877","volume":"144","author":"JE Albina","year":"1990","unstructured":"Albina JE, Mills CD, Henry WL Jr, Caldwell MD. Temporal expression of different pathways of 1-arginine metabolism in healing wounds. J Immunol. 1990;144:3877\u201380.","journal-title":"J Immunol."},{"key":"1029_CR6","first-page":"H1600","volume":"277","author":"PC Lee","year":"1999","unstructured":"Lee PC, Salyapongse AN, Bragdon GA, Shears LL 2nd, Watkins SC, Edington HD, Billiar TR. Impaired wound healing and angiogenesis in eNOS-deficient mice. Am J Physiol. 1999;277:H1600\u20138.","journal-title":"Am J Physiol."},{"key":"1029_CR7","doi-asserted-by":"crossref","first-page":"2484","DOI":"10.1161\/01.CIR.0000137969.87365.05","volume":"110","author":"JD Luo","year":"2004","unstructured":"Luo JD, Wang YY, Fu WL, Wu J, Chen AF. Gene therapy of endothelial nitric oxide synthase and manganese superoxide dismutase restores delayed wound healing in type 1 diabetic mice. Circulation. 2004;110:2484\u201393.","journal-title":"Circulation."},{"key":"1029_CR8","doi-asserted-by":"crossref","first-page":"E1423","DOI":"10.1152\/ajpendo.00150.2009","volume":"296","author":"L Tie","year":"2009","unstructured":"Tie L, Li XJ, Wang X, Channon KM, Chen AF. Endothelium-specific GTP cyclohydrolase I overexpression accelerates refractory wound healing by suppressing oxidative stress in diabetes. Am J Physiol Endocrinol Metab. 2009;296:E1423\u20139.","journal-title":"Am J Physiol Endocrinol Metab."},{"key":"1029_CR9","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/j.lfs.2012.04.018","volume":"90","author":"D Sun","year":"2012","unstructured":"Sun D, Wang Y, Liu C, Zhou X, Li X, Xiao A. Effects of nitric oxide on renal interstitial fibrosis in rats with unilateral ureteral obstruction. Life Sci. 2012;90:900\u20139.","journal-title":"Life Sci."},{"key":"1029_CR10","doi-asserted-by":"crossref","unstructured":"Kazakov A, Hall R, Jagoda P, Bachelier K, Muller-Best P, Semenov A, Lammert F, Bohm M, Laufs U. Inhibition of endothelial nitric oxide synthase induces and enhances myocardial fibrosis. Cardiovasc Res. 2013.","DOI":"10.1093\/cvr\/cvt181"},{"key":"1029_CR11","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1093\/ndt\/13.7.1782","volume":"13","author":"C Guldener van","year":"1998","unstructured":"van Guldener C, Janssen MJ, Lambert J, Steyn M, Donker AJ, Stehouwer CD. Endothelium-dependent vasodilatation is impaired in peritoneal dialysis patients. Nephrol Dial Transplant. 1998;13:1782\u20136.","journal-title":"Nephrol Dial Transplant."},{"key":"1029_CR12","doi-asserted-by":"crossref","first-page":"13176","DOI":"10.1073\/pnas.93.23.13176","volume":"93","author":"EG Shesely","year":"1996","unstructured":"Shesely EG, Maeda N, Kim HS, Desai KM, Krege JH, Laubach VE, Sherman PA, Sessa WC, Smithies O. Elevated blood pressures in mice lacking endothelial nitric oxide synthase. Proc Natl Acad Sci U S A. 1996;93:13176\u201381.","journal-title":"Proc Natl Acad Sci U S A."},{"key":"1029_CR13","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1093\/ndt\/gfp601","volume":"25","author":"T Miyamoto","year":"2010","unstructured":"Miyamoto T, Tamura M, Kabashima N, Serino R, Shibata T, Furuno Y, Miyazaki M, Baba R, Sato N, Doi Y, Okazaki M, Otsuji Y. An integrin-activating peptide, PHSRN, ameliorates inhibitory effects of conventional peritoneal dialysis fluids on peritoneal wound healing. Nephrol Dial Transplant. 2010;25:1109\u201319.","journal-title":"Nephrol Dial Transplant."},{"key":"1029_CR14","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1038\/ki.2012.475","volume":"83","author":"Y Nishi","year":"2013","unstructured":"Nishi Y, Satoh M, Nagasu H, Kadoya H, Ihoriya C, Kidokoro K, Sasaki T, Kashihara N. Selective estrogen receptor modulation attenuates proteinuria-induced renal tubular damage by modulating mitochondrial oxidative status. Kidney Int. 2013;83:662\u201373.","journal-title":"Kidney Int."},{"key":"1029_CR15","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/1465-9921-13-62","volume":"13","author":"T Meuten","year":"2012","unstructured":"Meuten T, Hickey A, Franklin K, Grossi B, Tobias J, Newman DR, Jennings SH, Correa M, Sannes PL. WNT7B in fibroblastic foci of idiopathic pulmonary fibrosis. Respir Res. 2012;13:62.","journal-title":"Respir Res."},{"key":"1029_CR16","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1111\/j.1440-1746.2007.05250.x","volume":"23","author":"YD Kim","year":"2008","unstructured":"Kim YD, Park CH, Kim HS, Choi SK, Rew JS, Kim DY, Koh YS, Jeung KW, Lee KH, Lee JS, Juhng SW, Lee JH. Genetic alterations of Wnt signaling pathway-associated genes in hepatocellular carcinoma. J Gastroenterol Hepatol. 2008;23:110\u20138.","journal-title":"J Gastroenterol Hepatol."},{"key":"1029_CR17","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1158\/1535-7163.MCT-13-0048","volume":"12","author":"N Li","year":"2013","unstructured":"Li N, Xi Y, Tinsley HN, Gurpinar E, Gary BD, Zhu B, Li Y, Chen X, Keeton AB, Abadi AH, Moyer MP, Grizzle WE, Chang WC, Clapper ML, Piazza GA. Sulindac selectively inhibits colon tumor cell growth by activating the cGMP\/PKG pathway to suppress Wnt\/beta-catenin signaling. Mol Cancer Ther. 2013;12:1848\u201359.","journal-title":"Mol Cancer Ther."},{"key":"1029_CR18","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1161\/01.CIR.0000014928.45119.73","volume":"105","author":"JP Cooke","year":"2002","unstructured":"Cooke JP, Losordo DW. Nitric oxide and angiogenesis. Circulation. 2002;105:2133\u20135.","journal-title":"Circulation."},{"key":"1029_CR19","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1161\/01.ATV.0000254684.80662.44","volume":"27","author":"O Dumont","year":"2007","unstructured":"Dumont O, Loufrani L, Henrion D. Key role of the NO-pathway and matrix metalloprotease-9 in high blood flow-induced remodeling of rat resistance arteries. Arterioscler Thromb Vasc Biol. 2007;27:317\u201324.","journal-title":"Arterioscler Thromb Vasc Biol."},{"key":"1029_CR20","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1080\/110241599750007153","volume":"165","author":"MR Schaffer","year":"1999","unstructured":"Schaffer MR, Tantry U, Thornton FJ, Barbul A. Inhibition of nitric oxide synthesis in wounds: pharmacology and effect on accumulation of collagen in wounds in mice. Eur J Surg. 1999;165:262\u20137.","journal-title":"Eur J Surg."},{"key":"1029_CR21","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1111\/j.1600-0560.2006.00472.x","volume":"33","author":"TP Amadeu","year":"2006","unstructured":"Amadeu TP, Costa AM. Nitric oxide synthesis inhibition alters rat cutaneous wound healing. J Cutan Pathol. 2006;33:465\u201373.","journal-title":"J Cutan Pathol."},{"key":"1029_CR22","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1056\/NEJM199909023411006","volume":"341","author":"AJ Singer","year":"1999","unstructured":"Singer AJ, Clark RA. Cutaneous wound healing. N Engl J Med. 1999;341:738\u201346.","journal-title":"N Engl J Med."},{"key":"1029_CR23","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/S0039-6109(05)70566-1","volume":"77","author":"MB Witte","year":"1997","unstructured":"Witte MB, Barbul A. General principles of wound healing. Surg Clin North Am. 1997;77:509\u201328.","journal-title":"Surg Clin North Am."},{"key":"1029_CR24","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.jss.2007.10.015","volume":"149","author":"TP Amadeu","year":"2008","unstructured":"Amadeu TP, Seabra AB, de Oliveira MG, Monte-Alto-Costa A. Nitric oxide donor improves healing if applied on inflammatory and proliferative phase. J Surg Res. 2008;149:84\u201393.","journal-title":"J Surg Res."},{"key":"1029_CR25","doi-asserted-by":"crossref","first-page":"C1","DOI":"10.1111\/j.1469-7793.1999.001af.x","volume":"277","author":"DW Powell","year":"1999","unstructured":"Powell DW, Mifflin RC, Valentich JD, Crowe SE, Saada JI, West AB. Myofibroblasts. I. Paracrine cells important in health and disease. Am J Physiol. 1999;277:C1\u20139.","journal-title":"Am J Physiol."},{"key":"1029_CR26","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/BF03403533","volume":"1","author":"R Bucala","year":"1994","unstructured":"Bucala R, Spiegel LA, Chesney J, Hogan M, Cerami A. Circulating fibrocytes define a new leukocyte subpopulation that mediates tissue repair. Mol Med. 1994;1:71\u201381.","journal-title":"Mol Med."},{"key":"1029_CR27","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1172\/JCI200320530","volume":"112","author":"R Kalluri","year":"2003","unstructured":"Kalluri R, Neilson EG. Epithelial-mesenchymal transition and its implications for fibrosis. J Clin Invest. 2003;112:1776\u201384.","journal-title":"J Clin Invest."},{"key":"1029_CR28","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1097\/00005344-199912000-00016","volume":"34","author":"LJ Ignarro","year":"1999","unstructured":"Ignarro LJ, Cirino G, Casini A, Napoli C. Nitric oxide as a signaling molecule in the vascular system: an overview. J Cardiovasc Pharmacol. 1999;34:879\u201386.","journal-title":"J Cardiovasc Pharmacol."},{"key":"1029_CR29","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1124\/jpet.106.108878","volume":"319","author":"A Pyriochou","year":"2006","unstructured":"Pyriochou A, Beis D, Koika V, Potytarchou C, Papadimitriou E, Zhou Z, Papapetropoulos A. Soluble guanylyl cyclase activation promotes angiogenesis. J Pharmacol Exp Ther. 2006;319:663\u201371.","journal-title":"J Pharmacol Exp Ther."},{"key":"1029_CR30","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1124\/jpet.113.205484","volume":"346","author":"S Kotzki","year":"2013","unstructured":"Kotzki S, Roustit M, Arnaud C, Boutonnat J, Blaise S, Godin-Ribuot D, Cracowski JL. Anodal iontophoresis of a soluble guanylate cyclase stimulator induces a sustained increase in skin blood flow in rats. J Pharmacol Exp Ther. 2013;346:424\u201331.","journal-title":"J Pharmacol Exp Ther."},{"key":"1029_CR31","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1136\/annrheumdis-2011-200862","volume":"71","author":"C Beyer","year":"2012","unstructured":"Beyer C, Reich N, Schindler SC, Akhmetshina A, Dees C, Tomcik M, Hirth-Dietrich C, von Degenfeld G, Sandner P, Distler O, Schett G, Distler JH. Stimulation of soluble guanylate cyclase reduces experimental dermal fibrosis. Ann Rheum Dis. 2012;71:1019\u201326.","journal-title":"Ann Rheum Dis."},{"key":"1029_CR32","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1056\/NEJMoa1209657","volume":"369","author":"HA Ghofrani","year":"2013","unstructured":"Ghofrani HA, D\u2019Armini AM, Grimminger F, Hoeper MM, Jansa P, Kim NH, Mayer E, Simonneau G, Wilkins MR, Fritsch A, Neuser D, Weimann G, Wang C. Riociguat for the treatment of chronic thromboembolic pulmonary hypertension. N Engl J Med. 2013;369:319\u201329.","journal-title":"N Engl J Med."},{"key":"1029_CR33","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1093\/ndt\/16.6.1262","volume":"16","author":"Y Ishii","year":"2001","unstructured":"Ishii Y, Sawada T, Shimizu A, Tojimbara T, Nakajima I, Fuchinoue S, Teraoka S. An experimental sclerosing encapsulating peritonitis model in mice. Nephrol Dial Transplant. 2001;16:1262\u20136.","journal-title":"Nephrol Dial Transplant."},{"issue":"Suppl 5","key":"1029_CR34","doi-asserted-by":"crossref","first-page":"S21","DOI":"10.1177\/089686080802805S05","volume":"28","author":"SH Park","year":"2008","unstructured":"Park SH, Kim YL, Lindholm B. Experimental encapsulating peritoneal sclerosis models: pathogenesis and treatment. Perit Dial Int. 2008;28(Suppl 5):S21\u20138.","journal-title":"Perit Dial Int."},{"key":"1029_CR35","doi-asserted-by":"crossref","first-page":"3831","DOI":"10.1093\/ndt\/gfn369","volume":"23","author":"KY Hung","year":"2008","unstructured":"Hung KY, Huang JW, Chiang CK, Tsai TJ. Preservation of peritoneal morphology and function by pentoxifylline in a rat model of peritoneal dialysis: molecular studies. Nephrol Dial Transplant. 2008;23:3831\u201340.","journal-title":"Nephrol Dial Transplant."},{"key":"1029_CR36","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1038\/nrneph.2012.144","volume":"8","author":"A Pletinck","year":"2012","unstructured":"Pletinck A, Vanholder R, Veys N, Van Biesen W. Protecting the peritoneal membrane: factors beyond peritoneal dialysis solutions. Nat Rev Nephrol. 2012;8:542\u201350.","journal-title":"Nat Rev Nephrol."},{"issue":"Suppl 2","key":"1029_CR37","doi-asserted-by":"crossref","first-page":"S19","DOI":"10.1177\/089686080002002S05","volume":"20","author":"RT Krediet","year":"2000","unstructured":"Krediet RT, Zweers MM, van der Wal AC, Struijk DG. Neoangiogenesis in the peritoneal membrane. Perit Dial Int. 2000;20(Suppl 2):S19\u201325.","journal-title":"Perit Dial Int."},{"key":"1029_CR38","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1093\/ndt\/gfl054","volume":"21","author":"AM Sherif","year":"2006","unstructured":"Sherif AM, Nakayama M, Maruyama Y, Yoshida H, Yamamoto H, Yokoyama K, Kawakami M. Quantitative assessment of the peritoneal vessel density and vasculopathy in CAPD patients. Nephrol Dial Transplant. 2006;21:1675\u201381.","journal-title":"Nephrol Dial Transplant."},{"key":"1029_CR39","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1177\/089686080302300604","volume":"23","author":"PJ Margetts","year":"2003","unstructured":"Margetts PJ, Bonniaud P. Basic mechanisms and clinical implications of peritoneal fibrosis. Perit Dial Int. 2003;23:530\u201341.","journal-title":"Perit Dial Int."}],"container-title":["Clinical and Experimental Nephrology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10157-014-1029-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10157-014-1029-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10157-014-1029-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,16]],"date-time":"2023-07-16T14:31:50Z","timestamp":1689517910000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10157-014-1029-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,13]]},"references-count":39,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["1029"],"URL":"https:\/\/doi.org\/10.1007\/s10157-014-1029-3","relation":{},"ISSN":["1342-1751","1437-7799"],"issn-type":[{"value":"1342-1751","type":"print"},{"value":"1437-7799","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,13]]}}}