{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:02:22Z","timestamp":1787061742110,"version":"build-2736575974"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2016,6,25]],"date-time":"2016-06-25T00:00:00Z","timestamp":1466812800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Exp Nephrol"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1007\/s10157-016-1301-9","type":"journal-article","created":{"date-parts":[[2016,6,26]],"date-time":"2016-06-26T07:39:05Z","timestamp":1466926745000},"page":"398-406","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["High serum level of methylglyoxal-derived AGE, N\u03b4-(5-hydro-5-methyl-4-imidazolone-2-yl)-ornithine, independently relates to renal dysfunction"],"prefix":"10.1007","volume":"21","author":[{"given":"Kenji","family":"Ito","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriyuki","family":"Sakata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryoji","family":"Nagai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-ichi","family":"Shirakawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maho","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayako","family":"Mimata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Abe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuhiko","family":"Yasuno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshie","family":"Sasatomi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuhisa","family":"Miyake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoko","family":"Ueki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aki","family":"Hamauchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Nakashima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,6,25]]},"reference":[{"issue":"6865","key":"1301_CR1","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1038\/414813a","volume":"414","author":"M Brownlee","year":"2001","unstructured":"Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature. 2001;414(6865):813\u201320.","journal-title":"Nature"},{"issue":"1","key":"1301_CR2","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s11892-004-0008-6","volume":"4","author":"M Peppa","year":"2004","unstructured":"Peppa M, Uribarri J, Vlassara H. The role of advanced glycation end products in the development of atherosclerosis. Curr Diabetes Rep. 2004;4(1):31\u20136.","journal-title":"Curr Diabetes Rep."},{"issue":"Pt 1","key":"1301_CR3","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1042\/bj3440109","volume":"344","author":"PJ Thornalley","year":"1999","unstructured":"Thornalley PJ, Langborg A, Minhas HS. Formation of glyoxal, methylglyoxal and 3-deoxyglucosone in the glycation of proteins by glucose. Biochem J. 1999;344(Pt 1):109\u201316.","journal-title":"Biochem J."},{"issue":"9","key":"1301_CR4","doi-asserted-by":"crossref","first-page":"2833","DOI":"10.2337\/diabetes.51.9.2833","volume":"51","author":"R Nagai","year":"2002","unstructured":"Nagai R, Unno Y, Hayashi MC, Masuda S, Hayase F, Kinae N et al. Peroxynitrite induces formation of N(epsilon)-(carboxymethyl) lysine by the cleavage of Amadori product and generation of glucosone and glyoxal from glucose: novel pathways for protein modification by peroxynitrite. Diabetes. 2002;51(9):2833\u20139.","journal-title":"Diabetes."},{"issue":"50","key":"1301_CR5","doi-asserted-by":"crossref","first-page":"48905","DOI":"10.1074\/jbc.M205688200","volume":"277","author":"R Nagai","year":"2002","unstructured":"Nagai R, Hayashi CM, Xia L, Takeya M, Horiuchi S. Identification in human atherosclerotic lesions of GA-pyridine, a novel structure derived from glycolaldehyde-modified proteins. J Biol Chem. 2002;277(50):48905\u201312.","journal-title":"J Biol Chem"},{"issue":"2","key":"1301_CR6","doi-asserted-by":"publisher","first-page":"1374","DOI":"10.1074\/jbc.M110.144097","volume":"286","author":"O Brouwers","year":"2011","unstructured":"Brouwers O, Niessen PM, Ferreira I, Miyata T, Scheffer PG, Teerlink T et al. Overexpression of glyoxalase-I reduces hyperglycemia-induced levels of advanced glycation end products and oxidative stress in diabetic rats. J Biol Chem. 2011;286(2):1374\u201380. doi:\n                        10.1074\/jbc.M110.144097\n                        \n                    .","journal-title":"J Biol Chem"},{"issue":"2","key":"1301_CR7","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/ki.1995.322","volume":"48","author":"H Makino","year":"1995","unstructured":"Makino H, Shikata K, Hironaka K, Kushiro M, Yamasaki Y, Sugimoto H et al. Ultrastructure of nonenzymatically glycated mesangial matrix in diabetic nephropathy. Kidney Int. 1995;48(2):517\u201326.","journal-title":"Kidney Int"},{"issue":"3","key":"1301_CR8","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1007\/s12020-012-9795-8","volume":"43","author":"P Matafome","year":"2013","unstructured":"Matafome P, Sena C, Seica R. Methylglyoxal, obesity, and diabetes. Endocrine. 2013;43(3):472\u201384. doi:\n                        10.1007\/s12020-012-9795-8\n                        \n                    .","journal-title":"Endocrine"},{"issue":"2","key":"1301_CR9","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1042\/BST20140001","volume":"42","author":"NM Hanssen","year":"2014","unstructured":"Hanssen NM, Stehouwer CD, Schalkwijk CG. Methylglyoxal and glyoxalase I in atherosclerosis. Biochem Soc Trans. 2014;42(2):443\u20139. doi:\n                        10.1042\/BST20140001\n                        \n                    .","journal-title":"Biochem Soc Trans"},{"issue":"1","key":"1301_CR10","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1093\/gerona\/gls100","volume":"68","author":"V Srikanth","year":"2013","unstructured":"Srikanth V, Westcott B, Forbes J, Phan TG, Beare R, Venn A et al. Methylglyoxal, cognitive function and cerebral atrophy in older people. J Gerontol A Biol Sci Med Sci. 2013;68(1):68\u201373. doi:\n                        10.1093\/gerona\/gls100\n                        \n                    .","journal-title":"J Gerontol Ser A Biol Sci Med Sci"},{"issue":"4","key":"1301_CR11","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/j.clinbiochem.2010.11.004","volume":"44","author":"J Lu","year":"2011","unstructured":"Lu J, Randell E, Han Y, Adeli K, Krahn J, Meng QH. Increased plasma methylglyoxal level, inflammation, and vascular endothelial dysfunction in diabetic nephropathy. Clin Biochem. 2011;44(4):307\u201311. doi:\n                        10.1016\/j.clinbiochem.2010.11.004\n                        \n                    .","journal-title":"Clin Biochem"},{"issue":"26","key":"1301_CR12","doi-asserted-by":"crossref","first-page":"18492","DOI":"10.1074\/jbc.274.26.18492","volume":"274","author":"T Oya","year":"1999","unstructured":"Oya T, Hattori N, Mizuno Y, Miyata S, Maeda S, Osawa T et al. Methylglyoxal modification of protein. Chemical and immunochemical characterization of methylglyoxal-arginine adducts. J Biol Chem. 1999;274(26):18492\u2013502.","journal-title":"J Biol Chem"},{"issue":"12","key":"1301_CR13","doi-asserted-by":"crossref","first-page":"5287","DOI":"10.1167\/iovs.03-0573","volume":"44","author":"N Ahmed","year":"2003","unstructured":"Ahmed N, Thornalley PJ, Dawczynski J, Franke S, Strobel J, Stein G et al. Methylglyoxal-derived hydroimidazolone advanced glycation end-products of human lens proteins. Invest Ophthalmol Vis Sci. 2003;44(12):5287\u201392.","journal-title":"Investig Ophthalmol Vis Sci"},{"issue":"10","key":"1301_CR14","doi-asserted-by":"publisher","first-page":"3234","DOI":"10.2337\/dc12-2689","volume":"36","author":"PJ Beisswenger","year":"2013","unstructured":"Beisswenger PJ, Howell SK, Russell GB, Miller ME, Rich SS, Mauer M. Early progression of diabetic nephropathy correlates with methylglyoxal-derived advanced glycation end products. Diabetes Care. 2013;36(10):3234\u20139. doi:\n                        10.2337\/dc12-2689\n                        \n                    .","journal-title":"Diabetes Care"},{"issue":"2","key":"1301_CR15","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.vascn.2004.08.005","volume":"51","author":"EW Randell","year":"2005","unstructured":"Randell EW, Vasdev S, Gill V. Measurement of methylglyoxal in rat tissues by electrospray ionization mass spectrometry and liquid chromatography. J Pharmacol Toxicol Methods. 2005;51(2):153\u20137.","journal-title":"J Pharmacol Toxicol Methods"},{"issue":"5","key":"1301_CR16","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1111\/j.2040-1124.2010.00074.x","volume":"1","author":"Y Seino","year":"2010","unstructured":"Seino Y, Nanjo K, Tajima N, Kadowaki T, Kashiwagi A, Araki E et al. Report of the committee on the classification and diagnostic criteria of diabetes mellitus. J Diabetes Investig. 2010;1(5):212\u201328. doi:\n                        10.1111\/j.2040-1124.2010.00074.x\n                        \n                    .","journal-title":"J Diabetes Investig"},{"issue":"6","key":"1301_CR17","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1053\/j.ajkd.2008.12.034","volume":"53","author":"S Matsuo","year":"2009","unstructured":"Matsuo S, Imai E, Horio M, Yasuda Y, Tomita K, Nitta K et al. Revised equations for estimated GFR from serum creatinine in Japan. Am J Kidney Dis. 2009;53(6):982\u201392. doi:\n                        10.1053\/j.ajkd.2008.12.034\n                        \n                    .","journal-title":"Am J Kidney Dis."},{"issue":"3","key":"1301_CR18","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1111\/acel.12204","volume":"13","author":"A Jo-Watanabe","year":"2014","unstructured":"Jo-Watanabe A, Ohse T, Nishimatsu H, Takahashi M, Ikeda Y, Wada T et al. Glyoxalase I reduces glycative and oxidative stress and prevents age-related endothelial dysfunction through modulation of endothelial nitric oxide synthase phosphorylation. Aging Cell. 2014;13(3):519\u201328. doi:\n                        10.1111\/acel.12204\n                        \n                    .","journal-title":"Aging Cell."},{"key":"1301_CR19","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.1007\/s00726-011-1180-z","volume":"44","author":"M Nakano","year":"2013","unstructured":"Nakano M, Kubota M, Owada S, Nagai R. The pentosidine concentration in human blood specimens is affected by heating. Amino Acids. 2013;44:1451\u20136. doi:\n                        10.1007\/s00726-011-1180-z\n                        \n                    .","journal-title":"Amino Acids"},{"issue":"38","key":"1301_CR20","doi-asserted-by":"publisher","first-page":"25772","DOI":"10.1074\/jbc.M109.019257","volume":"284","author":"N Frizzell","year":"2009","unstructured":"Frizzell N, Rajesh M, Jepson MJ, Nagai R, Carson JA, Thorpe SR et al. Succination of thiol groups in adipose tissue proteins in diabetes: succination inhibits polymerization and secretion of adiponectin. J Biol Chem. 2009;284(38):25772\u201381. doi:\n                        10.1074\/jbc.M109.019257\n                        \n                    .","journal-title":"J Biol Chem"},{"issue":"1","key":"1301_CR21","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1042\/cs0870021","volume":"87","author":"AC McLellan","year":"1994","unstructured":"McLellan AC, Thornalley PJ, Benn J, Sonksen PH. Glyoxalase system in clinical diabetes mellitus and correlation with diabetic complications. Clinical Sci (Lond). 1994;87(1):21\u20139.","journal-title":"Clinical Sci (Lond)"},{"issue":"1","key":"1301_CR22","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1515\/cclm-2012-0878","volume":"52","author":"JL Scheijen","year":"2014","unstructured":"Scheijen JL, Schalkwijk CG. Quantification of glyoxal, methylglyoxal and 3-deoxyglucosone in blood and plasma by ultra performance liquid chromatography tandem mass spectrometry: evaluation of blood specimen. Clin Chem Lab Med CCLM\/FESCC. 2014;52(1):85\u201391. doi:\n                        10.1515\/cclm-2012-0878\n                        \n                    .","journal-title":"Clin Chem Lab Med CCLM\/FESCC"},{"issue":"1","key":"1301_CR23","doi-asserted-by":"publisher","first-page":"266","DOI":"10.2337\/db14-0215","volume":"64","author":"S Genuth","year":"2015","unstructured":"Genuth S, Sun W, Cleary P, Gao X, Sell DR, Lachin J et al. Skin advanced glycation end products glucosepane and methylglyoxal hydroimidazolone are independently associated with long-term microvascular complication progression of type 1 diabetes. Diabetes. 2015;64(1):266\u201378. doi:\n                        10.2337\/db14-0215\n                        \n                    .","journal-title":"Diabetes"},{"issue":"3","key":"1301_CR24","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1515\/JBCPP.2002.13.3.201","volume":"13","author":"M Dworacka","year":"2002","unstructured":"Dworacka M, Winiarska H, Szymanska M, Szczawinska K, Wierusz-Wysocka B. Serum N-epsilon-(carboxymethyl)lysine is elevated in nondiabetic coronary heart disease patients. J Basic Clin Physiol Pharmacol. 2002;13(3):201\u201313.","journal-title":"J Basic Clin Physiol Pharmacol."},{"issue":"10","key":"1301_CR25","doi-asserted-by":"publisher","first-page":"2827","DOI":"10.1016\/j.jstrokecerebrovasdis.2014.07.002","volume":"23","author":"R Inoue","year":"2014","unstructured":"Inoue R, Sakata N, Nakai K, Aikawa H, Tsutsumi M, Nii K et al. Nepsilon-(Carboxymethyl)lysine in debris from carotid artery stenting: multiple versus nonmultiple postoperative lesions. J Stroke Cerebrovasc Dis. 2014;23(10):2827\u201333. doi:\n                        10.1016\/j.jstrokecerebrovasdis.2014.07.002\n                        \n                    .","journal-title":"J Stroke Cerebrovasc Dis"},{"issue":"6","key":"1301_CR26","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1159\/000075807","volume":"40","author":"N Sakata","year":"2003","unstructured":"Sakata N, Takeuchi K, Noda K, Saku K, Tachikawa Y, Tashiro T et al. Calcification of the medial layer of the internal thoracic artery in diabetic patients: relevance of glycoxidation. J Vasc Res. 2003;40(6):567\u201374.","journal-title":"J Vasc Res"},{"issue":"9","key":"1301_CR27","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1161\/CIRCRESAHA.110.223545","volume":"107","author":"F Giacco","year":"2010","unstructured":"Giacco F, Brownlee M. Oxidative stress and diabetic complications. Circ Res. 2010;107(9):1058\u201370. doi:\n                        10.1161\/CIRCRESAHA.110.223545\n                        \n                    .","journal-title":"Circ Res."},{"issue":"3","key":"1301_CR28","doi-asserted-by":"crossref","first-page":"670","DOI":"10.2337\/dc06-1508","volume":"30","author":"A Lapolla","year":"2007","unstructured":"Lapolla A, Piarulli F, Sartore G, Ceriello A, Ragazzi E, Reitano R et al. Advanced glycation end products and antioxidant status in type 2 diabetic patients with and without peripheral artery disease. Diabetes Care. 2007:30(3):670\u20136.","journal-title":"Diabetes Care"},{"issue":"4","key":"1301_CR29","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1007\/s00726-010-0783-0","volume":"42","author":"N Rabbani","year":"2012","unstructured":"Rabbani N, Thornalley PJ. Methylglyoxal, glyoxalase 1 and the dicarbonyl proteome. Amino Acids. 2012;42(4):1133\u201342. doi:\n                        10.1007\/s00726-010-0783-0\n                        \n                    .","journal-title":"Amino Acids"},{"key":"1301_CR30","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1196\/annals.1333.027","volume":"1043","author":"A Lapolla","year":"2005","unstructured":"Lapolla A, Flamini R, Lupo A, Arico NC, Rugiu C, Reitano R et al. Evaluation of glyoxal and methylglyoxal levels in uremic patients under peritoneal dialysis. Ann N Y Acad Sci. 2005;1043:217\u201324.","journal-title":"Ann N Y Acad Sci"},{"issue":"2","key":"1301_CR31","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1016\/j.atherosclerosis","volume":"203","author":"SW Shiu","year":"2009","unstructured":"Shiu SW, Tan KC, Wong Y, Leng L, Bucala R. Glycoxidized LDL increases lectin-like oxidized low density lipoprotein receptor-1 in diabetes mellitus. Atherosclerosis. 2009;203(2):522\u20137. doi:\n                        10.1016\/j.atherosclerosis.2008.07.012\n                        \n                    .","journal-title":"Atherosclerosis"},{"issue":"17","key":"1301_CR32","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1093\/eurheartj\/eht402","volume":"35","author":"NM Hanssen","year":"2014","unstructured":"Hanssen NM, Wouters K, Huijberts MS, Gijbels MJ, Sluimer JC, Scheijen JL et al. Higher levels of advanced glycation endproducts in human carotid atherosclerotic plaques are associated with a rupture-prone phenotype. Eur Heart J. 2014;35(17):1137\u201346. doi:\n                        10.1093\/eurheartj\/eht402\n                        \n                    .","journal-title":"Eur Heart J."}],"container-title":["Clinical and Experimental Nephrology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10157-016-1301-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10157-016-1301-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10157-016-1301-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10157-016-1301-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,9]],"date-time":"2017-06-09T13:18:23Z","timestamp":1497014303000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10157-016-1301-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,25]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["1301"],"URL":"https:\/\/doi.org\/10.1007\/s10157-016-1301-9","relation":{},"ISSN":["1342-1751","1437-7799"],"issn-type":[{"value":"1342-1751","type":"print"},{"value":"1437-7799","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,25]]}}}