{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T15:41:20Z","timestamp":1782834080580,"version":"3.54.5"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2017,8,23]],"date-time":"2017-08-23T00:00:00Z","timestamp":1503446400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Exp Nephrol"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1007\/s10157-017-1472-z","type":"journal-article","created":{"date-parts":[[2017,8,23]],"date-time":"2017-08-23T07:29:32Z","timestamp":1503473372000},"page":"420-425","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Risk factors for sodium valproate-induced renal tubular dysfunction"],"prefix":"10.1007","volume":"22","author":[{"given":"Satoko","family":"Koga","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahisa","family":"Kimata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sohsaku","family":"Yamanouchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoji","family":"Tsuji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Yoshimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Araki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazunari","family":"Kaneko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,8,23]]},"reference":[{"key":"1472_CR1","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1093\/qjmed\/hct258","volume":"107","author":"AM Hall","year":"2014","unstructured":"Hall AM, Bass P, Unwin RJ. Drug-induced renal Fanconi syndrome. Q J Med. 2014;107:261\u20139.","journal-title":"Q J Med"},{"key":"1472_CR2","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1053\/ajkd.2003.50037","volume":"41","author":"H Izzedine","year":"2003","unstructured":"Izzedine H, Launay-Vacher V, Isnard-Bagnis C, Deray G. Drug-induced Fanconi\u2019s syndrome. Am J Kidney Dis. 2003;41:292\u2013309.","journal-title":"Am J Kidney Dis"},{"key":"1472_CR3","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1055\/s-0031-1279783","volume":"42","author":"N Dhillon","year":"2011","unstructured":"Dhillon N, H\u00f6gler W. Fractures and Fanconi syndrome due to prolonged sodium valproate use. Neuropediatrics. 2011;42:119\u201321.","journal-title":"Neuropediatrics."},{"key":"1472_CR4","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1007\/s11606-011-1708-7","volume":"26","author":"SM Patel","year":"2011","unstructured":"Patel SM, Graff-Radford J, Wieland ML. Valproate-induced Fanconi syndrome in a 27-year-old woman. J Gen Intern Med. 2011;26:1072\u20134.","journal-title":"J Gen Intern Med"},{"key":"1472_CR5","first-page":"233","volume":"43","author":"T Inoue","year":"2011","unstructured":"Inoue T, Tanaka Y, Otani R, Itabashi H, Murakami N, Nagai T, et al. Three cases of Fanconi syndrome associated with valproate sodium treatment. No To Hattatsu. 2011;43:233\u20137.","journal-title":"No To Hattatsu."},{"key":"1472_CR6","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0387-7604(03)00094-9","volume":"26","author":"H Yoshikawa","year":"2004","unstructured":"Yoshikawa H, Yamazaki S, Abe T. Hypouricemia in severely disabled children: influence of elemental enteral nutrition on the serum uric acid levels. Brain Dev. 2004;26:43\u20136.","journal-title":"Brain Dev."},{"key":"1472_CR7","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1093\/clinchem\/40.5.817","volume":"40","author":"M Takahashi","year":"1994","unstructured":"Takahashi M, Ueda S, Misaki H, Sugiyama N, Matsumoto K, Matsuo N, et al. Carnitine determination by an enzymatic cycling method with carnitine dehydrogenase. Clin Chem. 1994;40:817\u201321.","journal-title":"Clin Chem"},{"key":"1472_CR8","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1007\/s00467-012-2217-6","volume":"27","author":"MG Madsen","year":"2012","unstructured":"Madsen MG, N\u00f8rregaard R, Palmfeldt J, Olsen LH, Fr\u00f8ki\u00e6r J, J\u00f8rgensen TM. Urinary NGAL, cystatin C, \u03b22-microglobulin, and osteopontin significance in hydronephrotic children. Pediatr Nephrol. 2012;27:2099\u2013106.","journal-title":"Pediatr Nephrol"},{"key":"1472_CR9","first-page":"281","volume":"35","author":"M Takayanagi","year":"2012","unstructured":"Takayanagi M. Abnormalities of carnitine metabolism in human diseases. J Anal Bio-Sci. 2012;35:281\u201392.","journal-title":"J Anal Bio-Sci."},{"key":"1472_CR10","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/S0022-3476(81)80736-6","volume":"98","author":"GR Lenoir","year":"1981","unstructured":"Lenoir GR, Perignon JL, Gubler MC, Broyer M. Valproic acid: a possible cause of proximal tubular renal syndrome. J Pediatr. 1981;98:503\u20134.","journal-title":"J Pediatr"},{"key":"1472_CR11","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/S0387-7604(02)00007-4","volume":"24","author":"H Yoshikawa","year":"2002","unstructured":"Yoshikawa H, Watanabe T, Abe T. Tubulo-interstitial nephritis caused by sodium valproate. Brain Dev. 2002;24:102\u20135.","journal-title":"Brain Dev."},{"key":"1472_CR12","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1053\/ejpn.2002.0585","volume":"6","author":"H Yoshikawa","year":"2002","unstructured":"Yoshikawa H, Watanabe T, Abe T. Fanconi syndrome caused by sodium valproate: report of three severely disabled children. Eur J Paediatr Neurol. 2002;6:165\u20137.","journal-title":"Eur J Paediatr Neurol."},{"key":"1472_CR13","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/S0887-8994(02)00447-2","volume":"27","author":"EL Zaki","year":"2002","unstructured":"Zaki EL, Springate JE. Renal injury from valproic acid: case report and literature review. Pediatr Neurol. 2002;27:318\u20139.","journal-title":"Pediatr Neurol"},{"key":"1472_CR14","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1159\/000188869","volume":"72","author":"Y Fukuda","year":"1996","unstructured":"Fukuda Y, Watanabe H, Ohtomo Y, Yabuta K. Immunologically mediated chronic tubulo-interstitial nephritis caused by valproate therapy. Nephron. 1996;72:328\u20139.","journal-title":"Nephron."},{"key":"1472_CR15","doi-asserted-by":"publisher","DOI":"10.1136\/bcr.12.2011.5359","author":"KL Keith","year":"2012","unstructured":"Keith KL, Koyelle P. Anticonvulsant-induced rickets and nephrocalcinosis. BMJ Case Rep. 2012;. doi: 10.1136\/bcr.12.2011.5359 .","journal-title":"BMJ Case Rep."},{"key":"1472_CR16","first-page":"844","volume":"13","author":"R Shiari","year":"2011","unstructured":"Shiari R, Bagherzade L, Alaei MR. Fanconi syndrome associated with valporic Acid: a case report. Iran Red Crescent Med J. 2011;13:844\u20135.","journal-title":"Iran Red Crescent Med J."},{"key":"1472_CR17","doi-asserted-by":"crossref","first-page":"182","DOI":"10.3165\/jjpn.21.182","volume":"21","author":"S Tanaka","year":"2008","unstructured":"Tanaka S, Suzukawa J, Araki A, Imai Y, Takaya J, Taniuchi S, et al. Hypouricemic acute renal failure in a patient with valproate-induced Fanconi syndrome. Jpn J Pediatr Nephrol. 2008;21:182\u20137.","journal-title":"Jpn J Pediatr Nephrol."},{"key":"1472_CR18","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1007\/s00467-013-2512-x","volume":"29","author":"MJ Knights","year":"2010","unstructured":"Knights MJ, Finlay E. The effects of sodium valproate on the renal function of children with epilepsy. Pediatr Nephrol. 2010;29:1131\u20138.","journal-title":"Pediatr Nephrol"},{"key":"1472_CR19","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.pediatrneurol.2009.12.003","volume":"42","author":"A Endo","year":"2010","unstructured":"Endo A, Fujita Y, Fuchigami T, Takahashi S, Mugishima H. Fanconi syndrome caused by valproic acid. Pediatr Neurol. 2010;42:287\u201390.","journal-title":"Pediatr Neurol"},{"key":"1472_CR20","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1111\/ped.12956","volume":"58","author":"S Yamazaki","year":"2016","unstructured":"Yamazaki S, Watanabe T, Sato S, Yoshikawa H. Outcomes of renal proximal tubular dysfunctions with Fanconi syndrome caused by sodium valproate. Pediatr Int. 2016;58:1023\u20136.","journal-title":"Pediatr Int"},{"key":"1472_CR21","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1007\/s00467-005-1827-7","volume":"20","author":"T Watanabe","year":"2005","unstructured":"Watanabe T, Yoshikawa H, Yamazaki S, Abe Y, Abe T. Secondary renal Fanconi syndrome caused by valproate therapy. Pediatr Nephrol. 2005;20:814\u20137.","journal-title":"Pediatr Nephrol"},{"key":"1472_CR22","doi-asserted-by":"crossref","first-page":"863","DOI":"10.3109\/15513819309048273","volume":"13","author":"E Hawkins","year":"1993","unstructured":"Hawkins E, Brewer E. Renal toxicity induced by valproic acid (Depakene). Pediatr Pathol. 1993;13:863\u20138.","journal-title":"Pediatr Pathol."},{"key":"1472_CR23","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1111\/j.0013-9580.2004.05504.x","volume":"45","author":"M Knorr","year":"2004","unstructured":"Knorr M, Schaper J, Harjes M, Mayatepek E, Rosenbaum T. Fanconi syndrome caused by antiepileptic therapy with valproic Acid. Epilepsia. 2004;45:868\u201371.","journal-title":"Epilepsia."},{"key":"1472_CR24","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/j.1442-200X.1990.tb00799.x","volume":"32","author":"N Igarashi","year":"1990","unstructured":"Igarashi N, Sato T, Kyouya S. Secondary carnitine deficiency in handicapped patients receiving valproic acid and\/or elemental diet. Acta Paediatr Jpn. 1990;32:139\u201345.","journal-title":"Acta Paediatr Jpn"},{"key":"1472_CR25","first-page":"1420","volume":"63","author":"J Bremer","year":"1983","unstructured":"Bremer J. Carnitine-metabolism and functions. Phys Rev. 1983;63:1420\u201379.","journal-title":"Phys Rev"},{"key":"1472_CR26","doi-asserted-by":"crossref","first-page":"3379","DOI":"10.1096\/fasebj.6.15.1464372","volume":"6","author":"CJ Rebouche","year":"1992","unstructured":"Rebouche CJ. Carnitine function and requirements during the life cycle. FASEB J. 1992;6:3379\u201386.","journal-title":"FASEB J."},{"key":"1472_CR27","first-page":"17","volume":"45","author":"A Kato","year":"2013","unstructured":"Kato A. Carnitine deficiency with Valproate sodium therapy\u2014the difference by normal diet and enteral nutrition. No To Hattatsu. 2013;45:17\u201320.","journal-title":"No To Hattatsu."},{"key":"1472_CR28","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s10545-008-0841-x","volume":"31","author":"MF Silva","year":"2008","unstructured":"Silva MF, Aires CC, Luis PB, Ruiter JP, IJlst L, et al. Valproic acid metabolism and its effects on mitochondrial fatty acid oxidation: a review. J Inherit Metab Dis. 2008;31:205\u201316.","journal-title":"J Inherit Metab Dis"},{"key":"1472_CR29","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1186\/cc3742","volume":"9","author":"ERL Philippe","year":"2005","unstructured":"Philippe ERL, Andrea P, Soheil Z, Mireille G. Science review: carnitine in the treatment of valproic acid-induced toxicity\u2014what is the evidence? Crit Care. 2005;9:431\u201340.","journal-title":"Crit Care"},{"key":"1472_CR30","first-page":"275","volume":"35","author":"J Nagata","year":"2012","unstructured":"Nagata J. Basics of carnitine in health foods: analysis, biochemistry and physiological functions. Int J Anal Bio-Sci. 2012;35:275\u201380.","journal-title":"Int J Anal Bio-Sci."},{"key":"1472_CR31","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1159\/000184867","volume":"48","author":"CY Lin","year":"1988","unstructured":"Lin CY, Chiang H. Sodium-valproate-induced interstitial nephritis. Nephron. 1988;48:43\u20136.","journal-title":"Nephron."},{"key":"1472_CR32","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1006\/phrs.1997.0134","volume":"35","author":"M Raza","year":"1997","unstructured":"Raza M, Al-Bekairi AM, Ageel AM, Qureshi S. Biochemical basis of sodium valproate hepatotoxicity and renal tubular disorder: time dependence of peroxidative injury. Pharmacol Res. 1997;35:153\u20137.","journal-title":"Pharmacol Res"}],"container-title":["Clinical and Experimental Nephrology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10157-017-1472-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10157-017-1472-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10157-017-1472-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,16]],"date-time":"2020-10-16T02:33:57Z","timestamp":1602815637000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10157-017-1472-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,23]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["1472"],"URL":"https:\/\/doi.org\/10.1007\/s10157-017-1472-z","relation":{},"ISSN":["1342-1751","1437-7799"],"issn-type":[{"value":"1342-1751","type":"print"},{"value":"1437-7799","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,23]]}}}