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Grants received: Hiroki Nishiwaki (Kyowa Hakko Kirin), Tsuyoshi Watanabe(Kyowa Hakko Kirin). Consultancies: Takeshi Hasegawa (Kyowa Hakko Kirin). Honoraria: Takeshi Hasegawa (Kyowa Hakko Kirin, Baxter, Pfizer, Takeda and Novartis), Hirofumi Makino (Kyowa Hakko Kirin). 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