{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T20:18:21Z","timestamp":1793391501199,"version":"4.5.0"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2018,5,26]],"date-time":"2018-05-26T00:00:00Z","timestamp":1527292800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Exp Nephrol"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1007\/s10157-018-1583-1","type":"journal-article","created":{"date-parts":[[2018,5,25]],"date-time":"2018-05-25T22:31:18Z","timestamp":1527287478000},"page":"1240-1250","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Expression of \u03b2-catenin in regenerating renal tubules of cisplatin-induced kidney failure in rats"],"prefix":"10.1007","volume":"22","author":[{"given":"Naomi","family":"Terada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3075-4327","authenticated-orcid":false,"given":"Mohammad Rabiul","family":"Karim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Izawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuru","family":"Kuwamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyoji","family":"Yamate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,5,26]]},"reference":[{"key":"1583_CR1","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.devcel.2009.06.016","volume":"17","author":"BT MacDonald","year":"2009","unstructured":"MacDonald BT, Tamai K, He X. Wnt\/\u03b2-catenin signaling: components, mechanisms, and diseases. Dev Cell. 2009;17:9\u201326.","journal-title":"Dev Cell"},{"key":"1583_CR2","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/567305","author":"X Tian","year":"2011","unstructured":"Tian X, Liu Z, Niu B, et al. E-cadherin\/\u03b2-catenin complex and the epithelial barrier. J Biomed Biotechnol. 2011. \n                    https:\/\/doi.org\/10.1155\/2011\/567305\n                    \n                  .","journal-title":"J Biomed Biotechnol"},{"key":"1583_CR3","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/j.cell.2006.10.018","volume":"127","author":"H Clevers","year":"2006","unstructured":"Clevers H. Wnt\/\u03b2-catenin signaling in development and disease. Cell. 2006;127:469\u201380.","journal-title":"Cell"},{"key":"1583_CR4","doi-asserted-by":"publisher","first-page":"2533","DOI":"10.1242\/dev.006155","volume":"134","author":"JS Park","year":"2007","unstructured":"Park JS, Valerius MT, McMahon AP. Wnt\/\u03b2-catenin signaling regulates nephron induction during mouse kidney development. Development. 2007;134:2533\u201339.","journal-title":"Development"},{"key":"1583_CR5","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1681\/ASN.2008060566","volume":"20","author":"W He","year":"2009","unstructured":"He W, Dai C, Li Y, et al. Wnt\/\u03b2-catenin signaling promotes renal interstitial fibrosis. J Am Soc Nephrol. 2009;20:765\u201376.","journal-title":"J Am Soc Nephrol"},{"key":"1583_CR6","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1038\/ki.2012.173","volume":"82","author":"D Zhou","year":"2012","unstructured":"Zhou D, Li Y, Lin L, et al. Tubule-specific ablation of endogenous beta-catenin aggravates acute kidney injury in mice. Kidney Int. 2012;82:537\u201347.","journal-title":"Kidney Int"},{"key":"1583_CR7","doi-asserted-by":"publisher","first-page":"1727","DOI":"10.1681\/ASN.2015040449","volume":"27","author":"L Xiao","year":"2016","unstructured":"Xiao L, Zhou D, Tan RJ, et al. Sustained activation of Wnt\/\u03b2-catenin signaling drives AKI to CKD progression. J Am Soc Nephrol. 2016;27:1727\u201340.","journal-title":"J Am Soc Nephrol"},{"key":"1583_CR8","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1007\/s007950200009","volume":"35","author":"MS Razzaque","year":"2002","unstructured":"Razzaque MS, Taguchi T. Cellular and molecular events leading to renal tubulointerstitial fibrosis. Med Electron Microsc. 2002;35:68\u201380.","journal-title":"Med Electron Microsc"},{"key":"1583_CR9","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1161\/CIRCULATIONAHA.106.678342","volume":"116","author":"EL Schiffrin","year":"2007","unstructured":"Schiffrin EL, Lipman ML, Mann JF. Chronic kidney disease: effects on the cardiovascular system. Circulation. 2007;116:85\u201397.","journal-title":"Circulation"},{"key":"1583_CR10","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1053\/jcpa.2000.0429","volume":"124","author":"M Ide","year":"2001","unstructured":"Ide M, Yamate J, Kuwamura M, et al. Immunohistochemical analysis of macrophages and myofibroblasts appearing in hepatic and renal fibrosis of dogs. J Comp Patho. 2001;124:60 \u2013 9.","journal-title":"J Comp Patho"},{"key":"1583_CR11","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1111\/j.1748-5827.2006.00200.x","volume":"47","author":"Y Kuwahara","year":"2006","unstructured":"Kuwahara Y, Ohba Y, Kitoh K, et al. Association of laboratory data and death within one month in cats with chronic renal failure. J Small Anim Pract. 2006;47:446\u201350.","journal-title":"J Small Anim Pract"},{"key":"1583_CR12","doi-asserted-by":"publisher","first-page":"2038","DOI":"10.1001\/jama.298.17.2038","volume":"298","author":"J Coresh","year":"2007","unstructured":"Coresh J, Selvin E, Stevens LA, et al. Prevalence of chronic kidney disease in the United States. JAMA. 2007;298:2038\u201347.","journal-title":"JAMA"},{"key":"1583_CR13","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1177\/019262339802600612","volume":"26","author":"J Yamate","year":"1998","unstructured":"Yamate J, Okado A, Kuwamura M, et al. Immunohistochemical analysis of macrophages, myofibroblasts, and transforming growth factor-\u03b2 localization during rat renal interstitial fibrosis following long-term unilateral ureteral obstruction. Toxicol Pathol. 1998;26:793\u2013801.","journal-title":"Toxicol Pathol"},{"key":"1583_CR14","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1354\/vp.39-3-322","volume":"39","author":"J Yamate","year":"2002","unstructured":"Yamate J, Sato K, Ide M, et al. Participation of different macrophage populations and myofibroblastic cells in chronically developed renal interstitial fibrosis after cisplatin-induced renal injury in rats. Vet Pathol. 2002;39:322 \u2013 33.","journal-title":"Vet Pathol"},{"key":"1583_CR15","doi-asserted-by":"publisher","first-page":"1340","DOI":"10.1016\/j.ajpath.2012.02.004","volume":"180","author":"B Hinz","year":"2012","unstructured":"Hinz B, Phan SH, Thannickal VJ, et al. Recent developments in myofibroblast biology: paradigms for connective tissue remodeling. Am J Pathol. 2012;180:1340\u201355.","journal-title":"Am J Pathol"},{"key":"1583_CR16","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1111\/j.1440-1681.2011.05531.x","volume":"38","author":"Y Kida","year":"2011","unstructured":"Kida Y, Duffield JS. Pivotal role of pericytes in kidney fibrosis. Clin Exp Pharmacol Physiol. 2011;38:467\u201373.","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"1583_CR17","doi-asserted-by":"publisher","first-page":"2149","DOI":"10.1093\/ndt\/gfs134","volume":"27","author":"SW Smith","year":"2012","unstructured":"Smith SW, Chand S, Savage CO. Biology of the renal pericyte. Nephrol Dial Transplant. 2012;27:2149\u201355.","journal-title":"Nephrol Dial Transplant"},{"key":"1583_CR18","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1038\/nm.3218","volume":"19","author":"VS LeBleu","year":"2013","unstructured":"LeBleu VS, Taduri G, O\u2019Connell J, et al. Origin and function of myofibroblasts in kidney fibrosis. Nat Med. 2013;19:1047\u201353.","journal-title":"Nat Med"},{"key":"1583_CR19","doi-asserted-by":"publisher","DOI":"10.1186\/1755-1536-4-11","author":"P Galichon","year":"2011","unstructured":"Galichon P, Hertig A. Epithelial to mesenchymal transition as a biomarker in renal fibrosis: are we ready for the bedside? Fibrogenesis Tissue Repair. 2011. \n                    https:\/\/doi.org\/10.1186\/1755-1536-4-11\n                    \n                  .","journal-title":"Fibrogenesis Tissue Repair"},{"key":"1583_CR20","doi-asserted-by":"publisher","DOI":"10.3390\/jcm5010004","author":"AH Tennakoon","year":"2016","unstructured":"Tennakoon AH, Izawa T, Kuwamura M, Yamate J. Pathogenesis of type 2 epithelial to mesenchymal transition (EMT) in renal and hepatic fibrosis. J Clin Med. 2016. \n                    https:\/\/doi.org\/10.3390\/jcm5010004\n                    \n                  .","journal-title":"J Clin Med"},{"key":"1583_CR21","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1293\/tox.13.237","volume":"13","author":"J Yamate","year":"2000","unstructured":"Yamate J, Sato K, Machida Y, et al. Cisplatin-induced rat renal interstitial fibrosis; a possible pathogenesis based on the data. J Toxicol Pathol. 2000;13:237\u201347.","journal-title":"J Toxicol Pathol"},{"key":"1583_CR22","doi-asserted-by":"publisher","first-page":"2490","DOI":"10.3390\/toxins2112490","volume":"2","author":"RP Miller","year":"2010","unstructured":"Miller RP, Tadagavadi RK, Ramesh G, Reeves WB. Mechanisms of cisplatin nephrotoxicity. Toxins. 2010;2:2490\u2013518.","journal-title":"Toxins"},{"key":"1583_CR23","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1293\/tox.23.271","volume":"23","author":"E Yamamoto","year":"2010","unstructured":"Yamamoto E, Izawa T, Juniantito V, et al. Relationship of cell proliferating marker expressions with PGE2 receptors in regenerating rat renal tubules after cisplatin injection. J Toxicol Pathol. 2010;23:271\u201375.","journal-title":"J Toxicol Pathol"},{"key":"1583_CR24","doi-asserted-by":"publisher","first-page":"S55","DOI":"10.1097\/01.ASN.0000067652.51441.21","volume":"14","author":"JV Bonventre","year":"2003","unstructured":"Bonventre JV. Dedifferentiation and proliferation of surviving epithelial cells in acute renal failure. J Am Soc Nephrol. 2003;14:S55\u201361.","journal-title":"J Am Soc Nephrol"},{"key":"1583_CR25","doi-asserted-by":"publisher","first-page":"1785","DOI":"10.1292\/jvms.17-0439","volume":"79","author":"N Terada","year":"2017","unstructured":"Terada N, Karim MR. Izawa T, et al. Immunolocalization of \u03b2-catenin, E-cadherin and N-cadherin in neonate and adult rat kidney. J Vet Med Sec. 2017;79:1785\u201390.","journal-title":"J Vet Med Sec"},{"key":"1583_CR26","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1002\/path.4125","volume":"229","author":"B Smeets","year":"2012","unstructured":"Smeets B, Boor P, Dijkman H, et al. Proximal tubular cells contain a phenotypically distinct, scattered cell population involved in tubular regeneration. J Pathol. 2012;229:645\u201369.","journal-title":"J Pathol"},{"key":"1583_CR27","doi-asserted-by":"publisher","first-page":"1681","DOI":"10.1177\/002215540305101212","volume":"51","author":"L Muskhelishvili","year":"2003","unstructured":"Muskhelishvili L, Latendresse JR, Kodell RL, Henderson EB. Evaluation of cell proliferation in rat tissues with BrdU, PCNA, Ki-67(MIB-5) immunohistochemistry and in situ hybridization for histone mRNA. J Histochem Cytochem. 2003;51:1681\u201388.","journal-title":"J Histochem Cytochem"},{"key":"1583_CR28","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/S0955-0674(03)00008-5","volume":"15","author":"DW Stacey","year":"2003","unstructured":"Stacey DW. Cyclin D1 serves as a cell cycle regulatory switch in actively proliferating cells. Curr Opin Cell Biol. 2003;15:158 \u2013 63.","journal-title":"Curr Opin Cell Biol"},{"key":"1583_CR29","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1038\/372679a0","volume":"372","author":"K Stark","year":"1994","unstructured":"Stark K, Vainio S, Vassileva G, McMahon AP. Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by Wnt-4. Nature. 1994;372:679\u201383.","journal-title":"Nature"},{"key":"1583_CR30","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1097\/01.ASN.0000060577.94532.06","volume":"14","author":"Y Terada","year":"2003","unstructured":"Terada Y, Tanaka H, Okado T, et al. Expression and function of the developmental gene Wnt-4 during experimental acute renal failure in rats. J Am Soc Nephrol. 2003;14:1223\u201333.","journal-title":"J Am Soc Nephrol"},{"key":"1583_CR31","doi-asserted-by":"publisher","first-page":"1919","DOI":"10.1681\/ASN.2009030253","volume":"20","author":"Z Wang","year":"2009","unstructured":"Wang Z, Havasi A, Gall JM, et al. Beta-catenin promotes survival of renal epithelial cells by inhibiting Bax. J Am Soc Nephrol. 2009;20:1919\u201328.","journal-title":"J Am Soc Nephrol"},{"key":"1583_CR32","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1042\/BC20070072","volume":"100","author":"P Bernard","year":"2008","unstructured":"Bernard P, Fleming A, Lacombe A, et al. Wnt4 inhibits beta-catenin\/TCF signalling by redirecting beta-catenin to the cell membrane. Biol Cell. 2008;100:167\u201377.","journal-title":"Biol Cell"},{"key":"1583_CR33","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1002\/sctm.17-0158","volume":"7","author":"A Brossa","year":"2018","unstructured":"Brossa A, Papadimitriou E, Collino F, et al. Role of CD133 molecule in Wnt response and renal repair. Stem Cells Transl Med. 2018;7:283\u201394.","journal-title":"Stem Cells Transl Med"},{"key":"1583_CR34","doi-asserted-by":"publisher","first-page":"e0120347","DOI":"10.1371\/journal.pone.0120347","volume":"10","author":"FJ Boivin","year":"2015","unstructured":"Boivin FJ, Sarin S, Lim J, et al. Stromally expressed \u03b2-catenin modulates Wnt9b signaling in the ureteric epithelium. PLoS One. 2015;10:e0120347.","journal-title":"PLoS One"}],"container-title":["Clinical and Experimental Nephrology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10157-018-1583-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10157-018-1583-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10157-018-1583-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,25]],"date-time":"2019-05-25T19:14:44Z","timestamp":1558811684000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10157-018-1583-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,26]]},"references-count":34,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["1583"],"URL":"https:\/\/doi.org\/10.1007\/s10157-018-1583-1","relation":{},"ISSN":["1342-1751","1437-7799"],"issn-type":[{"value":"1342-1751","type":"print"},{"value":"1437-7799","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,26]]},"assertion":[{"value":"20 December 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 April 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 May 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"There are no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Animal experiments were carried out in accordance with the guidelines set by the Graduate School of Life and Environmental Sciences, Osaka Prefecture University. The protocol was approved by the ethical committee for the Care and Use of Experimental Animals of Osaka Prefecture University (Permit No. 21-16 and 25-85) and conformed to the Guidelines for the Conduct of Animal Experimentation of the Ministry of Health, Labor and Welfare Standards relating to the Care and Management of Experimental Animals and the Act on Welfare and Management of Animals, Japan. All efforts were made to minimize animal suffering. Specimens from humans were not used.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical considerations"}}]}}