{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:39:49Z","timestamp":1762508389208,"version":"3.37.3"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Grants-in-Aid of the Japan Society of Promotion of Science","award":["JP15K09252"],"award-info":[{"award-number":["JP15K09252"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Exp Nephrol"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1007\/s10157-021-02039-2","type":"journal-article","created":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T10:03:58Z","timestamp":1614593038000},"page":"598-607","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["PPAR-\u03b4 activation reduces cisplatin-induced apoptosis via inhibiting p53\/Bax\/caspase-3 pathway without modulating autophagy in murine renal proximal tubular cells"],"prefix":"10.1007","volume":"25","author":[{"given":"Juanping","family":"Shan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1813-9847","authenticated-orcid":false,"given":"Hideki","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiji","family":"Yokoi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuko","family":"Kamiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toru","family":"Imamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Izumi","family":"Takeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mamiko","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Mikami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Kasuno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Sugaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"Iwano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,3,1]]},"reference":[{"key":"2039_CR1","doi-asserted-by":"publisher","first-page":"967826","DOI":"10.1155\/2014\/967826","volume":"2014","author":"A Ozkok","year":"2014","unstructured":"Ozkok A, Edelstein CL. Pathophysiology of cisplatin-induced acute kidney injury. Biomed Res Int. 2014;2014:967826. https:\/\/doi.org\/10.1155\/2014\/967826.","journal-title":"Biomed Res Int"},{"issue":"2","key":"2039_CR2","doi-asserted-by":"publisher","first-page":"55","DOI":"10.5049\/EBP.2014.12.2.55","volume":"12","author":"GS Oh","year":"2014","unstructured":"Oh GS, Kim HJ, Shen A, Lee SB, Khadka D, Pandit A, et al. Cisplatin-induced kidney dysfunction and perspectives on improving treatment strategies. Electrolyte Blood Press. 2014;12(2):55\u201365. https:\/\/doi.org\/10.5049\/EBP.2014.12.2.55.","journal-title":"Electrolyte Blood Press"},{"issue":"4","key":"2039_CR3","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1681\/ASN.V134858","volume":"13","author":"MS Park","year":"2002","unstructured":"Park MS, De Leon M, Devarajan P. Cisplatin induces apoptosis in LLC-PK1 cells via activation of mitochondrial pathways. J Am Soc Nephrol. 2002;13(4):858\u201365.","journal-title":"J Am Soc Nephrol"},{"issue":"6","key":"2039_CR4","doi-asserted-by":"publisher","first-page":"2680","DOI":"10.1111\/j.1523-1755.2005.00739.x","volume":"68","author":"KK Nagothu","year":"2005","unstructured":"Nagothu KK, Bhatt R, Kaushal GP, Portilla D. Fibrate prevents cisplatin-induced proximal tubule cell death. Kidney Int. 2005;68(6):2680\u201393. https:\/\/doi.org\/10.1111\/j.1523-1755.2005.00739.x.","journal-title":"Kidney Int"},{"issue":"1","key":"2039_CR5","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1038\/sj.ki.5002256","volume":"72","author":"Q Wei","year":"2007","unstructured":"Wei Q, Dong G, Franklin J, Dong Z. The pathological role of Bax in cisplatin nephrotoxicity. Kidney Int. 2007;72(1):53\u201362. https:\/\/doi.org\/10.1038\/sj.ki.5002256.","journal-title":"Kidney Int"},{"issue":"10","key":"2039_CR6","doi-asserted-by":"publisher","first-page":"2278","DOI":"10.1681\/ASN.2013080902","volume":"25","author":"D Zhang","year":"2014","unstructured":"Zhang D, Liu Y, Wei Q, Huo Y, Liu K, Liu F, et al. Tubular p53 regulates multiple genes to mediate AKI. J Am Soc Nephrol. 2014;25(10):2278\u201389. https:\/\/doi.org\/10.1681\/ASN.2013080902.","journal-title":"J Am Soc Nephrol"},{"issue":"4","key":"2039_CR7","doi-asserted-by":"publisher","first-page":"F777","DOI":"10.1152\/ajprenal.00590.2007","volume":"294","author":"C Yang","year":"2008","unstructured":"Yang C, Kaushal V, Shah SV, Kaushal GP. Autophagy is associated with apoptosis in cisplatin injury to renal tubular epithelial cells. Am J Physiol Renal Physiol. 2008;294(4):F777\u201387. https:\/\/doi.org\/10.1152\/ajprenal.00590.2007.","journal-title":"Am J Physiol Renal Physiol"},{"issue":"2","key":"2039_CR8","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1016\/j.ajpath.2011.11.001","volume":"180","author":"A Takahashi","year":"2012","unstructured":"Takahashi A, Kimura T, Takabatake Y, Namba T, Kaimori J, Kitamura H, et al. Autophagy guards against cisplatin-induced acute kidney injury. Am J Pathol. 2012;180(2):517\u201325. https:\/\/doi.org\/10.1016\/j.ajpath.2011.11.001.","journal-title":"Am J Pathol"},{"key":"2039_CR9","doi-asserted-by":"publisher","first-page":"23975","DOI":"10.1038\/srep23975","volume":"6","author":"J Li","year":"2016","unstructured":"Li J, Gui Y, Ren J, Liu X, Feng Y, Zeng Z, et al. Metformin protects against cisplatin-induced tubular cell apoptosis and acute kidney injury via AMPKalpha-regulated autophagy induction. Sci Rep. 2016;6:23975. https:\/\/doi.org\/10.1038\/srep23975.","journal-title":"Sci Rep"},{"issue":"12","key":"2039_CR10","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.1038\/ki.2012.261","volume":"82","author":"M Jiang","year":"2012","unstructured":"Jiang M, Wei Q, Dong G, Komatsu M, Su Y, Dong Z. Autophagy in proximal tubules protects against acute kidney injury. Kidney Int. 2012;82(12):1271\u201383. https:\/\/doi.org\/10.1038\/ki.2012.261.","journal-title":"Kidney Int"},{"issue":"1","key":"2039_CR11","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1046\/j.1523-1755.2001.00766.x","volume":"60","author":"Y Guan","year":"2001","unstructured":"Guan Y, Breyer MD. Peroxisome proliferator-activated receptors (PPARs): novel therapeutic targets in renal disease. Kidney Int. 2001;60(1):14\u201330. https:\/\/doi.org\/10.1046\/j.1523-1755.2001.00766.x.","journal-title":"Kidney Int"},{"issue":"3","key":"2039_CR12","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1172\/JCI27955","volume":"116","author":"GD Barish","year":"2006","unstructured":"Barish GD, Narkar VA, Evans RM. PPAR delta: a dagger in the heart of the metabolic syndrome. J Clin Invest. 2006;116(3):590\u20137. https:\/\/doi.org\/10.1172\/JCI27955.","journal-title":"J Clin Invest"},{"issue":"5644","key":"2039_CR13","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1126\/science.1087344","volume":"302","author":"CH Lee","year":"2003","unstructured":"Lee CH, Chawla A, Urbiztondo N, Liao D, Boisvert WA, Evans RM, et al. Transcriptional repression of atherogenic inflammation: modulation by PPARdelta. Science. 2003;302(5644):453\u20137. https:\/\/doi.org\/10.1126\/science.1087344.","journal-title":"Science"},{"issue":"4","key":"2039_CR14","doi-asserted-by":"publisher","first-page":"1560","DOI":"10.1210\/en.2009-1211","volume":"151","author":"T Coll","year":"2010","unstructured":"Coll T, Alvarez-Guardia D, Barroso E, Gomez-Foix AM, Palomer X, Laguna JC, et al. Activation of peroxisome proliferator-activated receptor-{delta} by GW501516 prevents fatty acid-induced nuclear factor-{kappa}B activation and insulin resistance in skeletal muscle cells. Endocrinology. 2010;151(4):1560\u20139. https:\/\/doi.org\/10.1210\/en.2009-1211.","journal-title":"Endocrinology"},{"issue":"5","key":"2039_CR15","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1038\/hr.2013.157","volume":"37","author":"D Mikami","year":"2014","unstructured":"Mikami D, Kimura H, Kamiyama K, Torii K, Kasuno K, Takahashi N, et al. Telmisartan activates endogenous peroxisome proliferator-activated receptor-delta and may have anti-fibrotic effects in human mesangial cells. Hypertens Res. 2014;37(5):422\u201331. https:\/\/doi.org\/10.1038\/hr.2013.157.","journal-title":"Hypertens Res"},{"issue":"2","key":"2039_CR16","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1016\/j.bbrc.2014.10.077","volume":"454","author":"H Kimura","year":"2014","unstructured":"Kimura H, Mikami D, Kamiyama K, Sugimoto H, Kasuno K, Takahashi N, et al. Telmisartan, a possible PPAR-delta agonist, reduces TNF-alpha-stimulated VEGF-C production by inhibiting the p38MAPK\/HSP27 pathway in human proximal renal tubular cells. Biochem Biophys Res Commun. 2014;454(2):320\u20137. https:\/\/doi.org\/10.1016\/j.bbrc.2014.10.077.","journal-title":"Biochem Biophys Res Commun"},{"issue":"10","key":"2039_CR17","doi-asserted-by":"publisher","first-page":"e294","DOI":"10.1371\/journal.pbio.0020294","volume":"2","author":"YX Wang","year":"2004","unstructured":"Wang YX, Zhang CL, Yu RT, Cho HK, Nelson MC, Bayuga-Ocampo CR, et al. Regulation of muscle fiber type and running endurance by PPARdelta. PLoS Biol. 2004;2(10):e294. https:\/\/doi.org\/10.1371\/journal.pbio.0020294.","journal-title":"PLoS Biol"},{"issue":"5","key":"2039_CR18","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1161\/CIRCRESAHA.109.206185","volume":"106","author":"P Wang","year":"2010","unstructured":"Wang P, Liu J, Li Y, Wu S, Luo J, Yang H, et al. Peroxisome proliferator-activated receptor delta is an essential transcriptional regulator for mitochondrial protection and biogenesis in adult heart. Circ Res. 2010;106(5):911\u20139. https:\/\/doi.org\/10.1161\/CIRCRESAHA.109.206185.","journal-title":"Circ Res"},{"issue":"9","key":"2039_CR19","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1007\/s00424-013-1274-4","volume":"465","author":"Q Li","year":"2013","unstructured":"Li Q, Li L, Wang F, Chen J, Zhao Y, Wang P, et al. Dietary capsaicin prevents nonalcoholic fatty liver disease through transient receptor potential vanilloid 1-mediated peroxisome proliferator-activated receptor delta activation. Pflugers Arch. 2013;465(9):1303\u201316. https:\/\/doi.org\/10.1007\/s00424-013-1274-4.","journal-title":"Pflugers Arch"},{"issue":"1","key":"2039_CR20","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.ijcard.2014.03.176","volume":"174","author":"X Palomer","year":"2014","unstructured":"Palomer X, Capdevila-Busquets E, Botteri G, Salvado L, Barroso E, Davidson MM, et al. PPARbeta\/delta attenuates palmitate-induced endoplasmic reticulum stress and induces autophagic markers in human cardiac cells. Int J Cardiol. 2014;174(1):110\u20138. https:\/\/doi.org\/10.1016\/j.ijcard.2014.03.176.","journal-title":"Int J Cardiol"},{"issue":"3","key":"2039_CR21","doi-asserted-by":"publisher","first-page":"737","DOI":"10.2353\/ajpath.2006.050656","volume":"168","author":"H Okada","year":"2006","unstructured":"Okada H, Kikuta T, Inoue T, Kanno Y, Ban S, Sugaya T, et al. Dexamethasone induces connective tissue growth factor expression in renal tubular epithelial cells in a mouse strain-specific manner. Am J Pathol. 2006;168(3):737\u201347. https:\/\/doi.org\/10.2353\/ajpath.2006.050656.","journal-title":"Am J Pathol"},{"issue":"7529","key":"2039_CR22","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1038\/nature13961","volume":"516","author":"JM Lee","year":"2014","unstructured":"Lee JM, Wagner M, Xiao R, Kim KH, Feng D, Lazar MA, et al. Nutrient-sensing nuclear receptors coordinate autophagy. Nature. 2014;516(7529):112\u20135. https:\/\/doi.org\/10.1038\/nature13961.","journal-title":"Nature"},{"issue":"6","key":"2039_CR23","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1016\/j.molcel.2008.06.001","volume":"30","author":"Y Wei","year":"2008","unstructured":"Wei Y, Pattingre S, Sinha S, Bassik M, Levine B. JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy. Mol Cell. 2008;30(6):678\u201388. https:\/\/doi.org\/10.1016\/j.molcel.2008.06.001.","journal-title":"Mol Cell"},{"issue":"6","key":"2039_CR24","doi-asserted-by":"publisher","first-page":"2033","DOI":"10.1097\/CCM.0b013e3181a005ba","volume":"37","author":"YS Kim","year":"2009","unstructured":"Kim YS, Jung MH, Choi MY, Kim YH, Sheverdin V, Kim JH, et al. Glutamine attenuates tubular cell apoptosis in acute kidney injury via inhibition of the c-Jun N-terminal kinase phosphorylation of 14-3-3. Crit Care Med. 2009;37(6):2033\u201344. https:\/\/doi.org\/10.1097\/CCM.0b013e3181a005ba.","journal-title":"Crit Care Med"},{"key":"2039_CR25","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.phrs.2015.03.008","volume":"95\u201396","author":"E Barlaka","year":"2015","unstructured":"Barlaka E, Gorbe A, Gaspar R, Paloczi J, Ferdinandy P, Lazou A. Activation of PPARbeta\/delta protects cardiac myocytes from oxidative stress-induced apoptosis by suppressing generation of reactive oxygen\/nitrogen species and expression of matrix metalloproteinases. Pharmacol Res. 2015;95\u201396:102\u201310. https:\/\/doi.org\/10.1016\/j.phrs.2015.03.008.","journal-title":"Pharmacol Res"},{"key":"2039_CR26","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.resp.2014.04.004","volume":"199","author":"XC Bao","year":"2014","unstructured":"Bao XC, Fang YQ, You P, Zhang S, Ma J. Protective role of peroxisome proliferator-activated receptor beta\/delta in acute lung injury induced by prolonged hyperbaric hyperoxia in rats. Respir Physiol Neurobiol. 2014;199:9\u201318. https:\/\/doi.org\/10.1016\/j.resp.2014.04.004.","journal-title":"Respir Physiol Neurobiol"},{"issue":"3","key":"2039_CR27","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1007\/s11011-016-9800-7","volume":"31","author":"YQ An","year":"2016","unstructured":"An YQ, Zhang CT, Du Y, Zhang M, Tang SS, Hu M, et al. PPARdelta agonist GW0742 ameliorates Abeta1-42-induced hippocampal neurotoxicity in mice. Metab Brain Dis. 2016;31(3):663\u201371. https:\/\/doi.org\/10.1007\/s11011-016-9800-7.","journal-title":"Metab Brain Dis"},{"issue":"4","key":"2039_CR28","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1016\/j.kint.2015.11.021","volume":"89","author":"GP Kaushal","year":"2016","unstructured":"Kaushal GP, Shah SV. Autophagy in acute kidney injury. Kidney Int. 2016;89(4):779\u201391. https:\/\/doi.org\/10.1016\/j.kint.2015.11.021.","journal-title":"Kidney Int"}],"container-title":["Clinical and Experimental Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10157-021-02039-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10157-021-02039-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10157-021-02039-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,8]],"date-time":"2021-05-08T05:08:27Z","timestamp":1620450507000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10157-021-02039-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,1]]},"references-count":28,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["2039"],"URL":"https:\/\/doi.org\/10.1007\/s10157-021-02039-2","relation":{},"ISSN":["1342-1751","1437-7799"],"issn-type":[{"type":"print","value":"1342-1751"},{"type":"electronic","value":"1437-7799"}],"subject":[],"published":{"date-parts":[[2021,3,1]]},"assertion":[{"value":"1 October 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 February 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 March 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that there is no conflict of interest regarding the publication of this paper.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"This article does not contain any studies with human participants or animals performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human and animal rights"}}]}}