{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T10:26:41Z","timestamp":1750760801655,"version":"3.37.3"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T00:00:00Z","timestamp":1619049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T00:00:00Z","timestamp":1619049600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Exp Nephrol"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1007\/s10157-021-02064-1","type":"journal-article","created":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T12:03:30Z","timestamp":1619093010000},"page":"963-969","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Regional citrate anti-coagulation dose titration: impact on dose of continuous renal replacement therapy"],"prefix":"10.1007","volume":"25","author":[{"given":"Charles Jun Han","family":"Ng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng Boon","family":"Poh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sreekanth","family":"Koduri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debajyoti Malakar","family":"Roy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuin","family":"Siau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noelle Louise","family":"Lim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2809-8321","authenticated-orcid":false,"given":"Chang Yin","family":"Chionh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,4,22]]},"reference":[{"key":"2064_CR1","unstructured":"Kidney Disease: Improving Global Outcomes (KDIGO) Acute Kidney Injury Work Group. KDIGO clinical practice guideline for acute kidney injury. Kidney Int 2012;2:1\u2013138."},{"key":"2064_CR2","doi-asserted-by":"publisher","unstructured":"RENAL Replacement Therapy Study Investigators, Bellomo R, Cass A, et al. Intensity of continuous renal-replacement therapy in critically ill patients. N Engl J Med. 2009;361(17):1627\u201338. https:\/\/doi.org\/10.1056\/NEJMoa0902413","DOI":"10.1056\/NEJMoa0902413"},{"key":"2064_CR3","doi-asserted-by":"publisher","unstructured":"VA\/NIH Acute Renal Failure Trial Network, Palevsky PM, Zhang JH, et al. Intensity of renal support in critically ill patients with acute kidney injury [published correction appears in N Engl J Med. 2009 Dec 10;361(24):2391]. N Engl J Med. 2008;359(1):7\u201320. https:\/\/doi.org\/10.1056\/NEJMoa0802639","DOI":"10.1056\/NEJMoa0802639"},{"issue":"12","key":"2064_CR4","doi-asserted-by":"publisher","first-page":"2098","DOI":"10.1007\/s00134-015-4099-0","volume":"41","author":"M Bai","year":"2015","unstructured":"Bai M, Zhou M, He L, et al. Citrate versus heparin anticoagulation for continuous renal replacement therapy: an updated meta-analysis of RCTs. Intensive Care Med. 2015;41(12):2098\u2013110.","journal-title":"Intensive Care Med"},{"issue":"1","key":"2064_CR5","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1186\/s13054-016-1299-0","volume":"20","author":"C Liu","year":"2016","unstructured":"Liu C, Mao Z, Kang H, Hu J, Zhou F. Regional citrate versus heparin anticoagulation for continuous renal replacement therapy in critically ill patients: a meta-analysis with trial sequential analysis of randomized controlled trials. Crit Care. 2016;20(1):144.","journal-title":"Crit Care"},{"issue":"5","key":"2064_CR6","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1038\/ki.1990.300","volume":"38","author":"RL Mehta","year":"1990","unstructured":"Mehta RL, McDonald BR, Aguilar MM, Ward DM. Regional citrate anticoagulation for continuous arteriovenous hemodialysis in critically ill patients. Kidney Int. 1990;38(5):976\u201381.","journal-title":"Kidney Int"},{"issue":"4","key":"2064_CR7","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1186\/cc5937","volume":"11","author":"M Joannidis","year":"2007","unstructured":"Joannidis M, Oudemans-van Straaten HM. Clinical review: patency of the circuit in continuous renal replacement therapy. Crit Care. 2007;11(4):218.","journal-title":"Crit Care"},{"issue":"6","key":"2064_CR8","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1097\/MCC.0000000000000547","volume":"24","author":"D Kindgen-Milles","year":"2018","unstructured":"Kindgen-Milles D, Brandenburger T, Dimski T. Regional citrate anticoagulation for continuous renal replacement therapy. Curr Opin Crit Care. 2018;24(6):450\u20134.","journal-title":"Curr Opin Crit Care"},{"issue":"12","key":"2064_CR9","doi-asserted-by":"publisher","first-page":"e0189745","DOI":"10.1371\/journal.pone.0189745","volume":"12","author":"MJ Brain","year":"2017","unstructured":"Brain MJ, Roodenburg OS, McNeil J. Comparison of pre-filter and post-filter ionised calcium monitoring in continuous veno-venous hemodiafiltration (CVVHD-F) with citrate anti-coagulation. PLoS ONE. 2017;12(12):e0189745.","journal-title":"PLoS ONE"},{"issue":"2","key":"2064_CR10","first-page":"72","volume":"13","author":"M Brain","year":"2011","unstructured":"Brain M, Parkes S, Fowler P, Robertson I, Brown A. Calcium flux in continuous venovenous haemodiafiltration with heparin and citrate anticoagulation. Crit Care Resusc. 2011;13(2):72\u201381.","journal-title":"Crit Care Resusc"},{"issue":"2","key":"2064_CR11","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1097\/CCM.0b013e3181953c5e","volume":"37","author":"HM Oudemans-van Straaten","year":"2009","unstructured":"Oudemans-van Straaten HM, Bosman RJ, Koopmans M, et al. Citrate anticoagulation for continuous venovenous hemofiltration. Crit Care Med. 2009;37(2):545\u201352.","journal-title":"Crit Care Med"},{"issue":"8","key":"2064_CR12","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1515\/CCLM.2006.164","volume":"44","author":"AJ Bakker","year":"2006","unstructured":"Bakker AJ, Boerma EC, Keidel H, Kingma P, van der Voort PH. Detection of citrate overdose in critically ill patients on citrate-anticoagulated venovenous haemofiltration: use of ionised and total\/ionised calcium. Clin Chem Lab Med. 2006;44(8):962\u20136.","journal-title":"Clin Chem Lab Med"},{"issue":"5","key":"2064_CR13","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1016\/S0272-6386(00)70248-4","volume":"35","author":"DJ Kutsogiannis","year":"2000","unstructured":"Kutsogiannis DJ, Mayers I, Chin WD, Gibney RT. Regional citrate anticoagulation in continuous venovenous hemodiafiltration. Am J Kidney Dis. 2000;35(5):802\u201311.","journal-title":"Am J Kidney Dis"},{"issue":"5","key":"2064_CR14","first-page":"602","volume":"20","author":"MG Betjes","year":"2007","unstructured":"Betjes MG, van Oosterom D, van Agteren M, van de Wetering J. Regional citrate versus heparin anticoagulation during venovenous hemofiltration in patients at low risk for bleeding: similar hemofilter survival but significantly less bleeding. J Nephrol. 2007;20(5):602\u20138.","journal-title":"J Nephrol"},{"issue":"12","key":"2064_CR15","doi-asserted-by":"publisher","first-page":"2173","DOI":"10.2215\/CJN.01280214","volume":"9","author":"S Morabito","year":"2014","unstructured":"Morabito S, Pistolesi V, Tritapepe L, Fiaccadori E. Regional citrate anticoagulation for RRTs in critically ill patients with AKI. Clin J Am Soc Nephrol. 2014;9(12):2173\u201388.","journal-title":"Clin J Am Soc Nephrol"},{"key":"2064_CR16","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1007\/s00134-003-1672-8","volume":"29","author":"S Uchino","year":"2003","unstructured":"Uchino S, Fealy N, Baldwin I, Morimatsu H, Bellomo R. Continuous is not continuous: the incidence and impact of circuit \u2018down-time\u2019\u2019 on uraemic control during continuous veno-venous haemofiltration.\u2019 Intensive Care Med. 2003;29:575\u20138.","journal-title":"Intensive Care Med"},{"key":"2064_CR17","doi-asserted-by":"publisher","first-page":"2505","DOI":"10.1056\/NEJMct1206045","volume":"367","author":"A Tolwani","year":"2012","unstructured":"Tolwani A. Continuous renal-replacement therapy for acute kidney injury. N Engl J Med. 2012;367:2505\u201314.","journal-title":"N Engl J Med"},{"key":"2064_CR18","doi-asserted-by":"publisher","first-page":"1154","DOI":"10.1046\/j.1523-1755.2001.0600031154.x","volume":"60","author":"RL Metha","year":"2001","unstructured":"Metha RL, McDonald B, Gabbai FB, et al. A randomized clinical trial of continuous vs intermittent dialysis for acute renal failure. Kidney Int. 2001;60:1154\u201363.","journal-title":"Kidney Int"},{"key":"2064_CR19","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1016\/S0272-6386(98)70127-1","volume":"32","author":"JA Evanson","year":"1998","unstructured":"Evanson JA, Himmelfarb J, Wingard R, et al. Prescribed versus delivered dialysis in acute renal failure patients. Am J Kidney Dis. 1998;32:731\u20138.","journal-title":"Am J Kidney Dis"},{"key":"2064_CR20","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1053\/jcrc.2002.36757","volume":"17","author":"R Venkataraman","year":"2002","unstructured":"Venkataraman R, Kellum JA, Palevsky P. Dosing patterns for continuous renal replacement therapy at a large academic medical center in the United States. J Crit Care. 2002;17:246\u201350.","journal-title":"J Crit Care"},{"issue":"3","key":"2064_CR21","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1093\/ndt\/gfr480","volume":"27","author":"WD Lyndon","year":"2012","unstructured":"Lyndon WD, Wille KM, Tolwani AJ. Solute clearance in CRRT: prescribed dose versus actual delivered dose. Nephrol Dial Transplant. 2012;27(3):952\u20136.","journal-title":"Nephrol Dial Transplant"},{"issue":"2","key":"2064_CR22","doi-asserted-by":"publisher","first-page":"R57","DOI":"10.1186\/cc7784","volume":"13","author":"S Vesconi","year":"2009","unstructured":"Vesconi S, Cruz DN, Fumagalli R, et al. Delivered dose of renal replacement therapy and mortality in critically ill patients with acute kidney injury. Crit Care. 2009;13(2):R57.","journal-title":"Crit Care"},{"key":"2064_CR23","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1159\/000448507","volume":"42","author":"S Bagshaw","year":"2016","unstructured":"Bagshaw S, Chakravarthi M, Ricci Z, et al. Precision continuous renal replacement therapy and solute control. Blood Purif. 2016;42:238\u201347.","journal-title":"Blood Purif"},{"key":"2064_CR24","doi-asserted-by":"publisher","DOI":"10.1111\/nep.13656","author":"CB Poh","year":"2019","unstructured":"Poh CB, Tan PC, Kam JW, et al. Regional citrate anticoagulation for continuous renal replacement therapy\u2014a safe and effective low-dose protocol. Nephrology (Carlton). 2019. https:\/\/doi.org\/10.1111\/nep.13656.","journal-title":"Nephrology (Carlton)"},{"key":"2064_CR25","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1186\/s13054-017-1880-1","volume":"21","author":"AG Schneider","year":"2017","unstructured":"Schneider AG, Journois D, Rimmel\u00e9 T. Complications of regional citrate anticoagulation: accumulation or overload? Crit Care. 2017;21:281.","journal-title":"Crit Care"}],"container-title":["Clinical and Experimental Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10157-021-02064-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10157-021-02064-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10157-021-02064-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T10:20:06Z","timestamp":1628677206000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10157-021-02064-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,22]]},"references-count":25,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["2064"],"URL":"https:\/\/doi.org\/10.1007\/s10157-021-02064-1","relation":{},"ISSN":["1342-1751","1437-7799"],"issn-type":[{"type":"print","value":"1342-1751"},{"type":"electronic","value":"1437-7799"}],"subject":[],"published":{"date-parts":[[2021,4,22]]},"assertion":[{"value":"28 December 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 April 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 April 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest. No funding was received for this study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee at which the studies were conducted (SingHealth CIRB-2013\/367\/C) and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Waiver of consent was obtained. This article does not contain any studies with animals performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}