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CKD\u2013MBD is highly prevalent in CKD patients, and its treatment is gaining attention from healthcare providers who manage these patients. Additional important pathologies often observed in CKD patients are chronic inflammation and malnutrition\/protein-energy wasting (PEW). These two pathologies coexist to form a vicious cycle that accelerates the progression of various other pathologies in CKD patients. This concept is integrated into the term \u201cmalnutrition\u2013inflammation\u2013atherosclerosis syndrome\u201d or \u201cmalnutrition\u2013inflammation complex syndrome (MICS)\u201d. Recent basic and clinical studies have shown that CKD\u2013MBD directly induces inflammation as well as malnutrition\/PEW. Indeed, higher circulating levels of inorganic phosphate, fibroblast growth factor 23, parathyroid hormone, and calciprotein particles, as markers for critical components and effectors of CKD\u2013MBD, were shown to directly induce inflammatory responses, thereby leading to malnutrition\/PEW, cardiovascular diseases, and clinically relevant complications. In this short review, we discuss the close interplay between CKD\u2013MBD and MICS and emphasize the significance of simultaneous control of these two seemingly distinct pathologies in patients with CKD, especially those receiving dialysis therapy, for better management of the CKD\/hemodialysis population.<\/jats:p>","DOI":"10.1007\/s10157-022-02216-x","type":"journal-article","created":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T07:02:38Z","timestamp":1648623758000},"page":"613-629","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Emerging cross-talks between chronic kidney disease\u2013mineral and bone disorder (CKD\u2013MBD) and malnutrition\u2013inflammation complex syndrome (MICS) in patients receiving dialysis"],"prefix":"10.1007","volume":"26","author":[{"given":"Shunsuke","family":"Yamada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiko","family":"Tsuruya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takanari","family":"Kitazono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiaki","family":"Nakano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,3,30]]},"reference":[{"key":"2216_CR1","unstructured":"Rowe P, Koller A, Sharma S. 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