{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T07:20:57Z","timestamp":1770880857031,"version":"3.50.1"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T00:00:00Z","timestamp":1682294400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T00:00:00Z","timestamp":1682294400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Exp Nephrol"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1007\/s10157-023-02349-7","type":"journal-article","created":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T15:02:36Z","timestamp":1682348556000},"page":"701-706","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Analysis of the ratio of urinary beta-2-microglobulin to total protein concentration in children with isolated tubulointerstitial disease"],"prefix":"10.1007","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4861-4293","authenticated-orcid":false,"given":"Tatsuya","family":"Nishimura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Uemura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Hibino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuki","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naomi","family":"Iwata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaki","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiji","family":"Matsukuma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshishige","family":"Miyake","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshimitsu","family":"Gotoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoya","family":"Fujita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,4,24]]},"reference":[{"key":"2349_CR1","doi-asserted-by":"publisher","first-page":"1242","DOI":"10.1542\/peds.105.6.1242","volume":"105","author":"RJ Hogg","year":"2000","unstructured":"Hogg RJ, Portman RJ, Milliner D, et al. Evaluation and management of proteinuria and nephrotic syndrome in children: recommendations from a pediatric nephrology panel established at the national kidney foundation conference on proteinuria, albuminuria, risk, assessment, detection, and elimination (PARADE). Pediatrics. 2000;105:1242\u20139.","journal-title":"Pediatrics"},{"key":"2349_CR2","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1046\/j.1523-1755.2003.00840.x","volume":"63","author":"G D\u2019Amico","year":"2003","unstructured":"D\u2019Amico G, Bazzi C. Pathophysiology of proteinuria. Kidney Int. 2003;63:809\u201325.","journal-title":"Kidney Int"},{"key":"2349_CR3","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1016\/j.ejim.2009.03.006","volume":"20","author":"A Regeniter","year":"2009","unstructured":"Regeniter A, Freidank H, Dickenmann M, Boesken WH, Siede WH. Evaluation of proteinuria and GFR to diagnose and classify kidney disease: systematic review and proof of concept. Eur J Intern Med. 2009;20:556\u201361.","journal-title":"Eur J Intern Med"},{"key":"2349_CR4","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1172\/JCI106083","volume":"48","author":"PA Peterson","year":"1969","unstructured":"Peterson PA, Evrin PE, Bergg\u00e5rd I. Differentiation of glomerular, tubular, and normal proteinuria: determinations of urinary excretion of beta-2-macroglobulin, albumin, and total protein. J Clin Invest. 1969;48:1189\u201398.","journal-title":"J Clin Invest"},{"key":"2349_CR5","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1007\/BF00866510","volume":"6","author":"PA Tomlinson","year":"1992","unstructured":"Tomlinson PA. Low molecular weight proteins in children with renal disease. Pediatr Nephrol. 1992;6:565\u201371.","journal-title":"Pediatr Nephrol"},{"key":"2349_CR6","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1038\/ki.1986.156","volume":"30","author":"RJ Portman","year":"1986","unstructured":"Portman RJ, Kissane JM, Robson AM. Use of \u03b22 microglobulin to diagnose tubulo-interstitial renal lesions in children. Kidney Int. 1986;30:91\u20138.","journal-title":"Kidney Int"},{"key":"2349_CR7","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1007\/s004670050278","volume":"11","author":"PA Tomlinson","year":"1997","unstructured":"Tomlinson PA, Dalton RN, Hartley B, Haycock GB, Chantler C. Low molecular weight protein excretion in glomerular disease: a comparative analysis. Pediatr Nephrol. 1997;11:285\u201390.","journal-title":"Pediatr Nephrol"},{"key":"2349_CR8","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1038\/nrneph.2010.174","volume":"7","author":"RJ Baines","year":"2011","unstructured":"Baines RJ, Brunskill NJ. Tubular toxicity of proteinuria. Nat Rev Nephrol. 2011;7:177\u201380.","journal-title":"Nat Rev Nephrol"},{"key":"2349_CR9","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1111\/ped.12470","volume":"57","author":"Y Hibi","year":"2015","unstructured":"Hibi Y, Uemura O, Nagai T, et al. The ratios of urinary \u03b22-microglobulin and NAG to creatinine vary with age in children. Pediatr Int. 2015;57:79\u201384.","journal-title":"Pediatr Int"},{"key":"2349_CR10","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1186\/1750-1172-5-28","volume":"5","author":"O Devuyst","year":"2010","unstructured":"Devuyst O, Thakker RV. Dent\u2019s disease. Orphanet J Rare Dis. 2010;5:28.","journal-title":"Orphanet J Rare Dis"},{"key":"2349_CR11","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1093\/ndt\/gft394","volume":"29","author":"T Sekine","year":"2014","unstructured":"Sekine T, Komoda F, Miura K, et al. Japanese Dent disease has a wider clinical spectrum than Dent disease in Europe\/USA: genetic and clinical studies of 86 unrelated patients with low-molecular-weight proteinuria. Nephrol Dial Transplant. 2014;29:376\u201384.","journal-title":"Nephrol Dial Transplant"},{"key":"2349_CR12","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.1002\/art.1780251101","volume":"25","author":"EM Tan","year":"1982","unstructured":"Tan EM, Cohen AS, Fries JF, et al. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 1982;25:1271\u20137.","journal-title":"Arthritis Rheum"},{"key":"2349_CR13","doi-asserted-by":"publisher","first-page":"1725","DOI":"10.1002\/art.1780400928","volume":"40","author":"MC Hochberg","year":"1997","unstructured":"Hochberg MC. Updating the American college of rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 1997;40:1725.","journal-title":"Arthritis Rheum"},{"key":"2349_CR14","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1007\/s10157-013-0856-y","volume":"18","author":"O Uemura","year":"2014","unstructured":"Uemura O, Nagai T, Ishikura K, et al. Creatinine-based equation to estimate the glomerular filtration rate in Japanese children and adolescents with chronic kidney disease. Clin Exp Nephrol. 2014;18:626\u201333.","journal-title":"Clin Exp Nephrol"},{"key":"2349_CR15","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1111\/j.1523-1755.2004.00443.x","volume":"65","author":"JJ Weening","year":"2004","unstructured":"Weening JJ, D\u2019Agati VD, Schwartz MM, et al. The classification of glomerulonephritis in systemic lupus erythematosus revisited. Kidney Int. 2004;65:521\u201330.","journal-title":"Kidney Int"},{"key":"2349_CR16","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1007\/s10157-014-1042-6","volume":"19","author":"O Uemura","year":"2015","unstructured":"Uemura O, Nagai T, Ishikura K, et al. Reference glomerular filtration rate levels in Japanese children: using the creatinine and cystatin C based estimated glomerular filtration rate. Clin Exp Nephrol. 2015;19:683\u20137.","journal-title":"Clin Exp Nephrol"},{"key":"2349_CR17","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1007\/s10157-012-0658-7","volume":"17","author":"Y Ikezumi","year":"2013","unstructured":"Ikezumi Y, Honda M, Matsuyama T, et al. Establishment of a normal reference value for serum \u03b22 microglobulin in Japanese children: reevaluation of its clinical usefulness. Clin Exp Nephrol. 2013;17:99\u2013105.","journal-title":"Clin Exp Nephrol"},{"key":"2349_CR18","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1016\/S0731-7085(00)00550-1","volume":"24","author":"C Donadio","year":"2001","unstructured":"Donadio C, Lucchesi A, Ardini M, Giordani R, Cystatin C. beta 2-microglobulin, and retinol-binding protein as indicators of glomerular filtration rate: comparison with plasma creatinine. J Pharm Biomed Anal. 2001;24:835\u201342.","journal-title":"J Pharm Biomed Anal"},{"key":"2349_CR19","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1007\/BF00862506","volume":"4","author":"MD Donaldson","year":"1990","unstructured":"Donaldson MD, Chambers RE, Woolridge MW, Whicher JT. Alpha 1-microglobulin, beta 2-microglobulin and retinol binding protein in childhood febrile illness and renal disease. Pediatr Nephrol. 1990;4:314\u20138.","journal-title":"Pediatr Nephrol"},{"key":"2349_CR20","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1046\/j.1523-1755.2000.00847.x","volume":"57","author":"AG Norden","year":"2000","unstructured":"Norden AG, Scheinman SJ, Deschodt-Lanckman MM, et al. Tubular proteinuria defined by a study of Dent\u2019s (CLCN5 mutation) and other tubular diseases. Kidney Int. 2000;57:240\u20139.","journal-title":"Kidney Int"},{"key":"2349_CR21","doi-asserted-by":"publisher","first-page":"46","DOI":"10.5582\/irdr.2017.01079","volume":"7","author":"H Zhang","year":"2018","unstructured":"Zhang H, Wang F, Xiao H, Yao Y. The ratio of urinary \u03b11-microglobulin to microalbumin can be used as a diagnostic criterion for tubuloproteinuria. Intractable Rare Dis Res. 2018;7:46\u201350.","journal-title":"Intractable Rare Dis Res"},{"key":"2349_CR22","doi-asserted-by":"publisher","first-page":"1534","DOI":"10.1093\/ndt\/gfr708","volume":"27","author":"ER Smith","year":"2012","unstructured":"Smith ER, Cai MM, McMahon LP, Wright DA, Holt SG. The value of simultaneous measurements of urinary albumin and total protein in proteinuric patients. Nephrol Dial Transplant. 2012;27:1534\u201341.","journal-title":"Nephrol Dial Transplant"},{"key":"2349_CR23","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1007\/s10157-006-0451-6","volume":"11","author":"N Ohisa","year":"2007","unstructured":"Ohisa N, Kanemitsu K, Matsuki R, et al. Evaluation of hematuria using the urinary albumin-to-total-protein ratio to differentiate glomerular and nonglomerular bleeding. Clin Exp Nephrol. 2007;11:61\u20135.","journal-title":"Clin Exp Nephrol"},{"key":"2349_CR24","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1007\/s00467-006-0103-9","volume":"21","author":"CL Abitbol","year":"2006","unstructured":"Abitbol CL, Chandar J, Onder AM, et al. Profiling proteinuria in pediatric patients. Pediatr Nephrol. 2006;21:995\u20131002.","journal-title":"Pediatr Nephrol"},{"key":"2349_CR25","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1007\/s00467-007-0661-5","volume":"23","author":"A Lun","year":"2008","unstructured":"Lun A, Suslovych M, Drube J, et al. Reliability of different expert systems for profiling proteinuria in children with kidney diseases. Pediatr Nephrol. 2008;23:285\u201390.","journal-title":"Pediatr Nephrol"},{"key":"2349_CR26","doi-asserted-by":"publisher","first-page":"1330","DOI":"10.1093\/clinchem\/28.6.1330","volume":"28","author":"PG Davey","year":"1982","unstructured":"Davey PG, Gosling P. Beta 2-microglobulin instability in pathological urine. Clin Chem. 1982;28:1330\u20133.","journal-title":"Clin Chem"}],"container-title":["Clinical and Experimental Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10157-023-02349-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10157-023-02349-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10157-023-02349-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,17]],"date-time":"2023-07-17T08:04:43Z","timestamp":1689581083000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10157-023-02349-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,24]]},"references-count":26,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["2349"],"URL":"https:\/\/doi.org\/10.1007\/s10157-023-02349-7","relation":{},"ISSN":["1342-1751","1437-7799"],"issn-type":[{"value":"1342-1751","type":"print"},{"value":"1437-7799","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,24]]},"assertion":[{"value":"30 August 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 April 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 April 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 May 2023","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Update","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The original version is updated due to spell error \"microgobulin\" which appeared inadvertently in the Article title, Abstract and keywords.","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that there are no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee at which the studies were conducted (IRB approval number: 2018038) and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"As only existing data were used, the requirement for informed consent was waived, but we provided information about this research and a means to opt out.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}