{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T04:39:58Z","timestamp":1777869598084,"version":"3.51.4"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T00:00:00Z","timestamp":1731628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T00:00:00Z","timestamp":1731628800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100000646","name":"Japan Society for the Promotion of Science London","doi-asserted-by":"publisher","award":["JP 20K08600"],"award-info":[{"award-number":["JP 20K08600"]}],"id":[{"id":"10.13039\/501100000646","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019868","name":"Chukyo Longevity Medical and Promotion Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019868","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Exp Nephrol"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1007\/s10157-024-02552-0","type":"journal-article","created":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T09:42:23Z","timestamp":1731663743000},"page":"259-268","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinical characteristics of monoclonal immunoglobulin-associated renal disease: a retrospective cohort study"],"prefix":"10.1007","volume":"29","author":[{"given":"Toshiyuki","family":"Narimiya","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6866-890X","authenticated-orcid":false,"given":"Hiroki","family":"Hayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soshiro","family":"Ogata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeo","family":"Hara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akinao","family":"Okamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuo","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigehisa","family":"Koide","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daijo","family":"Inaguma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Midori","family":"Hasegawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiro","family":"Tomita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukio","family":"Yuzawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naotake","family":"Tsuboi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,11,15]]},"reference":[{"key":"2552_CR1","doi-asserted-by":"publisher","first-page":"4292","DOI":"10.1182\/blood-2012-07-445304","volume":"120","author":"N Leung","year":"2012","unstructured":"Leung N, Bridoux F, Hutchison CA, Nasr SH, Cockwell P, Fermand JP, Dispenzieri A, Song KW, Kyle RA, International K, Monoclonal Gammopathy Research G. Monoclonal gammopathy of renal significance: when MGUS is no longer undetermined or insignificant. Blood. 2012;120:4292\u20135.","journal-title":"Blood"},{"key":"2552_CR2","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1038\/s41581-018-0077-4","volume":"15","author":"N Leung","year":"2019","unstructured":"Leung N, Bridoux F, Batuman V, Chaidos A, Cockwell P, D\u2019Agati VD, Dispenzieri A, Fervenza FC, Fermand JP, Gibbs S, Gillmore JD, Herrera GA, Jaccard A, Jevremovic D, Kastritis E, Kukreti V, Kyle RA, Lachmann HJ, Larsen CP, Ludwig H, Markowitz GS, Merlini G, Mollee P, Picken MM, Rajkumar VS, Royal V, Sanders PW, Sethi S, Venner CP, Voorhees PM, Wechalekar AD, Weiss BM, Nasr SH. The evaluation of monoclonal gammopathy of renal significance: a consensus report of the International Kidney and Monoclonal Gammopathy Research Group. Nat Rev Nephrol. 2019;15:45\u201359.","journal-title":"Nat Rev Nephrol"},{"key":"2552_CR3","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1038\/ki.2014.333","volume":"87","author":"P Yadav","year":"2015","unstructured":"Yadav P, Leung N, Sanders PW, Cockwell P. The use of immunoglobulin light chain assays in the diagnosis of paraprotein-related kidney disease. Kidney Int. 2015;87:692\u20137.","journal-title":"Kidney Int"},{"key":"2552_CR4","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1038\/ki.2014.408","volume":"87","author":"F Bridoux","year":"2015","unstructured":"Bridoux F, Leung N, Hutchison CA, Touchard G, Sethi S, Fermand JP, Picken MM, Herrera GA, Kastritis E, Merlini G, Roussel M, Fervenza FC, Dispenzieri A, Kyle RA, Nasr SH, International K, Monoclonal Gammopathy Research G. Diagnosis of monoclonal gammopathy of renal significance. Kidney Int. 2015;87:698\u2013711.","journal-title":"Kidney Int"},{"key":"2552_CR5","doi-asserted-by":"publisher","first-page":"1931","DOI":"10.1056\/NEJMra1810907","volume":"384","author":"N Leung","year":"2021","unstructured":"Leung N, Bridoux F, Nasr SH. Monoclonal gammopathy of renal significance. N Engl J Med. 2021;384:1931\u201341.","journal-title":"N Engl J Med"},{"key":"2552_CR6","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/S0272-6386(12)80314-3","volume":"20","author":"RL Heilman","year":"1992","unstructured":"Heilman RL, Velosa JA, Holley KE, Offord KP, Kyle RA. Long-term follow-up and response to chemotherapy in patients with light-chain deposition disease. Am J Kidney Dis. 1992;20:34\u201341.","journal-title":"Am J Kidney Dis"},{"key":"2552_CR7","doi-asserted-by":"publisher","first-page":"2055","DOI":"10.1681\/ASN.2009010110","volume":"20","author":"SH Nasr","year":"2009","unstructured":"Nasr SH, Satoskar A, Markowitz GS, Valeri AM, Appel GB, Stokes MB, Nadasdy T, D\u2019Agati VD. Proliferative glomerulonephritis with monoclonal IgG deposits. J Am Soc Nephrol. 2009;20:2055\u201364.","journal-title":"J Am Soc Nephrol"},{"key":"2552_CR8","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1111\/bjh.15987","volume":"186","author":"A Khera","year":"2019","unstructured":"Khera A, Panitsas F, Djebbari F, Kimberger K, Stern S, Quinn J, Rabin N, Kothari J, Alchi B, Haynes R, Winearls C, Roberts I, Ramasamy K. Long term outcomes in monoclonal gammopathy of renal significance. Br J Haematol. 2019;186:706\u201316.","journal-title":"Br J Haematol"},{"key":"2552_CR9","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1111\/nep.13685","volume":"25","author":"C Pena","year":"2020","unstructured":"Pena C, Schutz NP, Riva E, Valjalo R, Majlis A, Lopez-Vidal H, Lois V, Zamora D, Ochoa P, Shanley C, Gonzalez JT, Fantl D, Correa G, Ramirez J, Mur P, Silva G, Verri V, Rojas C, Escobar K, Glavic G, Mendez GP, Grupo de estudio latinoamericano de mieloma m. Epidemiological and clinical characteristics and outcome of monoclonal gammopathy of renal significance-related lesions in Latin America. Nephrology (Carlton). 2020;25:442\u20139.","journal-title":"Nephrology (Carlton)"},{"key":"2552_CR10","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1111\/nep.13633","volume":"25","author":"XJ Yu","year":"2020","unstructured":"Yu XJ, Zhang X, Li DY, Wang SX, Zhou FD, Zhao MH. Renal pathologic spectrum and clinical outcome of monoclonal gammopathy of renal significance: a large retrospective case series study from a single institute in China. Nephrology (Carlton). 2020;25:202\u201311.","journal-title":"Nephrology (Carlton)"},{"key":"2552_CR11","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1186\/s40001-021-00538-2","volume":"26","author":"X Tang","year":"2021","unstructured":"Tang X, Wan F, Yu J, Li X, Yang R, Zhu B. Clinicopathological characteristics of patients with paraproteinemia and renal damage. Eur J Med Res. 2021;26:68.","journal-title":"Eur J Med Res"},{"key":"2552_CR12","doi-asserted-by":"publisher","first-page":"e538","DOI":"10.1016\/S1470-2045(14)70442-5","volume":"15","author":"SV Rajkumar","year":"2014","unstructured":"Rajkumar SV, Dimopoulos MA, Palumbo A, Blade J, Merlini G, Mateos MV, Kumar S, Hillengass J, Kastritis E, Richardson P, Landgren O, Paiva B, Dispenzieri A, Weiss B, LeLeu X, Zweegman S, Lonial S, Rosinol L, Zamagni E, Jagannath S, Sezer O, Kristinsson SY, Caers J, Usmani SZ, Lahuerta JJ, Johnsen HE, Beksac M, Cavo M, Goldschmidt H, Terpos E, Kyle RA, Anderson KC, Durie BG, Miguel JF. International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma. Lancet Oncol. 2014;15:e538\u201348.","journal-title":"Lancet Oncol"},{"key":"2552_CR13","doi-asserted-by":"publisher","first-page":"1564","DOI":"10.1200\/JCO.2005.03.144","volume":"23","author":"MA Dimopoulos","year":"2005","unstructured":"Dimopoulos MA, Kyle RA, Anagnostopoulos A, Treon SP. Diagnosis and management of Waldenstrom\u2019s macroglobulinemia. J Clin Oncol. 2005;23:1564\u201377.","journal-title":"J Clin Oncol"},{"key":"2552_CR14","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1002\/cjp2.126","volume":"5","author":"T Rezk","year":"2019","unstructured":"Rezk T, Gilbertson JA, Mangione PP, Rowczenio D, Rendell NB, Canetti D, Lachmann HJ, Wechalekar AD, Bass P, Hawkins PN, Bellotti V, Taylor GW, Gillmore JD. The complementary role of histology and proteomics for diagnosis and typing of systemic amyloidosis. J Pathol Clin Res. 2019;5:145\u201353.","journal-title":"J Pathol Clin Res."},{"key":"2552_CR15","doi-asserted-by":"publisher","first-page":"c179","DOI":"10.1159\/000339789","volume":"120","author":"A Khwaja","year":"2012","unstructured":"Khwaja A. KDIGO clinical practice guidelines for acute kidney injury. Nephron Clin Pract. 2012;120:c179\u201384.","journal-title":"Nephron Clin Pract"},{"key":"2552_CR16","doi-asserted-by":"publisher","first-page":"2400","DOI":"10.1681\/ASN.2020010054","volume":"31","author":"N Klomjit","year":"2020","unstructured":"Klomjit N, Leung N, Fervenza F, Sethi S, Zand L. Rate and predictors of finding monoclonal gammopathy of renal significance (MGRS) lesions on kidney biopsy in patients with monoclonal gammopathy. J Am Soc Nephrol. 2020;31:2400\u201311.","journal-title":"J Am Soc Nephrol"},{"key":"2552_CR17","doi-asserted-by":"publisher","first-page":"527","DOI":"10.2215\/CJN.12890921","volume":"17","author":"ZH Yong","year":"2022","unstructured":"Yong ZH, Yu XJ, Liu JX, Zhou FD, Wang SX, Zhao MH. Kidney histopathologic spectrum and clinical indicators associated with MGRS. Clin J Am Soc Nephrol. 2022;17:527\u201334.","journal-title":"Clin J Am Soc Nephrol"},{"key":"2552_CR18","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/0165-2478(94)90036-1","volume":"42","author":"L Denoroy","year":"1994","unstructured":"Denoroy L, Deret S, Aucouturier P. Overrepresentation of the V kappa IV subgroup in light chain deposition disease. Immunol Lett. 1994;42:63\u20136.","journal-title":"Immunol Lett"},{"key":"2552_CR19","doi-asserted-by":"publisher","first-page":"1872","DOI":"10.1056\/NEJM200311063491920","volume":"349","author":"JC van der Hilst","year":"2003","unstructured":"van der Hilst JC, Simon A, Drenth JP. Molecular mechanisms of amyloidosis. N Engl J Med. 2003;349:1872\u20133 (author reply-3).","journal-title":"N Engl J Med"},{"key":"2552_CR20","doi-asserted-by":"publisher","first-page":"3713","DOI":"10.1093\/ndt\/gfs449","volume":"27","author":"A Davenport","year":"2012","unstructured":"Davenport A, Merlini G. Myeloma kidney: advances in molecular mechanisms of acute kidney injury open novel therapeutic opportunities. Nephrol Dial Transplant. 2012;27:3713\u20138.","journal-title":"Nephrol Dial Transplant"},{"key":"2552_CR21","doi-asserted-by":"publisher","first-page":"2049","DOI":"10.1681\/ASN.2015050581","volume":"27","author":"A Luciani","year":"2016","unstructured":"Luciani A, Sirac C, Terryn S, Javaugue V, Prange JA, Bender S, Bonaud A, Cogne M, Aucouturier P, Ronco P, Bridoux F, Devuyst O. Impaired lysosomal function underlies monoclonal light chain-associated renal fanconi syndrome. J Am Soc Nephrol. 2016;27:2049\u201361.","journal-title":"J Am Soc Nephrol"},{"key":"2552_CR22","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/j.kint.2016.09.004","volume":"91","author":"F Bridoux","year":"2017","unstructured":"Bridoux F, Javaugue V, Bender S, Leroy F, Aucouturier P, Debiais-Delpech C, Goujon JM, Quellard N, Bonaud A, Clavel M, Trouillas P, Di Meo F, Gombert JM, Fermand JP, Jaccard A, Cogne M, Touchard G, Sirac C. Unravelling the immunopathological mechanisms of heavy chain deposition disease with implications for clinical management. Kidney Int. 2017;91:423\u201334.","journal-title":"Kidney Int"},{"key":"2552_CR23","doi-asserted-by":"publisher","first-page":"2260","DOI":"10.3389\/fimmu.2018.02260","volume":"9","author":"S Chauvet","year":"2018","unstructured":"Chauvet S, Roumenina LT, Aucouturier P, Marinozzi MC, Dragon-Durey MA, Karras A, Delmas Y, Le Quintrec M, Guerrot D, Jourde-Chiche N, Ribes D, Ronco P, Bridoux F, Fremeaux-Bacchi V. Both monoclonal and polyclonal immunoglobulin contingents mediate complement activation in monoclonal gammopathy associated-C3 glomerulopathy. Front Immunol. 2018;9:2260.","journal-title":"Front Immunol"},{"key":"2552_CR24","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1182\/blood-2018-09-872028","volume":"133","author":"F Joly","year":"2019","unstructured":"Joly F, Cohen C, Javaugue V, Bender S, Belmouaz M, Arnulf B, Knebelmann B, Nouvier M, Audard V, Provot F, Gnemmi V, Nochy D, Goujon JM, Jaccard A, Touchard G, Fermand JP, Sirac C, Bridoux F. Randall-type monoclonal immunoglobulin deposition disease: novel insights from a nationwide cohort study. Blood. 2019;133:576\u201387.","journal-title":"Blood"},{"key":"2552_CR25","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1186\/s12882-020-01837-2","volume":"21","author":"M Turner","year":"2020","unstructured":"Turner M, Crawford A, Winterbottom C, Flossmann O, Alchi B, Soares M, Bhandary U. Heavy chain deposition disease presenting with raised anti-GBM antibody levels; a case report. BMC Nephrol. 2020;21:175.","journal-title":"BMC Nephrol"},{"key":"2552_CR26","doi-asserted-by":"publisher","first-page":"2520","DOI":"10.1182\/blood-2006-03-001164","volume":"108","author":"G Merlini","year":"2006","unstructured":"Merlini G, Stone MJ. Dangerous small B-cell clones. Blood. 2006;108:2520\u201330.","journal-title":"Blood"}],"container-title":["Clinical and Experimental Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10157-024-02552-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10157-024-02552-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10157-024-02552-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T17:10:06Z","timestamp":1741626606000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10157-024-02552-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,15]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["2552"],"URL":"https:\/\/doi.org\/10.1007\/s10157-024-02552-0","relation":{},"ISSN":["1342-1751","1437-7799"],"issn-type":[{"value":"1342-1751","type":"print"},{"value":"1437-7799","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,15]]},"assertion":[{"value":"26 March 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 August 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 November 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"T.N., H.H., S.O., S.H., A.O., K.T., S.K., D.I., M.H., and Y.Y. have no conflicts of interest to declare. A.T. has received grants from Chugai Pharmaceutical, Ono Pharmaceutical, and Perseus Proteomics; speaker fees from Chugai Pharmaceutical, Ono Pharmaceutical, Takeda Pharmaceutical, Nippon Shinyaku, and Astra Zeneca; and support for attending meetings from Astra Zeneca and AbbVie GK. N.T. has received grants from Chugai and Asahi KASEI Medical.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interest"}},{"value":"Study approval statement:\u00a0This study was performed following the principles of the Declaration of Helsinki and approved by the Ethics Review Board of Fujita Health University (Approval no. HM21-311).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Consent to participate statement: Opt-out informed consent protocol was used for this research. Patients could opt out on the Fujita Health University website ().","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}