{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T08:13:32Z","timestamp":1777796012394,"version":"3.51.4"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T00:00:00Z","timestamp":1737417600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T00:00:00Z","timestamp":1737417600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Key scientific research projects of natural science in colleges and universities in Anhui Province","award":["2022AH050747"],"award-info":[{"award-number":["2022AH050747"]}]},{"name":"Anhui Provincial Health Research Project","award":["AHWJ2023A30247"],"award-info":[{"award-number":["AHWJ2023A30247"]}]},{"name":"Youth\u00a0Project\u00a0of\u00a0the\u00a0National\u00a0Natural\u00a0Science\u00a0Foundation\u00a0of\u00a0China","award":["82405141"],"award-info":[{"award-number":["82405141"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Exp Nephrol"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1007\/s10157-024-02620-5","type":"journal-article","created":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T21:27:02Z","timestamp":1737408422000},"page":"734-744","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["HDAC9-mediated deacetylation of CALML6 promotes excessive proliferation of glomerular mesangial cells in IgA nephropathy"],"prefix":"10.1007","volume":"29","author":[{"given":"Xingxing","family":"Zhuang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feihu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoudong","family":"Ni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,1,21]]},"reference":[{"issue":"6","key":"2620_CR1","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1093\/ckj\/sfz023","volume":"12","author":"CM Zink","year":"2019","unstructured":"Zink CM, Ernst S, Riehl J, et al. Trends of renal diseases in Germany: review of a regional renal biopsy database from 1990 to 2013. Clin Kidney J. 2019;12(6):795\u2013800.","journal-title":"Clin Kidney J"},{"issue":"2","key":"2620_CR2","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1093\/ndt\/gfq665","volume":"26","author":"A Mcgrogan","year":"2011","unstructured":"Mcgrogan A, Franssen CFM, De Vries CS. The incidence of primary glomerulonephritis worldwide: a systematic review of the literature. Nephrol Dial Transplant. 2011;26(2):414\u201330.","journal-title":"Nephrol Dial Transplant"},{"issue":"1","key":"2620_CR3","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1007\/s10157-018-1582-2","volume":"23","author":"H Suzuki","year":"2019","unstructured":"Suzuki H. Biomarkers for IgA nephropathy on the basis of multi-hit pathogenesis. Clin Exp Nephrol. 2019;23(1):26\u201331.","journal-title":"Clin Exp Nephrol"},{"issue":"11","key":"2620_CR4","doi-asserted-by":"publisher","first-page":"2493","DOI":"10.3390\/jcm10112493","volume":"10","author":"CK Cheung","year":"2021","unstructured":"Cheung CK, Rajasekaran A, Barratt J, et al. An update on the current state of management and clinical trials for IgA nephropathy. J Clin Med. 2021;10(11):2493.","journal-title":"J Clin Med"},{"issue":"2","key":"2620_CR5","doi-asserted-by":"publisher","first-page":"36","DOI":"10.36469\/jheor.2021.26129","volume":"8","author":"CS Kwon","year":"2021","unstructured":"Kwon CS, Daniele P, Forsythe A, et al. A systematic literature review of the epidemiology, health-related quality of life impact, and economic Burden of immunoglobulin A nephropathy. J Health Econ Outcomes Res. 2021;8(2):36\u201345.","journal-title":"J Health Econ Outcomes Res"},{"issue":"1","key":"2620_CR6","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1038\/nrg2485","volume":"10","author":"M Haberland","year":"2009","unstructured":"Haberland M, Montgomery RL, Olson EN. The many roles of histone deacetylases in development and physiology: implications for disease and therapy. Nat Rev Genet. 2009;10(1):32\u201342.","journal-title":"Nat Rev Genet"},{"issue":"5","key":"2620_CR7","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1007\/s00467-012-2223-8","volume":"28","author":"S Chen","year":"2013","unstructured":"Chen S, El-Dahr SS. Histone deacetylases in kidney development: implications for disease and therapy. Pediatr Nephrol. 2013;28(5):689\u201398.","journal-title":"Pediatr Nephrol"},{"key":"2620_CR8","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/S0065-230X(02)86002-X","volume":"86","author":"H Lehrmann","year":"2002","unstructured":"Lehrmann H, Pritchard LL, Harel-Bellan A. Histone acetyltransferases and deacetylases in the control of cell proliferation and differentiation. Adv Cancer Res. 2002;86:41\u201365.","journal-title":"Adv Cancer Res"},{"issue":"3","key":"2620_CR9","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1007\/s10157-020-01995-5","volume":"25","author":"H Liu","year":"2021","unstructured":"Liu H. The roles of histone deacetylases in kidney development and disease. Clin Exp Nephrol. 2021;25(3):215\u201323.","journal-title":"Clin Exp Nephrol"},{"issue":"9","key":"2620_CR10","doi-asserted-by":"publisher","first-page":"1048","DOI":"10.1038\/s41551-021-00728-7","volume":"5","author":"Y Wang","year":"2021","unstructured":"Wang Y, Jiang Y, Wei D, et al. Nanoparticle-mediated convection-enhanced delivery of a DNA intercalator to gliomas circumvents temozolomide resistance. Nat Biomed Eng. 2021;5(9):1048\u201358.","journal-title":"Nat Biomed Eng"},{"issue":"1","key":"2620_CR11","doi-asserted-by":"publisher","first-page":"6498","DOI":"10.1038\/s41467-022-34271-z","volume":"13","author":"J Liao","year":"2022","unstructured":"Liao J, Qian J, Fang Y, et al. De novo analysis of bulk RNA-seq data at spatially resolved single-cell resolution. Nat Commun. 2022;13(1):6498.","journal-title":"Nat Commun"},{"key":"2620_CR12","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.710977","volume":"12","author":"H Li","year":"2021","unstructured":"Li H, Tang D, Chen J, et al. The clinical value of GDF15 and its prospective mechanism in sepsis. Front Immunol. 2021;12: 710977.","journal-title":"Front Immunol"},{"key":"2620_CR13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2022.104319","volume":"85","author":"J Wang","year":"2022","unstructured":"Wang J, Ren M, Yu J, et al. Single-cell RNA sequencing highlights the functional role of human endogenous retroviruses in gallbladder cancer. EBioMedicine. 2022;85: 104319.","journal-title":"EBioMedicine"},{"issue":"11","key":"2620_CR14","doi-asserted-by":"publisher","first-page":"3015","DOI":"10.1002\/hep4.1983","volume":"6","author":"A Chaidez","year":"2022","unstructured":"Chaidez A, Pan Z, Sundaram SS, et al. The discriminatory ability of FibroScan liver stiffness measurement, controlled attenuation parameter, and FibroScan-aspartate aminotransferase to predict severity of liver disease in children. Hepatol Commun. 2022;6(11):3015\u201323.","journal-title":"Hepatol Commun"},{"issue":"9","key":"2620_CR15","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.13278","volume":"55","author":"L Zhao","year":"2022","unstructured":"Zhao L, Lan Z, Peng L, et al. Triptolide promotes autophagy to inhibit mesangial cell proliferation in IgA nephropathy via the CARD9\/p38 MAPK pathway. Cell Prolif. 2022;55(9): e13278.","journal-title":"Cell Prolif"},{"key":"2620_CR16","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2019.106125","volume":"80","author":"M Xia","year":"2020","unstructured":"Xia M, Liu D, Tang X, et al. Dihydroartemisinin inhibits the proliferation of IgAN mesangial cells through the mTOR signaling pathway. Int Immunopharmacol. 2020;80: 106125.","journal-title":"Int Immunopharmacol"},{"key":"2620_CR17","doi-asserted-by":"publisher","first-page":"D607","DOI":"10.1093\/nar\/gky1131","volume":"47","author":"D Szklarczyk","year":"2019","unstructured":"Szklarczyk D, Gable AL, Lyon D, Junge A, Wyder S, Huerta-Cepas J, et al. STRING v11: protein\u2013protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets. Nucleic Acids Res. 2019;47:D607-613.","journal-title":"Nucleic Acids Res"},{"key":"2620_CR18","doi-asserted-by":"publisher","first-page":"e74","DOI":"10.1159\/000127359","volume":"108","author":"A Cove-Smith","year":"2008","unstructured":"Cove-Smith A, Hendry BM. The regulation of mesangial cell proliferation. Nephron Exp Nephrol. 2008;108:e74\u20139.","journal-title":"Nephron Exp Nephrol"},{"issue":"1","key":"2620_CR19","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1038\/s41421-021-00326-6","volume":"7","author":"Y Zhang","year":"2021","unstructured":"Zhang Y, Long X, Ruan X, et al. SIRT2-mediated deacetylation and deubiquitination of C\/EBP\u03b2 prevents ethanol-induced liver injury. Cell Discov. 2021;7(1):93.","journal-title":"Cell Discov"},{"issue":"6","key":"2620_CR20","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109988","volume":"37","author":"K Shimizu","year":"2021","unstructured":"Shimizu K, Gi M, Suzuki S, et al. Interplay between protein acetylation and ubiquitination controls MCL1 protein stability. Cell Rep. 2021;37(6): 109988.","journal-title":"Cell Rep"},{"issue":"9","key":"2620_CR21","doi-asserted-by":"publisher","first-page":"1736","DOI":"10.1111\/febs.13061","volume":"282","author":"M Parra","year":"2015","unstructured":"Parra M. Class IIa HDACs - new insights into their functions in physiology and pathology. FEBS J. 2015;282(9):1736\u201344.","journal-title":"FEBS J"},{"issue":"1","key":"2620_CR22","doi-asserted-by":"publisher","first-page":"3007","DOI":"10.1038\/s41467-023-38771-4","volume":"14","author":"Y Zhang","year":"2023","unstructured":"Zhang Y, Yang Y, Yang F, et al. HDAC9-mediated epithelial cell cycle arrest in G2\/M contributes to kidney fibrosis in male mice. Nat Commun. 2023;14(1):3007.","journal-title":"Nat Commun"},{"key":"2620_CR23","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2023.107009","volume":"198","author":"M Liu","year":"2023","unstructured":"Liu M, Zhang Y, Zhan P, et al. Histone deacetylase 9 exacerbates podocyte injury in hyperhomocysteinemia through epigenetic repression of Klotho. Pharmacol Res. 2023;198: 107009.","journal-title":"Pharmacol Res"},{"issue":"2","key":"2620_CR24","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1016\/j.intimp.2015.10.006","volume":"29","author":"NL Regna","year":"2015","unstructured":"Regna NL, Vieson MD, Gojmerac AM, Luo XM, Caudell DL, Reilly CM. HDAC expression and activity is upregulated in diseased lupus-prone mice. Int Immunopharmacol. 2015;29(2):494\u2013503.","journal-title":"Int Immunopharmacol"},{"issue":"2","key":"2620_CR25","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1111\/nph.14966","volume":"218","author":"J Kudla","year":"2018","unstructured":"Kudla J, Becker D, Grill E, et al. Advances and current challenges in calcium signaling. New Phytol. 2018;218(2):414\u201331.","journal-title":"New Phytol"},{"issue":"12","key":"2620_CR26","doi-asserted-by":"publisher","first-page":"2299","DOI":"10.1007\/s00018-019-03062-z","volume":"76","author":"A Villalobo","year":"2019","unstructured":"Villalobo A, Gonz\u00e1lez-Mu\u00f1oz M, Berchtold MW. Proteins with calmodulin-like domains: structures and functional roles. Cell Mol Life Sci. 2019;76(12):2299\u2013328.","journal-title":"Cell Mol Life Sci"},{"issue":"12","key":"2620_CR27","doi-asserted-by":"publisher","first-page":"2048","DOI":"10.1016\/j.biochi.2011.07.012","volume":"93","author":"A Perochon","year":"2011","unstructured":"Perochon A, Aldon D, Galaud JP, Ranty B. Calmodulin and calmodulin-like proteins in plant calcium signaling. Biochimie. 2011;93(12):2048\u201353.","journal-title":"Biochimie"},{"issue":"11","key":"2620_CR28","doi-asserted-by":"publisher","first-page":"3008","DOI":"10.4049\/jimmunol.1901042","volume":"204","author":"C Sheng","year":"2020","unstructured":"Sheng C, Wang Z, Yao C, et al. CALML6 controls TAK1 ubiquitination and confers protection against acute inflammation. J Immunol. 2020;204(11):3008\u201318.","journal-title":"J Immunol"},{"issue":"5","key":"2620_CR29","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.1016\/j.celrep.2019.01.030","volume":"26","author":"Z Wang","year":"2019","unstructured":"Wang Z, Sheng C, Yao C, Chen H, Wang D, Chen S. The EF-hand protein CALML6 suppresses antiviral innate immunity by impairing IRF3 dimerization. Cell Rep. 2019;26(5):1273\u201385.","journal-title":"Cell Rep"},{"issue":"2","key":"2620_CR30","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004901","volume":"11","author":"O Kiraly","year":"2015","unstructured":"Kiraly O, Gong G, Olipitz W, Muthupalani S, Engelward BP. Inflammation-induced cell proliferation potentiates DNA damage-induced mutations in vivo. PLoS Genet. 2015;11(2): e1004901.","journal-title":"PLoS Genet"},{"key":"2620_CR31","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.molimm.2021.10.012","volume":"140","author":"J Shen","year":"2021","unstructured":"Shen J, Wu Q, Liang T, et al. TRIM40 inhibits IgA1-induced proliferation of glomerular mesangial cells by inactivating NLRP3 inflammasome through ubiquitination. Mol Immunol. 2021;140:225\u201332.","journal-title":"Mol Immunol"},{"issue":"3","key":"2620_CR32","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1038\/s41580-018-0081-3","volume":"20","author":"T Narita","year":"2019","unstructured":"Narita T, Weinert BT, Choudhary C. Functions and mechanisms of non-histone protein acetylation. Nat Rev Mol Cell Biol. 2019;20(3):156\u201374.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2620_CR33","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2023.106950","volume":"197","author":"XY Li","year":"2023","unstructured":"Li XY, Yu JT, Dong YH, et al. Protein acetylation and related potential therapeutic strategies in kidney disease. Pharmacol Res. 2023;197: 106950.","journal-title":"Pharmacol Res"},{"issue":"5","key":"2620_CR34","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1038\/s41580-021-00441-y","volume":"23","author":"M Shvedunova","year":"2022","unstructured":"Shvedunova M, Akhtar A. Modulation of cellular processes by histone and non-histone protein acetylation. Nat Rev Mol Cell Biol. 2022;23(5):329\u201349.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"4","key":"2620_CR35","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1093\/emboj\/19.4.662","volume":"19","author":"MA Mart\u00ednez-Balb\u00e1s","year":"2000","unstructured":"Mart\u00ednez-Balb\u00e1s MA, Bauer UM, Nielsen SJ, Brehm A, Kouzarides T. Regulation of E2F1 activity by acetylation. EMBO J. 2000;19(4):662\u201371.","journal-title":"EMBO J"},{"key":"2620_CR36","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.canlet.2019.11.043","volume":"471","author":"J Xue","year":"2020","unstructured":"Xue J, Cao Z, Cheng Y, et al. Acetylation of alpha-fetoprotein promotes hepatocellular carcinoma progression. Cancer Lett. 2020;471:12\u201326.","journal-title":"Cancer Lett"},{"issue":"32","key":"2620_CR37","doi-asserted-by":"publisher","first-page":"10205","DOI":"10.1021\/jacs.5b04086","volume":"137","author":"R Collepardo-Guevara","year":"2015","unstructured":"Collepardo-Guevara R, Portella G, Vendruscolo M, Frenkel D, Schlick T, Orozco M. Chromatin unfolding by epigenetic modifications explained by dramatic impairment of internucleosome interactions: a multiscale computational study. J Am Chem Soc. 2015;137(32):10205\u201315.","journal-title":"J Am Chem Soc"},{"issue":"7","key":"2620_CR38","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1038\/s41419-020-02763-9","volume":"11","author":"L Liu","year":"2020","unstructured":"Liu L, Chen S, Yu M, et al. Deacetylation of HSD17B10 by SIRT3 regulates cell growth and cell resistance under oxidative and starvation stresses. Cell Death Dis. 2020;11(7):563.","journal-title":"Cell Death Dis"},{"issue":"2","key":"2620_CR39","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1007\/s12565-016-0334-1","volume":"92","author":"H Kurihara","year":"2017","unstructured":"Kurihara H, Sakai T. Cell biology of mesangial cells: the third cell that maintains the glomerular capillary. Anat Sci Int. 2017;92(2):173\u201386.","journal-title":"Anat Sci Int"},{"issue":"1","key":"2620_CR40","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1111\/cei.12154","volume":"174","author":"LL Liu","year":"2013","unstructured":"Liu LL, Liu N, Chen Y, et al. Glomerular mannose-binding lectin deposition is a useful prognostic predictor in immunoglobulin A nephropathy [J]. Clin Exp Immunol. 2013;174(1):152\u201360.","journal-title":"Clin Exp Immunol"}],"container-title":["Clinical and Experimental Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10157-024-02620-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10157-024-02620-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10157-024-02620-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T10:11:04Z","timestamp":1757499064000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10157-024-02620-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,21]]},"references-count":40,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["2620"],"URL":"https:\/\/doi.org\/10.1007\/s10157-024-02620-5","relation":{},"ISSN":["1342-1751","1437-7799"],"issn-type":[{"value":"1342-1751","type":"print"},{"value":"1437-7799","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,21]]},"assertion":[{"value":"19 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 December 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All the authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"This study was approved by the Ethics\u00a0Committee of the Chaohu\u00a0Hospital\u00a0of\u00a0Anhui\u00a0Medical\u00a0University (Approval number: KYXM-202404\u2013001).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"All patients were informed of the purpose and significance of this study, and written informed consent was obtained for publication.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Patient consent for publication"}}]}}