{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T18:20:38Z","timestamp":1783707638175,"version":"3.55.0"},"reference-count":68,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T00:00:00Z","timestamp":1757635200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T00:00:00Z","timestamp":1757635200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001691","name":"the Japan Society for the Promotion of Science","doi-asserted-by":"crossref","award":["23K24728"],"award-info":[{"award-number":["23K24728"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Exp Nephrol"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1007\/s10157-025-02764-y","type":"journal-article","created":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T09:46:10Z","timestamp":1757670370000},"page":"1-14","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Sedentary behavior as an emerging risk factor for chronic kidney disease: a narrative review"],"prefix":"10.1007","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7376-4277","authenticated-orcid":false,"given":"Shun","family":"Yoshikoshi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6001-578X","authenticated-orcid":false,"given":"Keisei","family":"Kosaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichiro","family":"Oka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiji","family":"Maeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunihiro","family":"Yamagata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,12]]},"reference":[{"issue":"10225","key":"2764_CR1","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1016\/S0140-6736(20)30045-3","volume":"395","author":"Collaboration GBDCKD","year":"2020","unstructured":"Collaboration GBDCKD. Global, regional, and national burden of chronic kidney disease, 1990\u20132017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 2020;395(10225):709\u201333. https:\/\/doi.org\/10.1016\/S0140-6736(20)30045-3.","journal-title":"Lancet"},{"issue":"4","key":"2764_CR2","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1097\/00000441-200304000-00002","volume":"325","author":"AJ Collins","year":"2003","unstructured":"Collins AJ. Cardiovascular mortality in end-stage renal disease. Am J Med Sci. 2003;325(4):163\u20137. https:\/\/doi.org\/10.1097\/00000441-200304000-00002.","journal-title":"Am J Med Sci"},{"issue":"9","key":"2764_CR3","doi-asserted-by":"publisher","first-page":"1586","DOI":"10.2215\/CJN.10481013","volume":"9","author":"R Minutolo","year":"2014","unstructured":"Minutolo R, Lapi F, Chiodini P, Simonetti M, Bianchini E, Pecchioli S, et al. Risk of ESRD and death in patients with CKD not referred to a nephrologist: a 7-year prospective study. Clin J Am Soc Nephrol. 2014;9(9):1586\u201393. https:\/\/doi.org\/10.2215\/CJN.10481013.","journal-title":"Clin J Am Soc Nephrol"},{"issue":"10","key":"2764_CR4","doi-asserted-by":"publisher","first-page":"3192","DOI":"10.1093\/ndt\/gfn222","volume":"23","author":"SJ Hwang","year":"2008","unstructured":"Hwang SJ, Lin MY, Chen HC, Hwang SC, Yang WC, Hsu CC, et al. Increased risk of mortality in the elderly population with late-stage chronic kidney disease: a cohort study in Taiwan. Nephrol Dial Transplant. 2008;23(10):3192\u20138. https:\/\/doi.org\/10.1093\/ndt\/gfn222.","journal-title":"Nephrol Dial Transplant"},{"issue":"4","key":"2764_CR5","doi-asserted-by":"publisher","first-page":"648","DOI":"10.2215\/CJN.07830520","volume":"16","author":"M Hannan","year":"2021","unstructured":"Hannan M, Ansari S, Meza N, Anderson AH, Srivastava A, Waikar S, et al. Risk factors for CKD progression: overview of findings from the CRIC study. Clin J Am Soc Nephrol. 2021;16(4):648\u201359. https:\/\/doi.org\/10.2215\/CJN.07830520.","journal-title":"Clin J Am Soc Nephrol"},{"issue":"1","key":"2764_CR6","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1681\/ASN.2020030384","volume":"32","author":"JT Kelly","year":"2021","unstructured":"Kelly JT, Su G, Zhang L, Qin X, Marshall S, Gonzalez-Ortiz A, et al. Modifiable lifestyle factors for primary prevention of CKD: a systematic review and meta-analysis. J Am Soc Nephrol. 2021;32(1):239\u201353. https:\/\/doi.org\/10.1681\/ASN.2020030384.","journal-title":"J Am Soc Nephrol"},{"issue":"19","key":"2764_CR7","doi-asserted-by":"publisher","first-page":"19221","DOI":"10.18632\/aging.103747","volume":"12","author":"Y Zhu","year":"2020","unstructured":"Zhu Y, Bu Y, Zhang G, Ding S, Zhai D, Wan Z, et al. Association of physical activity with chronic kidney disease: a systematic review and dose-response meta-analysis. Aging (Albany NY). 2020;12(19):19221\u201332. https:\/\/doi.org\/10.18632\/aging.103747.","journal-title":"Aging (Albany NY)"},{"issue":"3","key":"2764_CR8","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1007\/s10654-022-00961-7","volume":"38","author":"S Seidu","year":"2023","unstructured":"Seidu S, Abdool M, Almaqhawi A, Wilkinson TJ, Kunutsor SK, Khunti K, et al. Physical activity and risk of chronic kidney disease: systematic review and meta-analysis of 12 cohort studies involving 1,281,727 participants. Eur J Epidemiol. 2023;38(3):267\u201380. https:\/\/doi.org\/10.1007\/s10654-022-00961-7.","journal-title":"Eur J Epidemiol"},{"issue":"12","key":"2764_CR9","doi-asserted-by":"publisher","first-page":"1901","DOI":"10.2215\/cjn.01970309","volume":"4","author":"S Beddhu","year":"2009","unstructured":"Beddhu S, Baird BC, Zitterkoph J, Neilson J, Greene T. Physical activity and mortality in chronic kidney disease (NHANES III). Clin J Am Soc Nephrol. 2009;4(12):1901\u20136. https:\/\/doi.org\/10.2215\/cjn.01970309.","journal-title":"Clin J Am Soc Nephrol"},{"issue":"3","key":"2764_CR10","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1093\/eurjpc\/zwaa162","volume":"29","author":"CP Kuo","year":"2022","unstructured":"Kuo CP, Tsai MT, Lee KH, Lin YP, Huang SS, Huang CC, et al. Dose-response effects of physical activity on all-cause mortality and major cardiorenal outcomes in chronic kidney disease. Eur J Prev Cardiol. 2022;29(3):452\u201361. https:\/\/doi.org\/10.1093\/eurjpc\/zwaa162.","journal-title":"Eur J Prev Cardiol"},{"issue":"14","key":"2764_CR11","doi-asserted-by":"publisher","first-page":"1737","DOI":"10.1001\/jama.293.14.1737","volume":"293","author":"MG Shlipak","year":"2005","unstructured":"Shlipak MG, Fried LF, Cushman M, Manolio TA, Peterson D, Stehman-Breen C, et al. Cardiovascular mortality risk in chronic kidney disease: comparison of traditional and novel risk factors. JAMA. 2005;293(14):1737\u201345. https:\/\/doi.org\/10.1001\/jama.293.14.1737.","journal-title":"JAMA"},{"issue":"6","key":"2764_CR12","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1053\/j.ajkd.2022.05.007","volume":"80","author":"JW Bruinius","year":"2022","unstructured":"Bruinius JW, Hannan M, Chen J, Brown J, Kansal M, Meza N, et al. Self-reported physical activity and cardiovascular events in adults with CKD: findings from the CRIC (Chronic Renal Insufficiency Cohort) study. Am J Kidney Dis. 2022;80(6):751-61 e1. https:\/\/doi.org\/10.1053\/j.ajkd.2022.05.007.","journal-title":"Am J Kidney Dis"},{"issue":"1","key":"2764_CR13","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1186\/s12966-017-0525-8","volume":"14","author":"MS Tremblay","year":"2017","unstructured":"Tremblay MS, Aubert S, Barnes JD, Saunders TJ, Carson V, Latimer-Cheung AE, et al. Sedentary behavior research network (SBRN) - terminology consensus project process and outcome. Int J Behav Nutr Phys Act. 2017;14(1):75. https:\/\/doi.org\/10.1186\/s12966-017-0525-8.","journal-title":"Int J Behav Nutr Phys Act"},{"issue":"24","key":"2764_CR14","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.1136\/bjsports-2020-102955","volume":"54","author":"FC Bull","year":"2020","unstructured":"Bull FC, Al-Ansari SS, Biddle S, Borodulin K, Buman MP, Cardon G, et al. World Health Organization 2020 guidelines on physical activity and sedentary behaviour. Br J Sports Med. 2020;54(24):1451\u201362. https:\/\/doi.org\/10.1136\/bjsports-2020-102955.","journal-title":"Br J Sports Med"},{"key":"2764_CR15","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.003917","author":"A Derakhshan","year":"2016","unstructured":"Derakhshan A, Bagherzadeh-Khiabani F, Arshi B, Ramezankhani A, Azizi F, Hadaegh F. Different combinations of glucose tolerance and blood pressure status and incident diabetes, hypertension, and chronic kidney disease. J Am Heart Assoc. 2016. https:\/\/doi.org\/10.1161\/JAHA.116.003917.","journal-title":"J Am Heart Assoc"},{"issue":"4","key":"2764_CR16","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1016\/j.kint.2023.10.016","volume":"105","author":"A Levin","year":"2024","unstructured":"Levin A, Ahmed SB, Carrero JJ, Foster B, Francis A, Hall RK, et al. Executive summary of the KDIGO 2024 clinical practice guideline for the evaluation and management of chronic kidney disease: known knowns and known unknowns. Kidney Int. 2024;105(4):684\u2013701. https:\/\/doi.org\/10.1016\/j.kint.2023.10.016.","journal-title":"Kidney Int"},{"issue":"3\u20134","key":"2764_CR17","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1007\/s00508-020-01673-2","volume":"133","author":"K Volaklis","year":"2021","unstructured":"Volaklis K, Mamadjanov T, Meisinger C. Sedentary behavior and kidney function in adults: a narrative review. Wien Klin Wochenschr. 2021;133(3\u20134):144\u201352. https:\/\/doi.org\/10.1007\/s00508-020-01673-2.","journal-title":"Wien Klin Wochenschr"},{"issue":"1","key":"2764_CR18","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1186\/s12966-020-00972-1","volume":"17","author":"EA Bakker","year":"2020","unstructured":"Bakker EA, Hartman YAW, Hopman MTE, Hopkins ND, Graves LEF, Dunstan DW, et al. Validity and reliability of subjective methods to assess sedentary behaviour in adults: a systematic review and meta-analysis. Int J Behav Nutr Phys Act. 2020;17(1):75. https:\/\/doi.org\/10.1186\/s12966-020-00972-1.","journal-title":"Int J Behav Nutr Phys Act"},{"issue":"1","key":"2764_CR19","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1186\/s12966-018-0749-2","volume":"15","author":"KC Heesch","year":"2018","unstructured":"Heesch KC, Hill RL, Aguilar-Farias N, van Uffelen JGZ, Pavey T. Validity of objective methods for measuring sedentary behaviour in older adults: a systematic review. Int J Behav Nutr Phys Act. 2018;15(1):119. https:\/\/doi.org\/10.1186\/s12966-018-0749-2.","journal-title":"Int J Behav Nutr Phys Act"},{"issue":"3","key":"2764_CR20","doi-asserted-by":"publisher","first-page":"149","DOI":"10.2188\/jea.JE20170002","volume":"28","author":"K Ishii","year":"2018","unstructured":"Ishii K, Shibata A, Kurita S, Yano S, Inoue S, Sugiyama T, et al. Validity and reliability of Japanese-language self-reported measures for assessing adults domain-specific sedentary time. J Epidemiol. 2018;28(3):149\u201355. https:\/\/doi.org\/10.2188\/jea.JE20170002.","journal-title":"J Epidemiol"},{"issue":"3","key":"2764_CR21","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1123\/japa.2014-0164","volume":"23","author":"JA Harvey","year":"2015","unstructured":"Harvey JA, Chastin SF, Skelton DA. How sedentary are older people? A systematic review of the amount of sedentary behavior. J Aging Phys Act. 2015;23(3):471\u201387. https:\/\/doi.org\/10.1123\/japa.2014-0164.","journal-title":"J Aging Phys Act"},{"issue":"1","key":"2764_CR22","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1186\/s40798-022-00542-8","volume":"8","author":"MK Tsai","year":"2022","unstructured":"Tsai MK, Gao W, Chien KL, Baw CK, Hsu CC, Wen CP. Associations of prolonged occupational sitting with the spectrum of kidney disease: results from a cohort of a half-million Asian adults. Sports Med Open. 2022;8(1):147. https:\/\/doi.org\/10.1186\/s40798-022-00542-8.","journal-title":"Sports Med Open"},{"issue":"6","key":"2764_CR23","doi-asserted-by":"publisher","first-page":"285","DOI":"10.2188\/jea.JE20210155","volume":"33","author":"M Hara","year":"2023","unstructured":"Hara M, Nishida Y, Tanaka K, Shimanoe C, Koga K, Furukawa T, et al. Moderate-to-vigorous physical activity and sedentary behavior are independently associated with renal function: a cross-sectional study. J Epidemiol. 2023;33(6):285\u201393. https:\/\/doi.org\/10.2188\/jea.JE20210155.","journal-title":"J Epidemiol"},{"issue":"6","key":"2764_CR24","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1093\/ndt\/gfab153","volume":"37","author":"S Park","year":"2022","unstructured":"Park S, Lee S, Kim Y, Lee Y, Kang MW, Kim K, et al. Causal effects of physical activity or sedentary behaviors on kidney function: an integrated population-scale observational analysis and Mendelian randomization study. Nephrol Dial Transplant. 2022;37(6):1059\u201368. https:\/\/doi.org\/10.1093\/ndt\/gfab153.","journal-title":"Nephrol Dial Transplant"},{"issue":"4","key":"2764_CR25","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1123\/jpah.2013-0289","volume":"12","author":"M Hawkins","year":"2015","unstructured":"Hawkins M, Newman AB, Madero M, Patel KV, Shlipak MG, Cooper J, et al. Tv watching, but not physical activity, is associated with change in kidney function in older adults. J Phys Act Health. 2015;12(4):561\u20138. https:\/\/doi.org\/10.1123\/jpah.2013-0289.","journal-title":"J Phys Act Health"},{"issue":"1","key":"2764_CR26","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1186\/s12889-022-14929-5","volume":"23","author":"YS Jang","year":"2023","unstructured":"Jang YS, Park YS, Kim H, Hurh K, Park EC, Jang SY. Association between sedentary behavior and chronic kidney disease in Korean adults. BMC Public Health. 2023;23(1):306. https:\/\/doi.org\/10.1186\/s12889-022-14929-5.","journal-title":"BMC Public Health"},{"issue":"4","key":"2764_CR27","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1053\/j.ajkd.2012.04.024","volume":"60","author":"N Bharakhada","year":"2012","unstructured":"Bharakhada N, Yates T, Davies MJ, Wilmot EG, Edwardson C, Henson J, et al. Association of sitting time and physical activity with CKD: a cross-sectional study in family practices. Am J Kidney Dis. 2012;60(4):583\u201390. https:\/\/doi.org\/10.1053\/j.ajkd.2012.04.024.","journal-title":"Am J Kidney Dis"},{"issue":"4","key":"2764_CR28","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1123\/jpah.7.4.541","volume":"7","author":"M Hagstromer","year":"2010","unstructured":"Hagstromer M, Ainsworth BE, Oja P, Sjostrom M. Comparison of a subjective and an objective measure of physical activity in a population sample. J Phys Act Health. 2010;7(4):541\u201350. https:\/\/doi.org\/10.1123\/jpah.7.4.541.","journal-title":"J Phys Act Health"},{"issue":"7","key":"2764_CR29","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.1093\/ndt\/gfae038","volume":"39","author":"TG Vosters","year":"2024","unstructured":"Vosters TG, Kingma FM, Stel VS, van den Born BH, Huisman B, van Ittersum FJ, et al. Sex differences in CKD risk factors across ethnic groups. Nephrol Dial Transplant. 2024;39(7):1194\u20137. https:\/\/doi.org\/10.1093\/ndt\/gfae038.","journal-title":"Nephrol Dial Transplant"},{"issue":"4","key":"2764_CR30","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1053\/ajkd.2002.35677","volume":"40","author":"EM Briganti","year":"2002","unstructured":"Briganti EM, Branley P, Chadban SJ, Shaw JE, McNeil JJ, Welborn TA, et al. Smoking is associated with renal impairment and proteinuria in the normal population: the AusDiab kidney study. Australian Diabetes, Obesity and Lifestyle Study. Am J Kidney Dis. 2002;40(4):704\u201312. https:\/\/doi.org\/10.1053\/ajkd.2002.35677.","journal-title":"Am J Kidney Dis"},{"issue":"6","key":"2764_CR31","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1053\/j.ajkd.2024.05.007","volume":"84","author":"MK Sullivan","year":"2024","unstructured":"Sullivan MK, Lees JS, Rosales BM, Cutting R, Wyld ML, Woodward M, et al. Sex and the relationship between cardiometabolic risk factors and estimated GFR decline: a population-based cohort study. Am J Kidney Dis. 2024;84(6):731-41 e1. https:\/\/doi.org\/10.1053\/j.ajkd.2024.05.007.","journal-title":"Am J Kidney Dis"},{"issue":"1","key":"2764_CR32","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1186\/s12889-024-17771-z","volume":"24","author":"Y Shi","year":"2024","unstructured":"Shi Y, Xu Y, Zhou W. Dietary carotenoids intake and sex differences in relation to chronic kidney disease a cross-sectional assessment in the NHANES study. BMC Public Health. 2024;24(1):293. https:\/\/doi.org\/10.1186\/s12889-024-17771-z.","journal-title":"BMC Public Health"},{"issue":"6","key":"2764_CR33","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0234825","volume":"15","author":"J Lee","year":"2020","unstructured":"Lee J, Walker ME, Gabriel KP, Vasan RS, Xanthakis V. Associations of accelerometer-measured physical activity and sedentary time with chronic kidney disease: the Framingham Heart Study. PLoS ONE. 2020;15(6):e0234825. https:\/\/doi.org\/10.1371\/journal.pone.0234825.","journal-title":"PLoS ONE"},{"key":"2764_CR34","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2024.1403998","volume":"15","author":"X Suo","year":"2024","unstructured":"Suo X, Liu Y, Amoah AN, Bo Y, Lyu Q. Associations of accelerometer-measured physical activity and sedentary time with renal function and chronic kidney disease: a national population-based study. Front Endocrinol (Lausanne). 2024;15:1403998. https:\/\/doi.org\/10.3389\/fendo.2024.1403998.","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"4","key":"2764_CR35","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1053\/j.ajkd.2018.03.031","volume":"72","author":"T Glavinovic","year":"2018","unstructured":"Glavinovic T, Ferguson T, Komenda P, Rigatto C, Duhamel TA, Tangri N, et al. CKD and sedentary time: results from the Canadian health measures survey. Am J Kidney Dis. 2018;72(4):529\u201337. https:\/\/doi.org\/10.1053\/j.ajkd.2018.03.031.","journal-title":"Am J Kidney Dis"},{"issue":"1","key":"2764_CR36","doi-asserted-by":"publisher","first-page":"12308","DOI":"10.1038\/s41598-021-91525-4","volume":"11","author":"S Yamamoto","year":"2021","unstructured":"Yamamoto S, Inoue Y, Kuwahara K, Miki T, Nakagawa T, Honda T, et al. Leisure-time, occupational, and commuting physical activity and the risk of chronic kidney disease in a working population. Sci Rep. 2021;11(1):12308. https:\/\/doi.org\/10.1038\/s41598-021-91525-4.","journal-title":"Sci Rep"},{"key":"2764_CR37","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2022.101424","volume":"48","author":"Z Cao","year":"2022","unstructured":"Cao Z, Xu C, Zhang P, Wang Y. Associations of sedentary time and physical activity with adverse health conditions: outcome-wide analyses using isotemporal substitution model. EClinicalMedicine. 2022;48:101424. https:\/\/doi.org\/10.1016\/j.eclinm.2022.101424.","journal-title":"EClinicalMedicine"},{"issue":"1","key":"2764_CR38","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1002\/jcsm.13167","volume":"14","author":"W Oh","year":"2023","unstructured":"Oh W, Cho M, Jung SW, Moon JY, Lee SH, Hwang YC, et al. High physical activity alleviates the adverse effect of higher sedentary time on the incidence of chronic kidney disease. J Cachexia Sarcopenia Muscle. 2023;14(1):622\u201331. https:\/\/doi.org\/10.1002\/jcsm.13167.","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"2764_CR39","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.941111","volume":"29","author":"P Yu","year":"2023","unstructured":"Yu P, Zhao Z, Huang L, Zou H, Meng X, Kan R, et al. The impact of sedentary behavior on renal function decline in 132,123 middle aged and older adults: a nationwide cohort study. Med Sci Monit. 2023;29:e941111. https:\/\/doi.org\/10.12659\/MSM.941111.","journal-title":"Med Sci Monit"},{"issue":"8","key":"2764_CR40","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2019-030661","volume":"9","author":"M Pike","year":"2019","unstructured":"Pike M, Taylor J, Kabagambe E, Stewart TG, Robinson-Cohen C, Morse J, et al. The association of exercise and sedentary behaviours with incident end-stage renal disease: the Southern Community Cohort Study. BMJ Open. 2019;9(8):e030661. https:\/\/doi.org\/10.1136\/bmjopen-2019-030661.","journal-title":"BMJ Open"},{"issue":"1","key":"2764_CR41","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.13726","volume":"16","author":"Y He","year":"2025","unstructured":"He Y, Wang J, Zhang W, Chen X, Wu Q, Li Y, et al. Device-measured physical activity, sedentary behaviour and risk of chronic kidney diseases across levels of grip strength. J Cachexia Sarcopenia Muscle. 2025;16(1):e13726. https:\/\/doi.org\/10.1002\/jcsm.13726.","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"12","key":"2764_CR42","doi-asserted-by":"publisher","first-page":"RA173","DOI":"10.12659\/MSM.883589","volume":"18","author":"SS Thosar","year":"2012","unstructured":"Thosar SS, Johnson BD, Johnston JD, Wallace JP. Sitting and endothelial dysfunction: the role of shear stress. Med Sci Monit. 2012;18(12):RA173.","journal-title":"Med Sci Monit"},{"issue":"1","key":"2764_CR43","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1089\/ars.2013.5244","volume":"20","author":"S Lankhorst","year":"2014","unstructured":"Lankhorst S, Kappers MH, van Esch JH, Danser AH, van den Meiracker AH. Hypertension during vascular endothelial growth factor inhibition: focus on nitric oxide, endothelin-1, and oxidative stress. Antioxid Redox Signal. 2014;20(1):135\u201345. https:\/\/doi.org\/10.1089\/ars.2013.5244.","journal-title":"Antioxid Redox Signal"},{"issue":"1","key":"2764_CR44","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1053\/j.ajkd.2018.12.044","volume":"74","author":"E Ku","year":"2019","unstructured":"Ku E, Lee BJ, Wei J, Weir MR. Hypertension in CKD: core curriculum 2019. Am J Kidney Dis. 2019;74(1):120\u201331. https:\/\/doi.org\/10.1053\/j.ajkd.2018.12.044.","journal-title":"Am J Kidney Dis"},{"key":"2764_CR45","doi-asserted-by":"publisher","DOI":"10.3390\/app14166985","author":"D Fathima","year":"2024","unstructured":"Fathima D, Lobo J, Angioi M, B\u0142ach W, Rydzik \u0141, Ambro\u017cy T, et al. Sedentary lifestyle, heart rate variability, and the influence on spine posture in adults: a systematic review study. Appl Sci. 2024. https:\/\/doi.org\/10.3390\/app14166985.","journal-title":"Appl Sci"},{"issue":"5","key":"2764_CR46","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1161\/HYPERTENSIONAHA.118.11190","volume":"72","author":"PC Dempsey","year":"2018","unstructured":"Dempsey PC, Larsen RN, Dunstan DW, Owen N, Kingwell BA. Sitting less and moving more: implications for hypertension. Hypertension. 2018;72(5):1037\u201346. https:\/\/doi.org\/10.1161\/HYPERTENSIONAHA.118.11190.","journal-title":"Hypertension"},{"issue":"9","key":"2764_CR47","doi-asserted-by":"publisher","first-page":"2439","DOI":"10.1681\/ASN.2007020149","volume":"18","author":"A Sachse","year":"2007","unstructured":"Sachse A, Wolf G. Angiotensin II-induced reactive oxygen species and the kidney. J Am Soc Nephrol. 2007;18(9):2439\u201346. https:\/\/doi.org\/10.1681\/ASN.2007020149.","journal-title":"J Am Soc Nephrol"},{"issue":"3","key":"2764_CR48","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.trsl.2008.12.008","volume":"153","author":"R Nistala","year":"2009","unstructured":"Nistala R, Wei Y, Sowers JR, Whaley-Connell A. Renin-angiotensin-aldosterone system-mediated redox effects in chronic kidney disease. Transl Res. 2009;153(3):102\u201313. https:\/\/doi.org\/10.1016\/j.trsl.2008.12.008.","journal-title":"Transl Res"},{"issue":"5","key":"2764_CR49","doi-asserted-by":"publisher","first-page":"R1229","DOI":"10.1152\/ajpregu.00720.2010","volume":"301","author":"F Palm","year":"2011","unstructured":"Palm F, Nordquist L. Renal oxidative stress, oxygenation, and hypertension. Am J Physiol Regul Integr Comp Physiol. 2011;301(5):R1229\u201341. https:\/\/doi.org\/10.1152\/ajpregu.00720.2010.","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"1","key":"2764_CR50","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0054225","volume":"8","author":"TJ Saunders","year":"2013","unstructured":"Saunders TJ, Tremblay MS, Despres JP, Bouchard C, Tremblay A, Chaput JP. Sedentary behaviour, visceral fat accumulation and cardiometabolic risk in adults: a 6-year longitudinal study from the Quebec Family Study. PLoS ONE. 2013;8(1):e54225. https:\/\/doi.org\/10.1371\/journal.pone.0054225.","journal-title":"PLoS ONE"},{"issue":"Pt 23","key":"2764_CR51","doi-asserted-by":"publisher","first-page":"5559","DOI":"10.1113\/jphysiol.2009.179515","volume":"587","author":"BK Pedersen","year":"2009","unstructured":"Pedersen BK. The diseasome of physical inactivity\u2013and the role of myokines in muscle\u2013fat cross talk. J Physiol. 2009;587(Pt 23):5559\u201368. https:\/\/doi.org\/10.1113\/jphysiol.2009.179515.","journal-title":"J Physiol"},{"key":"2764_CR52","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2013.00071","volume":"4","author":"H Kwon","year":"2013","unstructured":"Kwon H, Pessin JE. Adipokines mediate inflammation and insulin resistance. Front Endocrinol (Lausanne). 2013;4:71. https:\/\/doi.org\/10.3389\/fendo.2013.00071.","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"1","key":"2764_CR53","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1007\/s11154-012-9229-1","volume":"14","author":"R Muniyappa","year":"2013","unstructured":"Muniyappa R, Sowers JR. Role of insulin resistance in endothelial dysfunction. Rev Endocr Metab Disord. 2013;14(1):5\u201312. https:\/\/doi.org\/10.1007\/s11154-012-9229-1.","journal-title":"Rev Endocr Metab Disord"},{"issue":"3","key":"2764_CR54","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1016\/j.mcna.2009.02.014","volume":"93","author":"C Manrique","year":"2009","unstructured":"Manrique C, Lastra G, Gardner M, Sowers JR. The renin angiotensin aldosterone system in hypertension: roles of insulin resistance and oxidative stress. Med Clin North Am. 2009;93(3):569\u201382. https:\/\/doi.org\/10.1016\/j.mcna.2009.02.014.","journal-title":"Med Clin North Am"},{"issue":"3","key":"2764_CR55","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1159\/000093632","volume":"26","author":"PA Sarafidis","year":"2006","unstructured":"Sarafidis PA, Ruilope LM. Insulin resistance, hyperinsulinemia, and renal injury: mechanisms and implications. Am J Nephrol. 2006;26(3):232\u201344. https:\/\/doi.org\/10.1159\/000093632.","journal-title":"Am J Nephrol"},{"key":"2764_CR56","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2021.111531","volume":"154","author":"K Kosaki","year":"2021","unstructured":"Kosaki K, Takahashi K, Matsui M, Yoshioka M, Mori S, Nishitani N, et al. Sedentary behavior and estimated nephron number in middle-aged and older adults with or without chronic kidney disease. Exp Gerontol. 2021;154:111531. https:\/\/doi.org\/10.1016\/j.exger.2021.111531.","journal-title":"Exp Gerontol"},{"issue":"12","key":"2764_CR57","doi-asserted-by":"publisher","first-page":"1370","DOI":"10.1038\/ki.2011.47","volume":"79","author":"T Isakova","year":"2011","unstructured":"Isakova T, Wahl P, Vargas GS, Gutierrez OM, Scialla J, Xie H, et al. Fibroblast growth factor 23 is elevated before parathyroid hormone and phosphate in chronic kidney disease. Kidney Int. 2011;79(12):1370\u20138. https:\/\/doi.org\/10.1038\/ki.2011.47.","journal-title":"Kidney Int"},{"issue":"1","key":"2764_CR58","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1038\/s41581-018-0078-3","volume":"15","author":"OM Kuro","year":"2019","unstructured":"Kuro OM. The Klotho proteins in health and disease. Nat Rev Nephrol. 2019;15(1):27\u201344. https:\/\/doi.org\/10.1038\/s41581-018-0078-3.","journal-title":"Nat Rev Nephrol"},{"issue":"1","key":"2764_CR59","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1681\/ASN.2014020218","volume":"26","author":"CM Rebholz","year":"2015","unstructured":"Rebholz CM, Grams ME, Coresh J, Selvin E, Inker LA, Levey AS, et al. Serum fibroblast growth factor-23 is associated with incident kidney disease. J Am Soc Nephrol. 2015;26(1):192\u2013200. https:\/\/doi.org\/10.1681\/ASN.2014020218.","journal-title":"J Am Soc Nephrol"},{"issue":"1","key":"2764_CR60","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1093\/ndt\/gfz266","volume":"36","author":"MA De Jong","year":"2021","unstructured":"De Jong MA, Eisenga MF, van Ballegooijen AJ, Beulens JWJ, Vervloet MG, Navis G, et al. Fibroblast growth factor 23 and new-onset chronic kidney disease in the general population: the prevention of renal and vascular endstage disease (PREVEND) study. Nephrol Dial Transplant. 2021;36(1):121\u20138. https:\/\/doi.org\/10.1093\/ndt\/gfz266.","journal-title":"Nephrol Dial Transplant"},{"issue":"3","key":"2764_CR61","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1038\/nrneph.2016.187","volume":"13","author":"DM Zelle","year":"2017","unstructured":"Zelle DM, Klaassen G, van Adrichem E, Bakker SJ, Corpeleijn E, Navis G. Physical inactivity: a risk factor and target for intervention in renal care. Nat Rev Nephrol. 2017;13(3):152\u201368. https:\/\/doi.org\/10.1038\/nrneph.2016.187.","journal-title":"Nat Rev Nephrol"},{"issue":"3","key":"2764_CR62","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1080\/1091367x.2015.1045908","volume":"19","author":"X Janssen","year":"2015","unstructured":"Janssen X, Cliff DP. Issues related to measuring and interpreting objectively measured sedentary behavior data. Meas Phys Educ Exerc Sci. 2015;19(3):116\u201324. https:\/\/doi.org\/10.1080\/1091367x.2015.1045908.","journal-title":"Meas Phys Educ Exerc Sci"},{"issue":"1 Suppl 1","key":"2764_CR63","doi-asserted-by":"publisher","first-page":"S39","DOI":"10.1249\/MSS.0b013e3182399d8f","volume":"44","author":"GJ Welk","year":"2012","unstructured":"Welk GJ, McClain J, Ainsworth BE. Protocols for evaluating equivalency of accelerometry-based activity monitors. Med Sci Sports Exerc. 2012;44(1 Suppl 1):S39-49. https:\/\/doi.org\/10.1249\/MSS.0b013e3182399d8f.","journal-title":"Med Sci Sports Exerc"},{"issue":"1 Suppl 1","key":"2764_CR64","doi-asserted-by":"publisher","first-page":"S77","DOI":"10.1249\/MSS.0b013e3182399eb1","volume":"44","author":"SJ Strath","year":"2012","unstructured":"Strath SJ, Pfeiffer KA, Whitt-Glover MC. Accelerometer use with children, older adults, and adults with functional limitations. Med Sci Sports Exerc. 2012;44(1 Suppl 1):S77-85. https:\/\/doi.org\/10.1249\/MSS.0b013e3182399eb1.","journal-title":"Med Sci Sports Exerc"},{"issue":"6","key":"2764_CR65","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1007\/s00467-011-1992-9","volume":"27","author":"KS Hodgkins","year":"2012","unstructured":"Hodgkins KS, Schnaper HW. Tubulointerstitial injury and the progression of chronic kidney disease. Pediatr Nephrol. 2012;27(6):901\u20139. https:\/\/doi.org\/10.1007\/s00467-011-1992-9.","journal-title":"Pediatr Nephrol"},{"key":"2764_CR66","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1186\/1479-5868-10-70","volume":"10","author":"EE Nang","year":"2013","unstructured":"Nang EE, Salim A, Wu Y, Tai ES, Lee J, Van Dam RM. Television screen time, but not computer use and reading time, is associated with cardio-metabolic biomarkers in a multiethnic Asian population: a cross-sectional study. Int J Behav Nutr Phys Act. 2013;10:70. https:\/\/doi.org\/10.1186\/1479-5868-10-70.","journal-title":"Int J Behav Nutr Phys Act"},{"issue":"5","key":"2764_CR67","doi-asserted-by":"publisher","first-page":"717","DOI":"10.2215\/CJN.12300720","volume":"16","author":"K Lyden","year":"2021","unstructured":"Lyden K, Boucher R, Wei G, Zhou N, Christensen J, Chertow GM, et al. Targeting sedentary behavior in CKD: a pilot and feasibility randomized controlled trial. Clin J Am Soc Nephrol. 2021;16(5):717\u201326. https:\/\/doi.org\/10.2215\/CJN.12300720.","journal-title":"Clin J Am Soc Nephrol"},{"key":"2764_CR68","doi-asserted-by":"publisher","DOI":"10.37526\/1526-744x.2024.51.2.153","author":"MF Hannan","year":"2024","unstructured":"Hannan MF, Sawatpanich A, Kringle E, Rivera E, Doorenbos AZ, Lash JP. An intervention to reduce sedentary behavior in adults with chronic kidney disease: a feasibility study. Nephrol Nurs J. 2024. https:\/\/doi.org\/10.37526\/1526-744x.2024.51.2.153.","journal-title":"Nephrol Nurs J"}],"container-title":["Clinical and Experimental Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10157-025-02764-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10157-025-02764-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10157-025-02764-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T06:38:28Z","timestamp":1768545508000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10157-025-02764-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,12]]},"references-count":68,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["2764"],"URL":"https:\/\/doi.org\/10.1007\/s10157-025-02764-y","relation":{},"ISSN":["1342-1751","1437-7799"],"issn-type":[{"value":"1342-1751","type":"print"},{"value":"1437-7799","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,12]]},"assertion":[{"value":"5 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 September 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}