{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T05:48:47Z","timestamp":1782193727424,"version":"3.54.5"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:00:00Z","timestamp":1775779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:00:00Z","timestamp":1775779200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Exp Nephrol"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1007\/s10157-026-02866-1","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T13:43:44Z","timestamp":1775828624000},"page":"998-1009","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Low-dose exposure to organophosphate pesticides and chronic kidney disease: insights from urinary dialkyl phosphate biomarkers"],"prefix":"10.1007","volume":"30","author":[{"given":"Xiaofen","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinxin","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongyuan","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing Qing","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binbin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5994-8320","authenticated-orcid":false,"given":"Zhigui","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,10]]},"reference":[{"issue":"2","key":"2866_CR1","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1159\/000534071","volume":"148","author":"M Ying","year":"2024","unstructured":"Ying M, Shao X, Qin H, Yin P, Lin Y, Wu J, et al. Disease burden and epidemiological trends of Chronic Kidney Disease at the global, regional, national levels from 1990 to 2019. Nephron. 2024;148(2):113\u201323. https:\/\/doi.org\/10.1159\/000534071.","journal-title":"Nephron"},{"issue":"8","key":"2866_CR2","doi-asserted-by":"publisher","first-page":"e1378","DOI":"10.1016\/s2214-109x(25)00198-6","volume":"13","author":"Q Rafferty","year":"2025","unstructured":"Rafferty Q, Stafford LK, Vos T, Thom\u00e9 FS, Aalruz H, Abate YH, et al. Global, regional, and national prevalence of kidney failure with replacement therapy and associated aetiologies, 1990\u20132023: a systematic analysis for the Global Burden of Disease Study 2023. Lancet Global Health. 2025;13(8):e1378\u201395. https:\/\/doi.org\/10.1016\/s2214-109x(25)00198-6.","journal-title":"Lancet Global Health"},{"key":"2866_CR3","doi-asserted-by":"publisher","first-page":"115492","DOI":"10.1016\/j.ecoenv.2023.115492","volume":"265","author":"ZH Li","year":"2023","unstructured":"Li ZH, Song WQ, Qiu CS, Li HM, Tang XL, Shen D, et al. Long-term air pollution exposure, habitual physical activity, and incident chronic kidney disease. Ecotoxicol Environ Saf. 2023;265:115492. https:\/\/doi.org\/10.1016\/j.ecoenv.2023.115492.","journal-title":"Ecotoxicol Environ Saf"},{"issue":"7","key":"2866_CR4","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1001\/jamainternmed.2024.0904","volume":"184","author":"J Danziger","year":"2024","unstructured":"Danziger J, Willetts J, Larkin J, Chaudhuri S, Mukamal KJ, Usvyat LA, et al. Household water Lead and hematologic toxic effects in Chronic Kidney Disease. JAMA Intern Med. 2024;184(7):788\u201396. https:\/\/doi.org\/10.1001\/jamainternmed.2024.0904.","journal-title":"JAMA Intern Med"},{"issue":"12","key":"2866_CR5","doi-asserted-by":"publisher","first-page":"2174","DOI":"10.34067\/kid.0007962021","volume":"3","author":"AV Kshirsagar","year":"2022","unstructured":"Kshirsagar AV, Zeitler EM, Weaver A, Franceschini N, Engel LS. Environmental exposures and kidney disease. Kidney360. 2022;3(12):2174\u201382. https:\/\/doi.org\/10.34067\/kid.0007962021.","journal-title":"Kidney360"},{"issue":"12","key":"2866_CR6","doi-asserted-by":"publisher","first-page":"e0315688","DOI":"10.1371\/journal.pone.0315688","volume":"19","author":"PF Kuo","year":"2024","unstructured":"Kuo PF, Huang YT, Chuang MH, Jiang MY. Association of low-level heavy metal exposure with risk of chronic kidney disease and long-term mortality. PLoS ONE. 2024;19(12):e0315688. https:\/\/doi.org\/10.1371\/journal.pone.0315688.","journal-title":"PLoS ONE"},{"key":"2866_CR7","doi-asserted-by":"publisher","first-page":"104904","DOI":"10.1016\/j.envint.2019.104904","volume":"130","author":"AJ Li","year":"2019","unstructured":"Li AJ, Martinez-Moral MP, Kannan K. Temporal variability in urinary pesticide concentrations in repeated-spot and first-morning-void samples and its association with oxidative stress in healthy individuals. Environ Int. 2019;130:104904. https:\/\/doi.org\/10.1016\/j.envint.2019.104904.","journal-title":"Environ Int"},{"issue":"7","key":"2866_CR8","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1177\/0748233710371110","volume":"26","author":"S Tripathi","year":"2010","unstructured":"Tripathi S, Srivastav AK. Nephrotoxicity induced by long-term oral administration of different doses of chlorpyrifos. Toxicol Ind Health. 2010;26(7):439\u201347. https:\/\/doi.org\/10.1177\/0748233710371110.","journal-title":"Toxicol Ind Health"},{"key":"2866_CR9","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.tox.2012.11.002","volume":"307","author":"C Tsitsimpikou","year":"2013","unstructured":"Tsitsimpikou C, Tzatzarakis M, Fragkiadaki P, Kovatsi L, Stivaktakis P, Kalogeraki A, et al. Histopathological lesions, oxidative stress and genotoxic effects in liver and kidneys following long term exposure of rabbits to diazinon and propoxur. Toxicology. 2013;307:109\u201314. https:\/\/doi.org\/10.1016\/j.tox.2012.11.002.","journal-title":"Toxicology"},{"issue":"2","key":"2866_CR10","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1556\/018.66.2015.2.1","volume":"66","author":"NH Zidan","year":"2015","unstructured":"Zidan NH. Hepato- and nephrotoxicity in male albino rats exposed to malathion and spinosad in stored wheat grains. Acta Biol Hung. 2015;66(2):133\u201348. https:\/\/doi.org\/10.1556\/018.66.2015.2.1.","journal-title":"Acta Biol Hung"},{"key":"2866_CR11","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph18063278","author":"KSM Abdul","year":"2021","unstructured":"Abdul KSM, De Silva PMCS, Ekanayake EMDV, Thakshila WAKG, Gunarathna SD, Gunasekara TDKSC, et al. Occupational Paraquat and Glyphosate exposure may decline renal functions among rural farming communities in Sri Lanka. Int J Environ Res Public Health. 2021. https:\/\/doi.org\/10.3390\/ijerph18063278.","journal-title":"Int J Environ Res Public Health"},{"key":"2866_CR12","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/1476-069x-14-6","volume":"14","author":"C Jayasumana","year":"2015","unstructured":"Jayasumana C, Paranagama P, Agampodi S, Wijewardane C, Gunatilake S, Siribaddana S. Drinking well water and occupational exposure to herbicides is associated with chronic kidney disease, in Padavi-Sripura, Sri Lanka. Environ Health. 2015;14:6. https:\/\/doi.org\/10.1186\/1476-069x-14-6.","journal-title":"Environ Health"},{"issue":"19","key":"2866_CR13","doi-asserted-by":"publisher","first-page":"10249","DOI":"10.3390\/ijerph181910249","volume":"18","author":"ET Wan","year":"2021","unstructured":"Wan ET, Darssan D, Karatela S, Reid SA, Osborne NJ. Association of pesticides and kidney function among adults in the US population 2001-2010. Int J Environ Res Public Health. 2021;18(19):10249. https:\/\/doi.org\/10.3390\/ijerph181910249.","journal-title":"Int J Environ Res Public Health"},{"key":"2866_CR14","volume-title":"Statistics for censored environmental data using Minitab and R","author":"DR Helsel","year":"2012","unstructured":"Helsel DR. Statistics for censored environmental data using Minitab and R. 2nd ed. Hoboken, NJ: John Wiley & Sons; 2012.","edition":"2"},{"issue":"9","key":"2866_CR15","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.1016\/j.jand.2023.05.014","volume":"123","author":"JL Lerman","year":"2023","unstructured":"Lerman JL, Herrick KA, Pannucci TE, Shams-White MM, Kahle LL, Zimmer M, et al. Evaluation of the healthy eating index-toddlers-2020. J Acad Nutr Diet. 2023;123(9):1307\u201319. https:\/\/doi.org\/10.1016\/j.jand.2023.05.014.","journal-title":"J Acad Nutr Diet"},{"issue":"9","key":"2866_CR16","doi-asserted-by":"publisher","first-page":"1280","DOI":"10.1016\/j.jand.2023.05.015","volume":"123","author":"MM Shams-White","year":"2023","unstructured":"Shams-White MM, Pannucci TE, Lerman JL, Herrick KA, Zimmer M, Meyers Mathieu K, et al. Healthy Eating Index-2020: review and update process to reflect the Dietary Guidelines for Americans,2020-2025. J Acad Nutr Diet. 2023;123(9):1280\u20138. https:\/\/doi.org\/10.1016\/j.jand.2023.05.015.","journal-title":"J Acad Nutr Diet"},{"key":"2866_CR17","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.tox.2018.07.019","volume":"406-407","author":"G Georgiadis","year":"2018","unstructured":"Georgiadis G, Mavridis C, Belantis C, Zisis IE, Skamagkas I, Fragkiadoulaki I, et al. Nephrotoxicity issues of organophosphates. Toxicology. 2018;406\u2013407:129\u201336. https:\/\/doi.org\/10.1016\/j.tox.2018.07.019.","journal-title":"Toxicology"},{"issue":"11","key":"2866_CR18","doi-asserted-by":"publisher","first-page":"1763","DOI":"10.1289\/ehp.9062","volume":"114","author":"DB Barr","year":"2006","unstructured":"Barr DB, Angerer J. Potential uses of biomonitoring data: a case study using the organophosphorus pesticides Chlorpyrifos and Malathion. Environ Health Perspect. 2006;114(11):1763\u20139. https:\/\/doi.org\/10.1289\/ehp.9062.","journal-title":"Environ Health Perspect"},{"issue":"7","key":"2866_CR19","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.2105\/ajph.2025.308073","volume":"115","author":"C Sellers","year":"2025","unstructured":"Sellers C, Kohl E, Sullivan M, Gehrke G, Varner J, Chambers M. History of risk assessments of the organophosphate pesticide Chlorpyrifos at the US Environmental Protection Agency, 1980\u20122024. Am J Public Health. 2025;115(7):1074\u201384. https:\/\/doi.org\/10.2105\/ajph.2025.308073.","journal-title":"Am J Public Health"},{"key":"2866_CR20","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1146\/annurev-phyto-102313-045900","volume":"52","author":"L Epstein","year":"2014","unstructured":"Epstein L. Fifty years since Silent Spring. Annu Rev Phytopathol. 2014;52:377\u2013402. https:\/\/doi.org\/10.1146\/annurev-phyto-102313-045900.","journal-title":"Annu Rev Phytopathol"},{"issue":"3","key":"2866_CR21","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1039\/c8tx00030a","volume":"7","author":"E Akbel","year":"2018","unstructured":"Akbel E, Arslan-Acaroz D, Demirel HH, Kucukkurt I, Ince S. The subchronic exposure to malathion, an organophosphate pesticide, causes lipid peroxidation, oxidative stress, and tissue damage in rats: the protective role of resveratrol. Toxicol Res. 2018;7(3):503\u201312. https:\/\/doi.org\/10.1039\/c8tx00030a.","journal-title":"Toxicol Res"},{"issue":"4","key":"2866_CR22","first-page":"725","volume":"28","author":"RA Eid","year":"2017","unstructured":"Eid RA. Apoptosis of rat renal cells by organophosphate pesticide, quinalphos: ultrastructural study. Saudi J Kidney Dis Transpl. 2017;28(4):725\u201336.","journal-title":"Saudi J Kidney Dis Transpl"},{"issue":"16","key":"2866_CR23","doi-asserted-by":"publisher","first-page":"8855","DOI":"10.3390\/ijms23168855","volume":"23","author":"VE Sobolev","year":"2022","unstructured":"Sobolev VE, Sokolova MO, Jenkins RO, Goncharov NV. Molecular mechanisms of acute Organophosphate nephrotoxicity. Int J Mol Sci. 2022;23(16):8855. https:\/\/doi.org\/10.3390\/ijms23168855.","journal-title":"Int J Mol Sci"},{"issue":"1","key":"2866_CR24","first-page":"7","volume":"35","author":"O Cakici","year":"2013","unstructured":"Cakici O, Akat E. Effects of oral exposure to diazinon on mice liver and kidney tissues: biometric analyses of histopathologic changes. Anal Quant Cytopathol Histpathol. 2013;35(1):7\u201316.","journal-title":"Anal Quant Cytopathol Histpathol"},{"issue":"17","key":"2866_CR25","doi-asserted-by":"publisher","first-page":"2497","DOI":"10.3390\/ani14172497","volume":"14","author":"FA Al-Saeed","year":"2024","unstructured":"Al-Saeed FA, Abd-Elghfar SS, Ali ME. Efficiency of thyme and oregano essential oils in counteracting the hazardous effects of Malathion in rats. Animals. 2024;14(17):2497. https:\/\/doi.org\/10.3390\/ani14172497.","journal-title":"Animals"},{"key":"2866_CR26","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1016\/j.chemosphere.2017.10.039","volume":"191","author":"JM Van Emon","year":"2018","unstructured":"Van Emon JM, Pan P, van Breukelen F. Effects of chlorpyrifos and trichloropyridinol on HEK 293 human embryonic kidney cells. Chemosphere. 2018;191:537\u201347. https:\/\/doi.org\/10.1016\/j.chemosphere.2017.10.039.","journal-title":"Chemosphere"},{"issue":"8","key":"2866_CR27","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1289\/ehp.1003185","volume":"119","author":"MF Bouchard","year":"2011","unstructured":"Bouchard MF, Chevrier J, Harley KG, Kogut K, Vedar M, Calderon N, et al. Prenatal exposure to organophosphate pesticides and IQ in 7-year-old children. Environ Health Perspect. 2011;119(8):1189\u201395. https:\/\/doi.org\/10.1289\/ehp.1003185.","journal-title":"Environ Health Perspect"},{"issue":"5","key":"2866_CR28","doi-asserted-by":"publisher","first-page":"417","DOI":"10.3892\/br.2018.1071","volume":"8","author":"K Tsarouhas","year":"2018","unstructured":"Tsarouhas K, Tsitsimpikou C, Papantoni X, Lazaridou D, Koutouzis M, Mazzaris S, et al. Oxidative stress and kidney injury in trans-radial catheterization. Biomed Rep. 2018;8(5):417\u201325. https:\/\/doi.org\/10.3892\/br.2018.1071.","journal-title":"Biomed Rep"},{"issue":"3","key":"2866_CR29","doi-asserted-by":"publisher","first-page":"F309","DOI":"10.1152\/ajprenal.00371.2021","volume":"322","author":"JC Oates","year":"2022","unstructured":"Oates JC, Russell DL, Van Beusecum JP. Endothelial cells: potential novel regulators of renal inflammation. Am J Physiol Renal Physiol. 2022;322(3):F309\u201321. https:\/\/doi.org\/10.1152\/ajprenal.00371.2021.","journal-title":"Am J Physiol Renal Physiol"},{"key":"2866_CR30","doi-asserted-by":"publisher","first-page":"107499","DOI":"10.1016\/j.envint.2022.107499","volume":"169","author":"J Lv","year":"2022","unstructured":"Lv J, Guo L, Gu Y, Xu Y, Xue Q, Yang X, et al. National temporal trend for organophosphate pesticide DDT exposure and associations with chronic kidney disease using age-adapted eGFR model. Environ Int. 2022;169:107499. https:\/\/doi.org\/10.1016\/j.envint.2022.107499.","journal-title":"Environ Int"},{"issue":"2","key":"2866_CR31","first-page":"1","volume":"1","author":"S Wimalawansa","year":"2015","unstructured":"Wimalawansa S. Agrochemicals and chronic kidney disease of multi-factorial origin: environmentally induced occupational exposure an occupational exposure disease. Int J Nephrol Kidney Failure. 2015;1(2):1\u20139.","journal-title":"Int J Nephrol Kidney Failure"},{"issue":"2","key":"2866_CR32","doi-asserted-by":"publisher","first-page":"sfae378","DOI":"10.1093\/ckj\/sfae378","volume":"18","author":"S Xie","year":"2025","unstructured":"Xie S, Perrais M, Golshayan D, Wuerzner G, Vaucher J, Thomas A, et al. Association between urinary heavy metal\/trace element concentrations and kidney function: a prospective study. Clin Kidney J. 2025;18(2):sfae378. https:\/\/doi.org\/10.1093\/ckj\/sfae378.","journal-title":"Clin Kidney J"},{"key":"2866_CR33","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.envres.2014.03.021","volume":"132","author":"L Oates","year":"2014","unstructured":"Oates L, Cohen M, Braun L, Schembri A, Taskova R. Reduction in urinary organophosphate pesticide metabolites in adults after a week-long organic diet. Environ Res. 2014;132:105\u201311. https:\/\/doi.org\/10.1016\/j.envres.2014.03.021.","journal-title":"Environ Res"},{"key":"2866_CR34","doi-asserted-by":"publisher","first-page":"114720","DOI":"10.1016\/j.ecoenv.2023.114720","volume":"254","author":"R Aimuzi","year":"2023","unstructured":"Aimuzi R, Xie Z, Qu Y, Jiang Y, Luo K. Associations of urinary organophosphate esters metabolites and diet quality with nonalcoholic\/metabolic dysfunction-associated fatty liver diseases in adults. Ecotoxicol Environ Saf. 2023;254:114720. https:\/\/doi.org\/10.1016\/j.ecoenv.2023.114720.","journal-title":"Ecotoxicol Environ Saf"},{"issue":"1","key":"2866_CR35","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.taap.2011.08.021","volume":"257","author":"S Singh","year":"2011","unstructured":"Singh S, Kumar V, Vashisht K, Singh P, Banerjee BD, Rautela RS, et al. Role of genetic polymorphisms of CYP1A1, CYP3A5, CYP2C9, CYP2D6, and PON1 in the modulation of DNA damage in workers occupationally exposed to organophosphate pesticides. Toxicol Appl Pharmacol. 2011;257(1):84\u201392. https:\/\/doi.org\/10.1016\/j.taap.2011.08.021.","journal-title":"Toxicol Appl Pharmacol"}],"container-title":["Clinical and Experimental Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10157-026-02866-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10157-026-02866-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10157-026-02866-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T05:40:27Z","timestamp":1782193227000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10157-026-02866-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,10]]},"references-count":35,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["2866"],"URL":"https:\/\/doi.org\/10.1007\/s10157-026-02866-1","relation":{},"ISSN":["1342-1751","1437-7799"],"issn-type":[{"value":"1342-1751","type":"print"},{"value":"1437-7799","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,10]]},"assertion":[{"value":"30 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The author declares no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The NCHS Research Ethics Review Board (ERB) approved the NHANES study protocol. All participants provided written informed consent.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}