{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T22:40:33Z","timestamp":1792276833527,"version":"4.4.0"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T00:00:00Z","timestamp":1792195200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T00:00:00Z","timestamp":1792195200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Basic Research of Natural Sciences in Shaanxi Province","award":["2023-JC-QN-0945"],"award-info":[{"award-number":["2023-JC-QN-0945"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Exp Nephrol"],"DOI":"10.1007\/s10157-026-02960-4","type":"journal-article","created":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T12:07:28Z","timestamp":1792238848000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dahuang Fuzi decoction attenuates renal fibrosis via suppression of the NF-\u03baB pathway"],"prefix":"10.1007","author":[{"given":"Yan","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeji","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingzhen","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wansen","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiping","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,17]]},"reference":[{"key":"2960_CR1","doi-asserted-by":"publisher","first-page":"112931","DOI":"10.1016\/j.biopha.2022.112931","volume":"149","author":"J Zou","year":"2022","unstructured":"Zou J, Zhou X, Ma Y, Yu R. Losartan ameliorates renal interstitial fibrosis through metabolic pathway and Smurfs-TGF-beta\/Smad. Biomed Pharmacother. 2022;149:112931. https:\/\/doi.org\/10.1016\/j.biopha.2022.112931.","journal-title":"Biomed Pharmacother"},{"key":"2960_CR2","doi-asserted-by":"publisher","first-page":"114830","DOI":"10.1016\/j.celrep.2024.114830","volume":"43","author":"Z Si","year":"2024","unstructured":"Si Z, Wang H, Wang T, Cao Y, Li Q, Liu K, et al. Gut Bacteroides ovatus ameliorates renal fibrosis by promoting the production of HDCA through upregulation of Clostridium scindens. Cell Rep. 2024;43:114830. https:\/\/doi.org\/10.1016\/j.celrep.2024.114830.","journal-title":"Cell Rep"},{"key":"2960_CR3","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1055\/a-2435-8264","volume":"57","author":"S Dwivedi","year":"2025","unstructured":"Dwivedi S, Sikarwar MS. Diabetic Nephropathy: Pathogenesis, Mechanisms, and Therapeutic Strategies. Horm Metab Res. 2025;57:7\u201317. https:\/\/doi.org\/10.1055\/a-2435-8264.","journal-title":"Horm Metab Res"},{"key":"2960_CR4","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1113\/JP277002","volume":"597","author":"S Koszegi","year":"2019","unstructured":"Koszegi S, Molnar A, Lenart L, Hodrea J, Balogh DB, Lakat T, et al. RAAS inhibitors directly reduce diabetes-induced renal fibrosis via growth factor inhibition. J Physiol. 2019;597:193\u2013209. https:\/\/doi.org\/10.1113\/JP277002.","journal-title":"J Physiol"},{"key":"2960_CR5","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.3390\/jpm14121141","volume":"14","author":"C Delrue","year":"2024","unstructured":"Delrue C, Eisenga MF, Delanghe JR, Speeckaert MM. Personalized Antifibrotic Therapy in CKD Progression. J Pers Med. 2024;14:1141. https:\/\/doi.org\/10.3390\/jpm14121141.","journal-title":"J Pers Med"},{"key":"2960_CR6","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1053\/j.ajkd.2021.11.010","volume":"80","author":"M Ruiz-Ortega","year":"2022","unstructured":"Ruiz-Ortega M, Lamas S, Ortiz A. Antifibrotic Agents for the Management of CKD: A Review. Am J Kidney Dis. 2022;80:251\u201363. https:\/\/doi.org\/10.1053\/j.ajkd.2021.11.010.","journal-title":"Am J Kidney Dis"},{"key":"2960_CR7","doi-asserted-by":"publisher","first-page":"116039","DOI":"10.1016\/j.biopha.2023.116039","volume":"170","author":"L Song","year":"2024","unstructured":"Song L, Zhang W, Tang SY, Luo SM, Xiong PY, Liu JY, et al. Natural products in traditional Chinese medicine: molecular mechanisms and therapeutic targets of renal fibrosis and state-of-the-art drug delivery systems. Biomed Pharmacother. 2024;170:116039. https:\/\/doi.org\/10.1016\/j.biopha.2023.116039.","journal-title":"Biomed Pharmacother"},{"key":"2960_CR8","doi-asserted-by":"publisher","first-page":"1739","DOI":"10.1142\/S0192415X22500744","volume":"50","author":"XJ Liu","year":"2022","unstructured":"Liu XJ, Hu XK, Yang H, Gui LM, Cai ZX, Qi MS, et al. A Review of Traditional Chinese Medicine on Treatment of Diabetic Nephropathy and the Involved Mechanisms. Am J Chin Med. 2022;50:1739\u201379. https:\/\/doi.org\/10.1142\/S0192415X22500744.","journal-title":"Am J Chin Med"},{"key":"2960_CR9","doi-asserted-by":"publisher","first-page":"1464477","DOI":"10.3389\/fnins.2024.1464477","volume":"18","author":"J Qu","year":"2024","unstructured":"Qu J, Gong Q, He S, Peng J, Chen L, Wang L, et al. Analgesic effect of Dahuang Fuzi Decoction in neuropathic pain through inhibiting TNF-\u03b1 and PI3K-AKT signaling. Front Neurosci. 2024;18:1464477. https:\/\/doi.org\/10.3389\/fnins.2024.1464477.","journal-title":"Front Neurosci"},{"key":"2960_CR10","doi-asserted-by":"publisher","first-page":"8489699","DOI":"10.1155\/2022\/8489699","volume":"2022","author":"M Gu","year":"2022","unstructured":"Gu M, Ying P, Miao Z, Yu X, Bao R, Xiao J, et al. Treatment of Modified Dahuang Fuzi Decoction on Cognitive Impairment Induced by Chronic Kidney Disease through Regulating AhR\/NF-kappaB\/JNK Signal Pathway. Evid Based Complement Alternat Med. 2022;2022:8489699. https:\/\/doi.org\/10.1155\/2022\/8489699.","journal-title":"Evid Based Complement Alternat Med"},{"key":"2960_CR11","doi-asserted-by":"publisher","first-page":"3017","DOI":"10.1016\/j.ymthe.2022.06.019","volume":"30","author":"J Chen","year":"2022","unstructured":"Chen J, Tang Y, Zhong Y, Wei B, Huang X, Tang PM, et al. P2Y12 inhibitor clopidogrel inhibits renal fibrosis by blocking macrophage-to-myofibroblast transition. Mol Ther. 2022;30:3017\u201333. https:\/\/doi.org\/10.1016\/j.ymthe.2022.06.019.","journal-title":"Mol Ther"},{"key":"2960_CR12","doi-asserted-by":"publisher","first-page":"2795","DOI":"10.7150\/ijbs.71595","volume":"18","author":"W Wu","year":"2022","unstructured":"Wu W, Wang X, Yu X, Lan H. Smad3 Signatures in Renal Inflammation and Fibrosis. Int J Biol Sci. 2022;18:2795\u2013806. https:\/\/doi.org\/10.7150\/ijbs.71595.","journal-title":"Int J Biol Sci"},{"key":"2960_CR13","doi-asserted-by":"publisher","first-page":"3084","DOI":"10.1016\/j.ymthe.2023.07.026","volume":"31","author":"L Gao","year":"2023","unstructured":"Gao L, Zhang J, Yang T, Jiang L, Liu X, Wang S, et al. STING\/ACSL4 axis-dependent ferroptosis and inflammation promote hypertension-associated chronic kidney disease. Mol Ther. 2023;31:3084\u2013103. https:\/\/doi.org\/10.1016\/j.ymthe.2023.07.026.","journal-title":"Mol Ther"},{"key":"2960_CR14","doi-asserted-by":"publisher","first-page":"114465","DOI":"10.1016\/j.ecoenv.2022.114465","volume":"249","author":"Z Gong","year":"2023","unstructured":"Gong Z, Liu W, Song R, Dong W, Zhang K, Li J, et al. Nuclear factor-kappaB mediates the survival of rat kidney cells after cadmium exposure via promoting autophagy and inhibiting apoptosis. Ecotoxicol Environ Saf. 2023;249:114465. https:\/\/doi.org\/10.1016\/j.ecoenv.2022.114465.","journal-title":"Ecotoxicol Environ Saf"},{"key":"2960_CR15","doi-asserted-by":"publisher","first-page":"118190","DOI":"10.1016\/j.jep.2024.118190","volume":"329","author":"J Yee","year":"2024","unstructured":"Yee J, Huang C, Yu Y, Huang SJ. Potential Mechanisms of Guizhi Fuling Wan in Treating Endometriosis: An Analysis Based on TCMSP and DisGeNET Databases. J Ethnopharmacol. 2024;329:118190. https:\/\/doi.org\/10.1016\/j.jep.2024.118190.","journal-title":"J Ethnopharmacol"},{"key":"2960_CR16","doi-asserted-by":"publisher","first-page":"D1197","DOI":"10.1093\/nar\/gkaa1063","volume":"49","author":"S Fang","year":"2021","unstructured":"Fang S, Dong L, Liu L, Guo J, Zhao L, Zhang J, et al. HERB: a high-throughput experiment- and reference-guided database of traditional Chinese medicine. Nucleic Acids Res. 2021;49:D1197\u2013206. https:\/\/doi.org\/10.1093\/nar\/gkaa1063.","journal-title":"Nucleic Acids Res"},{"key":"2960_CR17","doi-asserted-by":"publisher","first-page":"586","DOI":"10.23876\/j.krcp.23.156","volume":"43","author":"QY Nan","year":"2024","unstructured":"Nan QY, Piao SG, Jin JZ, Chung BH, Yang CW, Li C. Pathogenesis and management of renal fibrosis induced by unilateral ureteral obstruction. Kidney Res Clin Pract. 2024;43:586\u201399. https:\/\/doi.org\/10.23876\/j.krcp.23.156.","journal-title":"Kidney Res Clin Pract"},{"key":"2960_CR18","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1038\/s41467-023-37043-5","volume":"14","author":"Y Yang","year":"2023","unstructured":"Yang Y, Liu S, Wang P, Ouyang J, Zhou N, Zhang Y, et al. DNA-dependent protein kinase catalytic subunit (DNA-PKcs) drives chronic kidney disease progression in male mice. Nat Commun. 2023;14:1317\u201334. https:\/\/doi.org\/10.1038\/s41467-023-37043-5.","journal-title":"Nat Commun"},{"key":"2960_CR19","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1038\/s41419-024-06756-w","volume":"15","author":"Y Cui","year":"2024","unstructured":"Cui Y, Chen C, Tang Z, Yuan W, Yue K, Cui P, et al. TREM2 deficiency aggravates renal injury by promoting macrophage apoptosis and polarization via the JAK-STAT pathway in mice. Cell Death Dis. 2024;15:401. https:\/\/doi.org\/10.1038\/s41419-024-06756-w.","journal-title":"Cell Death Dis"},{"key":"2960_CR20","doi-asserted-by":"publisher","first-page":"2775434","DOI":"10.1155\/2022\/2775434","volume":"2022","author":"J Guo","year":"2022","unstructured":"Guo J, Zhao Y, Du Q, Ren Y, Wang Y, Wang Z, et al. The Network Pharmacology Study of Dahuang Fuzi Decoction for Treating Incomplete Intestinal Obstruction. Biomed Res Int. 2022;2022:2775434. https:\/\/doi.org\/10.1155\/2022\/2775434.","journal-title":"Biomed Res Int"}],"container-title":["Clinical and Experimental Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10157-026-02960-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10157-026-02960-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10157-026-02960-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T22:03:29Z","timestamp":1792274609000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10157-026-02960-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,17]]},"references-count":20,"alternative-id":["2960"],"URL":"https:\/\/doi.org\/10.1007\/s10157-026-02960-4","relation":{},"ISSN":["1342-1751","1437-7799"],"issn-type":[{"value":"1342-1751","type":"print"},{"value":"1437-7799","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,17]]},"assertion":[{"value":"9 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 September 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 October 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no competing interests.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The animal study was approved by The Biomedical Ethics Committee of Health Science Center of Xian Jiaotong University. All animal experiments complied with the ARRIVE guidelines. All methods were carried out in accordance with relevant guidelines and regulations.","order":2,"name":"Ethics","label":"Ethical approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":3,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":4,"name":"Ethics","label":"Clinical trial number","group":{"name":"EthicsHeading","label":"Declarations"}}]}}