{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T03:59:36Z","timestamp":1783483176099,"version":"3.55.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2013,12,3]],"date-time":"2013-12-03T00:00:00Z","timestamp":1386028800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JARO"],"published-print":{"date-parts":[[2014,2]]},"DOI":"10.1007\/s10162-013-0427-7","type":"journal-article","created":{"date-parts":[[2013,12,2]],"date-time":"2013-12-02T12:11:52Z","timestamp":1385986312000},"page":"45-55","source":"Crossref","is-referenced-by-count":13,"title":["Hearing Impairment in Hypothyroid Dwarf Mice Caused by Mutations of the Thyroid Peroxidase Gene"],"prefix":"10.1007","volume":"15","author":[{"given":"Kenneth R.","family":"Johnson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leona H.","family":"Gagnon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chantal M.","family":"Longo-Guess","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belinda S.","family":"Harris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,12,3]]},"reference":[{"key":"427_CR1","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/nmeth0410-248","volume":"7","author":"IA Adzhubei","year":"2010","unstructured":"Adzhubei IA, Schmidt S, Peshkin L, Ramensky VE, Gerasimova A, Bork P, Kondrashov AS, Sunyaev SR (2010) A method and server for predicting damaging missense mutations. Nat Methods 7:248\u2013249","journal-title":"Nat Methods"},{"key":"427_CR2","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1530\/eje.0.1450019","volume":"145","author":"P Ambrugger","year":"2001","unstructured":"Ambrugger P, Stoeva I, Biebermann H, Torresani T, Leitner C, Gruters A (2001) Novel mutations of the thyroid peroxidase gene in patients with permanent congenital hypothyroidism. Eur J Endocrinol 145:19\u201324","journal-title":"Eur J Endocrinol"},{"key":"427_CR3","doi-asserted-by":"crossref","first-page":"3708","DOI":"10.1210\/jcem.85.10.6878","volume":"85","author":"B Bakker","year":"2000","unstructured":"Bakker B, Bikker H, Vulsma T, de Randamie JS, Wiedijk BM, De Vijlder JJ (2000) Two decades of screening for congenital hypothyroidism in The Netherlands: TPO gene mutations in total iodide organification defects (an update). J Clin Endocrinol Metab 85:3708\u20133712","journal-title":"J Clin Endocrinol Metab"},{"key":"427_CR4","doi-asserted-by":"crossref","first-page":"3174","DOI":"10.1523\/JNEUROSCI.3965-06.2007","volume":"27","author":"N Brandt","year":"2007","unstructured":"Brandt N, Kuhn S, Munkner S, Braig C, Winter H, Blin N, Vonthein R, Knipper M, Engel J (2007) Thyroid hormone deficiency affects postnatal spiking activity and expression of Ca2+ and K+ channels in rodent inner hair cells. J Neurosci 27:3174\u20133186","journal-title":"J Neurosci"},{"key":"427_CR5","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1159\/000076000","volume":"9","author":"S Christ","year":"2004","unstructured":"Christ S, Biebel UW, Hoidis S, Friedrichsen S, Bauer K, Smolders JW (2004) Hearing loss in athyroid pax8 knockout mice and effects of thyroxine substitution. Audiol Neurootol 9:88\u2013106","journal-title":"Audiol Neurootol"},{"key":"427_CR6","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0140-6736(73)93310-2","volume":"2","author":"MS Deol","year":"1973","unstructured":"Deol MS (1973) Congenital deafness and hypothyroidism. Lancet 2:105\u2013106","journal-title":"Lancet"},{"key":"427_CR7","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1093\/hmg\/10.2.153","volume":"10","author":"LA Everett","year":"2001","unstructured":"Everett LA, Belyantseva IA, Noben-Trauth K, Cantos R, Chen A, Thakkar SI, Hoogstraten-Miller SL, Kachar B, Wu DK, Green ED (2001) Targeted disruption of mouse Pds provides insight about the inner-ear defects encountered in Pendred syndrome. Hum Mol Genet 10:153\u2013161","journal-title":"Hum Mol Genet"},{"key":"427_CR8","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1534\/genetics.111.130633","volume":"189","author":"Q Fang","year":"2011","unstructured":"Fang Q, Longo-Guess C, Gagnon LH, Mortensen AH, Dolan DF, Camper SA, Johnson KR (2011) A modifier gene alleviates hypothyroidism-induced hearing impairment in pou1f1dw dwarf mice. Genetics 189:665\u2013673","journal-title":"Genetics"},{"key":"427_CR9","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s10162-011-0302-3","volume":"13","author":"Q Fang","year":"2012","unstructured":"Fang Q, Giordimaina AM, Dolan DF, Camper SA, Mustapha M (2012) Genetic background of Prop1(df) mutants provides remarkable protection against hypothyroidism-induced hearing impairment. J Assoc Res Otolaryngol 13:173\u2013184","journal-title":"J Assoc Res Otolaryngol"},{"key":"427_CR10","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s101620010092","volume":"3","author":"AJ Griffith","year":"2002","unstructured":"Griffith AJ, Szymko YM, Kaneshige M, Quinonez RE, Kaneshige K, Heintz KA, Mastroianni MA, Kelley MW, Cheng SY (2002) Knock-in mouse model for resistance to thyroid hormone (RTH): an RTH mutation in the thyroid hormone receptor beta gene disrupts cochlear morphogenesis. J Assoc Res Otolaryngol 3:279\u2013288","journal-title":"J Assoc Res Otolaryngol"},{"key":"427_CR11","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.brainres.2006.02.021","volume":"1091","author":"KR Johnson","year":"2006","unstructured":"Johnson KR, Zheng QY, Noben-Trauth K (2006) Strain background effects and genetic modifiers of hearing in mice. Brain Res 1091:79\u201388","journal-title":"Brain Res"},{"key":"427_CR12","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1210\/me.2007-0085","volume":"21","author":"KR Johnson","year":"2007","unstructured":"Johnson KR, Marden CC, Ward-Bailey P, Gagnon LH, Bronson RT, Donahue LR (2007) Congenital hypothyroidism, dwarfism, and hearing impairment caused by a missense mutation in the mouse dual oxidase 2 gene, duox2. Mol Endocrinol 21:1593\u20131602","journal-title":"Mol Endocrinol"},{"key":"427_CR13","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.heares.2011.11.007","volume":"283","author":"KL Kane","year":"2012","unstructured":"Kane KL, Longo-Guess CM, Gagnon LH, Ding D, Salvi RJ, Johnson KR (2012) Genetic background effects on age-related hearing loss associated with Cdh23 variants in mice. Hear Res 283:80\u201388","journal-title":"Hear Res"},{"key":"427_CR14","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0378-5955(99)00150-1","volume":"138","author":"D Li","year":"1999","unstructured":"Li D, Henley CM, O\u2019Malley BW Jr (1999) Distortion product otoacoustic emissions and outer hair cell defects in the hyt\/hyt mutant mouse. Hear Res 138:65\u201372","journal-title":"Hear Res"},{"key":"427_CR15","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1038\/nature01059","volume":"419","author":"MC Liberman","year":"2002","unstructured":"Liberman MC, Gao J, He DZ, Wu X, Jia S, Zuo J (2002) Prestin is required for electromotility of the outer hair cell and for the cochlear amplifier. Nature 419:300\u2013304","journal-title":"Nature"},{"key":"427_CR16","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/S1043-2760(03)00137-1","volume":"14","author":"JC Moreno","year":"2003","unstructured":"Moreno JC, de Vijlder JJ, Vulsma T, Ris-Stalpers C (2003) Genetic basis of hypothyroidism: recent advances, gaps, and strategies for future research. Trends Endocrinol Metab 14:318\u2013326","journal-title":"Trends Endocrinol Metab"},{"key":"427_CR17","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1523\/JNEUROSCI.4957-08.2009","volume":"29","author":"M Mustapha","year":"2009","unstructured":"Mustapha M, Fang Q, Gong TW, Dolan DF, Raphael Y, Camper SA, Duncan RK (2009) Deafness and permanently reduced potassium channel gene expression and function in hypothyroid Pit1dw mutants. J Neurosci 29:1212\u20131223","journal-title":"J Neurosci"},{"key":"427_CR18","doi-asserted-by":"crossref","first-page":"3474","DOI":"10.1073\/pnas.0307402101","volume":"101","author":"L Ng","year":"2004","unstructured":"Ng L, Goodyear RJ, Woods CA, Schneider MJ, Diamond E, Richardson GP, Kelley MW, Germain DL, Galton VA, Forrest D (2004) Hearing loss and retarded cochlear development in mice lacking type 2 iodothyronine deiodinase. Proc Natl Acad Sci U S A 101:3474\u20133479","journal-title":"Proc Natl Acad Sci U S A"},{"key":"427_CR19","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1210\/en.2008-1419","volume":"150","author":"L Ng","year":"2008","unstructured":"Ng L, Hernandez A, He W, Ren T, Srinivas M, Ma M, Galton VA, St Germain DL, Forrest D (2008) A protective role for type 3 deiodinase, a thyroid hormone-inactivating enzyme, in cochlear development and auditory function. Endocrinology 150:1952\u20131960","journal-title":"Endocrinology"},{"key":"427_CR20","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0378-5955(95)00111-G","volume":"88","author":"BW O\u2019Malley Jr","year":"1995","unstructured":"O\u2019Malley BW Jr, Li D, Turner DS (1995) Hearing loss and cochlear abnormalities in the congenital hypothyroid (hyt\/hyt) mouse. Hear Res 88:181\u2013189","journal-title":"Hear Res"},{"key":"427_CR21","doi-asserted-by":"crossref","first-page":"2678","DOI":"10.1210\/jc.2006-0142","volume":"91","author":"N Pfarr","year":"2006","unstructured":"Pfarr N, Borck G, Turk A, Napiontek U, Keilmann A, Muller-Forell W, Kopp P, Pohlenz J (2006) Goitrous congenital hypothyroidism and hearing impairment associated with mutations in the TPO and SLC26A4\/PDS genes. J Clin Endocrinol Metab 91:2678\u20132681","journal-title":"J Clin Endocrinol Metab"},{"key":"427_CR22","doi-asserted-by":"crossref","first-page":"9792","DOI":"10.1523\/JNEUROSCI.21-24-09792.2001","volume":"21","author":"A Rusch","year":"2001","unstructured":"Rusch A, Ng L, Goodyear R, Oliver D, Lisoukov I, Vennstrom B, Richardson G, Kelley MW, Forrest D (2001) Retardation of cochlear maturation and impaired hair cell function caused by deletion of all known thyroid hormone receptors. J Neurosci 21:9792\u20139800","journal-title":"J Neurosci"},{"key":"427_CR23","doi-asserted-by":"crossref","first-page":"3163","DOI":"10.1523\/JNEUROSCI.3974-06.2007","volume":"27","author":"G Sendin","year":"2007","unstructured":"Sendin G, Bulankina AV, Riedel D, Moser T (2007) Maturation of ribbon synapses in hair cells is driven by thyroid hormone. J Neurosci 27:3163\u20133173","journal-title":"J Neurosci"},{"key":"427_CR24","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1007\/s10162-008-0140-0","volume":"9","author":"L Song","year":"2008","unstructured":"Song L, McGee J, Walsh EJ (2008) The influence of thyroid hormone deficiency on the development of cochlear nonlinearities. J Assoc Res Otolaryngol 9:464\u2013476","journal-title":"J Assoc Res Otolaryngol"},{"key":"427_CR25","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1007\/s101620010076","volume":"2","author":"PM Sprenkle","year":"2001","unstructured":"Sprenkle PM, McGee J, Bertoni JM, Walsh EJ (2001) Consequences of hypothyroidism on auditory system function in Tshr mutant (hyt) mice. J Assoc Res Otolaryngol 2:312\u2013329","journal-title":"J Assoc Res Otolaryngol"},{"key":"427_CR26","doi-asserted-by":"crossref","first-page":"2584","DOI":"10.1210\/me.2006-0099","volume":"20","author":"S Takabayashi","year":"2006","unstructured":"Takabayashi S, Umeki K, Yamamoto E, Suzuki T, Okayama A, Katoh H (2006) A novel hypothyroid dwarfism due to the missense mutation Arg479Cys of the thyroid peroxidase gene in the mouse. Mol Endocrinol 20:2584\u20132590","journal-title":"Mol Endocrinol"},{"issue":"52","key":"427_CR27","first-page":"54","volume":"29","author":"GE Truett","year":"2000","unstructured":"Truett GE, Heeger P, Mynatt RL, Truett AA, Walker JA, Warman ML (2000) Preparation of PCR-quality mouse genomic DNA with hot sodium hydroxide and tris (HotSHOT). Biotechniques 29(52):54","journal-title":"Biotechniques"},{"key":"427_CR28","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3109\/00016488609122726","volume":"429","author":"A Uziel","year":"1986","unstructured":"Uziel A (1986) Periods of sensitivity to thyroid hormone during the development of the organ of Corti. Acta Otolaryngol Suppl 429:23\u201327","journal-title":"Acta Otolaryngol Suppl"},{"key":"427_CR29","doi-asserted-by":"crossref","first-page":"2901","DOI":"10.1073\/pnas.052609899","volume":"99","author":"T Weber","year":"2002","unstructured":"Weber T, Zimmermann U, Winter H, Mack A, Kopschall I, Rohbock K, Zenner HP, Knipper M (2002) Thyroid hormone is a critical determinant for the regulation of the cochlear motor protein prestin. Proc Natl Acad Sci U S A 99:2901\u20132906","journal-title":"Proc Natl Acad Sci U S A"},{"key":"427_CR30","doi-asserted-by":"crossref","first-page":"2975","DOI":"10.1242\/jcs.03013","volume":"119","author":"H Winter","year":"2006","unstructured":"Winter H, Braig C, Zimmermann U, Geisler HS, Franzer JT, Weber T, Ley M, Engel J, Knirsch M, Bauer K, Christ S, Walsh EJ, McGee J, Kopschall I, Rohbock K, Knipper M (2006) Thyroid hormone receptors TRalpha1 and TRbeta differentially regulate gene expression of Kcnq4 and prestin during final differentiation of outer hair cells. J Cell Sci 119:2975\u20132984","journal-title":"J Cell Sci"},{"key":"427_CR31","doi-asserted-by":"crossref","first-page":"2581","DOI":"10.1523\/JNEUROSCI.3557-08.2009","volume":"29","author":"H Winter","year":"2009","unstructured":"Winter H, Ruttiger L, Muller M, Kuhn S, Brandt N, Zimmermann U, Hirt B, Bress A, Sausbier M, Conscience A, Flamant F, Tian Y, Zuo J, Pfister M, Ruth P, Lowenheim H, Samarut J, Engel J, Knipper M (2009) Deafness in TRbeta mutants is caused by malformation of the tectorial membrane. J Neurosci 29:2581\u20132587","journal-title":"J Neurosci"},{"key":"427_CR32","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1677\/joe.0.1720627","volume":"172","author":"JY Wu","year":"2002","unstructured":"Wu JY, Shu SG, Yang CF, Lee CC, Tsai FJ (2002) Mutation analysis of thyroid peroxidase gene in Chinese patients with total iodide organification defect: identification of five novel mutations. J Endocrinol 172:627\u2013635","journal-title":"J Endocrinol"}],"container-title":["Journal of the Association for Research in Otolaryngology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10162-013-0427-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10162-013-0427-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10162-013-0427-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,4]],"date-time":"2019-08-04T05:58:35Z","timestamp":1564898315000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10162-013-0427-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12,3]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["427"],"URL":"https:\/\/doi.org\/10.1007\/s10162-013-0427-7","relation":{},"ISSN":["1525-3961","1438-7573"],"issn-type":[{"value":"1525-3961","type":"print"},{"value":"1438-7573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,3]]}}}