{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T23:51:32Z","timestamp":1789343492744,"version":"build-2803163510"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2017,1,3]],"date-time":"2017-01-03T00:00:00Z","timestamp":1483401600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100003354","name":"Garnett Passe and Rodney Williams Memorial Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003354","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT1081478"],"award-info":[{"award-number":["GNT1081478"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004752","name":"State Government of Victoria","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004752","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["JARO"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1007\/s10162-016-0609-1","type":"journal-article","created":{"date-parts":[[2017,1,3]],"date-time":"2017-01-03T09:49:46Z","timestamp":1483436986000},"page":"291-299","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Gentamicin Applied to the Oval Window Suppresses Vestibular Function in Guinea Pigs"],"prefix":"10.1007","volume":"18","author":[{"given":"E. B.","family":"King","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. K.","family":"Shepherd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. J.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. B.","family":"Fallon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,1,3]]},"reference":[{"key":"609_CR1","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/0378-5955(94)00175-P","volume":"82","author":"JM Aran","year":"1995","unstructured":"Aran JM, Chappert C, Dulon D, Erre JP, Aurousseau C (1995) Uptake of amikacin by hair cells of the guinea pig cochlea and vestibule and ototoxicity: comparison with gentamicin. Hear Res 82:179\u2013183","journal-title":"Hear Res"},{"issue":"9","key":"609_CR2","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1097\/00005537-200209000-00015","volume":"112","author":"Z Becvarovski","year":"2002","unstructured":"Becvarovski Z, Bojrab DI, Michaelides EM et al (2002) Round window gentamicin absorption: an in vivo human model. Laryngoscope 112(9):1610\u20131613","journal-title":"Laryngoscope"},{"issue":"Pt1","key":"609_CR3","doi-asserted-by":"crossref","first-page":"120","DOI":"10.3109\/00016489509125206","volume":"520","author":"A Bohmer","year":"1995","unstructured":"Bohmer A (1995) Short latency vestibular evoked responses to linear acceleration stimuli in small mammals: masking effects and experimental applications. Acta Otolaryngol Suppl 520(Pt1):120\u2013123","journal-title":"Acta Otolaryngol Suppl"},{"key":"609_CR4","first-page":"498","volume":"16","author":"A Bohmer","year":"1995","unstructured":"Bohmer A, Hoffman LF, Honrubia V (1995) Characterization of vestibular potentials evoked by linear acceleration pulses in the chinchilla. Am J Otol 16:498\u2013504","journal-title":"Am J Otol"},{"key":"609_CR5","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1159\/000327256","volume":"17","author":"GH Bremer","year":"2012","unstructured":"Bremer GH, de Groot JC, Versnal H, Klis SF (2012) Combined administration of kanalycin and furosemide does not result in loss of vestibular function in Guinea pigs. Audiol Neurootol 17:25\u201338","journal-title":"Audiol Neurootol"},{"key":"609_CR6","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/j.otc.2004.06.002","volume":"37","author":"J Carey","year":"2004","unstructured":"Carey J (2004) Intratympanic gentamicin for the treatment of Meniere\u2019s disease and other forms of peripheral vertigo. Otolaryngol Clin N Am 37:1075\u20131090","journal-title":"Otolaryngol Clin N Am"},{"key":"609_CR7","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1097\/00129492-200407000-00023","volume":"25","author":"SH Chia","year":"2004","unstructured":"Chia SH, Garnst AC, Anderson JP, Harris JP (2004) Intratympanic gentamicin therapy for M\u00e8ni\u00e9re\u2019s disease: a meta analysis. Otol Neurotol 25:544\u2013552","journal-title":"Otol Neurotol"},{"issue":"2","key":"609_CR8","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s00221-013-3602-5","volume":"229","author":"Y Chihara","year":"2013","unstructured":"Chihara Y, Wang V, Brown DJ (2013) Evidence for the utricular origin of the vestibular short-latency-evoked potential (VsEP) to bone-conducted vibration in guinea pig. Exp Brain Res 229(2):157\u2013170","journal-title":"Exp Brain Res"},{"issue":"6","key":"609_CR9","doi-asserted-by":"crossref","first-page":"351","DOI":"10.2310\/7070.2003.13863","volume":"32","author":"C Diamond","year":"2003","unstructured":"Diamond C, O\u2019Connell DA, Hornig JD et al (2003) Systematic review of intratympanic gentamicin in Meniere\u2019s disease. J Otolaryngol 32(6):351\u2013361","journal-title":"J Otolaryngol"},{"issue":"1","key":"609_CR10","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1002\/jmri.24144","volume":"39","author":"JL Floc\u2019h","year":"2014","unstructured":"Floc\u2019h JL et al (2014) Markers of cochlear inflammation using MRI. J Magn Reson Imaging 39(1):150\u2013161","journal-title":"J Magn Reson Imaging"},{"issue":"4","key":"609_CR11","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1080\/000164801300366552","volume":"121","author":"MV Goycoolea","year":"2001","unstructured":"Goycoolea MV (2001) Clinical aspects of round window membrane permeability under normal and pathological conditions. Acta Otolaryngol 121(4):437\u2013447","journal-title":"Acta Otolaryngol"},{"issue":"5","key":"609_CR12","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1007\/s10162-014-0476-6","volume":"15","author":"K Hirose","year":"2014","unstructured":"Hirose K et al (2014) Systemic lipopolysaccharide compromises the blood-labyrinth barrier and increases entry of serum fluorescein into the perilymph. J Assoc Res Otolaryngol 15(5):707\u2013719","journal-title":"J Assoc Res Otolaryngol"},{"issue":"6","key":"609_CR13","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1007\/s10162-011-0280-5","volume":"12","author":"EB King","year":"2011","unstructured":"King EB, Salt AN, Eastwood HT, O\u2019Leary SJ (2011) Direct entry of gadolinium into the vestibule following intratympanic applications in Guinea pigs and the influence of cochlear implantation. JARO 12(6):741\u2013751","journal-title":"JARO"},{"key":"609_CR14","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.heares.2013.07.013","volume":"304","author":"EB King","year":"2013","unstructured":"King EB, Salt AN, Kel GE, Eastwood HT, O\u2019Leary SJ (2013) Gentamicin administration on the stapes footplate causes greater hearing loss and vestibulotoxicity than round window administration in guinea pigs. Hear Res 304:159\u2013166","journal-title":"Hear Res"},{"key":"609_CR15","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1007\/s00405-010-1298-8","volume":"267","author":"CM Kingma","year":"2010","unstructured":"Kingma CM, Wit HP (2010) The effect of changes in perilymphatic K+ on the vestibular evoked potential in the guinea pig. Eur Arch Otorhinolaryngol 267:1679\u20131684","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"609_CR16","doi-asserted-by":"crossref","first-page":"14077","DOI":"10.1523\/JNEUROSCI.2845-09.2009","volume":"29","author":"SG Kujawa","year":"2009","unstructured":"Kujawa SG, Liberman MC (2009) Adding insult to injury: cochlear nerve degeneration after \u201ctemporary\u201d noise-induced hearing loss. J Neuroscience 29:14077\u201314085","journal-title":"J Neuroscience"},{"issue":"5","key":"609_CR17","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/BF00463571","volume":"246","author":"G Lange","year":"1989","unstructured":"Lange G (1989) Gentamicin and other ototoxic antibiotics for the transtympanic treatment of Meni\u00e8re\u2019s disease. Arch Otorhinolaryngol 246(5):269\u2013270","journal-title":"Arch Otorhinolaryngol"},{"key":"609_CR18","doi-asserted-by":"crossref","unstructured":"Lindeman H (1969) \"Regional differences in structure of the vestibular sensory regions.\" The Journal of Laryngology & Otology 83.01: 1-17","DOI":"10.1017\/S0022215100070018"},{"key":"609_CR19","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1097\/AUD.0b013e3181c351f2","volume":"31","author":"AA McCall","year":"2010","unstructured":"McCall AA, Leary Swan EE, Borenstein JT, Sewell WF, Kujawa SG, McKenna MJ (2010) Drug delivery for treatment of inner ear disease: current state of knowledge. Ear & Hearing 31:156\u2013165","journal-title":"Ear & Hearing"},{"key":"609_CR20","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1097\/00005537-199910000-00004","volume":"109","author":"SN Merchant","year":"1999","unstructured":"Merchant SN (1999) A method for quantitative assessment of vestibular otopathology. Laryngoscope 109:1560\u20131569","journal-title":"Laryngoscope"},{"key":"609_CR21","unstructured":"Merchant SN, Nadol JB (2010) Schuknecht\u2019s Pathology of the Ear, People\u2019s Medical Publishing House USA, 3rd Edition"},{"key":"609_CR22","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1001\/archotol.1977.00780260054005","volume":"103","author":"JB Nadol","year":"1977","unstructured":"Nadol JB (1977) Positive Hennebert\u2019s sign in M\u00e9nier\u00e8\u2019s disease. Arch Otolaryngol 103:524\u2013530","journal-title":"Arch Otolaryngol"},{"key":"609_CR23","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1080\/00016480050218627","volume":"120","author":"T Nakashima","year":"2000","unstructured":"Nakashima T, Teranishi M, Hibi T, Kobayashi M, Umemura M (2000) Vestibular and cochlear toxicity of aminoglycosides: a review. Acta Otolaryngol 120:904\u2013911","journal-title":"Acta Otolaryngol"},{"key":"609_CR24","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1080\/000164801300006290","volume":"121","author":"MLYM Oei","year":"2001","unstructured":"Oei MLYM, Segenhout JM, Wit HP, Albers FW (2001) The vestibular evoked response to linear, alternating, acceleration pulses without acoustic masking as a parameter of vestibular function. Acta Otolaryngol 121:62\u201367","journal-title":"Acta Otolaryngol"},{"key":"609_CR25","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1097\/00129492-200201000-00016","volume":"23","author":"SKR Plontke","year":"2002","unstructured":"Plontke SKR, Wood AWW, Salt AN (2002) Analysis of gentamicin kinetics in fluids of the inner ear with round window administration. Otol Neurotol 23:67\u2013974","journal-title":"Otol Neurotol"},{"key":"609_CR26","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1111\/j.1749-6632.1999.tb08658.x","volume":"884","author":"A Quaranta","year":"1999","unstructured":"Quaranta A, Aloisi A, De Benedittis G, Scaringi A (1999) Intratympanic therapy for M\u00e9ni\u00e8re\u2019s disease. High-concentration gentamicin with round-window protection. Ann N Y Acad Sci 884:410\u2013424","journal-title":"Ann N Y Acad Sci"},{"key":"609_CR27","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1097\/MLG.0b013e31817d01cd","volume":"118","author":"AN Salt","year":"2008","unstructured":"Salt AN, Gill RM, Plontke SK (2008) Dependence of hearing changes on the dose of intratympanically applied gentamicin: a meta-analysis using mathematical simulations of clinical drug delivery protocols. Laryngoscope 118:1793\u20131800","journal-title":"Laryngoscope"},{"key":"609_CR28","volume-title":"Pathology of the ear","author":"HF Schuknecht","year":"1993","unstructured":"Schuknecht HF (1993) Pathology of the ear, 2nd edn. Lea & Febiger, Philadelphia\/Baltimore","edition":"2"},{"issue":"2","key":"609_CR29","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1097\/MAO.0000000000000196","volume":"35","author":"H Shi","year":"2014","unstructured":"Shi H, Li Y, Yin S, Zou J (2014) The predominant vestibular uptake of gadolinium through the oval window pathway is compromised by endolymphatic hydrops in M\u00e9ni\u00e8re\u2019s disease. Otol Neurotol 35(2):315\u2013322","journal-title":"Otol Neurotol"},{"issue":"6","key":"609_CR30","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1177\/019459987908700625","volume":"87","author":"BM Smith","year":"1979","unstructured":"Smith BM, Myers MG (1979) The penetration of gentamicin and neomycinin to perilymph across the round window membrane. Otolaryngol Head Neck Surg 87(6):888\u2013891","journal-title":"Otolaryngol Head Neck Surg"},{"key":"609_CR31","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/BF00464276","volume":"233","author":"K Tanaka","year":"1981","unstructured":"Tanaka K, Motomura S (1981) Permeability of the labyrinthine window in guinea pigs. Arch Otorhinolarygnol 233:67\u201373","journal-title":"Arch Otorhinolarygnol"},{"key":"609_CR32","first-page":"209","volume-title":"Meniere\u2019s disease: perspectives in the 90s","author":"PA Wackym","year":"1994","unstructured":"Wackym PA, Schuknecht HF, Ward PH, Linthicum FH, Kerner MM, Aframian D et al (1994) Blinded control study of endolymphatic duct and sac fibrosis in Meniere\u2019s disease. In: Filipo R, Barbara M (eds) Meniere\u2019s disease: perspectives in the 90s. Kugler Publishing, Amsterdam\/New York, pp. 209\u2013215"},{"key":"609_CR33","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1159\/000084024","volume":"10","author":"J Zou","year":"2005","unstructured":"Zou J, Pyykk\u00f6 I, Bjelke B, Dastidar P, Toppila E (2005) Communication between the perilymphatic scalae and spiral ligament visualized by in vivo MRI. Audiol Neurotol 10:145\u2013152","journal-title":"Audiol Neurotol"}],"container-title":["Journal of the Association for Research in Otolaryngology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10162-016-0609-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10162-016-0609-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10162-016-0609-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,25]],"date-time":"2017-06-25T03:10:09Z","timestamp":1498360209000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10162-016-0609-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,3]]},"references-count":33,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["609"],"URL":"https:\/\/doi.org\/10.1007\/s10162-016-0609-1","relation":{},"ISSN":["1525-3961","1438-7573"],"issn-type":[{"value":"1525-3961","type":"print"},{"value":"1438-7573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,3]]}}}