{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T11:52:42Z","timestamp":1771674762831,"version":"3.50.1"},"reference-count":82,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,10,18]],"date-time":"2017-10-18T00:00:00Z","timestamp":1508284800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2017,10,18]],"date-time":"2017-10-18T00:00:00Z","timestamp":1508284800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["DC005211"],"award-info":[{"award-number":["DC005211"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Tinnitus Research Consortium","award":["n\/a"],"award-info":[{"award-number":["n\/a"]}]},{"name":"David M. Rubenstein Fund for Hearing Research","award":["n\/a"],"award-info":[{"award-number":["n\/a"]}]},{"name":"Liquing Zeng","award":["n\/a"],"award-info":[{"award-number":["n\/a"]}]},{"DOI":"10.13039\/501100000703","name":"Action on Hearing Loss","doi-asserted-by":"publisher","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/501100000703","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["JARO"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1007\/s10162-017-0642-8","type":"journal-article","created":{"date-parts":[[2017,10,18]],"date-time":"2017-10-18T19:50:52Z","timestamp":1508356252000},"page":"67-81","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Behavioral Animal Model of the Emotional Response to Tinnitus and Hearing Loss"],"prefix":"10.1007","volume":"19","author":[{"given":"Amanda M.","family":"Lauer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gail","family":"Larkin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aikeen","family":"Jones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bradford J.","family":"May","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,10,18]]},"reference":[{"key":"642_CR1","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1016\/j.physbeh.2007.06.017","volume":"92","author":"M Altun","year":"2007","unstructured":"Altun M, Bergman E, Edstr\u00f6m E, Johnson H, Ulfhake B (2007) Behavioral impairments of the aging rat. Physiol Behav 92:911\u2013923","journal-title":"Physiol Behav"},{"key":"642_CR2","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1002\/jclp.10243","volume":"60","author":"G Andersson","year":"2004","unstructured":"Andersson G, Kaldo V (2004) Internet-based cognitive behavioral therapy for tinnitus. J Clin Psychol 60:171\u2013178","journal-title":"J Clin Psychol"},{"key":"642_CR3","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1080\/028457100750066405","volume":"29","author":"G Andersson","year":"2000","unstructured":"Andersson G, Vretblad P (2000) Anxiety sensitivity in patients with chronic tinnitus. Scand J Behav Ther 29:57\u201364","journal-title":"Scand J Behav Ther"},{"key":"642_CR4","first-page":"2S17","volume":"42 Suppl 2","author":"S Arlinger","year":"2003","unstructured":"Arlinger S (2003) Negative consequences of uncorrected hearing loss--a review. Int J Audiol 42 Suppl 2:2S17\u20132S20","journal-title":"Int J Audiol"},{"key":"642_CR5","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1016\/S0163-1047(79)90597-1","volume":"25","author":"KE Asin","year":"1979","unstructured":"Asin KE, Wirtshafter D, Kent EW (1979) Straight alley acquisition and extinction and open field activity following discrete electrolytic lesions of the mesencephalic raphe nuclei. Behav Neural Biol 25:242\u2013256","journal-title":"Behav Neural Biol"},{"key":"642_CR6","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.heares.2012.03.009","volume":"295","author":"CA Bauer","year":"2013","unstructured":"Bauer CA, Kurt W, Sybert LT, Brozoski TJ (2013) The cerebellum as a novel tinnitus generator. Hear Res 295:130\u2013139","journal-title":"Hear Res"},{"key":"642_CR7","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1016\/0022-3999(95)00512-9","volume":"39","author":"RJ Budd","year":"1995","unstructured":"Budd RJ, Pugh R (1995) The relationship between locus of control, tinnitus severity, and emotional distress in a group of tinnitus sufferers. J Psychosom Res 39:1015\u20131018","journal-title":"J Psychosom Res"},{"key":"642_CR8","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/S0165-0327(99)00068-3","volume":"57","author":"MP Caligiuri","year":"2000","unstructured":"Caligiuri MP, Ellwanger J (2000) Motor and cognitive aspects of motor retardation in depression. J Affect Disord 57:83\u201393","journal-title":"J Affect Disord"},{"key":"642_CR9","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1016\/j.neubiorev.2005.04.017","volume":"29","author":"A Carobrez","year":"2005","unstructured":"Carobrez A, Bertoglio L (2005) Ethological and temporal analyses of anxiety-like behavior: the elevated plus-maze model 20 years on. Neurosci Biobehav Rev 29:1193\u20131205","journal-title":"Neurosci Biobehav Rev"},{"key":"642_CR10","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.heares.2012.11.016","volume":"295","author":"G Chen","year":"2013","unstructured":"Chen G, Stolzberg D, Lobarinas E, Sun W, Ding D, Salvi R (2013) Salicylate-induced cochlear impairments, cortical hyperactivity and re-tuning, and tinnitus. Hear Res 295:100\u2013113","journal-title":"Hear Res"},{"key":"642_CR11","doi-asserted-by":"crossref","first-page":"e06576","DOI":"10.7554\/eLife.06576","volume":"4","author":"Y Chen","year":"2015","unstructured":"Chen Y, Li X, Liu L, Wang J, Lu C, Yang M, Jiao Y, Zang F, Radziwon K, Chen G (2015) Tinnitus and hyperacusis involve hyperactivity and enhanced connectivity in auditory-limbic-arousal-cerebellar network. elife 4:e06576","journal-title":"elife"},{"key":"642_CR12","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.heares.2016.01.001","volume":"333","author":"L Cheng","year":"2016","unstructured":"Cheng L, Wang S, Huang Y, Liao X (2016) The hippocampus may be more susceptible to environmental noise than the auditory cortex. Hear Res 333:93\u201397","journal-title":"Hear Res"},{"key":"642_CR13","unstructured":"Davis A, Rafaie EA (2000) Epidemiology of tinnitus. Tinnitus handbook:1\u201323"},{"key":"642_CR14","doi-asserted-by":"publisher","first-page":"e0119616","DOI":"10.1371\/journal.pone.0119616","volume":"10","author":"P Dawes","year":"2015","unstructured":"Dawes P, Emsley R, Cruickshanks KJ, Moore DR, Fortnum H, Edmondson-Jones M, McCormack A, Munro KJ (2015) Hearing loss and cognition: the role of hearing AIDS, social isolation and depression. PLoS One 10:e0119616","journal-title":"PLoS One"},{"key":"642_CR15","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/S0166-4328(01)00451-X","volume":"133","author":"RM Deacon","year":"2002","unstructured":"Deacon RM, Bannerman DM, Kirby BP, Croucher A, Rawlins JNP (2002a) Effects of cytotoxic hippocampal lesions in mice on a cognitive test battery. Behav Brain Res 133:57\u201368","journal-title":"Behav Brain Res"},{"key":"642_CR16","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/S0166-4328(01)00401-6","volume":"132","author":"RM Deacon","year":"2002","unstructured":"Deacon RM, Croucher A, Rawlins JNP (2002b) Hippocampal cytotoxic lesion effects on species-typical behaviours in mice. Behav Brain Res 132:203\u2013213","journal-title":"Behav Brain Res"},{"key":"642_CR17","doi-asserted-by":"publisher","first-page":"27","DOI":"10.3109\/03005364000000006","volume":"31","author":"R Dineen","year":"1997","unstructured":"Dineen R, Doyle J, Bench J (1997) Audiological and psychological characteristics of a group of tinnitus sufferers, prior to tinnitus management training. Br J Audiol 31:27\u201338","journal-title":"Br J Audiol"},{"key":"642_CR18","doi-asserted-by":"publisher","first-page":"168","DOI":"10.3109\/00206099209072912","volume":"31","author":"SI Erlandsson","year":"1992","unstructured":"Erlandsson SI, Hallberg LR, Axelsson A (1992) Psychological and audiological correlates of perceived tinnitus severity. Int J Audiol 31:168\u2013179","journal-title":"Int J Audiol"},{"key":"642_CR19","first-page":"39","volume":"3","author":"SI Erlandsson","year":"2001","unstructured":"Erlandsson SI, Holgers KM (2001) The impact of perceived tinnitus severity on health-related quality of life with aspects of gender. Noise Health 3:39\u201351","journal-title":"Noise Health"},{"key":"642_CR20","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/S0014-2999(03)01273-1","volume":"463","author":"SE File","year":"2003","unstructured":"File SE, Seth P (2003) A review of 25 years of the social interaction test. Eur J Pharmacol 463:35\u201353","journal-title":"Eur J Pharmacol"},{"key":"642_CR21","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/0006-8993(80)90695-2","volume":"199","author":"JS Fink","year":"1980","unstructured":"Fink JS, Smith GP (1980) Mesolimbicocortical dopamine terminal fields are necessary for normal locomotor and investigatory exploration in rats. Brain Res 199:359\u2013384","journal-title":"Brain Res"},{"key":"642_CR22","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1002\/cne.902880411","volume":"288","author":"D Fitzpatrick","year":"1989","unstructured":"Fitzpatrick D, Diamond IT, Raczkowski D (1989) Cholinergic and monoaminergic innervation of the cat\u2019s thalamus: comparison of the lateral geniculate nucleus with other principal sensory nuclei. J Comp Neurol 288:647\u2013675","journal-title":"J Comp Neurol"},{"key":"642_CR23","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/0197-4580(84)90084-8","volume":"5","author":"FH Gage","year":"1984","unstructured":"Gage FH, Dunnett SB, Bj\u00f6rklund A (1984) Spatial learning and motor deficits in aged rats. Neurobiol Aging 5:43\u201348","journal-title":"Neurobiol Aging"},{"key":"642_CR24","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1016\/S0140-6736(05)67423-5","volume":"366","author":"GA Gates","year":"2005","unstructured":"Gates GA, Mills JH (2005) Presbycusis. Lancet 366:1111\u20131120","journal-title":"Lancet"},{"key":"642_CR25","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/0166-4328(96)00065-4","volume":"73","author":"MA Geyer","year":"1995","unstructured":"Geyer MA (1995) Serotonergic functions in arousal and motor activity. Behav Brain Res 73:31\u201335","journal-title":"Behav Brain Res"},{"key":"642_CR26","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.heares.2009.03.002","volume":"253","author":"T Goble","year":"2009","unstructured":"Goble T, M\u00f8ller A, Thompson L (2009) Acute high-intensity sound exposure alters responses of place cells in hippocampus. Hear Res 253:52\u201359","journal-title":"Hear Res"},{"key":"642_CR27","doi-asserted-by":"crossref","unstructured":"Gould TD, Dao DT, Kovacsics CE (2009) The open field test. In: Gould TD (ed) Mood and anxiety related phenotypes in mice: characterization using behavioral tests. Humana Press, Totowa, p 1\u201320","DOI":"10.1007\/978-1-60761-303-9_1"},{"key":"642_CR28","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.jpsychores.2008.10.017","volume":"67","author":"MJ Guitton","year":"2009","unstructured":"Guitton MJ (2009) Tinnitus-provoking salicylate treatment triggers social impairments in mice. J Psychosom Res 67:273\u2013276","journal-title":"J Psychosom Res"},{"key":"642_CR29","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.bbr.2011.08.042","volume":"226","author":"IC Hall","year":"2012","unstructured":"Hall IC, Sell GL, Chester EM, Hurley LM (2012) Stress-evoked increases in serotonin in the auditory midbrain do not directly result from elevations in serum corticosterone. Behav Brain Res 226:41\u201349","journal-title":"Behav Brain Res"},{"key":"642_CR30","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1037\/a0024426","volume":"125","author":"IC Hall","year":"2011","unstructured":"Hall IC, Sell GL, Hurley LM (2011) Social regulation of serotonin in the auditory midbrain. Behav Neurosci 125:501\u2013511","journal-title":"Behav Neurosci"},{"key":"642_CR31","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1242\/jeb.035956","volume":"213","author":"IC Hall","year":"2010","unstructured":"Hall IC, Rebec GV, Hurley LM (2010) Serotonin in the inferior colliculus fluctuates with behavioral state and environmental stimuli. J Exp Biol 213:1009\u20131017","journal-title":"J Exp Biol"},{"key":"642_CR32","doi-asserted-by":"publisher","first-page":"19","DOI":"10.3109\/03005369309077885","volume":"27","author":"LR Hallberg","year":"1993","unstructured":"Hallberg LR, Erlandsson SI (1993) Tinnitus characteristics in tinnitus complainers and noncomplainers. Br J Audiol 27:19\u201327","journal-title":"Br J Audiol"},{"key":"642_CR33","doi-asserted-by":"publisher","first-page":"e176","DOI":"10.1097\/AUD.0000000000000148","volume":"36","author":"H Hesser","year":"2015","unstructured":"Hesser H, Bankestad E, Andersson G (2015) Acceptance of tinnitus as an independent correlate of tinnitus severity. Ear Hear 36:e176\u2013e182","journal-title":"Ear Hear"},{"key":"642_CR34","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1001\/archotol.132.12.1323","volume":"132","author":"W Hiller","year":"2006","unstructured":"Hiller W, Goebel G (2006) Factors influencing tinnitus loudness and annoyance. Arch Otolaryngol Head Neck Surg 132:1323\u20131330","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"642_CR35","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/0091-3057(95)02126-4","volume":"54","author":"S Hogg","year":"1996","unstructured":"Hogg S (1996) A review of the validity and variability of the elevated plus-maze as an animal model of anxiety. Pharmacol Biochem Behav 54:21\u201330","journal-title":"Pharmacol Biochem Behav"},{"key":"642_CR36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0378-5955(02)00365-9","volume":"168","author":"LM Hurley","year":"2002","unstructured":"Hurley LM, Thompson AM, Pollak GD (2002) Serotonin in the inferior colliculus. Hear Res 168:1\u201311","journal-title":"Hear Res"},{"key":"642_CR37","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.heares.2013.07.010","volume":"307","author":"FT Husain","year":"2014","unstructured":"Husain FT, Schmidt SA (2014) Using resting state functional connectivity to unravel networks of tinnitus. Hear Res 307:153\u2013162","journal-title":"Hear Res"},{"key":"642_CR38","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1037\/h0077262","volume":"90","author":"BL Jacobs","year":"1976","unstructured":"Jacobs BL, Cohen A (1976) Differential behavioral effects of lesions of the medial or dorsal raphe nuclei in rats: open field and pain-elicited aggression. J Comp Physiol Psychol 90:102","journal-title":"J Comp Physiol Psychol"},{"key":"642_CR39","doi-asserted-by":"publisher","first-page":"195","DOI":"10.3109\/00206098509070103","volume":"24","author":"SC Jakes","year":"1985","unstructured":"Jakes SC, Hallam RS, Chambers C, Hinchcliffe R (1985) A factor analytical study of tinnitus complaint behaviour. Audiology 24:195\u2013206","journal-title":"Audiology"},{"key":"642_CR40","unstructured":"Jones A, May BJ (2016) Improving the reliability of tinnitus screening in laboratory animals. J Assoc Res Otolaryngol:1\u201313"},{"key":"642_CR41","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/0149-7634(81)90005-1","volume":"5","author":"RJ Katz","year":"1981","unstructured":"Katz RJ, Roth KA, Carroll BJ (1981) Acute and chronic stress effects on open field activity in the rat: implications for a model of depression. Neurosci Biobehav Rev 5:247\u2013251","journal-title":"Neurosci Biobehav Rev"},{"key":"642_CR42","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/0006-8993(91)90134-H","volume":"557","author":"A Klepper","year":"1991","unstructured":"Klepper A, Herbert H (1991) Distribution and origin of noradrenergic and serotonergic fibers in the cochlear nucleus and inferior colliculus of the rat. Brain Res 557:190\u2013201","journal-title":"Brain Res"},{"key":"642_CR43","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.heares.2012.02.009","volume":"288","author":"KS Kraus","year":"2012","unstructured":"Kraus KS, Canlon B (2012) Neuronal connectivity and interactions between the auditory and limbic systems. Effects of noise and tinnitus. Hear Res 288:34\u201346","journal-title":"Hear Res"},{"key":"642_CR44","doi-asserted-by":"publisher","first-page":"1216","DOI":"10.1016\/j.neuroscience.2010.02.071","volume":"167","author":"KS Kraus","year":"2010","unstructured":"Kraus KS, Mitra S, Jimenez Z, Hinduja S, Ding D, Jiang H, Gray L, Lobarinas E, Sun W, Salvi RJ (2010) Noise trauma impairs neurogenesis in the rat hippocampus. Neuroscience 167:1216\u20131226","journal-title":"Neuroscience"},{"key":"642_CR45","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1038\/laban0509-154","volume":"38","author":"AM Lauer","year":"2009","unstructured":"Lauer AM, May BJ, Hao ZJ, Watson J (2009) Analysis of environmental sound levels in modern rodent housing rooms. Lab Anim (NY) 38:154\u2013160","journal-title":"Lab Anim (NY)"},{"key":"642_CR46","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.neuron.2010.12.002","volume":"69","author":"AM Leaver","year":"2011","unstructured":"Leaver AM, Renier L, Chevillet MA, Morgan S, Kim HJ, Rauschecker JP (2011) Dysregulation of limbic and auditory networks in tinnitus. Neuron 69:33\u201343","journal-title":"Neuron"},{"key":"642_CR47","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1001\/jamaoto.2014.42","volume":"140","author":"C Li","year":"2014","unstructured":"Li C, Zhang X, Hoffman HJ, Cotch MF, Themann CL, Wilson MR (2014) Hearing impairment associated with depression in US adults, National Health and Nutrition Examination Survey 2005-2010. JAMA Otolaryngol Head Neck Surg 140:293\u2013302","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"key":"642_CR48","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1001\/jamainternmed.2013.1868","volume":"173","author":"FR Lin","year":"2013","unstructured":"Lin FR, Yaffe K, Xia J, Xue Q, Harris TB, Purchase-Helzner E, Satterfield S, Ayonayon HN, Ferrucci L, Simonsick EM (2013) Hearing loss and cognitive decline in older adults. JAMA Intern Med 173:293\u2013299","journal-title":"JAMA Intern Med"},{"key":"642_CR49","doi-asserted-by":"publisher","first-page":"20374","DOI":"10.1038\/srep20374","volume":"6","author":"L Liu","year":"2016","unstructured":"Liu L, Shen P, He T, Chang Y, Shi L, Tao S, Li X, Xun Q, Guo X, Yu Z, Wang J (2016) Noise induced hearing loss impairs spatial learning\/memory and hippocampal neurogenesis in mice. Sci Rep 6:20374","journal-title":"Sci Rep"},{"key":"642_CR50","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/S0378-5955(04)00019-X","volume":"190","author":"E Lobarinas","year":"2004","unstructured":"Lobarinas E, Sun W, Cushing R, Salvi R (2004) A novel behavioral paradigm for assessing tinnitus using schedule-induced polydipsia avoidance conditioning (SIP-AC). Hear Res 190:109\u2013114","journal-title":"Hear Res"},{"key":"642_CR51","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.neulet.2006.01.037","volume":"399","author":"S Manikandan","year":"2006","unstructured":"Manikandan S, Padma MK, Srikumar R, Parthasarathy NJ, Muthuvel A, Devi RS (2006) Effects of chronic noise stress on spatial memory of rats in relation to neuronal dendritic alteration and free radical-imbalance in hippocampus and medial prefrontal cortex. Neurosci Lett 399:17\u201322","journal-title":"Neurosci Lett"},{"key":"642_CR52","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1017\/S0022215100131676","volume":"109","author":"J Marriage","year":"1995","unstructured":"Marriage J, Barnes N (1995) Is central hyperacusis a symptom of 5-hydroxytryptamine (5-HT) dysfunction? J Laryngol Otol 109:915\u2013921","journal-title":"J Laryngol Otol"},{"key":"642_CR53","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.1111\/jgs.12429","volume":"61","author":"DJ Mener","year":"2013","unstructured":"Mener DJ, Betz J, Genther DJ, Chen D, Lin FR (2013) Hearing loss and depression in older adults. J Am Geriatr Soc 61:1627\u20131629","journal-title":"J Am Geriatr Soc"},{"key":"642_CR54","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/S1734-1140(12)70731-4","volume":"64","author":"F Naqvi","year":"2012","unstructured":"Naqvi F, Haider S, Perveen T, Haleem DJ (2012) Sub-chronic exposure to noise affects locomotor activity and produces anxiogenic and depressive like behavior in rats. Pharmacol Rep 64:64\u201369","journal-title":"Pharmacol Rep"},{"key":"642_CR55","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1016\/S1388-2457(98)00034-0","volume":"110","author":"A Norena","year":"1999","unstructured":"Norena A, Cransac H, Chery-Croze S (1999) Towards an objectification by classification of tinnitus. Clin Neurophysiol 110:666\u2013675","journal-title":"Clin Neurophysiol"},{"key":"642_CR56","doi-asserted-by":"publisher","first-page":"e75011","DOI":"10.1371\/journal.pone.0075011","volume":"8","author":"E Pace","year":"2013","unstructured":"Pace E, Zhang J (2013) Noise-induced tinnitus using individualized gap detection analysis and its relationship with hyperacusis, anxiety, and spatial cognition. PLoS One 8:e75011","journal-title":"PLoS One"},{"key":"642_CR57","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.heares.2011.11.004","volume":"283","author":"MA Papesh","year":"2012","unstructured":"Papesh MA, Hurley LM (2012) Plasticity of serotonergic innervation of the inferior colliculus in mice following acoustic trauma. Hear Res 283:89\u201397","journal-title":"Hear Res"},{"key":"642_CR58","doi-asserted-by":"crossref","unstructured":"Pattyn T, Van Den Eede F, Vanneste S, Cassiers L, Veltman DJ, Van De Heyning P, Sabbe BC (2016) Tinnitus and anxiety disorders: a review. Hear Res 333:255\u2013265","DOI":"10.1016\/j.heares.2015.08.014"},{"key":"642_CR59","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1016\/0091-3057(86)90552-6","volume":"24","author":"S Pellow","year":"1986","unstructured":"Pellow S, File SE (1986) Anxiolytic and anxiogenic drug effects on exploratory activity in an elevated plus-maze: a novel test of anxiety in the rat. Pharmacol Biochem Behav 24:525\u2013529","journal-title":"Pharmacol Biochem Behav"},{"key":"642_CR60","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/0165-0270(85)90031-7","volume":"14","author":"S Pellow","year":"1985","unstructured":"Pellow S, Chopin P, File SE, Briley M (1985) Validation of open: closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. J Neurosci Methods 14:149\u2013167","journal-title":"J Neurosci Methods"},{"key":"642_CR61","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/S0014-2999(03)01272-X","volume":"463","author":"L Prut","year":"2003","unstructured":"Prut L, Belzung C (2003) The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review. Eur J Pharmacol 463:3\u201333","journal-title":"Eur J Pharmacol"},{"key":"642_CR62","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1016\/j.neuron.2010.04.032","volume":"66","author":"JP Rauschecker","year":"2010","unstructured":"Rauschecker JP, Leaver AM, M\u00fchlau M (2010) Tuning out the noise: limbic-auditory interactions in tinnitus. Neuron 66:819\u2013826","journal-title":"Neuron"},{"key":"642_CR63","doi-asserted-by":"crossref","unstructured":"Ropp TJ, Tiedemann KL, Young ED, May BJ (2014) Effects of unilateral acoustic trauma on tinnitus-related spontaneous activity in the inferior colliculus. J Assoc Res Otolaryngol 15(6):1007-1022","DOI":"10.1007\/s10162-014-0488-2"},{"key":"642_CR64","doi-asserted-by":"crossref","unstructured":"Rygula R, Abumaria N, Fl\u00fcgge G, Fuchs E, R\u00fcther E, Havemann-Reinecke U (2005) Anhedonia and motivational deficits in rats: impact of chronic social stress. Behav Brain Res 162(1):127\u201334","DOI":"10.1016\/j.bbr.2005.03.009"},{"key":"642_CR65","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.bbr.2003.07.002","volume":"151","author":"P Salchner","year":"2004","unstructured":"Salchner P, Lubec G, Singewald N (2004) Decreased social interaction in aged rats may not reflect changes in anxiety-related behaviour. Behav Brain Res 151:1\u20138","journal-title":"Behav Brain Res"},{"key":"642_CR66","doi-asserted-by":"publisher","first-page":"S83","DOI":"10.1016\/j.neuroimage.2010.05.050","volume":"54","author":"A S\u00e4lj\u00f6","year":"2011","unstructured":"S\u00e4lj\u00f6 A, Mayorga M, Bolouri H, Svensson B, Hamberger A (2011) Mechanisms and pathophysiology of the low-level blast brain injury in animal models. NeuroImage 54:S83\u2013S88","journal-title":"NeuroImage"},{"key":"642_CR67","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1037\/h0022861","volume":"61","author":"J Schwartzbaum","year":"1966","unstructured":"Schwartzbaum J, Gay PE (1966) Interacting behavioral effects of septal and amygdaloid lesions in the rat. J Comp Physiol Psychol 61:59","journal-title":"J Comp Physiol Psychol"},{"key":"642_CR68","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0378-5955(00)00093-9","volume":"145","author":"JJ Simpson","year":"2000","unstructured":"Simpson JJ, Davies WE (2000) A review of evidence in support of a role for 5-HT in the perception of tinnitus. Hear Res 145:1\u20137","journal-title":"Hear Res"},{"key":"642_CR69","doi-asserted-by":"publisher","first-page":"1477","DOI":"10.1037\/0735-7044.119.6.1477","volume":"119","author":"CJ Slawecki","year":"2005","unstructured":"Slawecki CJ (2005) Comparison of anxiety-like behavior in adolescent and adult Sprague-Dawley rats. Behav Neurosci 119:1477","journal-title":"Behav Neurosci"},{"key":"642_CR70","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1007\/BF00181945","volume":"95","author":"M Soffi\u00e9","year":"1988","unstructured":"Soffi\u00e9 M, Bronchart M (1988) Age-related scopolamine effects on social and individual behaviour in rats. Psychopharmacology 95:344\u2013350","journal-title":"Psychopharmacology"},{"key":"642_CR71","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1016\/0031-9384(87)90156-9","volume":"39","author":"WF Supple","year":"1987","unstructured":"Supple WF, Leaton RN, Fanselow MS (1987) Effects of cerebellar vermal lesions on species-specific fear responses, neophobia, and taste-aversion learning in rats. Physiol Behav 39:579\u2013586","journal-title":"Physiol Behav"},{"key":"642_CR72","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1016\/0091-3057(83)90347-7","volume":"19","author":"L Svensson","year":"1983","unstructured":"Svensson L, Ahlenius S (1983) Suppression of exploratory locomotor activity by the local application of dopamine or l-noradrenaline to the nucleus accumbens of the rat. Pharmacol Biochem Behav 19:693\u2013699","journal-title":"Pharmacol Biochem Behav"},{"key":"642_CR73","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1097\/01.psy.0000133328.03596.fb","volume":"66","author":"K Tambs","year":"2004","unstructured":"Tambs K (2004) Moderate effects of hearing loss on mental health and subjective well-being: results from the Nord-Tr\u00f8ndelag Hearing Loss Study. Psychosom Med 66:776\u2013782","journal-title":"Psychosom Med"},{"key":"642_CR74","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1044\/jshd.4802.150","volume":"48","author":"RS Tyler","year":"1983","unstructured":"Tyler RS, Baker LJ (1983) Difficulties experienced by tinnitus sufferers. J Speech Hear Disord 48:150\u2013154","journal-title":"J Speech Hear Disord"},{"key":"642_CR75","doi-asserted-by":"crossref","unstructured":"Valle FP (1970) Effects of strain, sex, and illumination on open-field behavior of rats. Am J Psychol:103\u2013111","DOI":"10.2307\/1420860"},{"key":"642_CR76","doi-asserted-by":"crossref","unstructured":"Van Dijken HH, Tilders FJ, Olivier B, Mos J (1992) Effects of anxiolytic and antidepressant drugs on longlasting behavioural deficits resulting from one short stress experience in male rats. Psychopharmacology 109(4):395\u2013402","DOI":"10.1007\/BF02247714"},{"key":"642_CR77","unstructured":"Walsh RN, Cummins RA (1976) The open-field test: A critical review. Psychol Bull 83(3):482"},{"key":"642_CR78","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1016\/j.bbr.2015.09.024","volume":"296","author":"S Wang","year":"2016","unstructured":"Wang S, Yu Y, Feng Y, Zou F, Zhang X, Huang J, Zhang Y, Zheng X, Huang X, Zhu Y (2016) Protective effect of the orientin on noise-induced cognitive impairments in mice. Behav Brain Res 296:290\u2013300","journal-title":"Behav Brain Res"},{"key":"642_CR79","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1097\/AUD.0b013e318177d9ac","volume":"29","author":"D Welch","year":"2008","unstructured":"Welch D, Dawes PJ (2008) Personality and perception of tinnitus. Ear Hear 29:684\u2013692","journal-title":"Ear Hear"},{"key":"642_CR80","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/0361-9230(84)90053-4","volume":"12","author":"F Willard","year":"1984","unstructured":"Willard F, Ho R, Martin G (1984) The neuronal types and the distribution of 5-hydroxytryptamine and enkephalin-like immunoreactive fibers in the dorsal cochlear nucleus of the North American opossum. Brain Res Bull 12:253\u2013266","journal-title":"Brain Res Bull"},{"key":"642_CR81","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1016\/j.heares.2006.06.013","volume":"226","author":"G Yang","year":"2007","unstructured":"Yang G, Lobarinas E, Zhang L, Turner J, Stolzberg D, Salvi R, Sun W (2007) Salicylate induced tinnitus: behavioral measures and neural activity in auditory cortex of awake rats. Hear Res 226:244\u2013253","journal-title":"Hear Res"},{"key":"642_CR82","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.neuroscience.2011.07.026","volume":"193","author":"Y Zheng","year":"2011","unstructured":"Zheng Y, Hamilton E, McNamara E, Smith P, Darlington C (2011) The effects of chronic tinnitus caused by acoustic trauma on social behaviour and anxiety in rats. Neuroscience 193:143\u2013153","journal-title":"Neuroscience"}],"container-title":["Journal of the Association for Research in Otolaryngology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10162-017-0642-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10162-017-0642-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10162-017-0642-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,17]],"date-time":"2020-05-17T07:14:23Z","timestamp":1589699663000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10162-017-0642-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,18]]},"references-count":82,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["642"],"URL":"https:\/\/doi.org\/10.1007\/s10162-017-0642-8","relation":{},"ISSN":["1525-3961","1438-7573"],"issn-type":[{"value":"1525-3961","type":"print"},{"value":"1438-7573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,18]]},"assertion":[{"value":"14 December 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 September 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 October 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}