{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:40:34Z","timestamp":1790836834104,"version":"4.1.0"},"reference-count":63,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T00:00:00Z","timestamp":1632960000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T00:00:00Z","timestamp":1632960000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["JARO"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1007\/s10162-021-00805-3","type":"journal-article","created":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T15:10:01Z","timestamp":1633014601000},"page":"659-680","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Distortion Product Otoacoustic Emission (DPOAE) Growth in Aging Ears with Clinically Normal Behavioral Thresholds"],"prefix":"10.1007","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9036-1878","authenticated-orcid":false,"given":"Courtney Coburn","family":"Glavin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Siegel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumitrajit","family":"Dhar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,9,30]]},"reference":[{"key":"805_CR1","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1007\/s10162-012-0319-2","volume":"13","author":"C Abdala","year":"2012","unstructured":"Abdala C, Dhar S (2012) Maturation and aging of the human cochlea: a view through the DPOAE looking glass. J Assoc Res Otolaryngol 13:403\u2013421. https:\/\/doi.org\/10.1007\/s10162-012-0319-2","journal-title":"J Assoc Res Otolaryngol"},{"key":"805_CR2","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1007\/s10162-018-0680-x","volume":"19","author":"C Abdala","year":"2018","unstructured":"Abdala C, Ortmann AJ, Shera CA (2018) Reflection- and distortion-source otoacoustic emissions: evidence for increased irregularity in the human cochlea during aging. J Assoc Res Otolaryngol 19:493\u2013510. https:\/\/doi.org\/10.1007\/s10162-018-0680-x","journal-title":"J Assoc Res Otolaryngol"},{"key":"805_CR3","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1121\/1.3523476","volume":"129","author":"R Badri","year":"2011","unstructured":"Badri R, Siegel JH, Wright BA (2011) Auditory filter shapes and high-frequency hearing in adults who have impaired speech in noise performance despite clinically normal audiograms. J Acoust Soc Am 129:852\u2013863. https:\/\/doi.org\/10.1121\/1.3523476","journal-title":"J Acoust Soc Am"},{"key":"805_CR4","doi-asserted-by":"publisher","unstructured":"Blackwell DL, Lucas JW, Clarke, Tainya C (2014) Summary health statistics for U.S. adults: National Health Interview Survey, 2012. Vital Health Stat 10.\u00a0https:\/\/doi.org\/10.1037\/e403882008-001","DOI":"10.1037\/e403882008-001"},{"key":"805_CR5","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/0378-5955(92)90083-Y","volume":"63","author":"NP Cooper","year":"1992","unstructured":"Cooper NP, Rhode WS (1992) Basilar membrane mechanics in the hook region of cat and guinea-pig cochleae: sharp tuning and nonlinearity in the absence of baseline position shifts. Hear Res 63:163\u2013190. https:\/\/doi.org\/10.1016\/0378-5955(92)90083-Y","journal-title":"Hear Res"},{"key":"805_CR6","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1097\/MAO.0000000000001427","volume":"38","author":"MG Crowson","year":"2017","unstructured":"Crowson MG, Hertzano R, Tucci DL (2017) Emerging therapies for sensorineural hearing loss. Otol Neurotol 38:792\u2013803. https:\/\/doi.org\/10.1097\/MAO.0000000000001427","journal-title":"Otol Neurotol"},{"key":"805_CR7","doi-asserted-by":"publisher","first-page":"2465","DOI":"10.1056\/NEJMra1616601","volume":"377","author":"LL Cunningham","year":"2017","unstructured":"Cunningham LL, Tucci DL (2017) Hearing loss in adults. N Eng J Med 377:2465\u20132473. https:\/\/doi.org\/10.1056\/NEJMra1616601","journal-title":"N Eng J Med"},{"key":"805_CR8","doi-asserted-by":"publisher","first-page":"1805","DOI":"10.1523\/JNEUROSCI.2608-18.2019","volume":"39","author":"JB Dewey","year":"2019","unstructured":"Dewey JB, Applegate BE, Oghalai JS (2019) Amplification and suppression of traveling waves along the mouse organ of Corti: evidence for spatial variation in the longitudinal coupling of outer hair cell-generated forces. J Neurosci 39:1805\u20131816. https:\/\/doi.org\/10.1523\/JNEUROSCI.2608-18.2019","journal-title":"J Neurosci"},{"key":"805_CR9","doi-asserted-by":"publisher","first-page":"2882","DOI":"10.1121\/1.1516757","volume":"112","author":"S Dhar","year":"2002","unstructured":"Dhar S, Talmadge CL, Long GR, Tubis A (2002) Multiple internal reflections in the cochlea and their effect on DPOAE fine structure. J Acoust Soc Am 112:2882\u20132897. https:\/\/doi.org\/10.1121\/1.1516757","journal-title":"J Acoust Soc Am"},{"key":"805_CR10","doi-asserted-by":"publisher","first-page":"3119","DOI":"10.1121\/1.1417524","volume":"110","author":"PA Dorn","year":"2001","unstructured":"Dorn PA, Konrad-Martin D, Neely ST et al (2001) Distortion product otoacoustic emission input\/output functions in normal-hearing and hearing-impaired human ears. J Acoust Soc Am 110:3119\u20133131. https:\/\/doi.org\/10.1121\/1.1417524","journal-title":"J Acoust Soc Am"},{"key":"805_CR11","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1121\/1.1381024","volume":"110","author":"JR Dubno","year":"2001","unstructured":"Dubno JR, Ahlstrom JB (2001) Psychophysical suppression measured with bandlimited noise extended below and\/or above the signal: effects of age and hearing loss. J Acoust Soc Am 110:1058\u20131066. https:\/\/doi.org\/10.1121\/1.1381024","journal-title":"J Acoust Soc Am"},{"key":"805_CR12","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1007\/s10162-013-0396-x","volume":"14","author":"JR Dubno","year":"2013","unstructured":"Dubno JR, Eckert MA, Lee F-S et al (2013) Classifying human audiometric phenotypes of age-related hearing loss from animal models. J Assoc Res Otolaryngol 14:687\u2013701. https:\/\/doi.org\/10.1007\/s10162-013-0396-x","journal-title":"J Assoc Res Otolaryngol"},{"key":"805_CR13","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/S0378-5955(01)00377-X","volume":"163","author":"GA Gates","year":"2002","unstructured":"Gates GA, Mills D, Nam B et al (2002) Effects of age on the distortion product otoacoustic emission growth functions. Hear Res 163:53\u201360. https:\/\/doi.org\/10.1016\/S0378-5955(01)00377-X","journal-title":"Hear Res"},{"key":"805_CR14","doi-asserted-by":"publisher","unstructured":"Gatlin\u00a0AE,\u00a0Dhar\u00a0S\u00a0(2021)\u00a0History and lingering impact of the arbitrary 25-dB cutoff for normal hearing. Am J Audiol 1\u20134 https:\/\/doi.org\/10.1044\/2020_AJA-20-00181","DOI":"10.1044\/2020_AJA-20-00181"},{"key":"805_CR15","doi-asserted-by":"publisher","first-page":"3275","DOI":"10.1121\/1.1570433","volume":"113","author":"MP Gorga","year":"2003","unstructured":"Gorga MP, Neely ST, Dorn PA, Hoover BM (2003) Further efforts to predict pure-tone thresholds from distortion product otoacoustic emission input\/output functions. J Acoust Soc Am 113:3275. https:\/\/doi.org\/10.1121\/1.1570433","journal-title":"J Acoust Soc Am"},{"key":"805_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0378-5955(97)00025-7","volume":"114","author":"MA Gratton","year":"1997","unstructured":"Gratton MA, Schulte BA, Smythe NM (1997) Quantification of the stria vascularis and strial capillary areas in quiet-reared young and aged gerbils. Hear Res 114:1\u20139. https:\/\/doi.org\/10.1016\/S0378-5955(97)00025-7","journal-title":"Hear Res"},{"key":"805_CR17","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/0378-5955(89)90065-8","volume":"38","author":"RP Hamernik","year":"1989","unstructured":"Hamernik RP, Patterson JH, Turrentine GA, Ahroon WA (1989) The quantitative relation between sensory cell loss and hearing thresholds. Hear Res 38:199\u2013211. https:\/\/doi.org\/10.1016\/0378-5955(89)90065-8","journal-title":"Hear Res"},{"key":"805_CR18","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1001\/jamaoto.2016.3527","volume":"143","author":"HJ Hoffman","year":"2017","unstructured":"Hoffman HJ, Dobie RA, Losonczy KG et al (2017) Declining prevalence of hearing loss in US adults aged 20 to 69 years. JAMA Otolaryngol Head Neck Surg 143:274\u2013285. https:\/\/doi.org\/10.1001\/jamaoto.2016.3527","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"key":"805_CR19","unstructured":"Hughson W, Westlake H (1944) Manual for program outline for rehabilitation of aural casualties both military and civilian. Trans Am Acad Ophthalmol Otolaryngol 48(Suppl):1\u201315"},{"key":"805_CR20","doi-asserted-by":"publisher","unstructured":"Hunter\u00a0LL,  Monson BB,  Moore DR et al (2020) Extended high frequency hearing and speech perception implications in adults and children. Hear Res 107922 https:\/\/doi.org\/10.1016\/j.heares.2020.107922","DOI":"10.1016\/j.heares.2020.107922"},{"key":"805_CR21","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1121\/1.2133714","volume":"119","author":"TA Johnson","year":"2006","unstructured":"Johnson TA, Neely ST, Garner CA, Gorga MP (2006) Influence of primary-level and primary-frequency ratios on human distortion product otoacoustic emissions. J Acoust Soc Am 119:418\u2013428. https:\/\/doi.org\/10.1121\/1.2133714","journal-title":"J Acoust Soc Am"},{"key":"805_CR22","doi-asserted-by":"publisher","first-page":"1386","DOI":"10.1121\/1.382104","volume":"64","author":"DT Kemp","year":"1978","unstructured":"Kemp DT (1978) Stimulated acoustic emissions from within the human auditory system. J Acoust Soc Am 64:1386\u20131391. https:\/\/doi.org\/10.1121\/1.382104","journal-title":"J Acoust Soc Am"},{"key":"805_CR23","doi-asserted-by":"publisher","first-page":"1704","DOI":"10.1121\/1.384297","volume":"67","author":"DO Kim","year":"1980","unstructured":"Kim DO, Molnar CE, Matthews JW (1980) Cochlear mechanics: nonlinear behavior in two-tone responses as reflected in cochlear-nerve-fiber responses and in ear-canal sound pressure. J Acoust Soc Am 67:1704\u20131721. https:\/\/doi.org\/10.1121\/1.384297","journal-title":"J Acoust Soc Am"},{"key":"805_CR24","doi-asserted-by":"publisher","first-page":"14077","DOI":"10.1523\/JNEUROSCI.2845-09.2009","volume":"29","author":"SG Kujawa","year":"2009","unstructured":"Kujawa SG, Liberman MC (2009) Adding insult to injury: cochlear nerve degeneration after \u201ctemporary\u201d noise-induced hearing loss. J Neurosci 29:14077\u201314085. https:\/\/doi.org\/10.1523\/JNEUROSCI.2845-09.2009","journal-title":"J Neurosci"},{"key":"805_CR25","doi-asserted-by":"publisher","first-page":"3431","DOI":"10.1121\/1.423054","volume":"103","author":"P Kummer","year":"1998","unstructured":"Kummer P, Janssen T, Arnold W (1998) The level and growth behavior of the 2f1\u2212f2 distortion product otoacoustic emission and its relationship to auditory sensitivity in normal hearing and cochlear hearing loss. J Acoust Soc Am 103:3431\u20133444. https:\/\/doi.org\/10.1121\/1.423054","journal-title":"J Acoust Soc Am"},{"key":"805_CR26","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1097\/AUD.0b013e31823d7917","volume":"33","author":"J Lee","year":"2012","unstructured":"Lee J, Dhar S, Abel R et al (2012) Behavioral hearing thresholds between 0.125 and 20 kHz using depth-compensated ear simulator calibration. Ear Hear 33:315\u2013329. https:\/\/doi.org\/10.1097\/AUD.0b013e31823d7917","journal-title":"Ear Hear"},{"key":"805_CR27","doi-asserted-by":"publisher","first-page":"1851","DOI":"10.1001\/archinternmed.2011.506","volume":"171","author":"FR Lin","year":"2011","unstructured":"Lin FR, Niparko JK, Ferrucci L (2011) Hearing loss prevalence in the United States. Arch Intern Med 171:1851\u20131853. https:\/\/doi.org\/10.1001\/archinternmed.2011.506","journal-title":"Arch Intern Med"},{"key":"805_CR28","doi-asserted-by":"publisher","first-page":"1749","DOI":"10.1121\/1.401009","volume":"89","author":"BL Lonsbury-Martin","year":"1991","unstructured":"Lonsbury-Martin BL, Cutler WM, Martin GK (1991) Evidence for the influence of aging on distortion-product otoacoustic emissions in humans. J Acoust Soc Am 89:1749\u20131759. https:\/\/doi.org\/10.1121\/1.401009","journal-title":"J Acoust Soc Am"},{"key":"805_CR29","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1121\/1.400513","volume":"89","author":"ME Lutman","year":"1991","unstructured":"Lutman ME, Gatehouse S, Worthington AG (1991) Frequency resolution as a function of hearing threshold level and age. J Acoust Soc Am 89:320\u2013328. https:\/\/doi.org\/10.1121\/1.400513","journal-title":"J Acoust Soc Am"},{"key":"805_CR30","doi-asserted-by":"publisher","first-page":"3090","DOI":"10.1121\/1.3560123","volume":"129","author":"GK Martin","year":"2011","unstructured":"Martin GK, Stagner BB, Chung YS, Lonsbury-Martin BL (2011) Characterizing distortion-product otoacoustic emission components across four species. J Acoust Soc Am 129:3090\u20133103. https:\/\/doi.org\/10.1121\/1.3560123","journal-title":"J Acoust Soc Am"},{"key":"805_CR31","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1121\/1.3073734","volume":"125","author":"GK Martin","year":"2009","unstructured":"Martin GK, Stagner BB, Fahey PF, Lonsbury-Martin BL (2009) Steep and shallow phase gradient distortion product otoacoustic emissions arising basal to the primary tones. J Acoust Soc Am 125:85\u201392. https:\/\/doi.org\/10.1121\/1.3073734","journal-title":"J Acoust Soc Am"},{"key":"805_CR32","doi-asserted-by":"publisher","first-page":"2199","DOI":"10.1121\/1.1791719","volume":"116","author":"M Mauermann","year":"2004","unstructured":"Mauermann M, Kollmeier B (2004) Distortion product otoacoustic emission (DPOAE) input\/output functions and the influence of the second DPOAE source. J Acoust Soc Am 116:2199\u20132212. https:\/\/doi.org\/10.1121\/1.1791719","journal-title":"J Acoust Soc Am"},{"key":"805_CR33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10162-003-4004-3","volume":"5","author":"DM Mills","year":"2004","unstructured":"Mills DM, Schmiedt RA (2004) Metabolic presbycusis: differential changes in the auditory brainstem and otoacoustic emission responses with chronic furosemide application in the gerbil. J Assoc Res Otolaryngol 5:1\u201310. https:\/\/doi.org\/10.1007\/s10162-003-4004-3","journal-title":"J Assoc Res Otolaryngol"},{"key":"805_CR34","doi-asserted-by":"publisher","first-page":"3055","DOI":"10.1002\/sim.1545","volume":"22","author":"VMR Muggeo","year":"2003","unstructured":"Muggeo VMR (2003) Estimating regression models with unknown break-points. Stat Med 22:3055\u20133071. https:\/\/doi.org\/10.1002\/sim.1545","journal-title":"Stat Med"},{"key":"805_CR35","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1080\/00949655.2016.1149855","volume":"59","author":"VMR Muggeo","year":"2017","unstructured":"Muggeo VMR (2017) Interval estimation for breakpoint in segmented regression: a smooth score-based approach. Aust NZ J Stat 59:311\u2013322. https:\/\/doi.org\/10.1080\/00949655.2016.1149855","journal-title":"Aust NZ J Stat"},{"key":"805_CR36","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1038\/nrd4533","volume":"14","author":"U M\u00fcller","year":"2015","unstructured":"M\u00fcller U, Barr-Gillespie PG (2015) New treatment options for hearing loss. Nat Rev Drug Discov 14:346\u2013365. https:\/\/doi.org\/10.1038\/nrd4533","journal-title":"Nat Rev Drug Discov"},{"key":"805_CR37","unstructured":"Neely S, Liu Z (1993) EMAV: otoacoustic emission averager. In: Technical memorandum. Omaha, NE: Boys Town National Research Hospital"},{"key":"805_CR38","doi-asserted-by":"publisher","first-page":"1556","DOI":"10.1121\/1.414732","volume":"99","author":"AL Nuttall","year":"1996","unstructured":"Nuttall AL, Dolan DF (1996) Steady-state sinusoidal velocity responses of the basilar membrane in guinea pig. J Acoust Soc Am 99:1556\u20131565. https:\/\/doi.org\/10.1121\/1.414732","journal-title":"J Acoust Soc Am"},{"key":"805_CR39","doi-asserted-by":"publisher","first-page":"725","DOI":"10.2471\/BLT.19.230367","volume":"97","author":"BO Olusanya","year":"2019","unstructured":"Olusanya BO, Davis AC, Hoffman HJ (2019) Hearing loss grades and the international classification of functioning, disability and health. Bull World Health Organ 97:725\u2013728. https:\/\/doi.org\/10.2471\/BLT.19.230367","journal-title":"Bull World Health Organ"},{"key":"805_CR40","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1097\/AUD.0000000000000319","volume":"37","author":"AJ Ortmann","year":"2016","unstructured":"Ortmann AJ, Abdala C (2016) Changes in the compressive nonlinearity of the cochlea during early aging: estimates from distortion OAE input\/output functions. Ear Hear 37:603\u2013614. https:\/\/doi.org\/10.1097\/AUD.0000000000000319","journal-title":"Ear Hear"},{"key":"805_CR41","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/j.jcomdis.2010.04.002","volume":"43","author":"K Oshima","year":"2010","unstructured":"Oshima K, Suchert S, Blevins NH, Heller S (2010) Curing hearing loss: patient expectations, health care practitioners, and basic science. J Commun Disord 43:311\u2013318. https:\/\/doi.org\/10.1016\/j.jcomdis.2010.04.002","journal-title":"J Commun Disord"},{"key":"805_CR42","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1121\/1.4845415","volume":"135","author":"GL Poling","year":"2014","unstructured":"Poling GL, Siegel JH, Lee J et al (2014) Characteristics of the 2f1-f2 distortion product otoacoustic emission in a normal hearing population. J Acoust Soc Am 135:287\u2013299. https:\/\/doi.org\/10.1121\/1.4845415","journal-title":"J Acoust Soc Am"},{"key":"805_CR43","unstructured":"R Core Team (2020) R: a language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. https:\/\/www.R-project.org\/"},{"key":"805_CR44","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/0378-5955(92)90179-Q","volume":"62","author":"G Rebillard","year":"1992","unstructured":"Rebillard G, Lavigne-Rebillard M (1992) Effect of reversible hypoxia on the compared time courses of endocochlear potential and 2f1-f2 distortion products. Hear Res 62:142\u2013148. https:\/\/doi.org\/10.1016\/0378-5955(92)90179-Q","journal-title":"Hear Res"},{"key":"805_CR45","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1038\/s42003-020-0762-2","volume":"3","author":"T Ren","year":"2020","unstructured":"Ren T, He W (2020) Two-tone distortion in reticular lamina vibration of the living cochlea. Commun Biol 3:35. https:\/\/doi.org\/10.1038\/s42003-020-0762-2","journal-title":"Commun Biol"},{"key":"805_CR46","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1523\/JNEUROSCI.11-04-01057.1991","volume":"11","author":"MA Ruggero","year":"1991","unstructured":"Ruggero MA, Rich NC (1991) Furosemide alters organ of Corti mechanics: evidence for feedback of outer hair cells upon the basilar membrane. J Neurosci 11:1057\u20131067. https:\/\/doi.org\/10.1523\/JNEUROSCI.11-04-01057.1991","journal-title":"J Neurosci"},{"key":"805_CR47","doi-asserted-by":"publisher","first-page":"2151","DOI":"10.1121\/1.418265","volume":"101","author":"MA Ruggero","year":"1997","unstructured":"Ruggero MA, Rich NC, Recio A et al (1997) Basilar-membrane responses to tones at the base of the chinchilla cochlea. J Acoust Soc Am 101:2151\u20132163. https:\/\/doi.org\/10.1121\/1.418265","journal-title":"J Acoust Soc Am"},{"key":"805_CR48","doi-asserted-by":"publisher","first-page":"9643","DOI":"10.1523\/JNEUROSCI.22-21-09643.2002","volume":"22","author":"RA Schmiedt","year":"2002","unstructured":"Schmiedt RA, Lang H, Okamura H, Schulte BA (2002) Effects of furosemide applied chronically to the round window: a model of metabolic presbyacusis. J Neurosci 22:9643\u20139650. https:\/\/doi.org\/10.1523\/JNEUROSCI.22-21-09643.2002","journal-title":"J Neurosci"},{"key":"805_CR49","doi-asserted-by":"publisher","unstructured":"Schuknecht\u00a0HF\u00a0(1964) Further observations on the pathology of presbycusis. Arch Otolaryngol 80:369\u2013382. https:\/\/doi.org\/10.1001\/archotol.1964.00750040381003","DOI":"10.1001\/archotol.1964.00750040381003"},{"key":"805_CR50","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1177\/00034894931020S101","volume":"102","author":"HF Schuknecht","year":"1993","unstructured":"Schuknecht HF, Gacek MR (1993) Cochlear pathology in presbycusis. Ann Otol Rhinol Laryngol 102:1\u201316. https:\/\/doi.org\/10.1177\/00034894931020S101","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"805_CR51","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/0378-5955(84)90057-1","volume":"14","author":"WF Sewell","year":"1984","unstructured":"Sewell WF (1984) The effects of furosemide on the endocochlear potential and auditory-nerve fiber tuning curves in cats. Hear Res 14:305\u2013314. https:\/\/doi.org\/10.1016\/0378-5955(84)90057-1","journal-title":"Hear Res"},{"key":"805_CR52","doi-asserted-by":"publisher","unstructured":"Shera\u00a0CA (2003) Wave interference in the generation of reflection- and distortion-source emissions. Biophysics of the Cochlea: from Molecules to Models 439\u2013453.\u00a0https:\/\/doi.org\/10.1142\/5219","DOI":"10.1142\/5219"},{"key":"805_CR53","doi-asserted-by":"publisher","unstructured":"Shibata\u00a0SB,  West\u00a0MB,\u00a0Du X et al (2020) Gene therapy for hair cell regeneration: review and new data. Hear Res 107981.\u00a0https:\/\/doi.org\/10.1016\/j.heares.2020.107981","DOI":"10.1016\/j.heares.2020.107981"},{"key":"805_CR54","doi-asserted-by":"publisher","first-page":"1768","DOI":"10.1121\/1.4894787","volume":"136","author":"NN Souza","year":"2014","unstructured":"Souza NN, Dhar S, Neely ST, Siegel JH (2014) Comparison of nine methods to estimate ear-canal stimulus levels. J Acoust Soc Am 136:1768\u20131787. https:\/\/doi.org\/10.1121\/1.4894787","journal-title":"J Acoust Soc Am"},{"key":"805_CR55","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/S0378-5955(02)00581-6","volume":"172","author":"SS Spicer","year":"2002","unstructured":"Spicer SS, Schulte BA (2002) Spiral ligament pathology in quiet-aged gerbils. Hear Res 172:172\u2013185. https:\/\/doi.org\/10.1016\/S0378-5955(02)00581-6","journal-title":"Hear Res"},{"key":"805_CR56","doi-asserted-by":"publisher","first-page":"2670","DOI":"10.1121\/1.407351","volume":"94","author":"L Stover","year":"1993","unstructured":"Stover L, Norton SJ (1993) The effects of aging on otoacoustic emissions. J Acoust Soc Am 94:2670\u20132681. https:\/\/doi.org\/10.1121\/1.407351","journal-title":"J Acoust Soc Am"},{"key":"805_CR57","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1044\/jshd.3201.82","volume":"32","author":"GA Studebaker","year":"1967","unstructured":"Studebaker GA (1967) Intertest variability and the air-bone gap. J Speech Hear Disord 32:82\u201386. https:\/\/doi.org\/10.1044\/jshd.3201.82","journal-title":"J Speech Hear Disord"},{"key":"805_CR58","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1121\/1.424584","volume":"105","author":"CL Talmadge","year":"1999","unstructured":"Talmadge CL, Long GR, Tubis A, Dhar S (1999) Experimental confirmation of the two-source interference model for the fine structure of distortion product otoacoustic emissions. J Acoust Soc Am 105:275\u2013292. https:\/\/doi.org\/10.1121\/1.424584","journal-title":"J Acoust Soc Am"},{"key":"805_CR59","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1097\/AUD.0b013e3181634eb8","volume":"29","author":"Y Uchida","year":"2008","unstructured":"Uchida Y, Ando F, Shimokata H et al (2008) The effects of aging on distortion-product otoacoustic emissions in adults with normal hearing. Ear Hear 29:176\u2013184. https:\/\/doi.org\/10.1097\/AUD.0b013e3181634eb8","journal-title":"Ear Hear"},{"key":"805_CR60","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.heares.2015.11.006","volume":"332","author":"MA Ueberfuhr","year":"2016","unstructured":"Ueberfuhr MA, Fehlberg H, Goodman SS, Withnell RH (2016) A DPOAE assessment of outer hair cell integrity in ears with age-related hearing loss. Hear Res 332:137\u2013150. https:\/\/doi.org\/10.1016\/j.heares.2015.11.006","journal-title":"Hear Res"},{"key":"805_CR61","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/S0378-5955(98)00100-2","volume":"123","author":"RH Withnell","year":"1998","unstructured":"Withnell RH, Yates GK (1998) Onset of basilar membrane non-linearity reflected in cubic distortion tone input-output functions. Hear Res 123:87\u201396. https:\/\/doi.org\/10.1016\/S0378-5955(98)00100-2","journal-title":"Hear Res"},{"key":"805_CR62","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1111\/j.0006-341X.2001.00240.x","volume":"57","author":"SN Wood","year":"2001","unstructured":"Wood SN (2001) Minimizing model fitting objectives that contain spurious local minima by bootstrap restarting. Biometrics 57:240\u2013244. https:\/\/doi.org\/10.1111\/j.0006-341X.2001.00240.x","journal-title":"Biometrics"},{"key":"805_CR63","doi-asserted-by":"publisher","first-page":"6357","DOI":"10.1523\/JNEUROSCI.0937-20.2020","volume":"40","author":"P Wu","year":"2020","unstructured":"Wu P, O\u2019Malley JT, de Gruttola V, Liberman MC (2020) Age-related hearing loss is dominated by damage to inner ear sensory cells, not the cellular battery that powers them. J Neurosci 40:6357\u20136366. https:\/\/doi.org\/10.1523\/JNEUROSCI.0937-20.2020","journal-title":"J Neurosci"}],"container-title":["Journal of the Association for Research in Otolaryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10162-021-00805-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10162-021-00805-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10162-021-00805-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,17]],"date-time":"2021-11-17T14:23:30Z","timestamp":1637159010000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10162-021-00805-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,30]]},"references-count":63,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["805"],"URL":"https:\/\/doi.org\/10.1007\/s10162-021-00805-3","relation":{},"ISSN":["1525-3961","1438-7573"],"issn-type":[{"value":"1525-3961","type":"print"},{"value":"1438-7573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,30]]},"assertion":[{"value":"3 February 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 June 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 September 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}