{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T06:40:52Z","timestamp":1770273652226,"version":"3.49.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2022,2,3]],"date-time":"2022-02-03T00:00:00Z","timestamp":1643846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,2,3]],"date-time":"2022-02-03T00:00:00Z","timestamp":1643846400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["JARO"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1007\/s10162-022-00838-2","type":"journal-article","created":{"date-parts":[[2022,2,3]],"date-time":"2022-02-03T18:08:38Z","timestamp":1643911718000},"page":"213-223","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["gom1 Mutant Mice as a Model of Otitis Media"],"prefix":"10.1007","volume":"23","author":[{"given":"Tihua","family":"Zheng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenyi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heping","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo Hua","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher M.","family":"McCarty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Jaster","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ge","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5827-4106","authenticated-orcid":false,"given":"Qing Yin","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,2,3]]},"reference":[{"key":"838_CR1","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1016\/S0895-6111(01)00021-0","volume":"25","author":"C Bilgen","year":"2001","unstructured":"Bilgen C, Bilgen IG, Sener RN (2001) Oculopharyngeal muscular dystrophy: clinical and CT findings. Comput Med Imaging Graph 25:527\u2013529","journal-title":"Comput Med Imaging Graph"},{"key":"838_CR2","doi-asserted-by":"publisher","first-page":"2125","DOI":"10.1001\/jama.282.22.2125","volume":"282","author":"ML Casselbrant","year":"1999","unstructured":"Casselbrant ML, Mandel EM, Fall PA, Rockette HE, Kurs-Lasky M, Bluestone CD, Ferrell RE (1999) The heritability of otitis media: a twin and triplet study. Jama 282:2125\u20132130","journal-title":"Jama"},{"key":"838_CR3","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.1542\/peds.103.6.1158","volume":"103","author":"KA Daly","year":"1999","unstructured":"Daly KA, Brown JE, Lindgren BR, Meland MH, Le CT, Giebink GS (1999) Epidemiology of otitis media onset by six months of age. Pediatrics 103:1158\u20131166","journal-title":"Pediatrics"},{"key":"838_CR4","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.3389\/fgene.2019.01395","volume":"10","author":"R Geng","year":"2019","unstructured":"Geng R, Wang Q, Chen E, Zheng QY (2019) Current understanding of host genetics of otitis media. Front Genet 10:1395","journal-title":"Front Genet"},{"key":"838_CR5","doi-asserted-by":"crossref","first-page":"2484","DOI":"10.4049\/jimmunol.123.6.2484","volume":"123","author":"MG Goodman","year":"1979","unstructured":"Goodman MG, Weigle WO (1979) T cell regulation of polyclonal B cell responsiveness. II. Evidence for a deficit in T cell function in mice with an X-linked B lymphocyte defect. J Immunol 123:2484\u20132487","journal-title":"J Immunol"},{"key":"838_CR6","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1111\/j.1365-2613.2009.00677.x","volume":"90","author":"F Han","year":"2009","unstructured":"Han F, Yu H, Zhang J, Tian C, Schmidt C, Nava C, Davisson MT, Zheng QY (2009) Otitis media in a mouse model for Down syndrome. Int J Exp Pathol 90:480\u2013488","journal-title":"Int J Exp Pathol"},{"key":"838_CR7","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1038\/tpj.2010.60","volume":"12","author":"F Han","year":"2012","unstructured":"Han F, Yu H, Tian C, Chen HE, Benedict-Alderfer C, Zheng Y, Wang Q, Han X, Zheng QY (2012) A new mouse mutant of the Cdh23 gene with early-onset hearing loss facilitates evaluation of otoprotection drugs. Pharmacogenomics J 12:30\u201344","journal-title":"Pharmacogenomics J"},{"key":"838_CR8","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1007\/s10162-002-3015-9","volume":"4","author":"RE Hardisty","year":"2003","unstructured":"Hardisty RE, Erven A, Logan K, Morse S, Guionaud S, Sancho-Oliver S, Hunter AJ, Brown SD, Steel KP (2003) The deaf mouse mutant Jeff (Jf) is a single gene model of otitis media. J Assoc Res Otolaryngol 4:130\u2013138","journal-title":"J Assoc Res Otolaryngol"},{"key":"838_CR9","first-page":"58","volume":"12","author":"F Heidari Phd","year":"2018","unstructured":"Heidari Phd F, Pourbakht A, Kamrava SK, Kamali M, Yousefi A (2018) Comparison of Cochlear Microphonics Magnitude with Broad and Narrow Band Stimuli in Healthy Adult Wistar Rats. Iran J Child Neurol 12:58\u201365","journal-title":"Iran J Child Neurol"},{"key":"838_CR10","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1038\/78146","volume":"25","author":"MH Hrabe de Angelis","year":"2000","unstructured":"Hrabe de Angelis MH et al (2000) Genome-wide, large-scale production of mutant mice by ENU mutagenesis. Nat Genet 25:444\u2013447","journal-title":"Nat Genet"},{"key":"838_CR11","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.brainres.2006.01.066","volume":"1091","author":"SM Jones","year":"2006","unstructured":"Jones SM, Jones TA, Johnson KR, Yu H, Erway LC, Zheng QY (2006) A comparison of vestibular and auditory phenotypes in inbred mouse strains. Brain Res 1091:40\u201346","journal-title":"Brain Res"},{"key":"838_CR12","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1046\/j.1365-2273.2000.00350.x","volume":"25","author":"H Kubba","year":"2000","unstructured":"Kubba H, Pearson JP, Birchall JP (2000) The aetiology of otitis media with effusion: a review. Clin Otolaryngol Allied Sci 25:181\u2013194","journal-title":"Clin Otolaryngol Allied Sci"},{"key":"838_CR13","doi-asserted-by":"publisher","first-page":"S41","DOI":"10.1177\/0194599816685559","volume":"156","author":"J Lin","year":"2017","unstructured":"Lin J, Hafren L, Kerschner J, Li JD, Brown S, Zheng QY, Preciado D, Nakamura Y, Huang Q, Zhang Y (2017) Panel 3: genetics and precision medicine of otitis media. Otolaryngol Head Neck Surg 156:S41\u2013S50","journal-title":"Otolaryngol Head Neck Surg"},{"key":"838_CR14","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1097\/01.moo.0000244193.97301.d7","volume":"14","author":"CJ MacArthur","year":"2006","unstructured":"MacArthur CJ, Trune DR (2006) Mouse models of otitis media. Curr Opin Otolaryngol Head Neck Surg 14:341\u2013346","journal-title":"Curr Opin Otolaryngol Head Neck Surg"},{"key":"838_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0378-5955(92)90094-4","volume":"59","author":"MD McGinn","year":"1992","unstructured":"McGinn MD, Bean-Knudsen D, Ermel RW (1992) Incidence of otitis media in CBA\/J and CBA\/CaJ mice. Hear Res 59:1\u20136","journal-title":"Hear Res"},{"key":"838_CR16","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1016\/S0194-5998(97)70014-7","volume":"117","author":"CR Mitchell","year":"1997","unstructured":"Mitchell CR, Kempton JB, Scott-Tyler B, Trune DR (1997) Otitis media incidence and impact on the auditory brain stem response in lipopolysaccharide-nonresponsive C3H\/HeJ mice. Otolaryngol Head Neck Surg 117:459\u2013464","journal-title":"Otolaryngol Head Neck Surg"},{"key":"838_CR17","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1038\/420517a","volume":"420","author":"JH Nadeau","year":"2002","unstructured":"Nadeau JH (2002) Single nucleotide polymorphisms: tackling complexity. Nature 420:517\u2013518","journal-title":"Nature"},{"key":"838_CR18","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1038\/78140","volume":"25","author":"PM Nolan","year":"2000","unstructured":"Nolan PM et al (2000) A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse. Nat Genet 25:440\u2013443","journal-title":"Nat Genet"},{"key":"838_CR19","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1542\/peds.99.3.318","volume":"99","author":"JL Paradise","year":"1997","unstructured":"Paradise JL, Rockette HE, Colborn DK, Bernard BS, Smith CG, Kurs-Lasky M, Janosky JE (1997) Otitis media in 2253 Pittsburgh-area infants: prevalence and risk factors during the first two years of life. Pediatrics 99:318\u2013333","journal-title":"Pediatrics"},{"key":"838_CR20","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.jneumeth.2003.11.003","volume":"134","author":"Polak M, Eshraghi AA, Nehme O, Ahsan S, Guzman J, Delgado RE, He J, Telischi FF, Balkany TJ, Van De Water TR","year":"2004","unstructured":"Polak M, Eshraghi AA, Nehme O, Ahsan S, Guzman J, Delgado RE, He J, Telischi FF, Balkany TJ, Van De Water TR (2004) Evaluation of hearing and auditory nerve function by combining ABR, DPOAE and eABR tests into a single recording session. J Neurosci Methods 134:141\u2013149","journal-title":"J Neurosci Methods"},{"key":"838_CR21","doi-asserted-by":"crossref","unstructured":"Richtsmeier JT, Baxter LL, Reeves RH (2000) Parallels of craniofacial maldevelopment in Down syndrome and Ts65Dn mice. Dev Dyn 217:137\u2013145","DOI":"10.1002\/(SICI)1097-0177(200002)217:2<137::AID-DVDY1>3.0.CO;2-N"},{"key":"838_CR22","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/0378-5955(87)90051-7","volume":"28","author":"KP Steel","year":"1987","unstructured":"Steel KP, Moorjani P, Bock GR (1987) Mixed conductive and sensorineural hearing loss in LP\/J mice. Hear Res 28:227\u2013236","journal-title":"Hear Res"},{"key":"838_CR23","doi-asserted-by":"crossref","unstructured":"Tian C, Yu H, Yang B, Han F, Zheng Y, Bartels CF, Schelling D, Arnold JE, Scacheri PC, Zheng QY (2012) Otitis media in a new mouse model for CHARGE syndrome with a deletion in the Chd7 gene. PLoS One 7:e34944","DOI":"10.1371\/journal.pone.0034944"},{"key":"838_CR24","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1002\/lary.20688","volume":"120","author":"ML Ubell","year":"2010","unstructured":"Ubell ML, Khampang P, Kerschner JE (2010) Mucin gene polymorphisms in otitis media patients. Laryngoscope 120:132\u2013138","journal-title":"Laryngoscope"},{"key":"838_CR25","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1001\/archoto.2007.10","volume":"134","author":"ML Ubell","year":"2008","unstructured":"Ubell ML, Kerschner JE, Wackym PA, Burrows A (2008) MUC2 expression in human middle ear epithelium of patients with otitis media. Arch Otolaryngol Head Neck Surg 134:39\u201344","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"838_CR26","doi-asserted-by":"crossref","unstructured":"Yang B, Tian C, Zhang ZG, Han FC, Azem R, Yu H, Zheng Y, Jin G, Arnold JE, Zheng QY (2011) Sh3pxd2b mice are a model for craniofacial dysmorphology and otitis media. PLoS One 6:e22622","DOI":"10.1371\/journal.pone.0022622"},{"key":"838_CR27","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1016\/j.ajpath.2012.05.031","volume":"181","author":"Y Zhang","year":"2012","unstructured":"Zhang Y, Yu H, Xu M, Han F, Tian C, Kim S, Fredman E, Zhang J, Benedict-Alderfer C, Zheng QY (2012) Pathological features in the LmnaDhe\/+ mutant mouse provide a novel model of human otitis media and laminopathies. Am J Pathol 181:761\u2013774","journal-title":"Am J Pathol"},{"key":"838_CR28","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/S0378-5955(99)00003-9","volume":"130","author":"QY Zheng","year":"1999","unstructured":"Zheng QY, Johnson KR, Erway LC (1999) Assessment of hearing in 80 inbred strains of mice by ABR threshold analyses. Hear Res 130:94\u2013107","journal-title":"Hear Res"},{"key":"838_CR29","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.brainres.2006.01.046","volume":"1091","author":"QY Zheng","year":"2006","unstructured":"Zheng QY, Hardisty-Hughes R, Brown SD (2006) Mouse models as a tool to unravel the genetic basis for human otitis media. Brain Res 1091:9\u201315","journal-title":"Brain Res"},{"key":"838_CR30","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.heares.2007.05.011","volume":"231","author":"QY Zheng","year":"2007","unstructured":"Zheng QY, Tong YC, Alagramam KN, Yu H (2007) Tympanometry assessment of 61 inbred strains of mice. Hear Res 231:23\u201331","journal-title":"Hear Res"}],"container-title":["Journal of the Association for Research in Otolaryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10162-022-00838-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10162-022-00838-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10162-022-00838-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T19:52:18Z","timestamp":1674676338000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10162-022-00838-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,3]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["838"],"URL":"https:\/\/doi.org\/10.1007\/s10162-022-00838-2","relation":{},"ISSN":["1525-3961","1438-7573"],"issn-type":[{"value":"1525-3961","type":"print"},{"value":"1438-7573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,3]]},"assertion":[{"value":"23 January 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 January 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 February 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.<b>Contribution to the Field<\/b>Many children experience OM, a leading cause of hearing loss in the pediatric population. OM is characterized by middle ear effusion. The Jackson Laboratory has established the Neuroscience Mutagenesis Facility to produce novel neurological mouse models for exploring basic neurobiological mechanisms and diseases. At present, a few mouse models have been identified for research of OM. However, the incidence of OM can differ among these mouse strains. Our study reveals that <i>gom1<\/i> mice are a valuable ENU mouse model for studying OM. In contrast to previously reported ENU models, almost 100 % of <i>gom1<\/i> mice demonstrate OM. These mice display the phenotypes of OM that mimic the clinically observed signs of OM in humans, such as fluid in the middle ear cavity and hearing loss. This study provides groundwork for future studies aiming at a better understanding of molecular mechanisms underlying the increased susceptibility of mutant mice to middle ear infection, which, in turn, is important for an understanding of individual variation in human vulnerability to OM.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}