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Clinical methods to alleviate FNS range from the reprogramming of processor settings to revision surgery. We systematically assessed different changes in CI stimulation modes that have been discussed in the literature as \u201crescue factors\u201d from FNS: electrode configuration (broad to focused), pulse shape (symmetric biphasic to pseudo-monophasic), and pulse polarity (cathodic to anodic). An FNS was assessed, based on electrophysiological thresholds, in 204 electrically evoked compound action potential (eCAP) input\/output functions recorded from 33 ears of 26 guinea pigs. The stimulation level difference between auditory nerve eCAP threshold and FNS threshold was expressed as the eCAP-to-FNS offset. Coincidental FNS occurred in all animals and in 45% of all recordings. A change from monopolar to focused (bipolar, tripolar) configurations minimized FNS. The Euclidean distance between the CI contacts and the facial nerve explained no more than 33% of the variance in FNS thresholds. For both the FNS threshold and the eCAP-to-FNS offset, the change from cathodic to anodic pulse polarity significantly reduced FNS and permitted a gain of 14\u201371% of the dynamic range of the eCAP response. This \u201canodic rescue effect\u201d was stronger for pseudo-monophasic pulses as compared to the symmetric biphasic pulse shape. These results provide possible mechanisms underlying recent clinical interventions to alleviate FNS. The \u201canodic-rescue effect\u201d may offer a non-invasive therapeutic option for FNS in human CI users that should be tested clinically, preferably in combination with current-focusing methods.\n<\/jats:p>","DOI":"10.1007\/s10162-022-00878-8","type":"journal-article","created":{"date-parts":[[2022,12,2]],"date-time":"2022-12-02T16:33:10Z","timestamp":1669998790000},"page":"31-46","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Anodic Polarity Minimizes Facial Nerve Stimulation as a Side Effect of Cochlear Implantation"],"prefix":"10.1007","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2758-6497","authenticated-orcid":false,"given":"Wiebke S.","family":"Konerding","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0632-9715","authenticated-orcid":false,"given":"Peter","family":"Baumhoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7762-4642","authenticated-orcid":false,"given":"Andrej","family":"Kral","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,12,2]]},"reference":[{"issue":"10","key":"878_CR1","doi-asserted-by":"publisher","first-page":"3789","DOI":"10.1007\/s00405-020-06486-7","volume":"278","author":"IA Aljazeeri","year":"2021","unstructured":"Aljazeeri IA, Khurayzi T, Al-Amro M, Alzhrani F, Alsanosi A (2021) Evaluation of computed tomography parameters in patients with facial nerve stimulation post-cochlear implantation. 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