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The phenotype is variable, and it may be associated with other comorbidities such as migraine, respiratory allergies, and several autoimmune disorders. The condition has a significant heritability according to epidemiological and familial segregation studies. Familial MD is found in 10% of cases, the most frequently found genes being\n                    <jats:italic>OTOG<\/jats:italic>\n                    ,\n                    <jats:italic>MYO7A<\/jats:italic>\n                    , and\n                    <jats:italic>TECTA<\/jats:italic>\n                    , previously associated with autosomal dominant and recessive non-syndromic SNHL. These findings suggest a new hypothesis where proteins involved in the extracellular structures in the apical surface of sensory epithelia (otolithic and tectorial membranes) and proteins in the stereocilia links would be key elements in the pathophysiology of MD. The ionic homeostasis of the otolithic and tectorial membranes could be critical to suppress the innate motility of individual hair cell bundles. Initially, focal detachment of these extracellular membranes may cause random depolarization of hair cells and will explain changes in tinnitus loudness or trigger vertigo attacks in early stages of MD. With the progression of the disease, a larger detachment will lead to an otolithic membrane herniation into the horizontal semicircular canal with dissociation in caloric and head impulse responses. Familial MD shows different types of inheritance, including autosomal dominant and compound recessive patterns and implementation of genetic testing will improve our understanding of the genetic structure of MD.\n                  <\/jats:p>","DOI":"10.1007\/s10162-023-00896-0","type":"journal-article","created":{"date-parts":[[2023,4,6]],"date-time":"2023-04-06T11:17:48Z","timestamp":1680779868000},"page":"269-279","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Types of Inheritance and Genes Associated with Familial Meniere Disease"],"prefix":"10.1007","volume":"24","author":[{"given":"Alberto M.","family":"Parra-Perez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8583-1430","authenticated-orcid":false,"given":"Jose A.","family":"Lopez-Escamez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,4,6]]},"reference":[{"key":"896_CR1","doi-asserted-by":"crossref","unstructured":"Perez-Carpena P, Lopez-Escamez JA (2019) Current understanding and clinical management of Meniere\u2019s disease: a systematic review. 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