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General information on the sample size, age, sex, tinnitus prevalence, severe tinnitus distribution, and sensorineural hearing loss was retrieved. Studies that did not include data on hearing assessment were excluded. Relative frequencies were used for qualitative variables to compare different studies and to obtain average values. Genetic variants and genes were listed and clustered according to their potential role in tinnitus development.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The average prevalence of tinnitus estimated from population-based studies was 26.3% for any tinnitus, and 20% of patients with tinnitus reported it as an annoying symptom. One study has reported population-specific differences in the prevalence of tinnitus, the white ancestry being the population with a higher prevalence. Genome-wide association studies have identified and replicated two common variants in the Chinese population (rs2846071; rs4149577) in the intron of <jats:italic>TNFRSF1A<\/jats:italic>, associated with noise-induced tinnitus. Moreover, gene burden analyses in sequencing data from Spanish and Swede patients with severe tinnitus have identified and replicated <jats:italic>ANK2<\/jats:italic>, <jats:italic>AKAP9<\/jats:italic>, and <jats:italic>TSC2<\/jats:italic> genes.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The genetic contribution to tinnitus is starting to be revealed and it shows population-specific effects in European and Asian populations. The common allelic variants associated with tinnitus that showed replication are associated with noise-induced tinnitus. Although severe tinnitus has been associated with rare variants with large effect, their role on hearing or hyperacusis has not been established.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s10162-024-00925-6","type":"journal-article","created":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T15:02:15Z","timestamp":1707490935000},"page":"13-33","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["A Systematic Review on the Genetic Contribution to Tinnitus"],"prefix":"10.1007","volume":"25","author":[{"given":"Patricia","family":"Perez-Carpena","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8583-1430","authenticated-orcid":false,"given":"Jose A.","family":"Lopez-Escamez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1lvaro","family":"Gallego-Martinez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,9]]},"reference":[{"key":"925_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2019.100963","volume":"56","author":"Z Jafari","year":"2019","unstructured":"Jafari Z, Kolb BE, Mohajerani MH (2019) Age-related hearing loss and tinnitus, dementia risk, and auditory amplification outcomes. 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