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Multiomic studies have identified genes in the SV that could contribute to the pathogenesis of Meni\u00e8re\u2019s Disease (MD), a disorder defined by episodic vertigo, sensorineural hearing loss, and tinnitus. This systematic review identified genes expressed in the SV cell types (marginal, intermediate, and basal) and gap junction proteins to evaluate their pathophysiological connections to MD.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>We conducted a literature search on 1293 articles relevant to MD and SV that were screened for SV genes involved in MD. Following quality assessment, 130 studies met the inclusion criteria, comprising 26 human studies, 101 animal studies, and three human-animal studies.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Seven immune-related and six auditory-related genes were identified: <jats:italic>CACNA1D<\/jats:italic>, <jats:italic>ESRRB<\/jats:italic>, <jats:italic>HGF<\/jats:italic>, <jats:italic>KCNE1<\/jats:italic>, <jats:italic>MDH1<\/jats:italic>, <jats:italic>QSOX1<\/jats:italic>, and <jats:italic>SLC12A2<\/jats:italic> (marginal cells); <jats:italic>ACTB<\/jats:italic>, <jats:italic>TMEM176A<\/jats:italic>, and <jats:italic>TMEM176B<\/jats:italic> (intermediate cells); and <jats:italic>ACTN1<\/jats:italic>, <jats:italic>COL11A2<\/jats:italic>, and <jats:italic>GSTM1<\/jats:italic> (basal cells). Gene-set-enrichment-analysis revealed pathways involving gap-junction assembly and electrical coupling. International Mouse Phenotyping Consortium data showed <jats:italic>Gja1<\/jats:italic> and <jats:italic>Kcne1<\/jats:italic> knockouts have immune system abnormalities. Single-cell RNA sequencing data of the lateral wall revealed high expression of <jats:italic>Coch<\/jats:italic>, <jats:italic>Dtna<\/jats:italic>, and <jats:italic>Prkcb<\/jats:italic> in fibrocytes, Reisner\u2019s cells, and immune cells. Furthermore, TWEAK released from intermediate cells and bound to its receptor (<jats:italic>TNFRSF12A<\/jats:italic>) in the marginal cells may upregulate NF-\u03baB inflammatory response in MD patients.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>We hypothesize that some SV genes may contribute to the audiovestibular phenotype in MD, but most of them play a role in the altered immune response found in Sporadic MD.\n<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s10162-025-01006-y","type":"journal-article","created":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T15:11:16Z","timestamp":1758640276000},"page":"491-513","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A Systematic Review on the Role of the Stria Vascularis in Meni\u00e8re\u2019s Disease Pathogenesis"],"prefix":"10.1007","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-1699-3617","authenticated-orcid":false,"given":"Pablo","family":"Cruz-Granados","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6721-6845","authenticated-orcid":false,"given":"Sreeparna","family":"Das","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9024-7600","authenticated-orcid":false,"given":"Kiana","family":"Bagheri-Loftabad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8583-1430","authenticated-orcid":false,"given":"Jose A.","family":"Lopez-Escamez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,23]]},"reference":[{"key":"1006_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3233\/VES-150549","volume":"25","author":"JA Lopez-Escamez","year":"2015","unstructured":"Lopez-Escamez JA, Carey J, Chung WH, Goebel JA, Magnusson M, Mandal\u00e0 M et al (2015) Diagnostic criteria for Meni\u00e8re\u2019s disease. 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