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This study was registered on ClinicalTrials.gov (ID\u2009=\u2009NCT04129775).","order":1,"name":"Ethics","label":"Ethics Approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Dr. Sanchez reported industry funding related to consulting or research support from Otonomy Inc., Spiral Therapeutics, Inc., Autifony Therapeutics Ltd., Boehringer Ingelheim, Frequency Therapeutics Ltd., Pipeline Therapeutics, Aerin Medical, Sensorion SA, Oticon Medical, Helen of Troy Ltd., Sonova Holding AG, and Phonak USA.Dr. Fuentes reported industry funding related to institutional research support from Otonomy Inc., Frequency Therapeutics Ltd., Aerin Medical, and Helen of Troy Ltd.Dr. Boyev reported industry funding related to institutional research support from Otonomy Inc., Frequency Therapeutics Ltd., and Autifony Therapeutics.Dr. Volsky reported industry funding related to research support from Otonomy Inc.Dr. Anderson is a prior employee of Otonomy, Inc.. He is currently employed with Regeneron Pharmaceuticals Inc.. Dr. Anderson contributed to this article as an employee of Otonomy, Inc. and the views expressed do not necessarily represent the views of Regeneron Pharmaceuticals Inc.Dr. Wang is a prior employee of Otonomy, Inc. She is currently an employee of Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc., Rahway, NJ, USA, and may own stock and\/or hold stock options in Merck & Co., In., Rahway, NJ, USA. The work described in this manuscript was performed while Dr. Wang was employed at Otonomy, Inc. Merck had no role in the conception, design, acquisition, conduct, analysis, interpretation, or reporting of this work.Dr. Foster is a prior employee of Otonomy, Inc. and reported industry funding related to consulting from Spiral Therapeutics Inc.All other authors do not declare any conflicts of interest.","order":2,"name":"Ethics","label":"Conflicts of Interest","group":{"name":"EthicsHeading","label":"Declarations"}}]}}