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We assessed the conceptual overlap between the two instruments with correlation matrices and exploratory factor analysis. Linear regression, tobit, mixture, and two-part models were used for mapping, accounting for repeated measurements, tenfold cross-validation was conducted to validate the models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 1010 observations from 410 patients. The EQ-5D showed a substantial ceiling effect (47.3% had the highest score) but no floor effect, while the HIT-6 showed a very small ceiling effect (0.5%). The correlation between the instruments\u2019 total scores was moderate (\u2212\u20090.30), and low to moderate among each domain (0.021\u20130.227). The exploratory factor analysis showed insufficient conceptual overlap between the instruments, as they load on different factors. Thus, there is reason to believe that the instruments\u2019 domains do not capture the same latent constructs. To facilitate future mapping, we provide coefficients and a variance\u2013covariance matrix for the preferred model, a two-part model with the total HIT-6 score as the explanatory variable.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study showed that the German EQ-5D and the HIT-6 lack the conceptual overlap needed for appropriate mapping. Thus, the estimated mapping algorithms should only be used as a last resort for estimating utilities to be employed in economic evaluations.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s10198-021-01342-9","type":"journal-article","created":{"date-parts":[[2021,7,10]],"date-time":"2021-07-10T11:02:35Z","timestamp":1625914955000},"page":"47-57","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["HIT-6 and EQ-5D-5L in patients with migraine: assessment of common latent constructs and development of a mapping algorithm"],"prefix":"10.1007","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5678-4137","authenticated-orcid":false,"given":"Ana Sofia","family":"Oliveira Gon\u00e7alves","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitra","family":"Panteli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1940-6399","authenticated-orcid":false,"given":"Lars","family":"Neeb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7169-2620","authenticated-orcid":false,"given":"Tobias","family":"Kurth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4891-8921","authenticated-orcid":false,"given":"Annette","family":"Aigner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,7,10]]},"reference":[{"key":"1342_CR1","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1111\/j.1526-4610.2008.01263.x","volume":"49","author":"A Radtke","year":"2009","unstructured":"Radtke, A., Neuhauser, H.: Prevalence and burden of headache and migraine in Germany. 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