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Among patients with T2D experiencing DFD, those who experienced complications either in 2015\u20132017 and in 2018 incurred the highest incremental costs (incremental cost of \u20ac 16,702) followed by those with complications in 2018 only (incremental cost of \u20ac 9,536) and from 2015 to 2017 (incremental cost of \u20ac 800).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>DFD significantly increase healthcare utilization and costs among patients with TD2. Healthcare costs of DFD among patients with T2D are associated with the timing and frequency of DFD. These findings should increase awareness among policymakers regarding resource reallocation toward preventive strategies among patients with T2D.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s10198-022-01462-w","type":"journal-article","created":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T07:03:57Z","timestamp":1651734237000},"page":"169-177","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Healthcare costs of diabetic foot disease in Italy: estimates for event and state costs"],"prefix":"10.1007","volume":"24","author":[{"given":"Chiara","family":"Seghieri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5781-517X","authenticated-orcid":false,"given":"Francesca","family":"Ferr\u00e8","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"Foresi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice","family":"Borghini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,5,5]]},"reference":[{"key":"1462_CR1","unstructured":"Rhys W, Stephen C, Reem A, Pablo AM, Abdul B, David B, St\u00e9phane B, Christian B, Wenche B, Edward B, Dominic B, Juliana C, Gisela D, Hema D, Alireza E, Nita PZ. 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