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Trial 1 recruited 340 parents\/carers of children aged 0\u201312\u00a0years and Trial 2 337 young people aged 13\u201325\u00a0years with eczema scored\u2009\u2265\u20095 on Patient-Oriented Eczema Measure (POEM). Participants were randomized (1:1) to online intervention plus usual care or usual care alone. Resource use, collected via medical notes review, was valued using published unit costs in UK \u00a3Sterling 2021. Quality-of-life was elicited using proxy CHU-9D in Trial 1 and self-report EQ-5D-5L in Trial 2.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The intervention was dominant (cost saving and more effective) with a high probability of cost-effectiveness (&gt;\u200968%) in most analyses. The exception was the complete case cost\u2013utility analysis for Trial 1 (omitting participants with children aged\u2009&lt;\u20092), with adjusted incremental cost savings of -\u00a334.15 (95% CI \u2009\u2013\u2009104.54 to 36.24) and incremental QALYs of \u2013\u20090.003 (95% CI \u2009\u2013\u20090.021 to 0.015) producing an incremental cost per QALY of \u00a312,466. In the secondary combined (Trials 1 and 2) cost-effectiveness analysis, the adjusted incremental cost was -\u00a320.35 (95% CI \u2009\u2013\u200955.41 to 14.70) with incremental success (\u2265\u20092-point change on POEM) of 10.3% (95% CI 2.3\u201318.1%).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The free at point of use online eczema self-management intervention was low cost to run and cost-effective.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Trial registration<\/jats:title>\n                <jats:p>This trial was registered prospectively with the ISRCTN registry (ISRCTN79282252). URL <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.EczemaCareOnline.org.uk\">www.EczemaCareOnline.org.uk<\/jats:ext-link>.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s10198-023-01649-9","type":"journal-article","created":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T11:02:23Z","timestamp":1704798143000},"page":"1165-1176","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Cost-effectiveness of two online interventions supporting self-care for eczema for parents\/carers and young people"],"prefix":"10.1007","volume":"25","clinical-trial-number":[{"clinical-trial-number":"isrctn79282252","registry":"10.18810\/isrctn"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8098-9220","authenticated-orcid":false,"given":"Tracey 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THS was a member of NIHR HTA Efficient Study Designs\u20142, HTA Efficient Study Designs Board, HTA End of Life Care and Add-on-Studies, HTA Primary Care Themed Call Board and the HTA Commissioning Board between 2013 and Dec 2019. She is a steering committee member of the UK Dermatology Clinical Trials Network and Chair of the NIHR Research for Patient Benefit Regional Advisory Panel for the East of England. THS had no part in the decision-making for funding this study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was conducted in compliance with the ethical principles of the Declaration of Helsinki and in compliance with all International Council for Harmonisation Good Clinical Practice guidelines. The study protocol was reviewed and approved by the Institutional Review board and\/or Independent Ethics Committee at each participating center. All participants provided written informed consent. Ethical approval for the trial was given by South Central-Oxford A Research Ethics Committee (19\/SC\/0351).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics statement"}}]}}