{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:55:39Z","timestamp":1785891339262,"version":"3.56.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2006,3,7]],"date-time":"2006-03-07T00:00:00Z","timestamp":1141689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomech Model Mechanobiol"],"published-print":{"date-parts":[[2006,10,24]]},"DOI":"10.1007\/s10237-006-0018-1","type":"journal-article","created":{"date-parts":[[2006,3,6]],"date-time":"2006-03-06T05:55:01Z","timestamp":1141624501000},"page":"217-225","source":"Crossref","is-referenced-by-count":47,"title":["The Mechanobiology of Pulmonary Vascular Remodeling in the Congenital Absence of eNOS"],"prefix":"10.1007","volume":"5","author":[{"given":"Ryan W.","family":"Kobs","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi C.","family":"Chesler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2006,3,7]]},"reference":[{"key":"18_CR1","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1002\/(SICI)1099-0496(1999)27:18+<201::AID-PPUL65>3.0.CO;2-F","volume":"18","author":"SH Abman","year":"1999","unstructured":"Abman SH (1999) New developments in the pathogenesis and treatment of neonatal pulmonary hypertension. Pediatr Pulmonol Suppl 18:201\u2013204","journal-title":"Pediatr Pulmonol Suppl"},{"issue":"5","key":"18_CR2","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1152\/jappl.1989.67.5.1903","volume":"67","author":"SL Archer","year":"1989","unstructured":"Archer SL, Nelson DP, Weir EK (1989) Simultaneous measurement of O2 radicals and pulmonary vascular reactivity in rat lung. J Appl Physiol 67(5):1903\u20131911","journal-title":"J Appl Physiol"},{"issue":"6","key":"18_CR3","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1161\/01.RES.73.6.1100","volume":"73","author":"SL Archer","year":"1993","unstructured":"Archer SL, Huang J, Henry T, Peterson D, Weir EK (1993) A redox-based O2 sensor in rat pulmonary vasculature. Circ Res 73(6):1100\u20131112","journal-title":"Circ Res"},{"issue":"2","key":"18_CR4","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/0304-4165(92)90111-7","volume":"1116","author":"DL Bader","year":"1992","unstructured":"Bader DL, Kempson GE, Egan J, Gilbey W, Barrett AJ (1992) The effects of selective matrix degradation on the short-term compressive properties of adult human articular cartilage. Biochim Biophys Acta 1116(2):147\u2013154","journal-title":"Biochim Biophys Acta"},{"issue":"3","key":"18_CR5","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/0735-1097(96)00218-5","volume":"28","author":"ML Blitzer","year":"1996","unstructured":"Blitzer ML, Loh E, Roddy MA, Stamler JS, Creager MA (1996) Endothelium-derived nitric oxide regulates systemic and pulmonary vascular resistance during acute hypoxia in humans. J Am Coll Cardiol 28(3):591\u2013596","journal-title":"J Am Coll Cardiol"},{"issue":"20","key":"18_CR6","doi-asserted-by":"crossref","first-page":"11715","DOI":"10.1073\/pnas.95.20.11715","volume":"95","author":"NS Chandel","year":"1998","unstructured":"Chandel NS, Maltepe E, Goldwasser E, Mathieu CE, Simon MC, Schumacker PT (1998) Mitochondrial reactive oxygen species trigger hypoxia-induced transcription. Proc Natl Acad Sci USA 95(20):11715\u201311720","journal-title":"Proc Natl Acad Sci USA"},{"issue":"2","key":"18_CR7","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1115\/1.1695578","volume":"126","author":"NC Chesler","year":"2004","unstructured":"Chesler NC, Thompson-Figueroa J, Millburne K (2004) Measurements of mouse pulmonary artery biomechanics. J Biomech Eng 126(2):309\u2013314","journal-title":"J Biomech Eng"},{"issue":"7","key":"18_CR8","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1056\/NEJM200002173420704","volume":"342","author":"RH Clark","year":"2000","unstructured":"Clark RH, Kueser TJ, Walker MW, Southgate WM, Huckaby JL, Perez JA, Roy BJ, Keszler M, Kinsella JP (2000) Low-dose nitric oxide therapy for persistent pulmonary hypertension of the newborn. N Engl J Med 342(7):469\u2013474","journal-title":"N Engl J Med"},{"issue":"6","key":"18_CR9","doi-asserted-by":"crossref","first-page":"H2268","DOI":"10.1152\/ajpheart.00542.2002","volume":"283","author":"RJ Coulson","year":"2002","unstructured":"Coulson RJ, Chesler NC, Vitullo L, Cipolla MJ (2002) Effects of ischemia and myogenic activity on active and passive mechanical properties of rat cerebral arteries. Am J Physiol Heart Circ Physiol 283(6):H2268\u2013H2275","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"1 Pt 2","key":"18_CR10","first-page":"H90","volume":"246","author":"RH Cox","year":"1984","unstructured":"Cox RH (1984) Viscoelastic properties of canine pulmonary arteries. Am J Physiol 246(1 Pt 2):H90\u2013H96","journal-title":"Am J Physiol"},{"issue":"2","key":"18_CR11","first-page":"H122","volume":"232","author":"P Dobrin","year":"1977","unstructured":"Dobrin P, Canfield T (1977) Identification of smooth muscle series elastic component in intact carotid artery. Am J Physiol 232(2):H122\u2013H130","journal-title":"Am J Physiol"},{"issue":"2","key":"18_CR12","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1172\/JCI3862","volume":"103","author":"KA Fagan","year":"1999","unstructured":"Fagan KA, Fouty BW, Tyler RC, Morris KG Jr, Hepler LK, Sato K, LeCras TD, Abman SH, Weinberger HD, Huang PL, McMurtry IF, Rodman DM (1999) The pulmonary circulation of homozygous or heterozygous eNOS-null mice is hyperresponsive to mild hypoxia. J Clin Invest 103(2):291\u2013299","journal-title":"J Clin Invest"},{"issue":"5 Pt 2","key":"18_CR13","first-page":"H1745","volume":"277","author":"G Faury","year":"1999","unstructured":"Faury G, Maher GM, Li DY, Keating MT, Mecham RP and Boyle WA (1999). Relation between outer and luminal diameter in cannulated arteries. Am J Physiol 277(5 Pt 2): H1745-H1753","journal-title":"Am J Physiol"},{"key":"18_CR14","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4757-2257-4","volume-title":"Biomechanics: mechanical properties of living tissues","author":"YC Fung","year":"1993","unstructured":"Fung YC (1993) Biomechanics: mechanical properties of living tissues 2nd ed. Springer, Berlin Heidelberg New York","edition":"2"},{"issue":"6","key":"18_CR15","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1152\/jappl.1991.70.6.2455","volume":"70","author":"YC Fung","year":"1991","unstructured":"Fung YC, Liu SQ (1991) Changes of zero-stress state of rat pulmonary arteries in hypoxic hypertension. J Appl Physiol 70(6):2455\u20132470","journal-title":"J Appl Physiol"},{"issue":"4","key":"18_CR16","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1056\/NEJM199507273330403","volume":"333","author":"A Giaid","year":"1995","unstructured":"Giaid A, Saleh D (1995) Reduced expression of endothelial nitric oxide synthase in the lungs of patients with pulmonary hypertension. N Engl J Med 333(4):214\u2013221","journal-title":"N Engl J Med"},{"issue":"1 Pt 2","key":"18_CR17","first-page":"H273","volume":"265","author":"T Kitoh","year":"1993","unstructured":"Kitoh T, Kawai Y, Ohhashi T (1993) Effects of collagenase, elastase, and hyaluronidase on mechanical properties of isolated dog jugular veins. Am J Physiol 265(1 Pt 2):H273\u2013H280","journal-title":"Am J Physiol"},{"issue":"3","key":"18_CR18","doi-asserted-by":"crossref","first-page":"H1209","DOI":"10.1152\/ajpheart.01129.2003","volume":"288","author":"RW Kobs","year":"2005","unstructured":"Kobs RW, Muvarak NE, Eickhoff JC, Chesler NC (2005) Linked mechanical and biological aspects of remodeling in mouse pulmonary arteries with hypoxia-induced hypertension. Am J Physiol Heart Circ Physiol 288(3):H1209\u2013H1217","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"18_CR19","volume-title":"Viscoelastic solids","author":"R Lakes","year":"1998","unstructured":"Lakes R (1998) Viscoelastic solids. CRC Press, Boca Raton"},{"issue":"1","key":"18_CR20","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/79226","volume":"26","author":"KB Lane","year":"2000","unstructured":"Lane KB, Machado RD, Pauciulo MW, Thomson JR, Phillips JA III, Loyd JE, Nichols WC and Trembath RC (2000) Heterozygous germline mutations in BMPR2, encoding a TGF-beta receptor, cause familial primary pulmonary hypertension. The international PPH consortium. Nat Genet 26(1):81\u201384","journal-title":"The international PPH consortium. Nat Genet"},{"issue":"2","key":"18_CR21","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/0735-1097(93)90682-Q","volume":"21","author":"WK Laskey","year":"1993","unstructured":"Laskey WK, Ferrari VA, Palevsky HI, Kussmaul WG (1993). Pulmonary artery hemodynamics in primary pulmonary hypertension. J Am Coll Cardiol 21(2):406\u2013412","journal-title":"J Am Coll Cardiol"},{"issue":"6 Pt 2","key":"18_CR22","first-page":"H2343","volume":"266","author":"M Leeman","year":"1994","unstructured":"Leeman M, de Beyl VZ, Delcroix M, Naeije R (1994) Effects of endogenous nitric oxide on pulmonary vascular tone in intact dogs. Am J Physiol 266(6 Pt 2):H2343\u2013H2347","journal-title":"Am J Physiol"},{"issue":"11","key":"18_CR23","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/0021-9290(84)90142-8","volume":"17","author":"WW Maltzahn von","year":"1984","unstructured":"von Maltzahn WW, Warriyar RG, Keitzer WF (1984) Experimental measurements of elastic properties of media and adventitia of bovine carotid arteries. J Biomech 17(11):839\u2013847","journal-title":"J Biomech"},{"issue":"2","key":"18_CR24","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1152\/physrev.1982.62.2.570","volume":"62","author":"MF O\u2019Rourke","year":"1982","unstructured":"O\u2019Rourke MF (1982) Vascular impedance in studies of arterial and cardiac function. Physiol Rev 62(2):570\u2013623","journal-title":"Physiol Rev"},{"issue":"4","key":"18_CR25","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1111\/j.1748-1716.1990.tb09021.x","volume":"140","author":"MG Persson","year":"1990","unstructured":"Persson MG, Gustafsson LE, Wiklund NP, Moncada S, Hedqvist P (1990) Endogenous nitric oxide as a probable modulator of pulmonary circulation and hypoxic pressor response in vivo. Acta Physiol Scand 140(4):449\u2013457","journal-title":"Acta Physiol Scand"},{"issue":"1","key":"18_CR26","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1161\/01.HYP.0000078357.92682.EC","volume":"42","author":"Q Pu","year":"2003","unstructured":"Pu Q, Neves MF, Virdis A, Touyz RM, Schiffrin EL (2003) Endothelin antagonism on aldosterone-induced oxidative stress and vascular remodeling. Hypertension 42(1):49\u201355","journal-title":"Hypertension"},{"issue":"2","key":"18_CR27","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1056\/NEJM199701093360207","volume":"336","author":"LJ Rubin","year":"1997","unstructured":"Rubin LJ (1997) Primary pulmonary hypertension. N Engl J Med 336(2):111\u2013117","journal-title":"N Engl J Med"},{"issue":"1","key":"18_CR28","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1161\/01.RES.81.1.34","volume":"81","author":"W Steudel","year":"1997","unstructured":"Steudel W, Ichinose F, Huang PL, Hurford WE, Jones RC, Bevan JA, Fishman MC, Zapol WM (1997) Pulmonary vasoconstriction and hypertension in mice with targeted disruption of the endothelial nitric oxide synthase (NOS 3) gene. Circ Res 81(1):34\u201341","journal-title":"Circ Res"},{"issue":"1","key":"18_CR29","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/0021-9290(87)90262-4","volume":"20","author":"K Takamizawa","year":"1987","unstructured":"Takamizawa K, Hayashi K (1987) Strain energy density function and uniform strain hypothesis for arterial mechanics. J Biomech 20(1):7\u201317","journal-title":"J Biomech"},{"issue":"5","key":"18_CR30","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1172\/JCI21968","volume":"115","author":"E Takimoto","year":"2005","unstructured":"Takimoto E, Champion HC, Li M, Ren S, Rodriguez ER, Tavazzi B, Lazzarino G, Paolocci N, Gabrielson KL, Wang Y, Kass DA (2005) Oxidant stress from nitric oxide synthase-3 uncoupling stimulates cardiac pathologic remodeling from chronic pressure load. J Clin Invest 115(5):1221\u20131231","journal-title":"J Clin Invest"},{"issue":"10","key":"18_CR31","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1136\/jmg.37.10.741","volume":"37","author":"JR Thomson","year":"2000","unstructured":"Thomson JR, Machado RD, Pauciulo MW, Morgan NV, Humbert M, Elliott GC, Ward K, Yacoub M, Mikhail G, Rogers P, Newman J, Wheeler L, Higenbottam T, Gibbs JS, Egan J, Crozier A, Peacock A, Allcock R, Corris P, Loyd JE, Trembath RC, Nichols WC (2000) Sporadic primary pulmonary hypertension is associated with germline mutations of the gene encoding BMPR-II, a receptor member of the TGF-beta family. J Med Genet 37(10):741\u2013745","journal-title":"J Med Genet"},{"key":"18_CR32","volume-title":"Theory of elasticity","author":"S Timoshenko","year":"1934","unstructured":"Timoshenko S (1934) Theory of elasticity. McGraw-Hill Book Company, New York"},{"issue":"3","key":"18_CR33","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1073\/pnas.98.3.1171","volume":"98","author":"PV Vaitkevicius","year":"2001","unstructured":"Vaitkevicius PV, Lane M, Spurgeon H, Ingram DK, Roth GS, Egan JJ, Vasan S, Wagle DR, Ulrich P, Brines M, Wuerth JP, Cerami A, Lakatta EG (2001) A cross-link breaker has sustained effects on arterial and ventricular properties in older rhesus monkeys. Proc Natl Acad Sci USA 98(3):1171\u20131175","journal-title":"Proc Natl Acad Sci USA"},{"issue":"8","key":"18_CR34","doi-asserted-by":"crossref","first-page":"4630","DOI":"10.1073\/pnas.95.8.4630","volume":"95","author":"BH Wolffenbuttel","year":"1998","unstructured":"Wolffenbuttel BH, Boulanger CM, Crijns FR, Huijberts MS, Poitevin P, Swennen GN, Vasan S, Egan JJ, Ulrich P, Cerami A, Levy BI (1998) Breakers of advanced glycation end products restore large artery properties in experimental diabetes. Proc Natl Acad Sci U S A 95(8):4630\u20134634","journal-title":"Proc Natl Acad Sci U S A"},{"key":"18_CR35","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4612-1282-9","volume-title":"The physics of pulsatile flow","author":"M Zamir","year":"2000","unstructured":"Zamir M (2000) The physics of pulsatile flow. AIP Press, New York"}],"container-title":["Biomechanics and Modeling in Mechanobiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10237-006-0018-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10237-006-0018-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10237-006-0018-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T07:29:13Z","timestamp":1559114953000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10237-006-0018-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,3,7]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,10,24]]}},"alternative-id":["18"],"URL":"https:\/\/doi.org\/10.1007\/s10237-006-0018-1","relation":{},"ISSN":["1617-7959","1617-7940"],"issn-type":[{"value":"1617-7959","type":"print"},{"value":"1617-7940","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,3,7]]}}}