{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:58:14Z","timestamp":1787065094144,"version":"build-2736575974"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomech Model Mechanobiol"],"published-print":{"date-parts":[[2011,10]]},"DOI":"10.1007\/s10237-010-0267-x","type":"journal-article","created":{"date-parts":[[2010,11,4]],"date-time":"2010-11-04T12:34:09Z","timestamp":1288874049000},"page":"701-712","source":"Crossref","is-referenced-by-count":26,"title":["Analysis of bone architecture sensitivity for changes in mechanical loading, cellular activity, mechanotransduction, and tissue properties"],"prefix":"10.1007","volume":"10","author":[{"given":"L. G. E.","family":"Cox","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"van Rietbergen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. C.","family":"van Donkelaar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,11,5]]},"reference":[{"issue":"1","key":"267_CR1","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.bone.2007.03.019","volume":"41","author":"MP Akhter","year":"2007","unstructured":"Akhter MP, Lappe JM, Davies KM, Recker RR (2007) Transmenopausal changes in the trabecular bone structure. Bone 41(1): 111\u2013116","journal-title":"Bone"},{"issue":"5","key":"267_CR2","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/0021-9290(84)90029-0","volume":"17","author":"RB Ashman","year":"1984","unstructured":"Ashman RB, Cowin SC, Buskirk WCV, Rice JC (1984) A continuous wave technique for the measurement of the elastic properties of cortical bone. J Biomech 17(5): 349\u2013361","journal-title":"J Biomech"},{"issue":"4","key":"267_CR3","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1007\/s002239900344","volume":"61","author":"CM Bagi","year":"1997","unstructured":"Bagi CM, Ammann P, Rizzoli R, Miller SC (1997) Effect of estrogen deficiency on cancellous and cortical bone structure and strength of the femoral neck in rats. Calcif Tissue Int 61(4): 336\u2013344","journal-title":"Calcif Tissue Int"},{"issue":"3","key":"267_CR4","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/S8756-3282(02)00982-1","volume":"32","author":"D Bobinac","year":"2003","unstructured":"Bobinac D, Spanjol J, Zoricic S, Maric I (2003) Changes in articular cartilage and subchondral bone histomorphometry in osteoarthritic knee joints in humans. Bone 32(3): 284\u2013290","journal-title":"Bone"},{"issue":"10","key":"267_CR5","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1138\/20060233","volume":"3","author":"LF Bonewald","year":"2006","unstructured":"Bonewald LF (2006) Mechanosensation and transduction in osteo-cytes. Bonekey Osteovision 3(10): 7\u201315","journal-title":"Bonekey Osteovision"},{"issue":"11","key":"267_CR6","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/0021-9290(90)90003-L","volume":"23","author":"K Choi","year":"1990","unstructured":"Choi K, Kuhn JL, Ciarelli MJ, Goldstein SA (1990) The elastic moduli of human subchondral, trabecular, and cortical bone tissue and the size-dependency of cortical bone modulus. J Biomech 23(11): 1103\u20131113","journal-title":"J Biomech"},{"issue":"2","key":"267_CR7","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.abb.2008.04.005","volume":"473","author":"R Civitelli","year":"2008","unstructured":"Civitelli R (2008) Cell-cell communication in the osteoblast\/osteocyte lineage. Arch Biochem Biophys 473(2): 188\u2013192","journal-title":"Arch Biochem Biophys"},{"issue":"1","key":"267_CR8","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s00223-004-0086-0","volume":"75","author":"B Cortet","year":"2004","unstructured":"Cortet B, Chappard D, Boutry N, Dubois P, Cotten A, Marchandise X (2004) Relationship between computed tomographic image analysis and histomorphometry for microarchitectural characterization of human calcaneus. Calcif Tissue Int 75(1): 23\u201331","journal-title":"Calcif Tissue Int"},{"issue":"2","key":"267_CR9","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1115\/1.2891234","volume":"113","author":"SC Cowin","year":"1991","unstructured":"Cowin SC, Moss-Salentijn L, Moss ML (1991) Candidates for the mechanosensory system in bone. J Biomech Eng 113(2): 191\u2013197","journal-title":"J Biomech Eng"},{"issue":"2","key":"267_CR10","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0021-9290(88)90006-1","volume":"21","author":"JD Currey","year":"1988","unstructured":"Currey JD (1988) The effect of porosity and mineral content on the young\u2019s modulus of elasticity of compact bone. J Biomech 21(2): 131\u2013139","journal-title":"J Biomech"},{"issue":"5","key":"267_CR11","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1016\/S0736-0266(01)00012-2","volume":"19","author":"JS Day","year":"2001","unstructured":"Day JS, Ding M, Linden JCVD, Hvid I, Sumner DR, Weinans H (2001) A decreased subchondral trabecular bone tissue elastic modulus is associated with pre-arthritic cartilage damage. J Orthop Res 19(5): 914\u2013918","journal-title":"J Orthop Res"},{"issue":"2","key":"267_CR12","first-page":"45","volume":"31","author":"EF Eriksen","year":"1992","unstructured":"Eriksen EF, Kassem M (1992) The cellular basis of bone remodeling. Triangle 31(2): 45\u201357","journal-title":"Triangle"},{"issue":"6","key":"267_CR13","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1053\/joca.1998.0141","volume":"6","author":"NL Fazzalari","year":"1998","unstructured":"Fazzalari NL, Parkinson IH (1998) Femoral trabecular bone of osteoarthritic and normal subjects in an age and sex matched group. Osteoarthritis Cartilage 6(6): 377\u2013382","journal-title":"Osteoarthritis Cartilage"},{"issue":"11","key":"267_CR14","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1359\/jbmr.1999.14.11.1816","volume":"14","author":"HM Frost","year":"1999","unstructured":"Frost HM (1999) On the trabecular \u201cthickness\u201d-number problem. J Bone Miner Res 14(11): 1816\u20131821","journal-title":"J Bone Miner Res"},{"issue":"1","key":"267_CR15","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1007\/BF02555898","volume":"49","author":"MD Grynpas","year":"1991","unstructured":"Grynpas MD, Alpert B, Katz I, Lieberman I, Pritzker KP (1991) Subchondral bone in osteoarthritis. Calcif Tissue Int 49(1): 20\u201326","journal-title":"Calcif Tissue Int"},{"issue":"4","key":"267_CR16","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1359\/jbmr.1997.12.4.498","volume":"12","author":"ZH Han","year":"1997","unstructured":"Han ZH, Palnitkar S, Rao DS, Nelson D, Parfitt AM (1997) Effects of ethnicity and age or menopause on the remodeling and turnover of iliac bone: implications for mechanisms of bone loss. J Bone Miner Res 12(4): 498\u2013508","journal-title":"J Bone Miner Res"},{"issue":"3","key":"267_CR17","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1177\/230949900801600312","volume":"16","author":"A Heijink","year":"2008","unstructured":"Heijink A, Zobitz ME, Nuyts R, Morrey BF, An KN (2008) Prosthesis design and stress profile after hip resurfacing: a finite element analysis. J Orthop Surg (Hong Kong) 16(3): 326\u2013332","journal-title":"J Orthop Surg (Hong Kong)"},{"issue":"5","key":"267_CR18","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1007\/s00198-006-0286-8","volume":"18","author":"K Henriksen","year":"2007","unstructured":"Henriksen K, Tanko LB, Qvist P, Delmas PD, Christiansen C, Karsdal MA (2007) Assessment of osteoclast number and function: application in the development of new and improved treatment modalities for bone diseases. Osteoporos Int 18(5): 681\u2013685","journal-title":"Osteoporos Int"},{"issue":"7","key":"267_CR19","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1359\/jbmr.1999.14.7.1167","volume":"14","author":"T Hildebrand","year":"1999","unstructured":"Hildebrand T, Laib A, Muller R, Dequeker J, Ruegsegger P (1999) Direct three-dimensional morphometric analysis of human cancellous bone: microstructural data from spine, femur, iliac crest, and calcaneus. J Bone Miner Res 14(7): 1167\u20131174","journal-title":"J Bone Miner Res"},{"issue":"6787","key":"267_CR20","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1038\/35015116","volume":"405","author":"R Huiskes","year":"2000","unstructured":"Huiskes R, Ruimerman R, van Lenthe GH, Janssen JD (2000) Effects of mechanical forces on maintenance and adaptation of form in trabecular bone. Nature 405(6787): 704\u2013706","journal-title":"Nature"},{"issue":"16","key":"267_CR21","doi-asserted-by":"crossref","first-page":"3405","DOI":"10.1016\/j.jbiomech.2008.09.011","volume":"41","author":"I Jonkers","year":"2008","unstructured":"Jonkers I, Sauwen N, Lenaerts G, Mulier M, der PGV, Jaecques S (2008) Relation between subject-specific hip joint loading, stress distribution in the proximal femur and bone mineral density changes after total hip replacement. J Biomech 41(16): 3405\u2013 3413","journal-title":"J Biomech"},{"issue":"5","key":"267_CR22","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1096\/fasebj.9.5.7896017","volume":"9","author":"J Klein-Nulend","year":"1995","unstructured":"Klein-Nulend J, van der PA, Semeins CM, Ajubi NE, Frangos JA, Nijweide PJ, Burger EH (1995) Sensitivity of osteocytes to biomechanical stress in vitro. FASEB J 9(5): 441\u2013445","journal-title":"FASEB J"},{"issue":"1","key":"267_CR23","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s11914-003-0002-y","volume":"1","author":"J Klein-Nulend","year":"2003","unstructured":"Klein-Nulend J, Nijweide PJ, Burger EH (2003) Osteocyte and bone structure. Curr Osteoporos Rep 1(1): 5\u201310","journal-title":"Curr Osteoporos Rep"},{"issue":"5","key":"267_CR24","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1007\/s00198-007-0495-9","volume":"19","author":"R Krug","year":"2008","unstructured":"Krug R, Carballido-Gamio J, Burghardt AJ, Kazakia G, Hyun BH, Jobke B, Banerjee S, Huber M, Link TM, Majumdar S (2008) Assessment of trabecular bone structure comparing magnetic resonance imaging at 3 tesla with high-resolution peripheral quantitative computed tomography ex vivo and in vivo. Osteoporos Int 19(5): 653\u2013661","journal-title":"Osteoporos Int"},{"issue":"3","key":"267_CR25","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1007\/BF02347054","volume":"38","author":"A Laib","year":"2000","unstructured":"Laib A, Barou O, Vico L, Lafage-Proust MH, Alexandre C, Rugsegger P (2000) 3d micro-computed tomography of trabecular and cortical bone architecture with application to a rat model of immobilisation osteoporosis. Med Biol Eng Comput 38(3): 326\u2013332","journal-title":"Med Biol Eng Comput"},{"issue":"Suppl 1","key":"267_CR26","doi-asserted-by":"crossref","first-page":"S102","DOI":"10.1007\/BF01673415","volume":"53","author":"LE Lanyon","year":"1993","unstructured":"Lanyon LE (1993) Osteocytes, strain detection, bone modeling and remodeling. Calcif Tissue Int 53(Suppl 1): S102\u2013S106","journal-title":"Calcif Tissue Int"},{"issue":"5","key":"267_CR27","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/8756-3282(94)90272-0","volume":"15","author":"BY Lin","year":"1994","unstructured":"Lin BY, Jee WS, Ma YF, Ke HZ, Kimmel DB, Li XJ (1994) Effects of prostaglandin e2 and risedronate administration on cancellous bone in older female rats. Bone 15(5): 489\u2013496","journal-title":"Bone"},{"issue":"10","key":"267_CR28","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1359\/jbmr.060716","volume":"21","author":"XS Liu","year":"2006","unstructured":"Liu XS, Sajda P, Saha PK, Wehrli FW, Guo XE (2006) Quantification of the roles of trabecular microarchitecture and trabecular type in determining the elastic modulus of human trabecular bone. J Bone Miner Res 21(10): 1608\u20131617","journal-title":"J Bone Miner Res"},{"key":"267_CR29","volume-title":"Quality through design. Experimental design, off-line quality control, and Taguchi\u2019s contributions","author":"N Logothetis","year":"1989","unstructured":"Logothetis N, Wynn HP (1989) Quality through design. Experimental design, off-line quality control, and Taguchi\u2019s contributions. Oxford Scientific Publications, Oxford University Press, Oxford"},{"issue":"1","key":"267_CR30","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1124\/mol.54.1.70","volume":"54","author":"M Machwate","year":"1998","unstructured":"Machwate M, Rodan SB, Rodan GA, Harada SI (1998) Sphingosine kinase mediates cyclic amp suppression of apoptosis in rat periosteal cells. Mol Pharmacol 54(1): 70\u201377","journal-title":"Mol Pharmacol"},{"issue":"2","key":"267_CR31","first-page":"93","volume":"4","author":"G Marotti","year":"1990","unstructured":"Marotti G, Cane V, Palazzini S, Palumbo C (1990) Structure-function relationships in the osteocyte. Ital J Miner Electrolyte Metab 4(2): 93\u2013106","journal-title":"Ital J Miner Electrolyte Metab"},{"issue":"1","key":"267_CR32","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S8756-3282(99)00242-2","volume":"26","author":"RB Martin","year":"2000","unstructured":"Martin RB (2000) Does osteocyte formation cause the nonlinear refilling of osteons?. Bone 26(1): 71\u201378","journal-title":"Bone"},{"issue":"1","key":"267_CR33","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1007\/BF02351006","volume":"42","author":"M Mullender","year":"2004","unstructured":"Mullender M, Haj AJE, Yang Y, van Duin MA, Burger EH, Klein-Nulend J (2004) Mechanotransduction of bone cells in vitro: mechanobiology of bone tissue. Med Biol Eng Comput 42(1): 14\u201321","journal-title":"Med Biol Eng Comput"},{"issue":"4","key":"267_CR34","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1002\/jor.1100130405","volume":"13","author":"MG Mullender","year":"1995","unstructured":"Mullender MG, Huiskes R (1995) Proposal for the regulatory mechanism of wolff\u2019s law. J Orthop Res 13(4): 503\u2013512","journal-title":"J Orthop Res"},{"issue":"5","key":"267_CR35","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s00223-005-0043-6","volume":"77","author":"MG Mullender","year":"2005","unstructured":"Mullender MG, Tan SD, Vico L, Alexandre C, Klein-Nulend J (2005) Differences in osteocyte density and bone histo-morphometry between men and women and between healthy and osteoporotic subjects. Calcif Tissue Int 77(5): 291\u2013296","journal-title":"Calcif Tissue Int"},{"issue":"3","key":"267_CR36","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1002\/jcb.240550303","volume":"55","author":"AM Parfitt","year":"1994","unstructured":"Parfitt AM (1994) Osteonal and hemi-osteonal remodeling: the spatial and temporal framework for signal traffic in adult human bone. J Cell Biochem 55(3): 273\u2013286","journal-title":"J Cell Biochem"},{"issue":"9633","key":"267_CR37","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0140-6736(08)61035-1","volume":"372","author":"SH Ralston","year":"2008","unstructured":"Ralston SH, Langston AL, Reid IR (2008) Pathogenesis and management of paget\u2019s disease of bone. Lancet 372(9633): 155\u2013163","journal-title":"Lancet"},{"issue":"6","key":"267_CR38","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/S8756-3282(00)00269-6","volume":"26","author":"F Rauch","year":"2000","unstructured":"Rauch F, Travers R, Parfitt AM, Glorieux FH (2000) Static and dynamic bone histomorphometry in children with osteogenesis imperfecta. Bone 26(6): 581\u2013589","journal-title":"Bone"},{"issue":"8","key":"267_CR39","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/S0041-624X(96)00078-9","volume":"34","author":"JY Rho","year":"1996","unstructured":"Rho JY (1996) An ultrasonic method for measuring the elastic properties of human tibial cortical and cancellous bone. Ultrasonics 34(8): 777\u2013783","journal-title":"Ultrasonics"},{"issue":"2","key":"267_CR40","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0021-9290(93)90042-D","volume":"26","author":"JY Rho","year":"1993","unstructured":"Rho JY, Ashman RB, Turner CH (1993) Young\u2019s modulus of trabecular and cortical bone material: ultrasonic and microtensile measurements. J Biomech 26(2): 111\u2013119","journal-title":"J Biomech"},{"issue":"5","key":"267_CR41","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1080\/10255840108908019","volume":"4","author":"R Ruimerman","year":"2001","unstructured":"Ruimerman R, Huiskes R, van Lenthe GH, Janssen JD (2001) A computer-simulation model relating bone-cell metabolism to mechanical adaptation of trabecular architecture. Comput Methods Biomech Biomed Eng 4(5): 433\u2013448","journal-title":"Comput Methods Biomech Biomed Eng"},{"issue":"1","key":"267_CR42","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s10439-005-8964-9","volume":"33","author":"R Ruimerman","year":"2005","unstructured":"Ruimerman R, van Rietbergen B, Hilbers P, Huiskes R (2005) The effects of trabecular-bone loading variables on the surface signaling potential for bone remodeling and adaptation. Ann Biomed Eng 33(1): 71\u201378","journal-title":"Ann Biomed Eng"},{"issue":"9","key":"267_CR43","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1016\/j.jbiomech.2004.08.017","volume":"38","author":"JL Schriefer","year":"2005","unstructured":"Schriefer JL, Warden SJ, Saxon LK, Robling AG, Turner CH (2005) Cellular accommodation and the response of bone to mechanical loading. J Biomech 38(9): 1838\u20131845","journal-title":"J Biomech"},{"issue":"6","key":"267_CR44","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.cmet.2007.05.001","volume":"5","author":"S Tatsumi","year":"2007","unstructured":"Tatsumi S, Ishii K, Amizuka N, Li M, Kobayashi T, Kohno K, Ito M, Takeshita S, Ikeda K (2007) Targeted ablation of osteocytes induces osteoporosis with defective mechanotransduction. Cell Metab 5(6): 464\u2013475","journal-title":"Cell Metab"},{"issue":"6","key":"267_CR45","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1084\/jem.20031454","volume":"199","author":"RL Bezooijen van","year":"2004","unstructured":"van Bezooijen RL, Roelen BA, Visser A, van der Wee-Pals L, de Wilt E, Karperien M, Hamersma H, Papapoulos SE, ten Dijke P, Lowik CW (2004) Sclerostin is an osteocyte-expressed negative regulator of bone formation, but not a classical bmp antagonist. J Exp Med 199(6): 805\u2013814","journal-title":"J Exp Med"},{"key":"267_CR46","doi-asserted-by":"crossref","unstructured":"van Oers RFM, van Rietbergen B, Hilbers P, K Ito RH (2010) A sclerostin-based theory for strain-induced bone formation. European Conference on Computational Mechanics","DOI":"10.1007\/s10237-010-0264-0"},{"issue":"1","key":"267_CR47","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/0021-9290(95)80008-5","volume":"28","author":"B Rietbergen van","year":"1995","unstructured":"van Rietbergen B, Weinans H, Huiskes R, Odgaard A (1995) A new method to determine trabecular bone elastic properties and loading using micromechanical finite-element models. J Biomech 28(1): 69\u201381","journal-title":"J Biomech"}],"container-title":["Biomechanics and Modeling in Mechanobiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10237-010-0267-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T22:39:02Z","timestamp":1559774342000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10237-010-0267-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11,5]]},"references-count":47,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["267"],"URL":"https:\/\/doi.org\/10.1007\/s10237-010-0267-x","relation":{},"ISSN":["1617-7959","1617-7940"],"issn-type":[{"value":"1617-7959","type":"print"},{"value":"1617-7940","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,11,5]]}}}