{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:59:55Z","timestamp":1791226795437,"version":"4.1.0"},"reference-count":62,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2015,6,17]],"date-time":"2015-06-17T00:00:00Z","timestamp":1434499200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001961","name":"AXA Research Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001961","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ecole Polytechnique"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biomech Model Mechanobiol"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.1007\/s10237-015-0691-z","type":"journal-article","created":{"date-parts":[[2015,6,16]],"date-time":"2015-06-16T17:54:50Z","timestamp":1434477290000},"page":"331-344","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Model of cellular mechanotransduction via actin stress fibers"],"prefix":"10.1007","volume":"15","author":[{"given":"Cecile L. M.","family":"Gouget","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongyun","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdul I.","family":"Barakat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,6,17]]},"reference":[{"key":"691_CR1","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/348346a0","volume":"348","author":"A Ashkin","year":"1990","unstructured":"Ashkin A, Sch\u00fctze K, Dziedzic J, Euteneuer U, Schliwa M (1990) Force generation of organelle transport measured in vivo by an infrared laser trap. Nature 348:346\u2013348","journal-title":"Nature"},{"issue":"5","key":"691_CR2","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.biomaterials.2005.07.036","volume":"27","author":"AI Barakat","year":"2006","unstructured":"Barakat AI, Lieu DK, Gojova A (2006) Secrets of the code: Do vascular endothelial cells use ion channels to decipher complex flow signals? Biomaterials 27(5):671\u2013678","journal-title":"Biomaterials"},{"issue":"5","key":"691_CR3","doi-asserted-by":"crossref","first-page":"1970","DOI":"10.1529\/biophysj.105.076703","volume":"91","author":"R Blumenfeld","year":"2006","unstructured":"Blumenfeld R (2006) Isostaticity and controlled force transmission in the cytoskeleton: a model awaiting experimental evidence. Biophys J 91(5):1970\u20131983","journal-title":"Biophys J"},{"key":"691_CR4","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1038\/2231159a0","volume":"223","author":"C Caro","year":"1969","unstructured":"Caro C, Fitz-Gerald J, Schroter R (1969) Arterial wall shear and distribution of early atheroma in man. Nature 223:1159\u20131161","journal-title":"Nature"},{"issue":"25","key":"691_CR5","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1016\/j.jacc.2007.02.059","volume":"49","author":"YS Chatzizisis","year":"2007","unstructured":"Chatzizisis YS, Coskun AU, Jonas M, Edelman ER, Feldman CL, Stone PH (2007) Role of endothelial shear stress in the natural history of coronary atherosclerosis and vascular remodeling. J Am Coll Cardiol 49(25):2379\u20132393","journal-title":"J Am Coll Cardiol"},{"issue":"3","key":"691_CR6","doi-asserted-by":"crossref","first-page":"H1209","DOI":"10.1152\/ajpheart.01047.2006","volume":"292","author":"S Chien","year":"2007","unstructured":"Chien S (2007) Mechanotransduction and endothelial cell homeostasis: the wisdom of the cell. Am J Physiol Heart Circ Physiol 292(3):H1209\u2013H1224","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"1","key":"691_CR7","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0092-8674(00)81856-5","volume":"88","author":"D Choquet","year":"1997","unstructured":"Choquet D, Felsenfeld DP, Sheetz MP (1997) Extracellular matrix rigidity causes strengthening of integrin-cytoskeleton linkages. Cell 88(1):39\u201348","journal-title":"Cell"},{"issue":"10","key":"691_CR8","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1242\/jcs.042986","volume":"122","author":"J Colombelli","year":"2009","unstructured":"Colombelli J, Besser A, Kress H, Reynaud EG, Girard P, Caussinus E, Haselmann U, Small JV, Schwarz US, Stelzer EH (2009) Mechanosensing in actin stress fibers revealed by a close correlation between force and protein localization. J Cell Sci 122(10):1665\u20131679","journal-title":"J Cell Sci"},{"issue":"2","key":"691_CR9","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1182\/blood.V80.2.437.437","volume":"80","author":"G Conforti","year":"1992","unstructured":"Conforti G, Dominguez-Jimenez C, Zanetti A, Gimbrone MA Jr, Cremona O, Marchisio P, Dejana E (1992) Human endothelial cells express integrin receptors on the luminal aspect of their membrane. Blood 80(2):437\u2013446","journal-title":"Blood"},{"issue":"23","key":"691_CR10","doi-asserted-by":"crossref","first-page":"4952","DOI":"10.1242\/jcs.03272","volume":"119","author":"M Costa","year":"2006","unstructured":"Costa M, Marchi M, Cardarelli F, Roy A, Beltram F, Maffei L, Ratto GM (2006) Dynamic regulation of ERK2 nuclear translocation and mobility in living cells. J Cell Sci 119(23):4952\u20134963","journal-title":"J Cell Sci"},{"issue":"1","key":"691_CR11","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1038\/ncpcardio1397","volume":"6","author":"PF Davies","year":"2008","unstructured":"Davies PF (2008) Hemodynamic shear stress and the endothelium in cardiovascular pathophysiology. Nat Clin Pract Cardiovasc Med 6(1):16\u201326","journal-title":"Nat Clin Pract Cardiovasc Med"},{"issue":"6","key":"691_CR12","doi-asserted-by":"crossref","first-page":"2640","DOI":"10.1172\/JCI116503","volume":"91","author":"PF Davies","year":"1993","unstructured":"Davies PF, Robotewskyj A, Griem M (1993) Endothelial cell adhesion in real time. measurements in vitro by tandem scanning confocal image analysis. J Clin Investig 91(6):2640","journal-title":"J Clin Investig"},{"issue":"5","key":"691_CR13","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1172\/JCI117197","volume":"93","author":"PF Davies","year":"1994","unstructured":"Davies PF, Robotewskyj A, Griem ML (1994) Quantitative studies of endothelial cell adhesion. directional remodeling of focal adhesion sites in response to flow forces. J Clin Investig 93(5):2031","journal-title":"J Clin Investig"},{"issue":"14","key":"691_CR14","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1016\/j.jbiomech.2005.08.026","volume":"39","author":"S Deguchi","year":"2006","unstructured":"Deguchi S, Ohashi T, Sato M (2006) Tensile properties of single stress fibers isolated from cultured vascular smooth muscle cells. J Biomech 39(14):2603\u20132610","journal-title":"J Biomech"},{"issue":"5914","key":"691_CR15","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1126\/science.1162912","volume":"323","author":"A Rio del","year":"2009","unstructured":"del Rio A, Perez-Jimenez R, Liu R, Roca-Cusachs P, Fernandez JM, Sheetz MP (2009) Stretching single talin rod molecules activates vinculin binding. Science 323(5914):638\u2013641","journal-title":"Science"},{"issue":"3","key":"691_CR16","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1115\/1.3138276","volume":"103","author":"C Dewey","year":"1981","unstructured":"Dewey C, Gimbrone M, Davies P, Bussolari S (1981) The dynamic response of vascular endothelial cells to fluid shear stress. J Biomech Eng 103(3):177\u2013185","journal-title":"J Biomech Eng"},{"issue":"1","key":"691_CR17","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1161\/01.RES.30.1.23","volume":"30","author":"JT Flaherty","year":"1972","unstructured":"Flaherty JT, Pierce JE, Ferrans VJ, Patel DJ, Tucker WK, Fry DL (1972) Endothelial nuclear patterns in the canine arterial tree with particular reference to hemodynamic events. Circ Res 30(1):23\u201333","journal-title":"Circ Res"},{"issue":"10","key":"691_CR18","doi-asserted-by":"crossref","first-page":"e136","DOI":"10.1161\/01.RES.0000101744.47866.D5","volume":"93","author":"JA Florian","year":"2003","unstructured":"Florian JA, Kosky JR, Ainslie K, Pang Z, Dull RO, Tarbell JM (2003) Heparan sulfate proteoglycan is a mechanosensor on endothelial cells. Circ Res 93(10):e136\u2013e142","journal-title":"Circ Res"},{"issue":"5914","key":"691_CR19","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1126\/science.1168441","volume":"323","author":"JC Friedland","year":"2009","unstructured":"Friedland JC, Lee MH, Boettiger D (2009) Mechanically activated integrin switch controls $$\\alpha 5\\beta 1$$ \u03b1 5 \u03b2 1 function. Science 323(5914):642\u2013644","journal-title":"Science"},{"issue":"4","key":"691_CR20","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1002\/(SICI)1097-0169(1998)40:4<317::AID-CM1>3.0.CO;2-8","volume":"40","author":"C Galbraith","year":"1998","unstructured":"Galbraith C, Skalak R, Chien S (1998) Shear stress induces spatial reorganization of the endothelial cell cytoskeleton. Cell Motil Cytoskelet 40(4):317\u2013330","journal-title":"Cell Motil Cytoskelet"},{"issue":"1","key":"691_CR21","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/nrm2593","volume":"10","author":"B Geiger","year":"2009","unstructured":"Geiger B, Spatz JP, Bershadsky AD (2009) Environmental sensing through focal adhesions. Nat Rev Mol Cell Biol 10(1):21\u201333","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"1","key":"691_CR22","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/nrm2596","volume":"10","author":"C Hahn","year":"2009","unstructured":"Hahn C, Schwartz MA (2009) Mechanotransduction in vascular physiology and atherogenesis. Nat Rev Mol Cell Biol 10(1):53\u201362","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"4","key":"691_CR23","doi-asserted-by":"crossref","first-page":"H1401","DOI":"10.1152\/ajpheart.2000.278.4.H1401","volume":"278","author":"MA Haidekker","year":"2000","unstructured":"Haidekker MA, L\u2019Heureux N, Frangos JA (2000) Fluid shear stress increases membrane fluidity in endothelial cells: a study with dcvj fluorescence. Am J Physiol Heart Circ Physiol 278(4):H1401\u2013H1406","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"52","key":"691_CR24","doi-asserted-by":"crossref","first-page":"54,793","DOI":"10.1074\/jbc.M406880200","volume":"279","author":"B Han","year":"2004","unstructured":"Han B, Bai XH, Lodyga M, Xu J, Yang BB, Keshavjee S, Post M, Liu M (2004) Conversion of mechanical force into biochemical signaling. J Biol Chem 279(52):54,793\u201354,801","journal-title":"J Biol Chem"},{"issue":"2","key":"691_CR25","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1115\/1.2891226","volume":"113","author":"G Helmlinger","year":"1991","unstructured":"Helmlinger G, Geiger R, Schreck S, Nerem R (1991) Effects of pulsatile flow on cultured vascular endothelial cell morphology. J Biomech Eng 113(2):123\u2013131","journal-title":"J Biomech Eng"},{"issue":"7356","key":"691_CR26","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/nature10316","volume":"475","author":"BD Hoffman","year":"2011","unstructured":"Hoffman BD, Grashoff C, Schwartz MA (2011) Dynamic molecular processes mediate cellular mechanotransduction. Nature 475(7356):316\u2013323","journal-title":"Nature"},{"issue":"2","key":"691_CR27","first-page":"49","volume":"3","author":"S Hu","year":"2006","unstructured":"Hu S, Wang N (2006) Control of stress propagation in the cytoplasm by prestress and loading frequency. Mol Cell Biomech 3(2):49","journal-title":"Mol Cell Biomech"},{"issue":"5","key":"691_CR28","doi-asserted-by":"crossref","first-page":"C1082","DOI":"10.1152\/ajpcell.00159.2003","volume":"285","author":"S Hu","year":"2003","unstructured":"Hu S, Chen J, Fabry B, Numaguchi Y, Gouldstone A, Ingber DE, Fredberg JJ, Butler JP, Wang N (2003) Intracellular stress tomography reveals stress focusing and structural anisotropy in cytoskeleton of living cells. Am J Physiol Cell Physiol 285(5):C1082\u2013C1090","journal-title":"Am J Physiol Cell Physiol"},{"issue":"5","key":"691_CR29","doi-asserted-by":"crossref","first-page":"C1184","DOI":"10.1152\/ajpcell.00224.2004","volume":"287","author":"S Hu","year":"2004","unstructured":"Hu S, Eberhard L, Chen J, Love JC, Butler JP, Fredberg JJ, Whitesides GM, Wang N (2004) Mechanical anisotropy of adherent cells probed by a three-dimensional magnetic twisting device. Am J Physiol Cell Physiol 287(5):C1184\u2013C1191","journal-title":"Am J Physiol Cell Physiol"},{"issue":"2","key":"691_CR30","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.bbrc.2005.02.026","volume":"329","author":"S Hu","year":"2005","unstructured":"Hu S, Chen J, Butler JP, Wang N (2005) Prestress mediates force propagation into the nucleus. Biochem Biophys Res Commun 329(2):423\u2013428","journal-title":"Biochem Biophys Res Commun"},{"issue":"4","key":"691_CR31","doi-asserted-by":"crossref","first-page":"e35,343","DOI":"10.1371\/journal.pone.0035343","volume":"7","author":"Y Hwang","year":"2012","unstructured":"Hwang Y, Barakat AI (2012) Dynamics of mechanical signal transmission through prestressed stress fibers. PloS One 7(4):e35,343","journal-title":"PloS One"},{"issue":"6","key":"691_CR32","doi-asserted-by":"crossref","first-page":"538","DOI":"10.4161\/cib.21633","volume":"5","author":"Y Hwang","year":"2012","unstructured":"Hwang Y, Gouget CLM, Barakat AI (2012) Mechanisms of cytoskeleton-mediated mechanical signal transmission in cells. Commun Integr Biol 5(6):538\u2013542","journal-title":"Commun Integr Biol"},{"issue":"3","key":"691_CR33","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1152\/physrev.1998.78.3.763","volume":"78","author":"PA Janmey","year":"1998","unstructured":"Janmey PA (1998) The cytoskeleton and cell signaling: component localization and mechanical coupling. Physiol Rev 78(3):763\u2013781","journal-title":"Physiol Rev"},{"issue":"5","key":"691_CR34","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1161\/01.RES.79.5.1000","volume":"79","author":"Y Kano","year":"1996","unstructured":"Kano Y, Katoh K, Masuda M, Fujiwara K (1996) Macromolecular composition of stress fiber-plasma membrane attachment sites in endothelial cells in situ. Circ Res 79(5):1000\u20131006","journal-title":"Circ Res"},{"issue":"6","key":"691_CR35","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.2147\/VHRM.S3933","volume":"4","author":"K Katoh","year":"2008","unstructured":"Katoh K, Kano Y, Ookawara S (2008) Role of stress fibers and focal adhesions as a mediator for mechano-signal transduction in endothelial cells in situ. Vasc Health Risk Manag 4(6):1273","journal-title":"Vasc Health Risk Manag"},{"issue":"6","key":"691_CR36","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1038\/nrm2901","volume":"11","author":"BN Kholodenko","year":"2010","unstructured":"Kholodenko BN, Hancock JF, Kolch W (2010) Signalling ballet in space and time. Nat Rev Mol Cell Biol 11(6):414\u2013426","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"10","key":"691_CR37","doi-asserted-by":"crossref","first-page":"3762","DOI":"10.1529\/biophysj.105.071506","volume":"90","author":"S Kumar","year":"2006","unstructured":"Kumar S, Maxwell IZ, Heisterkamp A, Polte TR, Lele TP, Salanga M, Mazur E, Ingber DE (2006) Viscoelastic retraction of single living stress fibers and its impact on cell shape, cytoskeletal organization, and extracellular matrix mechanics. Biophys J 90(10):3762\u20133773","journal-title":"Biophys J"},{"issue":"5","key":"691_CR38","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.ceb.2011.08.003","volume":"23","author":"DE Leckband","year":"2011","unstructured":"Leckband DE, le Duc Q, Wang N, de Rooij J (2011) Mechanotransduction at cadherin-mediated adhesions. Curr Opin Cell Biol 23(5):523\u2013530","journal-title":"Curr Opin Cell Biol"},{"issue":"1","key":"691_CR39","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/jcp.20550","volume":"207","author":"TP Lele","year":"2006","unstructured":"Lele TP, Pendse J, Kumar S, Salanga M, Karavitis J, Ingber DE (2006) Mechanical forces alter zyxin unbinding kinetics within focal adhesions of living cells. J Cell Physiol 207(1):187\u2013194","journal-title":"J Cell Physiol"},{"key":"691_CR40","doi-asserted-by":"crossref","unstructured":"Li S, Chen BP, Azuma N, Hu YL, Wu SZ, Sumpio BE, Shyy JYJ, Chien S (1999) Distinct roles for the small GTPases cdc42 and rho in endothelial responses to shear stress. J Clin Investig 103(8):1141\u20131150","DOI":"10.1172\/JCI5367"},{"issue":"12","key":"691_CR41","doi-asserted-by":"crossref","first-page":"6060","DOI":"10.1529\/biophysj.108.133462","volume":"95","author":"L Lu","year":"2008","unstructured":"Lu L, Oswald SJ, Ngu H, Yin FCP (2008) Mechanical properties of actin stress fibers in living cells. Biophys J 95(12):6060\u20136071","journal-title":"Biophys J"},{"issue":"21","key":"691_CR42","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1001\/jama.282.21.2035","volume":"282","author":"AM Malek","year":"1999","unstructured":"Malek AM, Alper SL, Izumo S (1999) Hemodynamic shear stress and its role in atherosclerosis. J Am Med Assoc 282(21):2035\u20132042","journal-title":"J Am Med Assoc"},{"issue":"18","key":"691_CR43","doi-asserted-by":"crossref","first-page":"6626","DOI":"10.1073\/pnas.0711704105","volume":"105","author":"S Na","year":"2008","unstructured":"Na S, Collin O, Chowdhury F, Tay B, Ouyang M, Wang Y, Wang N (2008) Rapid signal transduction in living cells is a unique feature of mechanotransduction. Proc Natl Acad Sci 105(18):6626\u20136631","journal-title":"Proc Natl Acad Sci"},{"issue":"1","key":"691_CR44","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.devcel.2005.12.006","volume":"10","author":"AW Orr","year":"2006","unstructured":"Orr AW, Helmke BP, Blackman BR, Schwartz MA (2006) Mechanisms of mechanotransduction. Dev Cell 10(1):11\u201320","journal-title":"Dev Cell"},{"issue":"11","key":"691_CR45","doi-asserted-by":"crossref","first-page":"e7886","DOI":"10.1371\/journal.pone.0007886","volume":"4","author":"YC Poh","year":"2009","unstructured":"Poh YC, Na S, Chowdhury F, Ouyang M, Wang Y, Wang N (2009) Rapid activation of Rac GTPase in living cells by force is independent of Src. PLoS One 4(11):e7886","journal-title":"PLoS One"},{"key":"691_CR46","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1038\/ncomms1873","volume":"3","author":"YC Poh","year":"2012","unstructured":"Poh YC, Shevtsov SP, Chowdhury F, Wu DC, Na S, Dundr M, Wang N (2012) Dynamic force-induced direct dissociation of protein complexes in a nuclear body in living cells. Nat Commun 3:866","journal-title":"Nat Commun"},{"issue":"4","key":"691_CR47","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1083\/jcb.200110068","volume":"156","author":"Y Sawada","year":"2002","unstructured":"Sawada Y, Sheetz MP (2002) Force transduction by triton cytoskeletons. J Cell Biol 156(4):609\u2013615","journal-title":"J Cell Biol"},{"issue":"5","key":"691_CR48","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.cell.2006.09.044","volume":"127","author":"Y Sawada","year":"2006","unstructured":"Sawada Y, Tamada M, Dubin-Thaler BJ, Cherniavskaya O, Sakai R, Tanaka S, Sheetz MP (2006) Force sensing by mechanical extension of the Src family kinase substrate p130Cas. Cell 127(5):1015\u20131026","journal-title":"Cell"},{"issue":"6","key":"691_CR49","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/embor.2013.49","volume":"14","author":"HB Schiller","year":"2013","unstructured":"Schiller HB, F\u00e4ssler R (2013) Mechanosensitivity and compositional dynamics of cell-matrix adhesions. EMBO Rep 14(6):509\u2013519","journal-title":"EMBO Rep"},{"issue":"8","key":"691_CR50","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1039\/b719788h","volume":"8","author":"A Shamloo","year":"2008","unstructured":"Shamloo A, Ma N, Mm Poo, Sohn LL, Heilshorn SC (2008) Endothelial cell polarization and chemotaxis in a microfluidic device. Lab Chip 8(8):1292\u20131299","journal-title":"Lab Chip"},{"issue":"9","key":"691_CR51","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1161\/01.RES.0000038487.19924.18","volume":"91","author":"JYJ Shyy","year":"2002","unstructured":"Shyy JYJ, Chien S (2002) Role of integrins in endothelial mechanosensing of shear stress. Circ Res 91(9):769\u2013775","journal-title":"Circ Res"},{"issue":"3","key":"691_CR52","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.devcel.2010.08.008","volume":"19","author":"MA Smith","year":"2010","unstructured":"Smith MA, Blankman E, Gardel ML, Luettjohann L, Waterman CM, Beckerle MC (2010) A zyxin-mediated mechanism for actin stress fiber maintenance and repair. Dev cell 19(3):365\u2013376","journal-title":"Dev cell"},{"issue":"6821","key":"691_CR53","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1038\/35055559","volume":"409","author":"S Sukharev","year":"2001","unstructured":"Sukharev S, Betanzos M, Chiang CS, Guy HR (2001) The gating mechanism of the large mechanosensitive channel mscl. Nature 409(6821):720\u2013724","journal-title":"Nature"},{"issue":"4","key":"691_CR54","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1111\/j.1365-2796.2006.01620.x","volume":"259","author":"JM Tarbell","year":"2006","unstructured":"Tarbell JM, Pahakis M (2006) Mechanotransduction and the glycocalyx. J Intern Med 259(4):339\u2013350","journal-title":"J Intern Med"},{"issue":"7057","key":"691_CR55","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/nature03952","volume":"437","author":"E Tzima","year":"2005","unstructured":"Tzima E, Irani-Tehrani M, Kiosses WB, Dejana E, Schultz DA, Engelhardt B, Cao G, DeLisser H, Schwartz MA (2005) A mechanosensory complex that mediates the endothelial cell response to fluid shear stress. Nature 437(7057):426\u2013431","journal-title":"Nature"},{"key":"691_CR56","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1146\/annurev.biophys.35.040405.102013","volume":"35","author":"V Vogel","year":"2006","unstructured":"Vogel V (2006) Mechanotransduction involving multimodular proteins: converting force into biochemical signals. Annu Rev Biophys Biomol Struct 35:459\u2013488","journal-title":"Annu Rev Biophys Biomol Struct"},{"issue":"6","key":"691_CR57","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1016\/S0006-3495(94)81014-8","volume":"66","author":"N Wang","year":"1994","unstructured":"Wang N, Ingber DE (1994) Control of cytoskeletal mechanics by extracellular matrix, cell shape, and mechanical tension. Biophys J 66(6):2181\u20132189","journal-title":"Biophys J"},{"issue":"4","key":"691_CR58","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/j.bbrc.2005.01.070","volume":"328","author":"N Wang","year":"2005","unstructured":"Wang N, Suo Z (2005) Long-distance propagation of forces in a cell. Biochem Biophys Res Commun 328(4):1133\u20131138","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"691_CR59","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/nrm2594","volume":"10","author":"N Wang","year":"2009","unstructured":"Wang N, Tytell JD, Ingber DE (2009) Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus. Nat Rev Mol Cell Biol 10(1):75\u201382","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"4586","key":"691_CR60","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1126\/science.6681677","volume":"219","author":"AJ Wong","year":"1983","unstructured":"Wong AJ, Pollard TD, Herman IM (1983) Actin filament stress fibers in vascular endothelial cells in vivo. Science 219(4586):867\u2013869","journal-title":"Science"},{"issue":"6","key":"691_CR61","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/ncb2055","volume":"12","author":"S Yonemura","year":"2010","unstructured":"Yonemura S, Wada Y, Watanabe T, Nagafuchi A, Shibata M (2010) $$\\alpha $$ \u03b1 -catenin as a tension transducer that induces adherens junction development. Nat Cell Biol 12(6):533\u2013542","journal-title":"Nat Cell Biol"},{"issue":"2","key":"691_CR62","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1083\/jcb.200505018","volume":"171","author":"M Yoshigi","year":"2005","unstructured":"Yoshigi M, Hoffman LM, Jensen CC, Yost HJ, Beckerle MC (2005) Mechanical force mobilizes zyxin from focal adhesions to actin filaments and regulates cytoskeletal reinforcement. J Cell Biol 171(2):209\u2013215","journal-title":"J Cell Biol"}],"container-title":["Biomechanics and Modeling in Mechanobiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10237-015-0691-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10237-015-0691-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10237-015-0691-z","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,3]],"date-time":"2020-09-03T16:00:30Z","timestamp":1599148830000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10237-015-0691-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,17]]},"references-count":62,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["691"],"URL":"https:\/\/doi.org\/10.1007\/s10237-015-0691-z","relation":{},"ISSN":["1617-7959","1617-7940"],"issn-type":[{"value":"1617-7959","type":"print"},{"value":"1617-7940","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,17]]}}}