{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T14:43:32Z","timestamp":1770907412186,"version":"3.50.1"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2017,3,25]],"date-time":"2017-03-25T00:00:00Z","timestamp":1490400000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100014181","name":"Junta de Extremadura","doi-asserted-by":"crossref","award":["GR15014"],"award-info":[{"award-number":["GR15014"]}],"id":[{"id":"10.13039\/501100014181","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biomech Model Mechanobiol"],"published-print":{"date-parts":[[2017,8]]},"DOI":"10.1007\/s10237-017-0898-2","type":"journal-article","created":{"date-parts":[[2017,3,25]],"date-time":"2017-03-25T10:16:57Z","timestamp":1490437017000},"page":"1447-1458","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Numerical and experimental analysis of the transitional flow across a real stenosis"],"prefix":"10.1007","volume":"16","author":[{"given":"R.","family":"Agujetas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Ferrera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. C.","family":"Marcos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. P.","family":"Alejo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. M.","family":"Montanero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,3,25]]},"reference":[{"key":"898_CR1","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/0021-9290(83)90065-9","volume":"16","author":"SA Ahmed","year":"1983","unstructured":"Ahmed SA, Giddens DP (1983) Velocity measurements in steady flow through axisymmetric stenoses at moderate reynolds numbers. J Biomech 16:505\u2013516","journal-title":"J Biomech"},{"key":"898_CR2","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/0021-9290(84)90123-4","volume":"17","author":"SA Ahmed","year":"1984","unstructured":"Ahmed SA, Giddens DP (1984) Pulsatile poststenotic flow studies with laser doppler anemometry. J Biomech 17:695\u2013705","journal-title":"J Biomech"},{"key":"898_CR3","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1016\/j.jbiomech.2006.07.008","volume":"40","author":"J Alastruey","year":"2007","unstructured":"Alastruey J, Parker KH, Peiro J, Byrd SM, Sherwin SJ (2007) Modelling the circle of willis to assess the effects of anatomical variations and occlusions on cerebral flows. J Biomech 40:1794\u20131805","journal-title":"J Biomech"},{"key":"898_CR4","unstructured":"Ansys (2015) Ansys fluent 16.2. user\u2019s guide. Ansys, Canonsburg"},{"key":"898_CR5","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1161\/CIRCRESAHA.114.302721","volume":"114","author":"JF Bentzon","year":"2014","unstructured":"Bentzon JF, Otsuka F, Virmani R, Falk E (2014) Mechanisms of plaque formation and rupture. Circ Res 114:1852\u20131866","journal-title":"Circ Res"},{"key":"898_CR6","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1114\/1.230","volume":"27","author":"D Bluestein","year":"1999","unstructured":"Bluestein D, Gutierrez C, Londono M, Schoephoerster RT (1999) Vortex shedding in steady flow through a model of an arterial stenosis and its relevance to mural platelet deposition. Ann Biomed Eng 27:763\u2013773","journal-title":"Ann Biomed Eng"},{"key":"898_CR7","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1007\/s10439-015-1295-6","volume":"43","author":"LD Browne","year":"2015","unstructured":"Browne LD, Griffin P, Bashar K, Walsh SR, Kavanagh EG, Walsh MT (2015) In vivo validation of the in silico predicted pressure drop across an arteriovenous fistula. Ann Biomed Eng 43:1275\u20131286","journal-title":"Ann Biomed Eng"},{"key":"898_CR8","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s13239-013-0146-6","volume":"4","author":"AD Caballero","year":"2013","unstructured":"Caballero AD, La\u00edn S (2013) A review on computational fluid dynamics modelling in human thoracic aorta. Cardiovasc Eng Technol 4:103\u2013130","journal-title":"Cardiovasc Eng Technol"},{"key":"898_CR9","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1126\/science.168.3934.977","volume":"168","author":"S Chien","year":"1970","unstructured":"Chien S (1970) Shear dependence of effective cell volume as a determinant of blood viscosity. Science 168:977\u2013979","journal-title":"Science"},{"key":"898_CR10","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1056\/NEJMe1600123","volume":"374","author":"J David-Spence","year":"2016","unstructured":"David-Spence J, Ross-Naylor A (2016) Endarterectomy, stenting, or neither for asymptomatic carotid-artery stenosis. N Engl J Med 374:1087\u20131088","journal-title":"N Engl J Med"},{"key":"898_CR11","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1017\/S0022112080002431","volume":"97","author":"MD Deshpande","year":"1980","unstructured":"Deshpande MD, Giddens DP (1980) Turbulence measurements in a constricted tube. J Fluid Mech 97:65\u201389","journal-title":"J Fluid Mech"},{"key":"898_CR12","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/j.mri.2012.05.001","volume":"30","author":"A Fedorov","year":"2012","unstructured":"Fedorov A et al (2012) 3d slicer as an image computing platform for the quantitative imaging network. Magn Reson Imaging 30:1323\u20131341","journal-title":"Magn Reson Imaging"},{"key":"898_CR13","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1137\/S003614290038296X","volume":"40","author":"L Formaggia","year":"2002","unstructured":"Formaggia L, Gerbeau JF, Nobile F, Quarteroni A (2002) Numerical treatment of defective boundary conditions for the Navier\u2013Stokes equations. SIAM J Numer Anal 40:376\u2013401","journal-title":"SIAM J Numer Anal"},{"key":"898_CR14","doi-asserted-by":"crossref","first-page":"061,002","DOI":"10.1115\/1.4001075","volume":"132","author":"R G\u00e5rdhagen","year":"2010","unstructured":"G\u00e5rdhagen R, Lantz J, Carlsson F, Karlsson M (2010) Quantifying turbulent wall shear stress in a stenosed pipe using large Eddy simulation. J Biomech Eng 132:061,002","journal-title":"J Biomech Eng"},{"key":"898_CR15","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1007\/s10439-011-0431-1","volume":"40","author":"D Gallo","year":"2012","unstructured":"Gallo D, Santis GD, Negri F, Tresoldi D, Ponzini R, Massai D, Deriu MA, Segers P, Verhegghe B, Rizzo G, Morbiducci U (2012) On the use of in vivo measured flow rates as boundary conditions for image-based hemodynamic models of the human aorta: Implications for indicators of abnormal flow. Ann Biomed Eng 40:729\u2013741","journal-title":"Ann Biomed Eng"},{"key":"898_CR16","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0006-355X(99)80011-0","volume":"35","author":"F Ghalichi","year":"1998","unstructured":"Ghalichi F, Deng X, Champlain A, Douville Y, King M, Guidoin R (1998) Low Reynolds number turbulence modeling of blood flow in arterial stenoses. Biorheology 35:281\u2013294","journal-title":"Biorheology"},{"key":"898_CR17","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1007\/s10439-008-9527-7","volume":"36","author":"L Grinberg","year":"2008","unstructured":"Grinberg L, Karniadakis GE (2008) Outflow boundary conditions for arterial networks with multiple outlets. Ann Biomed Eng 36:1496\u20131514","journal-title":"Ann Biomed Eng"},{"key":"898_CR18","doi-asserted-by":"crossref","first-page":"S15","DOI":"10.1016\/j.amjmed.2008.10.014","volume":"122","author":"B Iba\u00f1ez","year":"2009","unstructured":"Iba\u00f1ez B, Badimon JJ, Garc\u00eda MJ (2009) Diagnosis of atherosclerosis by imaging. Am J Med 122:S15\u2013S25","journal-title":"Am J Med"},{"key":"898_CR19","doi-asserted-by":"crossref","unstructured":"Jahangiri M, Saghafian M, Sadeghi MR (2015) Numerical study of trubulent pulsatile blood flow through stensosed artery using fluid-solid interaction. Comput Math Methods Med 2015:515613","DOI":"10.1155\/2015\/515613"},{"key":"898_CR20","doi-asserted-by":"crossref","DOI":"10.1201\/b15820","volume-title":"Biofluid dynamics: principles and selected applications","author":"C Kleinstreuer","year":"2006","unstructured":"Kleinstreuer C (2006) Biofluid dynamics: principles and selected applications. CRC Press, Boca Raton"},{"key":"898_CR21","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1146\/annurev.fluid.29.1.399","volume":"29","author":"DN Ku","year":"1997","unstructured":"Ku DN (1997) Blood flow in arteries. Annu Rev Fluid Mech 29:399\u2013434","journal-title":"Annu Rev Fluid Mech"},{"key":"898_CR22","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1002\/fld.550","volume":"42","author":"T Lee","year":"2003","unstructured":"Lee T, Liao W, Low H (2003) Numerical simulation of turbulent flow through series stenosis. Int J Numer Methods Fluids 42:717\u2013740","journal-title":"Int J Numer Methods Fluids"},{"key":"898_CR23","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1080\/10255842.2013.873033","volume":"18","author":"Z Li","year":"2015","unstructured":"Li Z, Tan FPP, Soloperto G, Wood NB, Xu XY, Gillard JH (2015) Flow pattern analysis in a highly stenotic patient-specific carotid bifurcation model using a turbulence model. Comput Methods Biomech Biomed Eng 18:1099\u20131107","journal-title":"Comput Methods Biomech Biomed Eng"},{"key":"898_CR24","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s10494-006-9047-1","volume":"77","author":"F Menter","year":"2006","unstructured":"Menter F, Langtry R, V\u00f6lker S (2006) Transition modelling for general purpose CFD codes. Flow Turbul Combust 77:277\u2013303","journal-title":"Flow Turbul Combust"},{"key":"898_CR25","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1056\/NEJMra1201534","volume":"369","author":"CJ Murray","year":"2013","unstructured":"Murray CJ, Lopez AD (2013) Measuring the global burden of disease. N Engl J Med 369:448\u2013457","journal-title":"N Engl J Med"},{"key":"898_CR26","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1016\/j.medengphy.2009.07.008","volume":"31","author":"MC Paul","year":"2009","unstructured":"Paul MC, Larman A (2009) Investigation of spiral blood flow in a model of arterial stenosis. Med Eng Phys 31:1195\u20131203","journal-title":"Med Eng Phys"},{"key":"898_CR27","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.medengphy.2008.04.014","volume":"31","author":"MC Paul","year":"2009","unstructured":"Paul MC, Mamun M, Roditi G (2009) Large-eddy simulation of pulsatile blood flow. Med Eng Phys 31:153\u2013159","journal-title":"Med Eng Phys"},{"key":"898_CR28","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1115\/1.1798055","volume":"126","author":"J Ryval","year":"2004","unstructured":"Ryval J, Straatman AG, Steinman DA (2004) Two-equation turbulence modeling of pulsatile flow in a stenosed tube. J Biomech Eng 126:625","journal-title":"J Biomech Eng"},{"key":"898_CR29","doi-asserted-by":"crossref","first-page":"537","DOI":"10.2514\/2.1679","volume":"40","author":"A Scotti","year":"2002","unstructured":"Scotti A, Piomelli U (2002) Turbulence models in pulsating flows. AIAA 40:537\u2013544","journal-title":"AIAA"},{"key":"898_CR30","doi-asserted-by":"crossref","first-page":"4375","DOI":"10.1118\/1.4922708","volume":"42","author":"K Sommer","year":"2015","unstructured":"Sommer K, Bernat D, Schmidt R, Breit H, Schreiber LM (2015) Resting myocardial blood flow quantification using contrast-enhanced magnetic resonance imaging in the presence of stenosis: A computational fluid dynamics study. Med Phys 42:4375\u20134384","journal-title":"Med Phys"},{"key":"898_CR31","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S0021-9290(99)00207-9","volume":"33","author":"JS Stroud","year":"2000","unstructured":"Stroud JS, Berger SA, Saloner D (2000) Influence of stenosis morphology on flow through severely stenotic vessels: implications for plaque rupture. J Biomech 33:443\u2013455","journal-title":"J Biomech"},{"key":"898_CR32","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1080\/10255842.2013.765411","volume":"17","author":"F Tan","year":"2014","unstructured":"Tan F, Soloperto G, Bashford S, Wood NB, Thom S, Hughes A, Xu XY (2014) Pulsatile spiral blood flow through arterial stenosis. Comput Methods Biomech Biomed Eng 17:1727\u20131737","journal-title":"Comput Methods Biomech Biomed Eng"},{"key":"898_CR33","doi-asserted-by":"crossref","first-page":"051001","DOI":"10.1115\/1.4003782","volume":"133","author":"FPP Tan","year":"2011","unstructured":"Tan FPP, Wood NB, Tabor G, Xu XY (2011) Comparison of LES of steady transitional flow in an idealized stenosed axisymmetric artery model with a RANS transitional model. J Biomech Eng 133:051001","journal-title":"J Biomech Eng"},{"key":"898_CR34","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1115\/1.1589774","volume":"125","author":"SS Varghese","year":"2003","unstructured":"Varghese SS, Frankel SH (2003) Numerical modeling of pulsatile turbulent flow in stenotic vessels. J Biomech Eng 125:445\u2013460","journal-title":"J Biomech Eng"},{"key":"898_CR35","doi-asserted-by":"crossref","unstructured":"Varghese SS, Frankel SH, Fischer PF (2007a) Direct numerical simulation of stenotic flows. Part 1. Steady flow. J Fluid Mech 582:253","DOI":"10.1017\/S0022112007005848"},{"key":"898_CR36","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1017\/S0022112007005836","volume":"582","author":"SS Varghese","year":"2007","unstructured":"Varghese SS, Frankel SH, Fischer PF (2007b) Direct numerical simulation of stenotic flows. Part 2. Pulsatile flow. J Fluid Mech 582:281","journal-title":"J Fluid Mech"},{"key":"898_CR37","doi-asserted-by":"crossref","first-page":"014503","DOI":"10.1115\/1.2800832","volume":"130","author":"SS Varghese","year":"2008","unstructured":"Varghese SS, Frankel SH, Fischer PF (2008) Modeling transition to turbulence in eccentric stenotic flows. J Biomech Eng 130:014503","journal-title":"J Biomech Eng"},{"key":"898_CR38","volume-title":"An introduction to computational fluid dynamics","author":"HK Versteeg","year":"2007","unstructured":"Versteeg HK, Malalasekera W (2007) An introduction to computational fluid dynamics. Pearson Education Limited, London"},{"key":"898_CR39","volume-title":"Turbulence modeling for CFD","author":"DC Wilcox","year":"2006","unstructured":"Wilcox DC (2006) Turbulence modeling for CFD. DCW Industries, Flintridge"}],"container-title":["Biomechanics and Modeling in Mechanobiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10237-017-0898-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10237-017-0898-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10237-017-0898-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,17]],"date-time":"2020-05-17T18:54:10Z","timestamp":1589741650000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10237-017-0898-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,25]]},"references-count":39,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["898"],"URL":"https:\/\/doi.org\/10.1007\/s10237-017-0898-2","relation":{},"ISSN":["1617-7959","1617-7940"],"issn-type":[{"value":"1617-7959","type":"print"},{"value":"1617-7940","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,25]]}}}