{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T05:41:18Z","timestamp":1792129278290,"version":"4.4.0"},"reference-count":95,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2020,4,30]],"date-time":"2020-04-30T00:00:00Z","timestamp":1588204800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,4,30]],"date-time":"2020-04-30T00:00:00Z","timestamp":1588204800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100008382","name":"Fundo Regional para a Ci\u00eancia e Tecnologia","doi-asserted-by":"crossref","award":["SFRH\/BD\/107860\/2015"],"award-info":[{"award-number":["SFRH\/BD\/107860\/2015"]}],"id":[{"id":"10.13039\/100008382","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biomech Model Mechanobiol"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1007\/s10237-020-01324-5","type":"journal-article","created":{"date-parts":[[2020,4,30]],"date-time":"2020-04-30T17:04:31Z","timestamp":1588266271000},"page":"2061-2079","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["On the mechanical response of the actomyosin cortex during cell indentations"],"prefix":"10.1007","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4310-2915","authenticated-orcid":false,"given":"Jo\u00e3o P. S.","family":"Ferreira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Kuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Marques","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco P. L.","family":"Parente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margot S.","family":"Damaser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato M.","family":"Natal Jorge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,4,30]]},"reference":[{"issue":"10","key":"1324_CR1","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1140\/epjp\/i2015-15202-6","volume":"130","author":"Y Abidine","year":"2015","unstructured":"Abidine Y, Laurent VM, Michel R, Duperray A, Verdier C (2015) Local mechanical properties of bladder cancer cells measured by AFM as a signature of metastatic potential. Eur Phys J Plus 130(10):202. https:\/\/doi.org\/10.1140\/epjp\/i2015-15202-6","journal-title":"Eur Phys J Plus"},{"issue":"21","key":"1324_CR2","doi-asserted-by":"publisher","first-page":"6527","DOI":"10.1073\/pnas.1507100112","volume":"112","author":"WW Ahmed","year":"2015","unstructured":"Ahmed WW, Betz T (2015) Dynamic cross-links tune the solid\u2013fluid behavior of living cells. Proc Natl Acad Sci 112(21):6527\u20136528. https:\/\/doi.org\/10.1073\/pnas.1507100112","journal-title":"Proc Natl Acad Sci"},{"issue":"2","key":"1324_CR3","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.jtbi.2006.03.021","volume":"242","author":"R Ananthakrishnan","year":"2006","unstructured":"Ananthakrishnan R, Guck J, Wottawah F, Schinkinger S, Lincoln B, Romeyke M, Moon T, K\u00e4s J (2006) Quantifying the contribution of actin networks to the elastic strength of fibroblasts. J Theor Biol 242(2):502\u2013516","journal-title":"J Theor Biol"},{"issue":"8","key":"1324_CR4","doi-asserted-by":"publisher","first-page":"1330","DOI":"10.1091\/mbc.e10-11-0891","volume":"22","author":"Y Aratyn-Schaus","year":"2011","unstructured":"Aratyn-Schaus Y, Oakes PW, Gardel ML (2011) Dynamic and structural signatures of lamellar actomyosin force generation. Mol Biol Cell 22(8):1330\u20131339. https:\/\/doi.org\/10.1091\/mbc.e10-11-0891","journal-title":"Mol Biol Cell"},{"issue":"11","key":"1324_CR5","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1088\/1367-2630\/9\/11\/430","volume":"9","author":"T Auth","year":"2007","unstructured":"Auth T, Safran SA, Gov NS (2007) Filament networks attached to membranes: cytoskeletal pressure and local bilayer deformation. New J Phys 9(11):430\u2013430","journal-title":"New J Phys"},{"issue":"1","key":"1324_CR6","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1002\/zamm.19860660108","volume":"66","author":"P Ba\u017eant","year":"1986","unstructured":"Ba\u017eant P, Oh BH (1986) Efficient numerical integration on the surface of a sphere. ZAMM J Appl Math Mech\/Z Angew Math Mech 66(1):37\u201349. https:\/\/doi.org\/10.1002\/zamm.19860660108","journal-title":"ZAMM J Appl Math Mech\/Z Angew Math Mech"},{"issue":"1","key":"1324_CR7","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1152\/physrev.00018.2013","volume":"94","author":"L Blanchoin","year":"2014","unstructured":"Blanchoin L, Boujemaa-Paterski R, Sykes C, Plastino J (2014) Actin dynamics, architecture, and mechanics in cell motility. Physiol Rev 94(1):235\u2013263. https:\/\/doi.org\/10.1152\/physrev.00018.2013","journal-title":"Physiol Rev"},{"issue":"3","key":"1324_CR8","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1103\/RevModPhys.86.995","volume":"86","author":"CP Broedersz","year":"2014","unstructured":"Broedersz CP, MacKintosh FC (2014) Modeling semiflexible polymer networks. Rev Mod Phys 86(3):995\u20131036. https:\/\/doi.org\/10.1103\/RevModPhys.86.995","journal-title":"Rev Mod Phys"},{"issue":"3 Pt 1","key":"1324_CR9","doi-asserted-by":"publisher","first-page":"C569","DOI":"10.1152\/ajpcell.1992.262.3.C569","volume":"262","author":"S Burlacu","year":"1992","unstructured":"Burlacu S, Janmey PA, Borejdo J (1992) Distribution of actin filament lengths measured by fluorescence microscopy. Am J Physiol 262(3 Pt 1):C569\u2013C577. https:\/\/doi.org\/10.1152\/ajpcell.1992.262.3.C569","journal-title":"Am J Physiol"},{"issue":"5","key":"1324_CR10","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.1103\/PhysRevLett.80.1106","volume":"80","author":"A Caspi","year":"1998","unstructured":"Caspi A, Elbaum M, Granek R, Lachish A, Zbaida D (1998) Semiflexible polymer network: a view from inside. Phys Rev Lett 80(5):1106\u20131109. https:\/\/doi.org\/10.1103\/PhysRevLett.80.1106","journal-title":"Phys Rev Lett"},{"issue":"6","key":"1324_CR11","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.devcel.2016.09.011","volume":"38","author":"KJ Chalut","year":"2016","unstructured":"Chalut KJ, Paluch EK (2016) The actin cortex: a bridge between cell shape and function. Dev Cell 38(6):571\u2013573","journal-title":"Dev Cell"},{"issue":"10","key":"1324_CR12","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1038\/nmat4009","volume":"13","author":"O Chaudhuri","year":"2014","unstructured":"Chaudhuri O, Koshy ST, da Cunha CB, Shin J-W, Verbeke CS, Allison KH, Mooney DJ (2014) Extracellular matrix stiffness and composition jointly regulate the induction of malignant phenotypes in mammary epithelium. Nat Mater 13(10):970\u2013978","journal-title":"Nat Mater"},{"issue":"1","key":"1324_CR13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1146\/annurev-biophys-051013-023102","volume":"44","author":"B Chen","year":"2015","unstructured":"Chen B, Ji B, Gao H (2015) Modeling active mechanosensing in cell\u2013matrix interactions. Ann Rev Biophys 44(1):1\u201332. https:\/\/doi.org\/10.1146\/annurev-biophys-051013-023102","journal-title":"Ann Rev Biophys"},{"key":"1324_CR14","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.plrev.2017.06.016","volume":"22\u201323","author":"B Cheng","year":"2017","unstructured":"Cheng B, Lin M, Huang G, Li Y, Ji B, Genin GM, Deshpande VS, Lu TJ, Xu F (2017) Cellular mechanosensing of the biophysical microenvironment: a review of mathematical models of biophysical regulation of cell responses. Phys Life Rev 22\u201323:88\u2013119","journal-title":"Phys Life Rev"},{"issue":"1","key":"1324_CR15","first-page":"1","volume":"8","author":"YH Chim","year":"2018","unstructured":"Chim YH, Mason LM, Rath N, Olson MF, Tassieri M, Yin H (2018) A one-step procedure to probe the viscoelastic properties of cells by atomic force microscopy. Sci Rep 8(1):1\u201312","journal-title":"Sci Rep"},{"issue":"3","key":"1324_CR16","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.bpj.2013.05.057","volume":"105","author":"AG Clark","year":"2013","unstructured":"Clark AG, Dierkes K, Paluch EK (2013) Monitoring actin cortex thickness in live cells. Biophys J 105(3):570\u2013580","journal-title":"Biophys J"},{"issue":"10","key":"1324_CR17","doi-asserted-by":"crossref","first-page":"R484","DOI":"10.1016\/j.cub.2014.03.059","volume":"24","author":"AG Clark","year":"2014","unstructured":"Clark AG, Wartlick O, Salbreux G, Paluch EK (2014) Stresses at the cell surface during animal cell morphogenesis. Curr Biol 24(10):R484\u201394","journal-title":"Curr Biol"},{"issue":"4","key":"1324_CR18","doi-asserted-by":"publisher","first-page":"888","DOI":"10.1103\/PhysRevLett.85.888","volume":"85","author":"JC Crocker","year":"2000","unstructured":"Crocker JC, Valentine MT, Weeks ER, Gisler T, Kaplan PD, Yodh AG, Weitz DA (2000) Two-point microrheology of inhomogeneous soft materials. Phys Rev Lett 85(4):888\u2013891. https:\/\/doi.org\/10.1103\/PhysRevLett.85.888","journal-title":"Phys Rev Lett"},{"issue":"38","key":"1324_CR19","doi-asserted-by":"crossref","first-page":"14015","DOI":"10.1073\/pnas.0605837103","volume":"103","author":"VS Deshpande","year":"2006","unstructured":"Deshpande VS, McMeeking RM, Evans AG (2006) A bio-chemo-mechanical model for cell contractility. Proc Natl Acad Sci 103(38):14015\u201314020","journal-title":"Proc Natl Acad Sci"},{"issue":"5751","key":"1324_CR20","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1126\/science.1116995","volume":"310","author":"DE Discher","year":"2005","unstructured":"Discher DE, Janmey P, Wang Y-l (2005) Tissue cells feel and respond to the stiffness of their substrate. Science 310(5751):1139\u20131143","journal-title":"Science"},{"issue":"2","key":"1324_CR21","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.tcb.2012.09.006","volume":"23","author":"A Diz-Mu\u00f1oz","year":"2013","unstructured":"Diz-Mu\u00f1oz A, Fletcher DA, Weiner OD (2013) Use the force: membrane tension as an organizer of cell shape and motility. Trends Cell Biol 23(2):47\u201353. https:\/\/doi.org\/10.1016\/j.tcb.2012.09.006","journal-title":"Trends Cell Biol"},{"issue":"6","key":"1324_CR22","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1016\/j.bpj.2015.01.016","volume":"108","author":"F Eghiaian","year":"2015","unstructured":"Eghiaian F, Rigato A, Scheuring S (2015) Structural, mechanical, and dynamical variability of the actin cortex in living cells. Biophys J 108(6):1330\u20131340","journal-title":"Biophys J"},{"issue":"5","key":"1324_CR23","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/ncb3336","volume":"18","author":"A Elosegui-Artola","year":"2016","unstructured":"Elosegui-Artola A, Oria R, Chen Y, Kosmalska A, Perez-Gonzalez C, Castro N, Zhu C, Trepat X, Roca-Cusachs P (2016) Mechanical regulation of a molecular clutch defines force transmission and transduction in response to matrix rigidity. Nat Cell Biol 18(5):540","journal-title":"Nat Cell Biol"},{"issue":"5","key":"1324_CR24","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.cub.2015.12.069","volume":"26","author":"H Ennomani","year":"2016","unstructured":"Ennomani H, Letort G, Gu\u00e9rin C, Martiel J-L, Cao W, N\u00e9d\u00e9lec F, De La Cruz EM, Th\u00e9ry M, Blanchoin L (2016) Architecture and connectivity govern actin network contractility. Curr Biol 26(5):616\u2013626","journal-title":"Curr Biol"},{"key":"1324_CR25","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevLett.87.148102","author":"B Fabry","year":"2001","unstructured":"Fabry B, Maksym GN, Butler JP, Glogauer M, Navajas D, Fredberg JJ (2001) Scaling the microrheology of living cells. Phys Rev Lett. https:\/\/doi.org\/10.1103\/PhysRevLett.87.148102","journal-title":"Phys Rev Lett"},{"key":"1324_CR26","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.jmps.2017.09.009","volume":"110","author":"JPS Ferreira","year":"2018","unstructured":"Ferreira JPS, Parente MPL, Natal Jorge RM (2018) Continuum mechanical model for cross-linked actin networks with contractile bundles. J Mech Phys Solids 110:100\u2013117","journal-title":"J Mech Phys Solids"},{"issue":"1","key":"1324_CR27","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/srep06213","volume":"4","author":"E Fischer-Friedrich","year":"2014","unstructured":"Fischer-Friedrich E, Hyman AA, J\u00fclicher F, Muller DJ, Helenius J (2014) Quantification of surface tension and internal pressure generated by single mitotic cells. Sci Rep 4(1):137\u2013138","journal-title":"Sci Rep"},{"issue":"36","key":"1324_CR28","doi-asserted-by":"crossref","first-page":"13075","DOI":"10.1073\/pnas.1411785111","volume":"111","author":"J Fouchard","year":"2014","unstructured":"Fouchard J, Bimbard C, Bufi N, Durand-Smet P, Proag A, Richert A, Cardoso O, Asnacios A (2014) Three-dimensional cell body shape dictates the onset of traction force generation and growth of focal adhesions. Proc Natl Acad Sci USA 111(36):13075\u201313080","journal-title":"Proc Natl Acad Sci USA"},{"key":"1324_CR29","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevLett.91.158302","author":"ML Gardel","year":"2003","unstructured":"Gardel ML, Valentine MT, Crocker JC, Bausch AR, Weitz DA (2003) Microrheology of entangled F-actin solutions. Phys Rev Lett. https:\/\/doi.org\/10.1103\/PhysRevLett.91.158302","journal-title":"Phys Rev Lett"},{"issue":"8","key":"1324_CR30","doi-asserted-by":"publisher","first-page":"2038","DOI":"10.1103\/PhysRevLett.96.088102","volume":"96","author":"ML Gardel","year":"2006","unstructured":"Gardel ML, Nakamura F, Hartwig J, Crocker JC, Stossel TP, Weitz DA (2006) Stress-dependent elasticity of composite actin networks as a model for cell behavior. Phys Rev Lett 96(8):2038. https:\/\/doi.org\/10.1103\/PhysRevLett.96.088102","journal-title":"Phys Rev Lett"},{"issue":"6","key":"1324_CR31","doi-asserted-by":"publisher","first-page":"1762","DOI":"10.1073\/pnas.0504777103","volume":"103","author":"ML Gardel","year":"2006","unstructured":"Gardel ML, Nakamura F, Hartwig JH, Crocker JC, Stossel TP, Weitz DA (2006) Prestressed F-actin networks cross-linked by hinged filamins replicate mechanical properties of cells. Proc Natl Acad Sci 103(6):1762\u20131767. https:\/\/doi.org\/10.1073\/pnas.0504777103","journal-title":"Proc Natl Acad Sci"},{"issue":"6","key":"1324_CR32","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1083\/jcb.200810060","volume":"183","author":"ML Gardel","year":"2008","unstructured":"Gardel ML, Sabass B, Ji L, Danuser G, Schwarz US, Waterman CM (2008) Traction stress in focal adhesions correlates biphasically with actin retrograde flow speed. J Cell Biol 183(6):999\u20131005","journal-title":"J Cell Biol"},{"key":"1324_CR33","first-page":"487","volume":"89","author":"ML Gardel","year":"2008","unstructured":"Gardel ML, Kasza KE, Brangwynne CP, Liu J, Weitz DA (2008) Mechanical response of cytoskeletal networks. Biophys Tools Biol 89:487","journal-title":"Biophys Tools Biol"},{"issue":"1","key":"1324_CR34","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1002\/jemt.22776","volume":"80","author":"N Gavara","year":"2017","unstructured":"Gavara N (2017) A beginner\u2019s guide to atomic force microscopy probing for cell mechanics. Microsc Res Tech 80(1):75\u201384. https:\/\/doi.org\/10.1002\/jemt.22776","journal-title":"Microsc Res Tech"},{"issue":"3","key":"1324_CR35","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1007\/s10237-015-0706-9","volume":"15","author":"N Gavara","year":"2016","unstructured":"Gavara N, Chadwick RS (2016) Relationship between cell stiffness and stress fiber amount, assessed by simultaneous atomic force microscopy and live-cell fluorescence imaging. Biomech Model Mechanobiol 15(3):511\u2013523. https:\/\/doi.org\/10.1007\/s10237-015-0706-9","journal-title":"Biomech Model Mechanobiol"},{"issue":"3","key":"1324_CR36","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.bpj.2014.06.033","volume":"107","author":"N Guz","year":"2014","unstructured":"Guz N, Dokukin M, Kalaparthi V, Sokolov I (2014) If cell mechanics can be described by elastic modulus: study of different models and probes used in indentation experiments. Biophys J 107(3):564\u2013575","journal-title":"Biophys J"},{"issue":"1","key":"1324_CR37","doi-asserted-by":"crossref","first-page":"C99","DOI":"10.1152\/ajpcell.1988.254.1.C99","volume":"254","author":"CM Hai","year":"1988","unstructured":"Hai CM, Murphy RA (1988) Cross-bridge phosphorylation and regulation of latch state in smooth muscle. Am J Physiol Cell Physiol 254(1):C99\u2013C106","journal-title":"Am J Physiol Cell Physiol"},{"issue":"1","key":"1324_CR38","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1039\/C5TB02077H","volume":"4","author":"F Han","year":"2016","unstructured":"Han F, Zhu C, Guo Q, Yang H, Li B (2016) Cellular modulation by the elasticity of biomaterials. J Mater Chem B 4(1):9\u201326","journal-title":"J Mater Chem B"},{"issue":"7","key":"1324_CR39","doi-asserted-by":"publisher","first-page":"7320","DOI":"10.1016\/j.actbio.2013.03.001","volume":"9","author":"GA Holzapfel","year":"2013","unstructured":"Holzapfel GA, Ogden RW (2013) Elasticity of biopolymer filaments. Acta Biomater 9(7):7320\u20137325. https:\/\/doi.org\/10.1016\/j.actbio.2013.03.001","journal-title":"Acta Biomater"},{"key":"1324_CR40","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevLett.113.118101","author":"TH Hui","year":"2014","unstructured":"Hui TH, Zhou ZL, Qian J, Lin Y, Ngan AHW, Gao H (2014) Volumetric deformation of live cells induced by pressure-activated cross-membrane ion transport. Phys Rev Lett. https:\/\/doi.org\/10.1103\/PhysRevLett.113.118101","journal-title":"Phys Rev Lett"},{"issue":"6879","key":"1324_CR41","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1038\/416413","volume":"416","author":"D Humphrey","year":"2002","unstructured":"Humphrey D, Duggan C, Saha D, Smith D, Kas J (2002) Active fluidization of polymer networks through molecular motors. Nature 416(6879):413\u2013416. https:\/\/doi.org\/10.1038\/416413","journal-title":"Nature"},{"issue":"12","key":"1324_CR42","first-page":"825","volume":"15","author":"T Iskratsch","year":"2014","unstructured":"Iskratsch T, Wolfenson H, Sheetz MP (2014) Appreciating force and shape\u2014the rise of mechanotransduction in cell biology. Nature 15(12):825\u2013833","journal-title":"Nature"},{"issue":"6270","key":"1324_CR43","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1038\/345089a0","volume":"345","author":"PA Janmey","year":"1990","unstructured":"Janmey PA, Hvidt S, Lamb J, Stossel TP (1990) Resemblance of actin-binding protein\/actin gels to covalently crosslinked networks. Nature 345(6270):89\u201392. https:\/\/doi.org\/10.1038\/345089a0","journal-title":"Nature"},{"issue":"1","key":"1324_CR44","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.ceb.2006.12.002","volume":"19","author":"KE Kasza","year":"2007","unstructured":"Kasza KE, Rowat AC, Liu J, Angelini TE, Brangwynne CP, Koenderink GH, Weitz DA (2007) The cell as a material. Curr Opin Cell Biol 19(1):101\u2013107","journal-title":"Curr Opin Cell Biol"},{"issue":"3","key":"1324_CR45","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1093\/oxfordjournals.jbchem.a129267","volume":"67","author":"M Kawamura","year":"1970","unstructured":"Kawamura M, Maruyama K (1970) Electron microscopic particle length of F-actin polymerized in vitro. J Biochem 67(3):437\u2013457","journal-title":"J Biochem"},{"issue":"10","key":"1324_CR46","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1038\/ncb1965","volume":"11","author":"K Keren","year":"2009","unstructured":"Keren K, Yam PT, Kinkhabwala A, Mogilner A, Theriot JA (2009) Intracellular fluid flow in rapidly moving cells. Nat Cell Biol 11(10):1219\u20131224","journal-title":"Nat Cell Biol"},{"key":"1324_CR47","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.ceb.2018.01.015","volume":"50","author":"GH Koenderink","year":"2018","unstructured":"Koenderink GH, Paluch EK (2018) Architecture shapes contractility in actomyosin networks. Curr Opin Cell Biol 50:79\u201385. https:\/\/doi.org\/10.1016\/j.ceb.2018.01.015","journal-title":"Curr Opin Cell Biol"},{"issue":"36","key":"1324_CR48","doi-asserted-by":"crossref","first-page":"15192","DOI":"10.1073\/pnas.0903974106","volume":"106","author":"GH Koenderink","year":"2009","unstructured":"Koenderink GH, Dogic Z, Nakamura F, Bendix PM, MacKintosh FC, Hartwig JH, Stossel TP, Weitz DA (2009) An active biopolymer network controlled by molecular motors. Proc Natl Acad Sci 106(36):15192\u201315197","journal-title":"Proc Natl Acad Sci"},{"issue":"10","key":"1324_CR49","doi-asserted-by":"crossref","first-page":"2437","DOI":"10.1016\/j.bpj.2015.04.005","volume":"108","author":"C Labouesse","year":"2015","unstructured":"Labouesse C, Verkhovsky AB, Meister J-J, Gabella C, Vianay B (2015) Cell shape dynamics reveal balance of elasticity and contractility in peripheral arcs. Biophys J 108(10):2437\u20132447","journal-title":"Biophys J"},{"issue":"1","key":"1324_CR50","doi-asserted-by":"crossref","first-page":"23722","DOI":"10.1038\/srep23722","volume":"6","author":"C Labouesse","year":"2016","unstructured":"Labouesse C, Gabella C, Meister J-J, Vianay B, Verkhovsky AB (2016) Microsurgery-aided in-situ force probing reveals extensibility and viscoelastic properties of individual stress fibers. Sci Rep 6(1):23722","journal-title":"Sci Rep"},{"issue":"8","key":"1324_CR51","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/nrm2222","volume":"8","author":"T Lecuit","year":"2007","unstructured":"Lecuit T, Lenne P-F (2007) Cell surface mechanics and the control of cell shape, tissue patterns and morphogenesis. Nat Rev Mol Cell Biol 8(8):633\u2013644","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"4","key":"1324_CR52","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1016\/j.actbio.2009.10.044","volume":"6","author":"H Lee","year":"2010","unstructured":"Lee H, Ferrer JM, Nakamura F, Lang MJ, Kamm RD (2010) Passive and active microrheology for cross-linked F-actin networks in vitro. Acta Biomater 6(4):1207\u20131218","journal-title":"Acta Biomater"},{"issue":"2","key":"1324_CR53","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.tcb.2011.10.001","volume":"22","author":"R Levayer","year":"2012","unstructured":"Levayer R, Lecuit T (2012) Biomechanical regulation of contractility: spatial control and dynamics. Trends Cell Biol 22(2):61\u201381","journal-title":"Trends Cell Biol"},{"issue":"1","key":"1324_CR54","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1146\/annurev.bioeng.7.060804.100340","volume":"7","author":"S Li","year":"2005","unstructured":"Li S, Guan JL, Chien S (2005) Biochemistry and biomechanics of cell motility. Annu Rev Biomed Eng 7(1):105\u2013150. https:\/\/doi.org\/10.1146\/annurev.bioeng.7.060804.100340","journal-title":"Annu Rev Biomed Eng"},{"issue":"2","key":"1324_CR55","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1039\/B912163N","volume":"6","author":"O Lieleg","year":"2010","unstructured":"Lieleg O, Claessens MMAE, Bausch AR (2010) Structure and dynamics of cross-linked actin networks. Soft Matter 6(2):218\u2013225","journal-title":"Soft Matter"},{"issue":"5","key":"1324_CR56","doi-asserted-by":"crossref","first-page":"2705","DOI":"10.1016\/S0006-3495(02)75280-6","volume":"83","author":"X Liu","year":"2002","unstructured":"Liu X, Pollack G (2002) Mechanics of F-actin characterized with microfabricated cantilevers. Biophys J 83(5):2705\u20132715","journal-title":"Biophys J"},{"issue":"1","key":"1324_CR57","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S0006-3495(04)74111-9","volume":"86","author":"X Liu","year":"2004","unstructured":"Liu X, Pollack GH (2004) Stepwise sliding of single actin and myosin filaments. Biophys J 86(1):353\u2013358","journal-title":"Biophys J"},{"issue":"1","key":"1324_CR58","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0955-0674(01)00288-5","volume":"14","author":"D Louvard","year":"2002","unstructured":"Louvard D, Schroer T (2002) Cell structure and dynamics. Curr Opin Cell Biol 14(1):15\u201317","journal-title":"Curr Opin Cell Biol"},{"issue":"10","key":"1324_CR59","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1016\/j.jmps.2005.04.006","volume":"53","author":"C Miehe","year":"2005","unstructured":"Miehe C, G\u00f6ktepe S (2005) A micro\u2013macro approach to rubber-like materials. Part II: the micro-sphere model of finite rubber viscoelasticity. J Mech Phys Solids 53(10):2231\u20132258","journal-title":"J Mech Phys Solids"},{"issue":"3","key":"1324_CR60","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.semcdb.2008.01.008","volume":"19","author":"TJ Mitchison","year":"2008","unstructured":"Mitchison TJ, Charras GT, Mahadevan L (2008) Implications of a poroelastic cytoplasm for the dynamics of animal cell shape. Semin Cell Dev Biol 19(3):215\u2013223","journal-title":"Semin Cell Dev Biol"},{"issue":"5810","key":"1324_CR61","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1126\/science.1134404","volume":"315","author":"D Mizuno","year":"2007","unstructured":"Mizuno D, Tardin C, Schmidt CF, MacKintosh FC (2007) Nonequilibrium mechanics of active cytoskeletal networks. Science 315(5810):370\u2013373. https:\/\/doi.org\/10.1126\/science.1134404","journal-title":"Science"},{"issue":"3","key":"1324_CR62","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/nmat3517","volume":"12","author":"E Moeendarbary","year":"2013","unstructured":"Moeendarbary E, Valon L, Fritzsche M, Harris AR, Moulding DA, Thrasher AJ, Stride E, Mahadevan L, Charras GT (2013) The cytoplasm of living cells behaves as a poroelastic material. Nat Mater 12(3):253\u2013261","journal-title":"Nat Mater"},{"issue":"17","key":"1324_CR63","doi-asserted-by":"crossref","first-page":"R762","DOI":"10.1016\/j.cub.2009.06.053","volume":"19","author":"A Mogilner","year":"2009","unstructured":"Mogilner A, Keren K (2009) The shape of motile cells. Curr Biol 19(17):R762\u2013R771","journal-title":"Curr Biol"},{"issue":"6","key":"1324_CR64","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1007\/s10237-010-0276-9","volume":"10","author":"E Monteiro","year":"2010","unstructured":"Monteiro E, Yvonnet J, He QC, Cardoso O, Asnacios A (2010) Analyzing the interplay between single cell rheology and force generation through large deformation finite element models. Biomech Model Mechanobiol 10(6):813\u2013830","journal-title":"Biomech Model Mechanobiol"},{"key":"1324_CR65","doi-asserted-by":"crossref","unstructured":"Mulla Y, Koenderink GH (2018) Crosslinker mobility weakens transient polymer networks. arXiv.org. arxiv:1805.12431v1","DOI":"10.1103\/PhysRevE.98.062503"},{"issue":"23","key":"1324_CR66","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1103\/PhysRevLett.112.238102","volume":"112","author":"KW M\u00fcller","year":"2014","unstructured":"M\u00fcller KW, Bruinsma RF, Lieleg O, Bausch AR, Wall WA, Levine AJ (2014) Rheology of semiflexible bundle networks with transient linkers. Phys Rev Lett 112(23):955\u20135. https:\/\/doi.org\/10.1103\/PhysRevLett.112.238102","journal-title":"Phys Rev Lett"},{"issue":"8","key":"1324_CR67","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1038\/nrm4012","volume":"16","author":"M Murrell","year":"2015","unstructured":"Murrell M, Oakes PW, Lenz M, Gardel ML (2015) Forcing cells into shape: the mechanics of actomyosin contractility. Nature 16(8):486\u2013498. https:\/\/doi.org\/10.1038\/nrm4012","journal-title":"Nature"},{"issue":"6","key":"1324_CR68","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1007\/s10237-010-0211-0","volume":"9","author":"S-I Murtada","year":"2010","unstructured":"Murtada S-I, Kroon M, Holzapfel GA (2010) A calcium-driven mechanochemical model for prediction of force generation in smooth muscle. Biomech Model Mechanobiol 9(6):749\u2013762. https:\/\/doi.org\/10.1007\/s10237-010-0211-0","journal-title":"Biomech Model Mechanobiol"},{"issue":"9","key":"1324_CR69","doi-asserted-by":"publisher","first-page":"e45297","DOI":"10.1371\/journal.pone.0045297","volume":"7","author":"S Nawaz","year":"2012","unstructured":"Nawaz S, S\u00e1nchez P, Bodensiek K, Li S, Simons M, Schaap IAT (2012) Cell visco-elasticity measured with AFM and optical trapping at sub-micrometer deformations. PLoS ONE 7(9):e45297. https:\/\/doi.org\/10.1371\/journal.pone.0045297","journal-title":"PLoS ONE"},{"issue":"3","key":"1324_CR70","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.actbio.2007.12.007","volume":"4","author":"JS Palmer","year":"2008","unstructured":"Palmer JS, Boyce MC (2008) Constitutive modeling of the stress-strain behavior of F-actin filament networks. Acta Biomater 4(3):597\u2013612","journal-title":"Acta Biomater"},{"issue":"1","key":"1324_CR71","doi-asserted-by":"publisher","first-page":"e0146588","DOI":"10.1371\/journal.pone.0146588","volume":"11","author":"M Perepelyuk","year":"2016","unstructured":"Perepelyuk M, Chin L, Cao X, van Oosten A, Shenoy VB, Janmey PA, Wells RG (2016) Normal and fibrotic rat livers demonstrate shear strain softening and compression stiffening: a model for soft tissue mechanics. PLoS ONE 11(1):e0146588. https:\/\/doi.org\/10.1371\/journal.pone.0146588","journal-title":"PLoS ONE"},{"issue":"3","key":"1324_CR72","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1016\/S0021-9258(19)40015-X","volume":"265","author":"JL Podolski","year":"1990","unstructured":"Podolski JL, Steck TL (1990) Length distribution of F-actin in dictyostelium discoideum. J Biol Chem 265(3):1312\u20131318","journal-title":"J Biol Chem"},{"issue":"4","key":"1324_CR73","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/S0092-8674(03)00120-X","volume":"112","author":"TD Pollard","year":"2003","unstructured":"Pollard TD, Borisy GG (2003) Cellular motility driven by assembly and disassembly of actin filaments. Cell 112(4):453\u2013465","journal-title":"Cell"},{"issue":"1","key":"1324_CR74","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1146\/annurev.biochem.73.011303.073844","volume":"73","author":"SM Rafelski","year":"2004","unstructured":"Rafelski SM, Theriot JA (2004) Crawling toward a unified model of cell motility: spatial and temporal regulation of actin dynamics. Annu Rev Biochem 73(1):209\u2013239. https:\/\/doi.org\/10.1146\/annurev.biochem.73.011303.073844","journal-title":"Annu Rev Biochem"},{"issue":"15","key":"1324_CR75","doi-asserted-by":"publisher","first-page":"E1361","DOI":"10.1073\/pnas.1220723110","volume":"110","author":"P Roca-Cusachs","year":"2013","unstructured":"Roca-Cusachs P, del Rio A, Puklin-Faucher E, Gauthier NC, Biais N, Sheetz MP (2013) Integrin-dependent force transmission to the extracellular matrix by alpha-actinin triggers adhesion maturation. Proc Natl Acad Sci 110(15):E1361\u2013E1370. https:\/\/doi.org\/10.1073\/pnas.1220723110","journal-title":"Proc Natl Acad Sci"},{"issue":"6","key":"1324_CR76","doi-asserted-by":"crossref","first-page":"0801","DOI":"10.1115\/1.4025355","volume":"65","author":"ML Rodriguez","year":"2013","unstructured":"Rodriguez ML, McGarry PJ, Sniadecki NJ (2013) Review on cell mechanics: experimental and modeling approaches. Appl Mech Rev 65(6):0801","journal-title":"Appl Mech Rev"},{"issue":"10","key":"1324_CR77","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1016\/j.tcb.2012.07.001","volume":"22","author":"G Salbreux","year":"2012","unstructured":"Salbreux G, Charras G, Paluch E (2012) Actin cortex mechanics and cellular morphogenesis. Trends Cell Biol 22(10):536\u2013545. https:\/\/doi.org\/10.1016\/j.tcb.2012.07.001","journal-title":"Trends Cell Biol"},{"issue":"7","key":"1324_CR78","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","volume":"9","author":"J Schindelin","year":"2012","unstructured":"Schindelin J, Arganda-Carreras I, Frise E, Kaynig V, Longair M, Pietzsch T, Preibisch S, Rueden C, Saalfeld S, Schmid B, Tinevez J-Y, White DJ, Hartenstein V, Eliceiri K, Tomancak P, Cardona A (2012) Fiji: an open-source platform for biological-image analysis. Nat Methods 9(7):676\u2013682","journal-title":"Nat Methods"},{"key":"1324_CR79","doi-asserted-by":"publisher","DOI":"10.1098\/rsif.2014.1080","author":"DK Schlueter","year":"2015","unstructured":"Schlueter DK, Ramis-Conde I, Chaplain MAJ (2015) Multi-scale modelling of the dynamics of cell colonies: insights into cell-adhesion forces and cancer invasion from in silico simulations. J R Soc Interface. https:\/\/doi.org\/10.1098\/rsif.2014.1080","journal-title":"J R Soc Interface"},{"issue":"1","key":"1324_CR80","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1146\/annurev.cellbio.14.1.305","volume":"14","author":"A Schmidt","year":"1998","unstructured":"Schmidt A, Hall MN (1998) Signaling to the actin cytoskeleton. Annu Rev Cell Dev Biol 14(1):305\u2013338","journal-title":"Annu Rev Cell Dev Biol"},{"issue":"10","key":"1324_CR81","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1242\/jcs.162891","volume":"128","author":"AK Schroer","year":"2015","unstructured":"Schroer AK, Merryman WD (2015) Mechanobiology of myofibroblast adhesion in fibrotic cardiac disease. J Cell Sci 128(10):1865\u20131875","journal-title":"J Cell Sci"},{"issue":"6","key":"1324_CR82","doi-asserted-by":"crossref","first-page":"2911","DOI":"10.1016\/S0006-3495(99)77124-9","volume":"77","author":"D Sept","year":"1999","unstructured":"Sept D, Xu J, Pollard TD, Andrew McCammon J (1999) Annealing accounts for the length of actin filaments formed by spontaneous polymerization. Biophys J 77(6):2911\u20132919","journal-title":"Biophys J"},{"key":"1324_CR83","unstructured":"Storm C, Pastore JJ, MacKintosh FC, Lubensky TC, Janmey PA (2004) Nonlinear elasticity in biological gels. arXiv.org. http:\/\/arxiv.org\/abs\/cond-mat\/0406016v1"},{"key":"1324_CR84","doi-asserted-by":"crossref","unstructured":"Swift J, Ivanovska IL, Buxboim A, Harada T, Dingal P, Pinter J, Pajerowski JD, Spinler K, Shin J-W, Tewari M, Rehfeldt F, Speicher DW, Discher DE (2013) Nuclear lamin-A scales with tissue stiffness and enhances matrix-directed differentiation. Mol Biol Cell 24. http:\/\/gateway.webofknowledge.com\/gateway\/Gateway.cgi?GWVersion=2&SrcAuth=mekentosj&SrcApp=Papers&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000209348703110","DOI":"10.1126\/science.1240104"},{"key":"1324_CR85","volume-title":"ABAQUS v6.12 documentation","author":"D System\u00e8s","year":"2012","unstructured":"System\u00e8s D (2012) ABAQUS v6.12 documentation. Dassault Syst\u00e8mes, Providence"},{"issue":"12","key":"1324_CR86","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1038\/nmat4729","volume":"15","author":"A Tajik","year":"2016","unstructured":"Tajik A, Zhang Y, Wei F, Sun J, Jia Q, Zhou W, Singh R, Khanna N, Belmont AS, Wang N (2016) Transcription upregulation via force-induced direct stretching of chromatin. Nat Mater 15(12):1287\u20131296","journal-title":"Nat Mater"},{"issue":"4","key":"1324_CR87","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1073\/pnas.0235407100","volume":"100","author":"JL Tan","year":"2003","unstructured":"Tan JL, Tien J, Pirone DM, Gray DS, Bhadriraju K, Chen CS (2003) Cells lying on a bed of microneedles: an approach to isolate mechanical force. Proc Natl Acad Sci 100(4):1484\u20131489","journal-title":"Proc Natl Acad Sci"},{"key":"1324_CR88","first-page":"1","volume":"81","author":"DD Tang","year":"2018","unstructured":"Tang DD (2018) The dynamic actin cytoskeleton in smooth muscle. Adv Pharmacol (San Diego, Calif.) 81:1\u201338","journal-title":"Adv Pharmacol (San Diego, Calif.)"},{"issue":"8","key":"1324_CR89","doi-asserted-by":"publisher","first-page":"088103","DOI":"10.1103\/PhysRevLett.98.088103","volume":"98","author":"R Tharmann","year":"2007","unstructured":"Tharmann R, Claessens MMAE, Bausch AR (2007) Viscoelasticity of isotropically cross-linked actin networks. Phys Rev Lett 98(8):088103. https:\/\/doi.org\/10.1103\/PhysRevLett.98.088103","journal-title":"Phys Rev Lett"},{"issue":"18","key":"1324_CR90","doi-asserted-by":"publisher","first-page":"6933","DOI":"10.1073\/pnas.1117810109","volume":"109","author":"L Trichet","year":"2012","unstructured":"Trichet L, Le Digabel J, Hawkins RJ, Vedula SRK, Gupta M, Ribrault C, Hersen P, Voituriez R, Ladoux B (2012) Evidence of a large-scale mechanosensing mechanism for cellular adaptation to substrate stiffness. Proc Natl Acad Sci 109(18):6933\u20136938. https:\/\/doi.org\/10.1073\/pnas.1117810109","journal-title":"Proc Natl Acad Sci"},{"key":"1324_CR91","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.jmbbm.2012.11.019","volume":"22","author":"MJ Unterberger","year":"2013","unstructured":"Unterberger MJ, Schmoller KM, Bausch AR, Holzapfel GA (2013) A new approach to model cross-linked actin networks: multi-scale continuum formulation and computational analysis. J Mech Behav Biomed Mater 22:95\u2013114","journal-title":"J Mech Behav Biomed Mater"},{"issue":"1","key":"1324_CR92","doi-asserted-by":"crossref","first-page":"19270","DOI":"10.1038\/srep19270","volume":"6","author":"ASG van Oosten","year":"2016","unstructured":"van Oosten ASG, Vahabi M, Licup AJ, Sharma A, Galie PA, MacKintosh FC, Janmey PA (2016) Uncoupling shear and uniaxial elastic moduli of semiflexible biopolymer networks: compression-softening and stretch-stiffening. Sci Rep 6(1):19270","journal-title":"Sci Rep"},{"issue":"8","key":"1324_CR93","doi-asserted-by":"publisher","first-page":"1284","DOI":"10.1007\/s11538-013-9812-y\/fulltext.html","volume":"75","author":"PP Weafer","year":"2013","unstructured":"Weafer PP, Ronan W, Jarvis SP, McGarry JP (2013) Experimental and computational investigation of the role of stress fiber contractility in the resistance of osteoblasts to compression. Bull Math Biol 75(8):1284\u20131303. https:\/\/doi.org\/10.1007\/s11538-013-9812-y\/fulltext.html","journal-title":"Bull Math Biol"},{"key":"1324_CR94","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-018-0015-1","author":"P-H Wu","year":"2018","unstructured":"Wu P-H, Aroush DR-B, Asnacios A, Chen W-C, Dokukin ME, Doss BL, Durand-Smet P, Ekpenyong A, Guck J, Guz NV, Janmey PA, Lee JSH, Moore NM, Ott A, Poh Y-C, Ros R, Sander M, Sokolov I, Staunton JR, Wang N, Whyte G, Wirtz D (2018) A comparison of methods to assess cell mechanical properties. Nat Methods. https:\/\/doi.org\/10.1038\/s41592-018-0015-1","journal-title":"Nat Methods"},{"key":"1324_CR95","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.semcdb.2017.07.029","volume":"71","author":"S Xia","year":"2017","unstructured":"Xia S, Kanchanawong P (2017) Nanoscale mechanobiology of cell adhesions. Semin Cell Dev Biol 71:53\u201367","journal-title":"Semin Cell Dev Biol"}],"container-title":["Biomechanics and Modeling in Mechanobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10237-020-01324-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10237-020-01324-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10237-020-01324-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T14:03:21Z","timestamp":1696082601000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10237-020-01324-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,30]]},"references-count":95,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["1324"],"URL":"https:\/\/doi.org\/10.1007\/s10237-020-01324-5","relation":{},"ISSN":["1617-7959","1617-7940"],"issn-type":[{"value":"1617-7959","type":"print"},{"value":"1617-7940","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,30]]},"assertion":[{"value":"9 October 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 April 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 April 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"There are no conflicts of interest to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}