{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T23:04:44Z","timestamp":1769209484862,"version":"3.49.0"},"reference-count":71,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100010665","name":"H2020 Marie Sklodowska-Curie Actions","doi-asserted-by":"publisher","award":["642458"],"award-info":[{"award-number":["642458"]}],"id":[{"id":"10.13039\/100010665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biomech Model Mechanobiol"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cardiac growth is an important mechanism for the human body to respond to changes in blood flow demand. Being able to predict the development of chronic growth is clinically relevant, but so far models to predict growth have not reached consensus on the stimulus\u2013effect relation. In a previously published study, we modeled cardiac and hemodynamic function through a lumped parameter approach. We evaluated cardiac growth in response to valve disease using various stimulus\u2013effect relations and observed an unphysiological decline pump function. Here we extend that model with a model of hemodynamic feedback that maintains mean arterial pressure and cardiac output through adaptation of peripheral resistance and circulatory unstressed volume. With the combined model, we obtain stable growth and restoration of pump function for most growth laws. We conclude that a mixed combination of stress and strain stimuli to drive cardiac growth is most promising since it (1) reproduces clinical observations on cardiac growth well, (2) requires only a small, clinically realistic adaptation of the properties of the circulatory system and (3) is robust in the sense that results were fairly insensitive to the exact choice of the chosen mechanics loading measure. This finding may be used to guide the choice of growth laws in more complex finite element models of cardiac growth, suitable for predicting the response to spatially varying changes in tissue load. Eventually, the current model may form a basis for a tool to predict patient-specific growth in response to spatially homogeneous changes in tissue load, since it is computationally inexpensive.<\/jats:p>","DOI":"10.1007\/s10237-020-01327-2","type":"journal-article","created":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T10:02:27Z","timestamp":1588327347000},"page":"2111-2126","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Stimulus\u2013effect relations for left ventricular growth obtained with a simple multi-scale model: the influence of hemodynamic feedback"],"prefix":"10.1007","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3249-3167","authenticated-orcid":false,"given":"Emanuele","family":"Rondanina","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter H. M.","family":"Bovendeerd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,5,1]]},"reference":[{"issue":"5","key":"1327_CR1","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/j.amjhyper.2004.02.006","volume":"17","author":"OO Akinboboye","year":"2004","unstructured":"Akinboboye OO, Chou RL, Bergmann SR (2004) Myocardial blood flow and efficiency in concentric and eccentric left ventricular hypertrophy. Am J Hypertens 17(5):433\u2013438. https:\/\/doi.org\/10.1016\/j.amjhyper.2004.02.006","journal-title":"Am J Hypertens"},{"issue":"1","key":"1327_CR2","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/S0006-3495(91)82201-9","volume":"59","author":"T Arts","year":"1991","unstructured":"Arts T, Bovendeerd PHM, Prinzen FW, Reneman RS (1991) Relation between left ventricular cavity pressure and volume and systolic fiber stress and strain in the wall. Biophys J 59(1):93\u2013102. https:\/\/doi.org\/10.1016\/S0006-3495(91)82201-9","journal-title":"Biophys J"},{"issue":"4","key":"1327_CR3","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1016\/S0006-3495(94)80876-8","volume":"66","author":"T Arts","year":"1994","unstructured":"Arts T, Prinzen FW, Snoeckx L, Rijcken JM, Reneman RS (1994) Adaptation of cardiac structure by mechanical feedback in the environment of the cell: a model study. Biophys J 66(4):953\u2013961. https:\/\/doi.org\/10.1016\/S0006-3495(94)80876-8","journal-title":"Biophys J"},{"issue":"4","key":"1327_CR4","doi-asserted-by":"publisher","first-page":"H1943","DOI":"10.1152\/ajpheart.00444.2004","volume":"288","author":"T Arts","year":"2005","unstructured":"Arts T, Delhaas T, Bovendeerd PHM, Verbeek X, Prinzen FW (2005) Adaptation to mechanical load determines shape and properties of heart and circulation: the circadapt model. Am J Physiol Heart Circ Physiol 288(4):H1943\u2013H1954. https:\/\/doi.org\/10.1152\/ajpheart.00444.2004","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"4","key":"1327_CR5","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1111\/echo.14299","volume":"36","author":"A Barbieri","year":"2019","unstructured":"Barbieri A, Bartolacelli Y, Bursi F, Manicardi M, Boriani G (2019a) Remodeling classification system considering left ventricular volume in patients with aortic valve stenosis: association with adverse cardiovascular outcomes. Echocardiography 36(4):639\u2013650. https:\/\/doi.org\/10.1111\/echo.14299","journal-title":"Echocardiography"},{"issue":"1","key":"1327_CR6","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1111\/echo.14190","volume":"36","author":"A Barbieri","year":"2019","unstructured":"Barbieri A, Giubertoni E, Bartolacelli Y, Bursi F, Manicardi M, Boriani G (2019b) New classification of geometric patterns considering left ventricular volume in patients with chronic aortic valve regurgitation: prevalence and association with adverse cardiovascular outcomes. Echocardiography 36(1):38\u201346. https:\/\/doi.org\/10.1111\/echo.14190","journal-title":"Echocardiography"},{"key":"1327_CR7","doi-asserted-by":"publisher","unstructured":"Beard DA, Pettersen KH, Carlson BE, Omholt SW, Bugenhagen SM (2013) A computational analysis of the long-term regulation of arterial pressure. F1000Research 2(208). https:\/\/doi.org\/10.12688\/f1000research.2-208.v2","DOI":"10.12688\/f1000research.2-208.v2"},{"issue":"5","key":"1327_CR8","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1016\/j.jbiomech.2011.11.029","volume":"45","author":"PHM Bovendeerd","year":"2012","unstructured":"Bovendeerd PHM (2012) Modeling of cardiac growth and remodeling of myofiber orientation. J Biomech 45(5):872\u2013881. https:\/\/doi.org\/10.1016\/j.jbiomech.2011.11.029","journal-title":"J Biomech"},{"issue":"12","key":"1327_CR9","doi-asserted-by":"publisher","first-page":"1833","DOI":"10.1007\/s10439-006-9189-2","volume":"34","author":"PHM Bovendeerd","year":"2006","unstructured":"Bovendeerd PHM, Borsje P, Arts T, van De Vosse FN (2006) Dependence of intramyocardial pressure and coronary flow on ventricular loading and contractility: a model study. Ann Biomed Eng 34(12):1833\u20131845. https:\/\/doi.org\/10.1007\/s10439-006-9189-2","journal-title":"Ann Biomed Eng"},{"issue":"4","key":"1327_CR10","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1161\/01.cir.86.4.1099","volume":"86","author":"JD Carroll","year":"1992","unstructured":"Carroll JD, Carroll EP, Feldman T, Ward DM, Lang RM, McGaughey D, Karp RB (1992) Sex-associated differences in left ventricular function in aortic stenosis of the elderly. Circulation 86(4):1099\u20131107. https:\/\/doi.org\/10.1161\/01.cir.86.4.1099","journal-title":"Circulation"},{"issue":"1","key":"1327_CR11","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1152\/physrev.1992.72.1.231","volume":"72","author":"AW Cowley Jr","year":"1992","unstructured":"Cowley AW Jr (1992) Long-term control of arterial blood pressure. Physiol Rev 72(1):231\u2013300. https:\/\/doi.org\/10.1152\/physrev.1992.72.1.231","journal-title":"Physiol Rev"},{"key":"1327_CR12","doi-asserted-by":"publisher","unstructured":"Dallaire F, Sarkola T (2018) Growth of cardiovascular structures from the fetus to the young adult. In: Sex-specific analysis of cardiovascular function. Springer, pp 347\u2013360. https:\/\/doi.org\/10.1007\/978-3-319-77932-4_22","DOI":"10.1007\/978-3-319-77932-4_22"},{"issue":"4","key":"1327_CR13","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1046\/j.1440-1681.2002.03640.x","volume":"29","author":"R Dampney","year":"2002","unstructured":"Dampney R, Coleman M, Fontes M, Hirooka Y, Horiuchi J, Li YW, Polson J, Potts P, Tagawa T (2002) Central mechanisms underlying short-and long-term regulation of the cardiovascular system. Clin Exp Pharmacol Physiol 29(4):261\u2013268. https:\/\/doi.org\/10.1046\/j.1440-1681.2002.03640.x","journal-title":"Clin Exp Pharmacol Physiol"},{"issue":"1","key":"1327_CR14","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1186\/1532-429X-14-50","volume":"14","author":"MR Dweck","year":"2012","unstructured":"Dweck MR, Joshi S, Murigu T, Gulati A, Alpendurada F, Jabbour A, Maceira A, Roussin I, Northridge DB, Kilner PJ et al (2012) Left ventricular remodeling and hypertrophy in patients with aortic stenosis: insights from cardiovascular magnetic resonance. J Cardiovasc Magn Reson 14(1):50. https:\/\/doi.org\/10.1186\/1532-429X-14-50","journal-title":"J Cardiovasc Magn Reson"},{"key":"1327_CR15","doi-asserted-by":"publisher","unstructured":"Folkow B (1978) Cardiovascular structural adaptation; its role in the initiation and maintenance of primary hypertension. https:\/\/doi.org\/10.1042\/cs055003s","DOI":"10.1042\/cs055003s"},{"issue":"6","key":"1327_CR16","doi-asserted-by":"publisher","first-page":"2761","DOI":"10.1161\/01.CIR.90.6.2761","volume":"90","author":"SP Friedrich","year":"1994","unstructured":"Friedrich SP, Lorell BH, Rousseau MF, Hayashida W, Hess OM, Douglas PS, Gordon S, Keighley CS, Benedict C, Krayenbuehl HP (1994) Intracardiac angiotensin-converting enzyme inhibition improves diastolic function in patients with left ventricular hypertrophy due to aortic stenosis. Circulation 90(6):2761\u20132771. https:\/\/doi.org\/10.1161\/01.CIR.90.6.2761","journal-title":"Circulation"},{"issue":"17","key":"1327_CR17","doi-asserted-by":"publisher","first-page":"1733","DOI":"10.1016\/j.jacc.2011.07.022","volume":"58","author":"WH Gaasch","year":"2011","unstructured":"Gaasch WH, Zile MR (2011) Left ventricular structural remodeling in health and disease: with special emphasis on volume, mass, and geometry. J Am Coll Cardiol 58(17):1733\u20131740. https:\/\/doi.org\/10.1016\/j.jacc.2011.07.022","journal-title":"J Am Coll Cardiol"},{"issue":"7","key":"1327_CR18","doi-asserted-by":"publisher","first-page":"1550","DOI":"10.1016\/0735-1097(92)90617-V","volume":"19","author":"A Ganau","year":"1992","unstructured":"Ganau A, Devereux RB, Roman MJ, De Simone G, Pickering TG, Saba PS, Vargiu P, Simongini I, Laragh JH (1992) Patterns of left ventricular hypertrophy and geometric remodeling in essential hypertension. J Am Coll Cardiol 19(7):1550\u20131558. https:\/\/doi.org\/10.1016\/0735-1097(92)90617-V","journal-title":"J Am Coll Cardiol"},{"issue":"3","key":"1327_CR19","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/j.jtbi.2010.04.023","volume":"265","author":"S G\u00f6ktepe","year":"2010","unstructured":"G\u00f6ktepe S, Abilez OJ, Parker KK, Kuhl E (2010) A multiscale model for eccentric and concentric cardiac growth through sarcomerogenesis. J Theor Biol 265(3):433\u2013442. https:\/\/doi.org\/10.1016\/j.jtbi.2010.04.023","journal-title":"J Theor Biol"},{"issue":"5","key":"1327_CR20","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1161\/01.cir.50.5.1025","volume":"50","author":"DJ Goodman","year":"1974","unstructured":"Goodman DJ, Rossen RM, Holloway EL, Alderman EL, Harrison DC (1974) Effect of nitroprusside on left ventricular dynamics in mitral regurgitation. Circulation 50(5):1025\u20131032. https:\/\/doi.org\/10.1161\/01.cir.50.5.1025","journal-title":"Circulation"},{"issue":"1","key":"1327_CR21","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1113\/jphysiol.1972.sp009979","volume":"226","author":"G Goodwin","year":"1972","unstructured":"Goodwin G, McCloskey D, Mitchell J (1972) Cardiovascular and respiratory responses to changes in central command during isometric exercise at constant muscle tension. J Physiol 226(1):173\u2013190. https:\/\/doi.org\/10.1113\/jphysiol.1972.sp009979","journal-title":"J Physiol"},{"key":"1327_CR22","doi-asserted-by":"publisher","first-page":"S27","DOI":"10.1097\/01.hjh.0000165625.79933.9a","volume":"23","author":"P Gosse","year":"2005","unstructured":"Gosse P (2005) Left ventricular hypertrophy as a predictor of cardiovascular risk. J Hypertens 23:S27\u2013S33. https:\/\/doi.org\/10.1097\/01.hjh.0000165625.79933.9a","journal-title":"J Hypertens"},{"issue":"2","key":"1327_CR23","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1161\/01.CIR.63.2.263","volume":"63","author":"BH Greenberg","year":"1981","unstructured":"Greenberg BH, DeMots H, Murphy E, Rahimtoola SH (1981) Mechanism for improved cardiac performance with arteriolar dilators in aortic insufficiency. Circulation 63(2):263\u2013268. https:\/\/doi.org\/10.1161\/01.CIR.63.2.263","journal-title":"Circulation"},{"issue":"4","key":"1327_CR24","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1016\/0002-9343(80)90471-4","volume":"69","author":"W Grossman","year":"1980","unstructured":"Grossman W (1980) Cardiac hypertrophy: useful adaptation or pathologic process? Am J Med 69(4):576\u2013584. https:\/\/doi.org\/10.1016\/0002-9343(80)90471-4","journal-title":"Am J Med"},{"issue":"5","key":"1327_CR25","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1038\/nrn1902","volume":"7","author":"PG Guyenet","year":"2006","unstructured":"Guyenet PG (2006) The sympathetic control of blood pressure. Nat Rev Neurosci 7(5):335. https:\/\/doi.org\/10.1038\/nrn1902","journal-title":"Nat Rev Neurosci"},{"issue":"1\u20132","key":"1327_CR26","doi-asserted-by":"publisher","first-page":"167","DOI":"10.3109\/10641969509087063","volume":"17","author":"P Guyenet","year":"1995","unstructured":"Guyenet P, Koshiya N (1995) Working model of the sympathetic chemoreflex in rats. Clin Exp Hypertens 17(1\u20132):167\u2013179. https:\/\/doi.org\/10.3109\/10641969509087063","journal-title":"Clin Exp Hypertens"},{"issue":"15","key":"1327_CR27","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1056\/NEJM196710122771509","volume":"277","author":"AC Guyton","year":"1967","unstructured":"Guyton AC (1967) Regulation of cardiac output. New Engl J Med 277(15):805\u2013812. https:\/\/doi.org\/10.1056\/NEJM196710122771509","journal-title":"New Engl J Med"},{"issue":"6","key":"1327_CR28","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1161\/01.cir.64.6.1079","volume":"64","author":"AC Guyton","year":"1981","unstructured":"Guyton AC (1981) The relationship of cardiac output and arterial pressure control. Circulation 64(6):1079\u20131088. https:\/\/doi.org\/10.1161\/01.cir.64.6.1079","journal-title":"Circulation"},{"issue":"3","key":"1327_CR29","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1152\/ajplegacy.1955.180.3.463","volume":"180","author":"AC Guyton","year":"1955","unstructured":"Guyton AC, Lindsey AW, Kaufmann BN (1955) Effect of mean circulatory filling pressure and other peripheral circulatory factors on cardiac output. Am J Physiol Legacy Content 180(3):463\u2013468. https:\/\/doi.org\/10.1152\/ajplegacy.1955.180.3.463","journal-title":"Am J Physiol Legacy Content"},{"issue":"1","key":"1327_CR30","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.amjcard.2018.09.015","volume":"123","author":"E Guzzetti","year":"2019","unstructured":"Guzzetti E, Annabi MS, Ong G, Zenses AS, Dagenais F, Tastet L, Salaun E, Shen M, Pich\u00e9 ME, Poirier P, Voisine P, Pibarot P, Clavel MA (2019) Impact of metabolic syndrome and\/or diabetes mellitus on left ventricular mass and remodeling in patients with aortic stenosis before and after aortic valve replacement. Am J Cardiol 123(1):123\u2013131. https:\/\/doi.org\/10.1016\/j.amjcard.2018.09.015","journal-title":"Am J Cardiol"},{"key":"1327_CR31","volume-title":"Guyton and Hall textbook of medical physiology e-Book","author":"JE Hall","year":"2015","unstructured":"Hall JE (2015) Guyton and Hall textbook of medical physiology e-Book. Elsevier Health Sciences, Amsterdam"},{"issue":"2\u20133","key":"1327_CR32","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/0006-8993(75)90418-7","volume":"87","author":"S Hilton","year":"1975","unstructured":"Hilton S (1975) Ways of viewing the central nervous control of the circulation-old and new. Brain Res 87(2\u20133):213\u2013219. https:\/\/doi.org\/10.1016\/0006-8993(75)90418-7","journal-title":"Brain Res"},{"issue":"3","key":"1327_CR33","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.ijge.2011.09.037","volume":"5","author":"YT Huang","year":"2011","unstructured":"Huang YT, Wang CH, Wu YF (2011) Adhering to a tai chi chuan exercise program improves vascular resistance and cardiac function. Int J Gerontol 5(3):150\u2013154. https:\/\/doi.org\/10.1016\/j.ijge.2011.09.037","journal-title":"Int J Gerontol"},{"issue":"03","key":"1327_CR34","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1142\/S0218202502001714","volume":"12","author":"J Humphrey","year":"2002","unstructured":"Humphrey J, Rajagopal K (2002) A constrained mixture model for growth and remodeling of soft tissues. Math Models Methods Appl Sci 12(03):407\u2013430. https:\/\/doi.org\/10.1142\/S0218202502001714","journal-title":"Math Models Methods Appl Sci"},{"issue":"8","key":"1327_CR35","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1007\/BF03013162","volume":"44","author":"E Jacobsohn","year":"1997","unstructured":"Jacobsohn E, Chorn R, O\u2019Connor M (1997) The role of the vasculature in regulating venous return and cardiac output: historical and graphical approach. Can J Anaesth 44(8):849\u2013867. https:\/\/doi.org\/10.1007\/BF03013162","journal-title":"Can J Anaesth"},{"issue":"4","key":"1327_CR36","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1016\/j.jtcvs.2010.11.031","volume":"142","author":"S Kainuma","year":"2011","unstructured":"Kainuma S, Taniguchi K, Toda K, Funatsu T, Kondoh H, Nishino M, Daimon T, Sawa Y (2011) Pulmonary hypertension predicts adverse cardiac events after restrictive mitral annuloplasty for severe functional mitral regurgitation. J Thoracic Cardiovasc Surg 142(4):783\u2013792. https:\/\/doi.org\/10.1016\/j.jtcvs.2010.11.031","journal-title":"J Thoracic Cardiovasc Surg"},{"issue":"10","key":"1327_CR37","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1093\/eurheartj\/ehv680","volume":"37","author":"V Kamperidis","year":"2015","unstructured":"Kamperidis V, Marsan NA, Delgado V, Bax JJ (2015) Left ventricular systolic function assessment in secondary mitral regurgitation: left ventricular ejection fraction vs. speckle tracking global longitudinal strain. Eur Heart J 37(10):811\u2013816. https:\/\/doi.org\/10.1093\/eurheartj\/ehv680","journal-title":"Eur Heart J"},{"issue":"suppl\u20135","key":"1327_CR38","doi-asserted-by":"publisher","first-page":"v65","DOI":"10.1093\/europace\/eus274","volume":"14","author":"RC Kerckhoffs","year":"2012","unstructured":"Kerckhoffs RC, Omens JH, McCulloch AD (2012a) Mechanical discoordination increases continuously after the onset of left bundle branch block despite constant electrical dyssynchrony in a computational model of cardiac electromechanics and growth. Europace 14(suppl\u20135):v65\u2013v72. https:\/\/doi.org\/10.1093\/europace\/eus274","journal-title":"Europace"},{"key":"1327_CR39","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.mechrescom.2011.11.004","volume":"42","author":"RCP Kerckhoffs","year":"2012","unstructured":"Kerckhoffs RCP, Omens JH, McCulloch AD (2012b) A single strain-based growth law predicts concentric and eccentric cardiac growth during pressure and volume overload. Mech Res Commun 42:40\u201350. https:\/\/doi.org\/10.1016\/j.mechrescom.2011.11.004","journal-title":"Mech Res Commun"},{"issue":"1","key":"1327_CR40","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1152\/physrev.1976.56.1.100","volume":"56","author":"HR Kirchheim","year":"1976","unstructured":"Kirchheim HR (1976) Systemic arterial baroreceptor reflexes. Physiol Rev 56(1):100\u2013177. https:\/\/doi.org\/10.1152\/physrev.1976.56.1.100","journal-title":"Physiol Rev"},{"issue":"6","key":"1327_CR41","doi-asserted-by":"publisher","first-page":"H1034","DOI":"10.1152\/ajpheart.1988.254.6.H1034","volume":"254","author":"JP Kleaveland","year":"1988","unstructured":"Kleaveland JP, Kussmaul WG, Vinciguerra T, Diters R, Carabello BA (1988) Volume overload hypertrophy in a closed-chest model of mitral regurgitation. Am J Physiol Heart Circ Physiol 254(6):H1034\u2013H1041. https:\/\/doi.org\/10.1152\/ajpheart.1988.254.6.H1034","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"4","key":"1327_CR42","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1007\/s10237-008-0136-z","volume":"8","author":"W Kroon","year":"2009","unstructured":"Kroon W, Delhaas T, Arts T, Bovendeerd PHM (2009) Computational modeling of volumetric soft tissue growth: application to the cardiac left ventricle. Biomech Model Mechanobiol 8(4):301\u2013309. https:\/\/doi.org\/10.1007\/s10237-008-0136-z","journal-title":"Biomech Model Mechanobiol"},{"issue":"3","key":"1327_CR43","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1093\/ehjci\/jev014","volume":"16","author":"RM Lang","year":"2015","unstructured":"Lang RM, Badano LP, Mor-Avi V, Afilalo J, Armstrong A, Ernande L, Flachskampf FA, Foster E, Goldstein SA, Kuznetsova T et al (2015) Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the american society of echocardiography and the european association of cardiovascular imaging. Eur Heart J Cardiovasc Imaging 16(3):233\u2013271. https:\/\/doi.org\/10.1093\/ehjci\/jev014","journal-title":"Eur Heart J Cardiovasc Imaging"},{"issue":"3","key":"1327_CR44","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1115\/1.2794190","volume":"117","author":"IE Lin","year":"1995","unstructured":"Lin IE, Taber L (1995) A model for stress-induced growth in the developing heart. J Biomech Eng 117(3):343\u2013349. https:\/\/doi.org\/10.1115\/1.2794190","journal-title":"J Biomech Eng"},{"issue":"11","key":"1327_CR45","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1016\/j.jacc.2017.07.736","volume":"70","author":"JW Lloyd","year":"2017","unstructured":"Lloyd JW, Nishimura RA, Borlaug BA, Eleid MF (2017) Hemodynamic response to nitroprusside in patients with low-gradient severe aortic stenosis and preserved ejection fraction. J Am Coll Cardiol 70(11):1339\u20131348. https:\/\/doi.org\/10.1016\/j.jacc.2017.07.736","journal-title":"J Am Coll Cardiol"},{"issue":"5","key":"1327_CR46","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1053\/j.jvca.2007.02.003","volume":"21","author":"S Lorsomradee","year":"2007","unstructured":"Lorsomradee S, Lorsomradee S, Cromheecke S, De Hert SG (2007) Uncalibrated arterial pulse contour analysis versus continuous thermodilution technique: effects of alterations in arterial waveform. J Cardiothoracic Vasc Anesthesia 21(5):636\u2013643. https:\/\/doi.org\/10.1053\/j.jvca.2007.02.003","journal-title":"J Cardiothoracic Vasc Anesthesia"},{"issue":"7","key":"1327_CR47","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1002\/ccd.24303","volume":"80","author":"CA Martinez","year":"2012","unstructured":"Martinez CA, Singh V, Londo\u00f1o JC, Cohen MG, Alfonso CE, O\u2019Neill WW, Heldman AW (2012) Percutaneous retrograde left ventricular assist support for interventions in patients with aortic stenosis and left ventricular dysfunction. Catheter Cardiovasc Interv 80(7):1201\u20131209. https:\/\/doi.org\/10.1002\/ccd.24303","journal-title":"Catheter Cardiovasc Interv"},{"issue":"4","key":"1327_CR48","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1161\/01.HYP.0000121223.44837.de","volume":"43","author":"ML Muiesan","year":"2004","unstructured":"Muiesan ML, Salvetti M, Monteduro C, Bonzi B, Paini A, Viola S, Poisa P, Rizzoni D, Castellano M, Agabiti-Rosei E (2004) Left ventricular concentric geometry during treatment adversely affects cardiovascular prognosis in hypertensive patients. Hypertension 43(4):731\u2013738. https:\/\/doi.org\/10.1161\/01.HYP.0000121223.44837.de","journal-title":"Hypertension"},{"issue":"6","key":"1327_CR49","doi-asserted-by":"publisher","first-page":"2077","DOI":"10.1172\/JCI115238","volume":"87","author":"K Nakano","year":"1991","unstructured":"Nakano K, Swindle MM, Spinale F, Ishihara K, Kanazawa S, Smith A, Biederman RW, Clamp L, Hamada Y, Zile MR (1991) Depressed contractile function due to canine mitral regurgitation improves after correction of the volume overload. J Clin Investig 87(6):2077\u20132086. https:\/\/doi.org\/10.1172\/JCI115238","journal-title":"J Clin Investig"},{"issue":"5\u20136","key":"1327_CR50","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1111\/j.1440-1681.2005.04200.x","volume":"32","author":"JW Osborn","year":"2005","unstructured":"Osborn JW (2005) Hypothesis: set-points and long-term control of arterial pressure. a theoretical argument for a long-term arterial pressure control system in the brain rather than the kidney. Clin Exp Pharmacol Physiol 32(5\u20136):384\u2013393. https:\/\/doi.org\/10.1111\/j.1440-1681.2005.04200.x","journal-title":"Clin Exp Pharmacol Physiol"},{"issue":"10","key":"1327_CR51","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1038\/jhh.2011.24","volume":"25","author":"S Pierdomenico","year":"2011","unstructured":"Pierdomenico S, Di Nicola M, Pierdomenico A, Lapenna D, Cuccurullo F (2011) Cardiovascular risk in subjects with left ventricular concentric remodeling at baseline examination: a meta-analysis. J Hum Hypertens 25(10):585. https:\/\/doi.org\/10.1038\/jhh.2011.24","journal-title":"J Hum Hypertens"},{"issue":"9","key":"1327_CR52","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1136\/hrt.2009.181644","volume":"96","author":"R Rajani","year":"2010","unstructured":"Rajani R, Rimington H, Chambers JB (2010) Treadmill exercise in apparently asymptomatic patients with moderate or severe aortic stenosis: relationship between cardiac index and revealed symptoms. Heart 96(9):689\u2013695. https:\/\/doi.org\/10.1136\/hrt.2009.181644","journal-title":"Heart"},{"issue":"1","key":"1327_CR53","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1111\/j.1475-097X.2004.00582.x","volume":"25","author":"J Remmen","year":"2005","unstructured":"Remmen J, Aengevaeren W, Verheugt F, Bos A, Jansen R (2005) Lower body positive pressure by anti-g garment inflation: a suitable method to increase pulmonary capillary wedge pressure in healthy elderly subjects. Clin Physiol Funct Imaging 25(1):27\u201333. https:\/\/doi.org\/10.1111\/j.1475-097X.2004.00582.x","journal-title":"Clin Physiol Funct Imaging"},{"issue":"20","key":"1327_CR54","doi-asserted-by":"publisher","first-page":"1671","DOI":"10.1136\/heartjnl-2016-309576","volume":"102","author":"JC Rodrigues","year":"2016","unstructured":"Rodrigues JC, Amadu AM, Dastidar AG, Szantho GV, Lyen SM, Godsave C, Ratcliffe LE, Burchell AE, Hart EC, Hamilton MC et al (2016) Comprehensive characterisation of hypertensive heart disease left ventricular phenotypes. Heart 102(20):1671\u20131679. https:\/\/doi.org\/10.1136\/heartjnl-2016-309576","journal-title":"Heart"},{"issue":"5","key":"1327_CR55","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1016\/S0002-8703(97)80016-6","volume":"134","author":"VL Roger","year":"1997","unstructured":"Roger VL, Seward JB, Bailey KR, Oh JK, Mullany CJ (1997) Aortic valve resistance in aortic stenosis: Doppler echocardiographic study and surgical correlation. Am Heart J 134(5):924\u2013929. https:\/\/doi.org\/10.1016\/S0002-8703(97)80016-6","journal-title":"Am Heart J"},{"issue":"1","key":"1327_CR56","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1007\/s10237-019-01209-2","volume":"19","author":"E Rondanina","year":"2020","unstructured":"Rondanina E, Bovendeerd PH (2020) Evaluation of stimulus-effect relations in left ventricular growth using a simple multiscale model. Biomech Model Mechanobiol 19(1):263\u2013273. https:\/\/doi.org\/10.1007\/s10237-019-01209-2","journal-title":"Biomech Model Mechanobiol"},{"issue":"3","key":"1327_CR57","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/0895-7061(94)00000-2","volume":"8","author":"GA Rongen","year":"1995","unstructured":"Rongen GA, Bos WJW, Lenders JW, van Montfrans GA, van Lier HJ, van Goudoever J, Wesseling KH, Thien T (1995) Comparison of intrabrachial and finger blood pressure in healthy elderly volunteers. Am J Hypertens 8(3):237\u2013248. https:\/\/doi.org\/10.1016\/0895-7061(94)00000-2","journal-title":"Am J Hypertens"},{"issue":"11","key":"1327_CR58","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1016\/0002-9149(93)91065-P","volume":"72","author":"C R\u00f6thlisberger","year":"1993","unstructured":"R\u00f6thlisberger C, Sareli P, Wisenbaugh T (1993) Comparison of single-dose nifedipine and captopril for chronic severe aortic regurgitation. Am J Cardiol 72(11):799\u2013804. https:\/\/doi.org\/10.1016\/0002-9149(93)91065-P","journal-title":"Am J Cardiol"},{"issue":"5","key":"1327_CR59","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1113\/jphysiol.2010.201541","volume":"589","author":"TW Secomb","year":"2011","unstructured":"Secomb TW, Pries AR (2011) The microcirculation: physiology at the mesoscale. J Physiol 589(5):1047\u20131052. https:\/\/doi.org\/10.1113\/jphysiol.2010.201541","journal-title":"J Physiol"},{"key":"1327_CR60","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2018.11.013","author":"S Seldrum","year":"2018","unstructured":"Seldrum S, de Meester C, Pierard S, Pasquet A, Lazam S, Boulif J, Vanoverschelde JL, Gerber BL (2018) Assessment of left ventricular reverse remodeling by cardiac mri in patients undergoing repair surgery for severe aortic or mitral regurgitation. J Cardiothoracic Vasc Anesthesia. https:\/\/doi.org\/10.1053\/j.jvca.2018.11.013","journal-title":"J Cardiothoracic Vasc Anesthesia"},{"issue":"6","key":"1327_CR61","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1111\/cpf.12114","volume":"34","author":"J Selmeryd","year":"2014","unstructured":"Selmeryd J, Sundstedt M, Nilsson G, Henriksen E, Hedberg P (2014) Impact of left ventricular geometry on long-term survival in elderly men and women. Clin Physiol Funct Imaging 34(6):442\u2013448. https:\/\/doi.org\/10.1111\/cpf.12114","journal-title":"Clin Physiol Funct Imaging"},{"issue":"24","key":"1327_CR62","doi-asserted-by":"publisher","first-page":"1778","DOI":"10.1056\/NEJM200006153422403","volume":"342","author":"P Spirito","year":"2000","unstructured":"Spirito P, Bellone P, Harris KM, Bernab\u00f2 P, Bruzzi P, Maron BJ (2000) Magnitude of left ventricular hypertrophy and risk of sudden death in hypertrophic cardiomyopathy. New Engl J Med 342(24):1778\u20131785. https:\/\/doi.org\/10.1056\/NEJM200006153422403","journal-title":"New Engl J Med"},{"issue":"1","key":"1327_CR63","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1007\/s10237-002-0002-3","volume":"1","author":"L Taber","year":"2002","unstructured":"Taber L, Chabert S (2002) Theoretical and experimental study of growth and remodeling in the developing heart. Biomech Model Mechanobiol 1(1):29\u201343. https:\/\/doi.org\/10.1007\/s10237-002-0002-3","journal-title":"Biomech Model Mechanobiol"},{"issue":"2","key":"1327_CR64","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1006\/jtbi.1997.0618","volume":"193","author":"LA Taber","year":"1998","unstructured":"Taber LA (1998) Biomechanical growth laws for muscle tissue. J Theor Biol 193(2):201\u2013213. https:\/\/doi.org\/10.1006\/jtbi.1997.0618","journal-title":"J Theor Biol"},{"issue":"3","key":"1327_CR65","doi-asserted-by":"publisher","first-page":"140","DOI":"10.3109\/08037051.2010.481816","volume":"19","author":"N Tuseth","year":"2010","unstructured":"Tuseth N, Cramariuc D, Rieck \u00c5E, Wachtell K, Gerdts E (2010) Asymmetric septal hypertrophy-a marker of hypertension in aortic stenosis (a seas substudy). Blood Pressure 19(3):140\u2013144. https:\/\/doi.org\/10.3109\/08037051.2010.481816","journal-title":"Blood Pressure"},{"issue":"5","key":"1327_CR66","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1016\/j.medengphy.2011.09.004","volume":"34","author":"MB van der Hout-van","year":"2012","unstructured":"van der Hout-van MB, Oei SG, Bovendeerd PHM (2012) A mathematical model for simulation of early decelerations in the cardiotocogram during labor. Med Eng Phys 34(5):579\u2013589. https:\/\/doi.org\/10.1016\/j.medengphy.2011.09.004","journal-title":"Med Eng Phys"},{"key":"1327_CR67","doi-asserted-by":"publisher","unstructured":"van Osta N, van\u00a0der Donk L, Rondanina E, Bovendeerd P (2019) Modeling cardiac growth: an alternative approach. In: International conference on functional imaging and modeling of the heart, pp 258\u2013265. https:\/\/doi.org\/10.1007\/978-3-030-21949-9_28","DOI":"10.1007\/978-3-030-21949-9_28"},{"issue":"4","key":"1327_CR68","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1016\/S0735-1097(84)80349-6","volume":"3","author":"T Wisenbaugh","year":"1984","unstructured":"Wisenbaugh T, Spann JF, Carabello BA (1984) Differences in myocardial performance and load between patients with similar amounts of chronic aortic versus chronic mitral regurgitation. J Am Coll Cardiol 3(4):916\u2013923. https:\/\/doi.org\/10.1016\/S0735-1097(84)80349-6","journal-title":"J Am Coll Cardiol"},{"key":"1327_CR69","doi-asserted-by":"publisher","unstructured":"Witzenburg C, Holmes JW (2019) The impact of hemodynamic reflex compensation following myocardial infarction on subsequent ventricular remodeling. J Biomech Eng 141(9). https:\/\/doi.org\/10.1115\/1.4043867","DOI":"10.1115\/1.4043867"},{"issue":"1\u20132","key":"1327_CR70","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1007\/s10659-017-9631-8","volume":"129","author":"CM Witzenburg","year":"2017","unstructured":"Witzenburg CM, Holmes JW (2017) A comparison of phenomenologic growth laws for myocardial hypertrophy. J Elast 129(1\u20132):257\u2013281. https:\/\/doi.org\/10.1007\/s10659-017-9631-8","journal-title":"J Elast"},{"issue":"2","key":"1327_CR71","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1007\/s12265-018-9793-1","volume":"11","author":"CM Witzenburg","year":"2018","unstructured":"Witzenburg CM, Holmes JW (2018) Predicting the time course of ventricular dilation and thickening using a rapid compartmental model. J Cardiovasc Transl Res 11(2):109\u2013122. https:\/\/doi.org\/10.1007\/s12265-018-9793-1","journal-title":"J Cardiovasc Transl Res"}],"container-title":["Biomechanics and Modeling in Mechanobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10237-020-01327-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10237-020-01327-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10237-020-01327-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T13:06:16Z","timestamp":1620047176000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10237-020-01327-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,1]]},"references-count":71,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["1327"],"URL":"https:\/\/doi.org\/10.1007\/s10237-020-01327-2","relation":{},"ISSN":["1617-7959","1617-7940"],"issn-type":[{"value":"1617-7959","type":"print"},{"value":"1617-7940","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,1]]},"assertion":[{"value":"11 October 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 April 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 May 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}