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Spinal motion segments were divided into two groups: the control (C), and the group in which it was analysed the impact of posterior column in the load-bearing system of the spine\u2014specimens with intact posterior column (IPC) and without posterior column (WPC). To evaluate the structural and mechanical changes, the specimens were tested with simulation of 100,000 compression-flexion load cycles after which it was performed macroscopic analysis. Mechanical properties of the annulus fibrosis (AF) from the anterior and posterior regions of the IVD were tested at the uniaxial tension test. The stiffness coefficient values were statistically 32% higher in the WPC group (110\u00a0N\/mm) than in the IPC (79\u00a0N\/mm). The dynamics of increase in this parameter does not correspond with the course of decrease in height loss. WPC segments revealed clear structural changes that mainly involve the posterior regions of the IVD (bulging and delamination with the effect of separation of collagen fibre bundles). Pathological changes also caused decreases in the value of stress in the AF. The greatest changes in the stress value about group C (7.43\u2009\u00b1\u20094.49\u00a0MPa) were observed in the front part of the fibrous ring, where this value was for IPC 4.49\u2009\u00b1\u20094.78\u00a0MPa and WPC 2.56\u2009\u00b1\u20091.01\u00a0MPa. The research indicates that the applied load model allows simulating damage that occurs in pathological IVD. And the posterior column\u2019s presence affects this change\u2019s dynamics, structural and mechanical properties of AF.<\/jats:p>","DOI":"10.1007\/s10237-021-01505-w","type":"journal-article","created":{"date-parts":[[2021,8,24]],"date-time":"2021-08-24T18:02:38Z","timestamp":1629828158000},"page":"2259-2267","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Effect of overload on changes in mechanical and structural properties of the annulus fibrosus of the intervertebral disc"],"prefix":"10.1007","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9237-7021","authenticated-orcid":false,"given":"Ma\u0142gorzata","family":"\u017bak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Celina","family":"Pezowicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,8,24]]},"reference":[{"issue":"24","key":"1505_CR1","doi-asserted-by":"publisher","first-page":"2690","DOI":"10.1097\/00007632-199512150-00010","volume":"20","author":"ER Acaroglu","year":"1995","unstructured":"Acaroglu ER, Iatridis JC, Setton LA, Foster RJ, Mow VC, Weidenbaum M (1995) Degeneration and aging affect the tensile behavior of human lumbar anulus fibrosus. 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