{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T02:25:20Z","timestamp":1789784720253,"version":"4.0.1"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,1,25]],"date-time":"2022-01-25T00:00:00Z","timestamp":1643068800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,1,25]],"date-time":"2022-01-25T00:00:00Z","timestamp":1643068800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Royal Society-Newton Advanced Fellowship","award":["NA170094"],"award-info":[{"award-number":["NA170094"]}]},{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","award":["EP\/R512540\/1"],"award-info":[{"award-number":["EP\/R512540\/1"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biomech Model Mechanobiol"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>False lumen thrombosis (FLT) in type<jats:italic>B<\/jats:italic>aortic dissection has been associated with the progression of dissection and treatment outcome. Existing computational models mostly assume rigid wall behavior which ignores the effect of flap motion on flow and thrombus formation within the FL. In this study, we have combined a fully coupled fluid\u2013structure interaction (FSI) approach with a shear-driven thrombosis model described by a series of convection\u2013diffusion reaction equations. The integrated FSI-thrombosis model has been applied to an idealized dissection geometry to investigate the interaction between vessel wall motion and growing thrombus. Our simulation results show that wall compliance and flap motion can influence the progression of FLT. The main difference between the rigid and FSI models is the continuous development of vortices near the tears caused by drastic flap motion up to 4.45\u00a0mm. Flap-induced high shear stress and shear rates around tears help to transport activated platelets further to the neighboring region, thus speeding up thrombus formation during the accelerated phase in the FSI models. Reducing flap mobility by increasing the Young\u2019s modulus of the flap slows down the thrombus growth. Compared to the rigid model, the predicted thrombus volume is 25% larger using the FSI-thrombosis model with a relatively mobile flap. Furthermore, our FSI-thrombosis model can capture the gradual effect of thrombus growth on the flow field, leading to flow obstruction in the FL, increased blood viscosity and reduced flap motion. This model is a step closer toward simulating realistic thrombus growth in aortic dissection, by taking into account the effect of intimal flap and vessel wall motion.<\/jats:p>","DOI":"10.1007\/s10237-021-01534-5","type":"journal-article","created":{"date-parts":[[2022,1,25]],"date-time":"2022-01-25T21:02:12Z","timestamp":1643144532000},"page":"261-275","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["An integrated fluid\u2013structure interaction and thrombosis model for type B aortic dissection"],"prefix":"10.1007","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3153-2080","authenticated-orcid":false,"given":"Mei Yan","family":"Chong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boram","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chl\u00f6e Harriet","family":"Armour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Socrates","family":"Dokos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi Chao","family":"Ong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8267-621X","authenticated-orcid":false,"given":"Xiao Yun","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2037-4213","authenticated-orcid":false,"given":"Einly","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,1,25]]},"reference":[{"key":"1534_CR1","doi-asserted-by":"publisher","DOI":"10.1186\/s12938-015-0032-6","author":"M Alimohammadi","year":"2015","unstructured":"Alimohammadi M, Sherwood JM, Karimpour M et al (2015) Aortic dissection simulation models for clinical support: fluid-structure interaction vs. rigid wall models. Biomed Eng Online. https:\/\/doi.org\/10.1186\/s12938-015-0032-6","journal-title":"Biomed Eng Online"},{"issue":"3","key":"1534_CR2","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1177\/1526602820917962","volume":"27","author":"CH Armour","year":"2020","unstructured":"Armour CH, Menichini C, Milinis K, Gibbs RGJ, Xu XY (2020) Location of reentry tears affects false lumen thrombosis in aortic dissection following TEVAR. J Endovasc Ther 27(3):396\u2013404. https:\/\/doi.org\/10.1177\/1526602820917962","journal-title":"J Endovasc Ther"},{"key":"1534_CR3","doi-asserted-by":"crossref","unstructured":"Armour C, Menichini C, Hanna L, Gibbs R, Xu X (2021) Computational modeling of flow and thrombus formation in type B aortic dissection: the influence of flase lumen perfused side branches. Studies in Mechanobiology, Tissue Engineering and Biomaterials (Book chapter accepted, due to be published late 2021).","DOI":"10.1007\/978-3-030-92339-6_2"},{"key":"1534_CR4","doi-asserted-by":"publisher","DOI":"10.1007\/s10237-020-01294-8","author":"K Baumler","year":"2020","unstructured":"Baumler K, Vedula V, Sailer AM et al (2020) Fluid-structure interaction simulations of patient-specific aortic dissection. Biomech Model Mechanobiol. https:\/\/doi.org\/10.1007\/s10237-020-01294-8","journal-title":"Biomech Model Mechanobiol"},{"issue":"2","key":"1534_CR5","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1205\/fbp.05020","volume":"83","author":"AS Bedekar","year":"2005","unstructured":"Bedekar AS, Pant K, Ventikos Y, Sundaram S (2005) A computational model combining vascular biology and haemodynamics for thrombosis prediction in anatomically accurate cerebral aneurysms. Food Bioprod Process 83(2):118\u2013126. https:\/\/doi.org\/10.1205\/fbp.05020","journal-title":"Food Bioprod Process"},{"key":"1534_CR6","doi-asserted-by":"publisher","first-page":"266","DOI":"10.3389\/fphys.2012.00266","volume":"3","author":"J Biasetti","year":"2012","unstructured":"Biasetti J, Spazzini PG, Swedenborg J, Gasser TC (2012) An integrated fluid-chemical model toward modeling the formation of intra-luminal thrombus in abdominal aortic aneurysms. Front Physiol 3:266. https:\/\/doi.org\/10.3389\/fphys.2012.00266","journal-title":"Front Physiol"},{"key":"1534_CR7","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1101\/593780","volume":"71","author":"M Bonfanti","year":"2019","unstructured":"Bonfanti M, Franzetti G, Maritati G et al (2019) Patient-specific haemodynamic simulations of complex aortic dissections informed by commonly available clinical datasets. Med Eng Phys 71:45\u201355. https:\/\/doi.org\/10.1101\/593780","journal-title":"Med Eng Phys"},{"key":"1534_CR8","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1186\/1475-925X-12-65","volume":"12","author":"D Chen","year":"2013","unstructured":"Chen D, M\u00fcller-Eschner M, von Tengg-Kobligk H et al (2013) A patient-specific study of type-B aortic dissection: evaluation of true-false lumen blood exchange. Biomed Eng Online 12:65. https:\/\/doi.org\/10.1186\/1475-925X-12-65","journal-title":"Biomed Eng Online"},{"issue":"5","key":"1534_CR9","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1016\/j.ejvs.2016.07.006","volume":"52","author":"HY Chen","year":"2016","unstructured":"Chen HY, Peelukhana SV, Berwick ZC et al (2016) Fluid-structure interaction simulations of aortic dissection with bench validation. Eur J Vasc Endovasc Surg 52(5):589\u2013595. https:\/\/doi.org\/10.1016\/j.ejvs.2016.07.006","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"1534_CR10","doi-asserted-by":"publisher","DOI":"10.1115\/1.4000964","author":"Z Cheng","year":"2010","unstructured":"Cheng Z, Tan FPP, Riga CV et al (2010) Analysis of flow patterns in a patient-specific aortic dissection model. J Biomech Eng. https:\/\/doi.org\/10.1115\/1.4000964","journal-title":"J Biomech Eng"},{"issue":"12","key":"1534_CR11","doi-asserted-by":"publisher","first-page":"e3399","DOI":"10.1002\/cnm.3399","volume":"36","author":"MY Chong","year":"2020","unstructured":"Chong MY, Gu B, Chan BT et al (2020) Effect of intimal flap motion on flow in acute type B aortic dissection by using fluid-structure interaction. Int J Numer Method Biomed Eng 36(12):e3399. https:\/\/doi.org\/10.1002\/cnm.3399","journal-title":"Int J Numer Method Biomed Eng"},{"issue":"2","key":"1534_CR12","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/S0997-7546(99)80026-0","volume":"18","author":"R Cucitore","year":"1999","unstructured":"Cucitore R, Quadrio M, Baron A (1999) On the effectiveness and limitations of local criteria for the identification of a vortex. Eur J Mech B Fluids 18(2):261\u2013282. https:\/\/doi.org\/10.1016\/S0997-7546(99)80026-0","journal-title":"Eur J Mech B Fluids"},{"key":"1534_CR13","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.ejrad.2008.06.024","volume":"72","author":"M Ganten","year":"2009","unstructured":"Ganten M, Weber T, Tengg-Kobligk VH et al (2009) Motion characterization of aortic wall and intimal flap by ECG-gated CT in patients with chronic B-dissection. Eur J Radiol 72:146\u2013153. https:\/\/doi.org\/10.1016\/j.ejrad.2008.06.024","journal-title":"Eur J Radiol"},{"key":"1534_CR14","first-page":"13","volume":"7","author":"A Jafarinia","year":"2020","unstructured":"Jafarinia A, M\u00fcller TS, Windberger U, Brenn G, Hochrainer T (2020) Blood rheology influence on false lumen thrombosis in type B aortic dissection. J Biomed Eng Biosci 7:13\u201324","journal-title":"J Biomed Eng Biosci"},{"key":"1534_CR15","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1017\/S0022112095000462","volume":"285","author":"J Jeong","year":"2006","unstructured":"Jeong J, Hussain F (2006) On the identification of a vortex. J Fluid Mech 285:69\u201394. https:\/\/doi.org\/10.1017\/S0022112095000462","journal-title":"J Fluid Mech"},{"issue":"2","key":"1534_CR16","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1016\/j.jtcvs.2019.07.091","volume":"160","author":"D Li","year":"2020","unstructured":"Li D, Peng L, Wang Y et al (2020) Predictor of false lumen thrombosis after thoracic endovascular aortic repair for type B dissection. J Thorac Cardiovasc Surg 160(2):360\u2013367. https:\/\/doi.org\/10.1016\/j.jtcvs.2019.07.091","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"1","key":"1534_CR17","doi-asserted-by":"publisher","first-page":"7267","DOI":"10.1038\/s41598-019-43856-6","volume":"9","author":"J Lortz","year":"2019","unstructured":"Lortz J, Papathanasiou M, Rammos C et al (2019) High intimal flap mobility assessed by intravascular ultrasound is associated with better short-term results after TEVAR in chronic aortic dissection. Sci Rep 9(1):7267. https:\/\/doi.org\/10.1038\/s41598-019-43856-6","journal-title":"Sci Rep"},{"issue":"5","key":"1534_CR18","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1007\/s00285-016-0986-4","volume":"73","author":"C Menichini","year":"2016","unstructured":"Menichini C, Xu XY (2016) Mathematical modeling of thrombus formation in idealized models of aortic dissection: initial findings and potential applications. J Math Biol 73(5):1205\u20131226. https:\/\/doi.org\/10.1007\/s00285-016-0986-4","journal-title":"J Math Biol"},{"issue":"124","key":"1534_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1098\/rsif.2016.0759","volume":"13","author":"C Menichini","year":"2016","unstructured":"Menichini C, Cheng Z, Gibbs RG, Xu XY (2016) Predicting false lumen thrombosis in patient-specific models of aortic dissection. J R Soc Interface 13(124):1\u201311. https:\/\/doi.org\/10.1098\/rsif.2016.0759","journal-title":"J R Soc Interface"},{"key":"1534_CR20","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.jbiomech.2017.10.029","volume":"66","author":"C Menichini","year":"2018","unstructured":"Menichini C, Cheng Z, Gibbs RGJ, Xu XY (2018) A computational model for false lumen thrombosis in type B aortic dissection following thoracic endovascular repair. J Biomech 66:36\u201343. https:\/\/doi.org\/10.1016\/j.jbiomech.2017.10.029","journal-title":"J Biomech"},{"issue":"5","key":"1534_CR21","doi-asserted-by":"publisher","first-page":"e2961","DOI":"10.1002\/cnm.2961","volume":"34","author":"WN Naim","year":"2018","unstructured":"Naim WN, Ganesan PB, Sun Z et al (2018) Flow pattern analysis in type B aortic dissection patients after stent-grafting repair: Comparison between complete and incomplete false lumen thrombosis. Int J Numer Method Biomed Eng 34(5):e2961. https:\/\/doi.org\/10.1002\/cnm.2961","journal-title":"Int J Numer Method Biomed Eng"},{"key":"1534_CR22","first-page":"693","volume":"41","author":"P Neofytou","year":"2004","unstructured":"Neofytou P (2004) Comparison of blood rheological models for physiological flow simulation. Biorheology 41:693\u2013714","journal-title":"Biorheology"},{"issue":"1","key":"1534_CR23","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1017\/S0022112072003003","volume":"52","author":"RM Nerem","year":"2006","unstructured":"Nerem RM, Seed WA, Wood NB (2006) An experimental study of the velocity distribution and transition to turbulence in the aorta. J Fluid Mech 52(1):137\u2013160. https:\/\/doi.org\/10.1017\/S0022112072003003","journal-title":"J Fluid Mech"},{"issue":"1","key":"1534_CR24","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.cpc.2008.01.021","volume":"179","author":"R Ouared","year":"2008","unstructured":"Ouared R, Chopard B, Stahl B et al (2008) Thrombosis modeling in intracranial aneurysms: a lattice Boltzmann numerical algorithm. Comput Phys Commun 179(1):128\u2013131. https:\/\/doi.org\/10.1016\/j.cpc.2008.01.021","journal-title":"Comput Phys Commun"},{"issue":"4","key":"1534_CR25","first-page":"319","volume":"11","author":"MH Periayah","year":"2017","unstructured":"Periayah MH, Halim AS, Mat Saad AZ (2017) Mechanism action of platelets and crucial blood coagulation pathways in hemostasis. Int J Hematol Oncol Stem Cell Res 11(4):319\u2013327","journal-title":"Int J Hematol Oncol Stem Cell Res"},{"issue":"6","key":"1534_CR26","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1080\/10255842.2019.1577398","volume":"22","author":"Y Qiao","year":"2019","unstructured":"Qiao Y, Zeng Y, Ding Y et al (2019) Numerical simulation of two-phase non-Newtonian blood flow with fluid-structure interaction in aortic dissection. Comput Methods Biomech Biomed Eng 22(6):620\u2013630. https:\/\/doi.org\/10.1080\/10255842.2019.1577398","journal-title":"Comput Methods Biomech Biomed Eng"},{"issue":"10","key":"1534_CR27","doi-asserted-by":"publisher","first-page":"3058","DOI":"10.1007\/s10439-010-0065-8","volume":"38","author":"VL Rayz","year":"2010","unstructured":"Rayz VL, Boussel L, Ge L et al (2010) Flow residence time and regions of intraluminal thrombus deposition in intracranial aneurysms. Ann Biomed Eng 38(10):3058\u20133069. https:\/\/doi.org\/10.1007\/s10439-010-0065-8","journal-title":"Ann Biomed Eng"},{"issue":"11","key":"1534_CR28","doi-asserted-by":"publisher","first-page":"1793","DOI":"10.1007\/s10439-008-9561-5","volume":"36","author":"VL Rayz","year":"2008","unstructured":"Rayz VL, Boussel L, Lawton MT et al (2008) Numerical modeling of the flow in intracranial aneurysms: prediction of regions prone to thrombus formation. Ann Biomed Eng 36(11):1793\u20131804. https:\/\/doi.org\/10.1007\/s10439-008-9561-5","journal-title":"Ann Biomed Eng"},{"issue":"4","key":"1534_CR29","doi-asserted-by":"publisher","first-page":"e0124011","DOI":"10.1371\/journal.pone.0124011","volume":"10","author":"PA Rudenick","year":"2015","unstructured":"Rudenick PA, Bijnens BH, Segers P, Garc\u00eda-Dorado D, Evangelista A (2015) Assessment of wall elasticity variations on intraluminal haemodynamics in descending aortic dissections using a lumped-parameter model. PLoS One 10(4):e0124011. https:\/\/doi.org\/10.1371\/journal.pone.0124011","journal-title":"PLoS One"},{"issue":"1","key":"1534_CR30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.iccl.2016.08.001","volume":"6","author":"M Tomaiuolo","year":"2017","unstructured":"Tomaiuolo M, Brass LF, Stalker TJ (2017) Regulation of platelet activation and coagulation and its role in vascular injury and arterial thrombosis. Interv Cardiol Clin 6(1):1\u201312. https:\/\/doi.org\/10.1016\/j.iccl.2016.08.001","journal-title":"Interv Cardiol Clin"},{"issue":"3 Supplement","key":"1534_CR31","doi-asserted-by":"publisher","first-page":"S208","DOI":"10.1016\/j.jtcvs.2012.11.048","volume":"145","author":"S Trimarchi","year":"2013","unstructured":"Trimarchi S, Tolenaar JL, Jonker FHW et al (2013) Importance of false lumen thrombosis in type B aortic dissection prognosis. J Thorac Cardiovasc 145(3 Supplement):S208\u2013S212. https:\/\/doi.org\/10.1016\/j.jtcvs.2012.11.048","journal-title":"J Thorac Cardiovasc"},{"issue":"4","key":"1534_CR32","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1056\/NEJMoa063232","volume":"357","author":"TT Tsai","year":"2007","unstructured":"Tsai TT, Evangelista A, Nienaber CA et al (2007) Partial thrombosis of the false lumen in patients with acute type B aortic dissection. N Engl J Med 357(4):349\u2013359. https:\/\/doi.org\/10.1056\/NEJMoa063232","journal-title":"N Engl J Med"},{"issue":"5","key":"1534_CR33","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1016\/j.jbiomech.2010.12.014","volume":"44","author":"KM Tse","year":"2011","unstructured":"Tse KM, Chiu P, Lee HP, Ho P (2011) Investigation of hemodynamics in the development of dissecting aneurysm within patient-specific dissecting aneurismal aortas using computational fluid dynamics (CFD) simulations. J Biomech 44(5):827\u2013836. https:\/\/doi.org\/10.1016\/j.jbiomech.2010.12.014","journal-title":"J Biomech"},{"key":"1534_CR34","doi-asserted-by":"publisher","first-page":"104709","DOI":"10.1016\/j.compbiomed.2021.104709","volume":"136","author":"Y Wang","year":"2021","unstructured":"Wang Y, Luo K, Qiao Y, Fan J (2021) An integrated fluid-chemical model toward modeling the thrombus formation in an idealized model of aortic dissection. Comput Biol Med 136:104709. https:\/\/doi.org\/10.1016\/j.compbiomed.2021.104709","journal-title":"Comput Biol Med"},{"issue":"24","key":"1534_CR35","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1098\/rsif.2007.1202","volume":"5","author":"Z Xu","year":"2008","unstructured":"Xu Z, Chen N, Kamocka MM, Rosen ED, Alber M (2008) A multiscale model of thrombus development. J R Soc Interface 5(24):705\u2013722. https:\/\/doi.org\/10.1098\/rsif.2007.1202","journal-title":"J R Soc Interface"},{"issue":"2","key":"1534_CR36","doi-asserted-by":"publisher","first-page":"e87664","DOI":"10.1371\/journal.pone.0087664","volume":"9","author":"S Yang","year":"2014","unstructured":"Yang S, Li X, Chao B et al (2014) Abdominal aortic intimal flap motion characterization in acute ortic dissection: assessed with retrospective ECG-gated thoracoabdominal aorta dual-source CT angiography. PLoS One 9(2):e87664. https:\/\/doi.org\/10.1371\/journal.pone.0087664","journal-title":"PLoS One"},{"issue":"4","key":"1534_CR37","doi-asserted-by":"publisher","first-page":"e1007709","DOI":"10.1371\/journal.pcbi.1007709","volume":"16","author":"X Zheng","year":"2020","unstructured":"Zheng X, Yazdani A, Li H, Humphrey JD, Karniadakis GE (2020) A three-dimensional phase-field model for multiscale modeling of thrombus biomechanics in blood vessels. PLOS Comput Biol 16(4):e1007709. https:\/\/doi.org\/10.1371\/journal.pcbi.1007709","journal-title":"PLOS Comput Biol"}],"container-title":["Biomechanics and Modeling in Mechanobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10237-021-01534-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10237-021-01534-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10237-021-01534-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,24]],"date-time":"2023-01-24T19:21:39Z","timestamp":1674588099000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10237-021-01534-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,25]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["1534"],"URL":"https:\/\/doi.org\/10.1007\/s10237-021-01534-5","relation":{},"ISSN":["1617-7959","1617-7940"],"issn-type":[{"value":"1617-7959","type":"print"},{"value":"1617-7940","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,25]]},"assertion":[{"value":"7 May 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 October 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 January 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}