{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T09:23:07Z","timestamp":1790846587678,"version":"4.1.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2022,1,9]],"date-time":"2022-01-09T00:00:00Z","timestamp":1641686400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,1,9]],"date-time":"2022-01-09T00:00:00Z","timestamp":1641686400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100000266","name":"engineering and physical sciences research council","doi-asserted-by":"publisher","award":["EP\/R010811\/1"],"award-info":[{"award-number":["EP\/R010811\/1"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]},{"name":"European Research Council (ERC) under the European Union\u2019s Horizon 2020 research and innovation programme","award":["864313"],"award-info":[{"award-number":["864313"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biomech Model Mechanobiol"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Potts shunt (PS) was suggested as palliation for patients with suprasystemic pulmonary arterial hypertension (PAH) and right ventricular (RV) failure. PS, however, can result in poorly understood mortality. Here, a patient-specific geometrical multiscale model of PAH physiology and PS is developed for a paediatric PAH patient with stent-based PS. In the model, 7.6mm-diameter PS produces near-equalisation of the aortic and PA pressures and <jats:inline-formula><jats:alternatives><jats:tex-math>$$Q_p\/Q_s$$<\/jats:tex-math><mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\">\n                  <mml:mrow>\n                    <mml:msub>\n                      <mml:mi>Q<\/mml:mi>\n                      <mml:mi>p<\/mml:mi>\n                    <\/mml:msub>\n                    <mml:mo>\/<\/mml:mo>\n                    <mml:msub>\n                      <mml:mi>Q<\/mml:mi>\n                      <mml:mi>s<\/mml:mi>\n                    <\/mml:msub>\n                  <\/mml:mrow>\n                <\/mml:math><\/jats:alternatives><\/jats:inline-formula> (oxygenated vs deoxygenated blood flow) ratio of 0.72 associated with a 16% decrease of left ventricular (LV) output and 18% increase of RV output. The flow from LV to aortic arch branches increases by 16%, while LV contribution to the lower body flow decreases by 29%. Total flow in the descending aorta (DAo) increases by 18% due to RV contribution through the PS with flow into the distal PA branches decreasing. PS induces 18% increase of RV work due to its larger stroke volume pumped against lower afterload. Nonetheless, larger RV work does not lead to increased RV end-diastolic volume. Three-dimensional flow assessment demonstrates the PS jet impinging with a high velocity and wall shear stress on the opposite DAo wall with the most of the shunt flow being diverted to the DAo. Increasing the PS diameter from 5mm up to 10mm results in a nearly linear increase in post-operative shunt flow and a nearly linear decrease in shunt pressure-drop. In conclusion, this model reasonably represents patient-specific haemodynamics pre- and post-creation of the PS, providing insights into physiology of this complex condition, and presents a predictive tool that could be useful for clinical decision-making regarding suitability for PS in PAH patients with drug-resistant suprasystemic PAH.<\/jats:p>","DOI":"10.1007\/s10237-021-01545-2","type":"journal-article","created":{"date-parts":[[2022,1,9]],"date-time":"2022-01-09T16:02:41Z","timestamp":1641744161000},"page":"471-511","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Multiscale modelling of Potts shunt as a potential palliative treatment for suprasystemic idiopathic pulmonary artery hypertension: a paediatric case study"],"prefix":"10.1007","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2081-308X","authenticated-orcid":false,"given":"Sanjay","family":"Pant","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksander","family":"Sizarov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Knepper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ga\u00ebtan","family":"Gossard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Noferi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Younes","family":"Boudjemline","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Vignon-Clementel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,1,9]]},"reference":[{"issue":"3","key":"1545_CR1","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1007\/s13239-015-0212-3","volume":"6","author":"G Arbia","year":"2015","unstructured":"Arbia G, Corsini C, Baker C, Pennati G, Hsia T-Y, Vignon-Clementel IE (2015) Pulmonary hemodynamics simulations before stage 2 single ventricle surgery: patient-specific parameter identification and clinical data assessment. Cardiovasc Eng Technol 6(3):268\u2013280","journal-title":"Cardiovasc Eng Technol"},{"issue":"1","key":"1545_CR2","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/S0006-3495(91)82201-9","volume":"59","author":"T Arts","year":"1991","unstructured":"Arts T, Bovendeerd PH, Prinzen FW, Reneman RS (1991) Relation between left ventricular cavity pressure and volume and systolic fiber stress and strain in the wall. Biophys J 59(1):93\u2013102","journal-title":"Biophys J"},{"key":"1545_CR3","unstructured":"Baretta A (2014) Patient-specific modeling of the cardiovascular system for surgical planning of single-ventricle defects. PhD thesis, Politecnico di Milano"},{"issue":"3","key":"1545_CR4","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1183\/09031936.00056110","volume":"37","author":"RJ Barst","year":"2011","unstructured":"Barst RJ, Ertel SI, Beghetti M, Ivy DD (2011) Pulmonary arterial hypertension: a comparison between children and adults. Eur Respir J 37(3):665\u2013677","journal-title":"Eur Respir J"},{"issue":"3","key":"1545_CR5","doi-asserted-by":"publisher","first-page":"e105","DOI":"10.1093\/ejcts\/ezu445","volume":"47","author":"AE Baruteau","year":"2014","unstructured":"Baruteau AE, Belli E, Boudjemline Y, Laux D, L\u00e9vy M, Simonneau G, Carotti A, Humbert M, Bonnet D (2014) Palliative potts shunt for the treatment of children with drug-refractory pulmonary arterial hypertension: updated data from the first 24 patients. Eur J Cardio-Thorac Surg 47(3):e105\u2013e110","journal-title":"Eur J Cardio-Thorac Surg"},{"issue":"3","key":"1545_CR6","doi-asserted-by":"publisher","first-page":"e105","DOI":"10.1093\/ejcts\/ezu445","volume":"47","author":"A-E Baruteau","year":"2015","unstructured":"Baruteau A-E, Belli E, Boudjemline Y, Laux D, L\u00e9vy M, Simonneau G, Carotti A, Humbert M, Bonnet D (2015) Palliative potts shunt for the treatment of children with drug-refractory pulmonary arterial hypertension: updated data from the first 24 patients. Eur J Cardio-Thorac Surg 47(3):e105\u2013e110","journal-title":"Eur J Cardio-Thorac Surg"},{"issue":"6","key":"1545_CR7","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1056\/NEJM200402053500623","volume":"350","author":"J Blanc","year":"2004","unstructured":"Blanc J, Vouh\u00e9 P, Bonnet D (2004) Potts shunt in patients with pulmonary hypertension. New Engl J Med 350(6):623\u2013623","journal-title":"New Engl J Med"},{"issue":"2","key":"1545_CR8","first-page":"e18","volume":"6","author":"Y Boudjemline","year":"2013","unstructured":"Boudjemline Y, Patel M, Malekzadeh-Milani S, Szezepanski I, L\u00e9vy M, Bonnet D (2013) Patent ductus arteriosus stenting (transcatheter potts shunt) for palliation of suprasystemic pulmonary arterial hypertension: a case series. Circul Cardiovasc Interv 6(2):e18\u2013e20","journal-title":"Circul Cardiovasc Interv"},{"issue":"9","key":"1545_CR9","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.1016\/j.cjca.2017.06.004","volume":"33","author":"Y Boudjemline","year":"2017","unstructured":"Boudjemline Y, Sizarov A, Malekzadeh-Milani S, Mirabile C, Lenoir M, Khraiche D, L\u00e9vy M, Bonnet D (2017) Safety and feasibility of the transcatheter approach to create a reverse potts shunt in children with idiopathic pulmonary arterial hypertension. Canadian J Cardiol 33(9):1188\u20131196","journal-title":"Canadian J Cardiol"},{"issue":"12","key":"1545_CR10","doi-asserted-by":"publisher","first-page":"1833","DOI":"10.1007\/s10439-006-9189-2","volume":"34","author":"PHM Bovendeerd","year":"2006","unstructured":"Bovendeerd PHM, Borsje P, Arts T, van De Vosse FN (2006) Dependence of intramyocardial pressure and coronary flow on ventricular loading and contractility: a model study. Ann Biomed Eng 34(12):1833\u20131845","journal-title":"Ann Biomed Eng"},{"key":"1545_CR11","first-page":"A7334","volume":"193","author":"D Chemla","year":"2016","unstructured":"Chemla D, Zhu K, Castelain V, Attal P, Humbert M, Herv\u00e9 P, Lau E (2016) Time-constant of the pulmonary arterial windkessel in precapillary pulmonary hypertension: a reappraisal. Am J Respir Crit Care Med 193:A7334","journal-title":"Am J Respir Crit Care Med"},{"issue":"3","key":"1545_CR12","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1097\/01.RVI.0000200061.90658.08","volume":"17","author":"NA Chigogidze","year":"2006","unstructured":"Chigogidze NA, Bilbao J, Avaliani MV, Cherkasov VA, Vivas I, Kolesnik DI (2006) Intervascular anastomoses created by an endovascular approach: technical aspects and initial results in an animal study. J Vasc Interv Radiol 17(3):521\u2013531","journal-title":"J Vasc Interv Radiol"},{"key":"1545_CR13","doi-asserted-by":"publisher","first-page":"1252","DOI":"10.3389\/fphys.2018.01252","volume":"9","author":"T Delhaas","year":"2018","unstructured":"Delhaas T, Koeken Y, Latus H, Apitz C, Schranz D (2018) Potts shunt to be preferred above atrial septostomy in pediatric pulmonary arterial hypertension patients: a modeling study. Frontiers Physiol 9:1252","journal-title":"Frontiers Physiol"},{"issue":"7","key":"1545_CR14","doi-asserted-by":"publisher","first-page":"1411","DOI":"10.1007\/s10439-012-0695-0","volume":"41","author":"JM Dolan","year":"2013","unstructured":"Dolan JM, Kolega J, Meng H (2013) High wall shear stress and spatial gradients in vascular pathology: a review. Ann Biomed Eng 41(7):1411\u20131427","journal-title":"Ann Biomed Eng"},{"issue":"4","key":"1545_CR15","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/j.healun.2013.01.1049","volume":"32","author":"JJ Esch","year":"2013","unstructured":"Esch JJ, Shah PB, Cockrill BA, Farber HW, Landzberg MJ, Mehra MR, Mullen MP, Opotowsky AR, Waxman AB, Lock JE et al (2013) Transcatheter potts shunt creation in patients with severe pulmonary arterial hypertension: initial clinical experience. J Heart Lung Transpl 32(4):381\u2013387","journal-title":"J Heart Lung Transpl"},{"issue":"4","key":"1545_CR16","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.1016\/j.athoracsur.2015.08.068","volume":"101","author":"RM Grady","year":"2016","unstructured":"Grady RM, Eghtesady P (2016) Potts shunt and pediatric pulmonary hypertension: what we have learned. Ann Thorac Surg 101(4):1539\u20131543","journal-title":"Ann Thorac Surg"},{"issue":"20","key":"1545_CR17","doi-asserted-by":"publisher","first-page":"2551","DOI":"10.1016\/j.jacc.2017.03.575","volume":"69","author":"G Hansmann","year":"2017","unstructured":"Hansmann G (2017) Pulmonary hypertension in infants, children, and young adults. J Am College Cardiol 69(20):2551\u20132569","journal-title":"J Am College Cardiol"},{"issue":"25 Supplement","key":"1545_CR18","doi-asserted-by":"publisher","first-page":"D42","DOI":"10.1016\/j.jacc.2013.10.032","volume":"62","author":"MM Hoeper","year":"2013","unstructured":"Hoeper MM, Bogaard HJ, Condliffe R, Frantz R, Khanna D, Kurzyna M, Langleben D, Manes A, Satoh T, Torres F et al (2013) Definitions and diagnosis of pulmonary hypertension. J Am College Cardiol 62(25 Supplement):D42\u2013D50","journal-title":"J Am College Cardiol"},{"issue":"1","key":"1545_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/srep37684","volume":"6","author":"C-H Hsu","year":"2016","unstructured":"Hsu C-H, Roan J-N, Chen J-H, Lam C-F (2016) Functional improvement and regression of medial hypertrophy in the remodeled pulmonary artery after correction of systemic left-to-right shunt. Sci Rep 6(1):1\u201310","journal-title":"Sci Rep"},{"issue":"25 Supplement","key":"1545_CR20","doi-asserted-by":"publisher","first-page":"D117","DOI":"10.1016\/j.jacc.2013.10.028","volume":"62","author":"DD Ivy","year":"2013","unstructured":"Ivy DD, Abman SH, Barst RJ, Berger RMF, Bonnet D, Fleming TR, Haworth SG, Raj JU, Rosenzweig EB, Neick IS et al (2013) Pediatric pulmonary hypertension. J Am College Cardiol 62(25 Supplement):D117\u2013D126","journal-title":"J Am College Cardiol"},{"issue":"2","key":"1545_CR21","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.ijcard.2008.06.078","volume":"133","author":"PJ Kilner","year":"2009","unstructured":"Kilner PJ, Balossino R, Dubini G, Babu-Narayan SV, Taylor AM, Pennati G, Migliavacca F (2009) Pulmonary regurgitation: the effects of varying pulmonary artery compliance, and of increased resistance proximal or distal to the compliance. Int J Cardiol 133(2):157\u2013166","journal-title":"Int J Cardiol"},{"issue":"9","key":"1545_CR22","doi-asserted-by":"publisher","first-page":"091008","DOI":"10.1115\/1.4004996","volume":"133","author":"JF LaDisa","year":"2011","unstructured":"LaDisa JF, Alberto FC, Vignon-Clementel Irene E, Hyun JK, Nan X, Ellwein Laura M, Chan Frandics P, Feinstein Jeffrey A, Taylor Charles A (2011) Computational simulations for aortic coarctation: representative results from a sampling of patients. J Biomech Eng 133(9):091008","journal-title":"J Biomech Eng"},{"issue":"2","key":"1545_CR23","doi-asserted-by":"publisher","first-page":"024501","DOI":"10.1115\/1.4038751","volume":"140","author":"H Lan","year":"2018","unstructured":"Lan H, Updegrove A, Wilson NM, Maher GD, Shadden SC, Marsden A (2018) A re-engineered software interface and workflow for the open-source simvascular cardiovascular modeling package. J Biomech Eng 140(2):024501","journal-title":"J Biomech Eng"},{"issue":"11","key":"1545_CR24","doi-asserted-by":"publisher","first-page":"2234","DOI":"10.1007\/s10439-009-9774-2","volume":"37","author":"J Lumens","year":"2009","unstructured":"Lumens J, Delhaas T, Kirn B, Arts T (2009) Three-wall segment (triseg) model describing mechanics and hemodynamics of ventricular interaction. Ann Biomed Eng 37(11):2234\u20132255","journal-title":"Ann Biomed Eng"},{"issue":"4","key":"1545_CR25","doi-asserted-by":"publisher","first-page":"H1083","DOI":"10.1152\/ajpheart.00607.2010","volume":"299","author":"J Lumens","year":"2010","unstructured":"Lumens J, Blanchard DG, Arts T, Mahmud E, Delhaas T (2010) Left ventricular underfilling and not septal bulging dominates abnormal left ventricular filling hemodynamics in chronic thromboembolic pulmonary hypertension. Am J Physiol-Heart Circulat Physiol 299(4):H1083\u2013H1091","journal-title":"Am J Physiol-Heart Circulat Physiol"},{"issue":"2","key":"1545_CR26","doi-asserted-by":"publisher","first-page":"H259","DOI":"10.1152\/ajpheart.00128.2013","volume":"305","author":"RV Mackenzie Ross","year":"2013","unstructured":"Mackenzie Ross RV, Toshner MR, Soon E, Naeije R, Pepke-Zaba J (2013) Decreased time constant of the pulmonary circulation in chronic thromboembolic pulmonary hypertension. Am J Phys-Heart Circulat Physiol 305(2):H259\u2013H264","journal-title":"Am J Phys-Heart Circulat Physiol"},{"issue":"1","key":"1545_CR27","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.jacc.2014.04.031","volume":"64","author":"E Manders","year":"2014","unstructured":"Manders E, Bogaard H-J, Handoko ML, van\u00a0de Veerdonk MC, Keogh A, Westerhof N, Stienen GJM, Dos\u00a0Remedios CG, Humbert M, Dorfm\u00fcller P et al (2014) Contractile dysfunction of left ventricular cardiomyocytes in patients with pulmonary arterial hypertension. J Am College Cardiol 64(1):28\u201337","journal-title":"J Am College Cardiol"},{"issue":"5","key":"1545_CR28","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1016\/S0021-9290(99)00219-5","volume":"33","author":"F Migliavacca","year":"2000","unstructured":"Migliavacca F, Dubini G, Pennati G, Pietrabissa R, Fumero R, Hsia T-Y, de Leval MR (2000) Computational model of the fluid dynamics in systemic-to-pulmonary shunts. J Biomech 33(5):549\u2013557","journal-title":"J Biomech"},{"issue":"5","key":"1545_CR29","doi-asserted-by":"publisher","first-page":"H2076","DOI":"10.1152\/ajpheart.2001.280.5.H2076","volume":"280","author":"F Migliavacca","year":"2001","unstructured":"Migliavacca F, Pennati G, Dubini G, Fumero R, Pietrabissa R, Urcelay G, Bove EL, Hsia T-Y, de Leval MR (2001) Modeling of the norwood circulation: effects of shunt size, vascular resistances, and heart rate. Am J Phys-Heart Circulat Physiol 280(5):H2076\u2013H2086","journal-title":"Am J Phys-Heart Circulat Physiol"},{"key":"1545_CR30","unstructured":"Mimics Innovation Suite kernel description. https:\/\/www.materialise.com\/en\/medical\/mimics-innovation-suite-22. Accessed 26 Dec 2019"},{"key":"1545_CR31","doi-asserted-by":"crossref","unstructured":"Moghadam ME, Vignon-Clementel IE, Figliola R, Marsden AL, (2013) Modeling of\u00a0Congenital Hearts Alliance (MOCHA)\u00a0Investigators, et\u00a0al. A modular numerical method for implicit 0d\/3d coupling in cardiovascular finite element simulations. J Comput Phys, 244:63\u201379","DOI":"10.1016\/j.jcp.2012.07.035"},{"issue":"3","key":"1545_CR32","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1007\/s00466-011-0599-0","volume":"48","author":"ME Moghadam","year":"2011","unstructured":"Moghadam ME, Bazilevs Y, Hsia T-Y, Vignon-Clementel IE, Marsden AL et al (2011) A comparison of outlet boundary treatments for prevention of backflow divergence with relevance to blood flow simulations. Comput Mech 48(3):277\u2013291","journal-title":"Comput Mech"},{"issue":"6\u20137","key":"1545_CR33","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1002\/cnm.1466","volume":"28","author":"JP Mynard","year":"2012","unstructured":"Mynard JP, Davidson MR, Penny DJ, Smolich JJ (2012) A simple, versatile valve model for use in lumped parameter and one-dimensional cardiovascular models. Int J Numer Methods Biomed Eng 28(6\u20137):626\u2013641","journal-title":"Int J Numer Methods Biomed Eng"},{"issue":"12","key":"1545_CR34","doi-asserted-by":"publisher","first-page":"1614","DOI":"10.1002\/cnm.2692","volume":"30","author":"Sanjay Pant","year":"2014","unstructured":"Pant Sanjay, Fabr\u00e8ges Benoit, Gerbeau J-F, Vignon-Clementel IE (2014) A methodological paradigm for patient-specific multi-scale cfd simulations: from clinical measurements to parameter estimates for individual analysis. Int J Numer Methods Biomed Eng 30(12):1614\u20131648","journal-title":"Int J Numer Methods Biomed Eng"},{"issue":"126","key":"1545_CR35","doi-asserted-by":"publisher","first-page":"20160513","DOI":"10.1098\/rsif.2016.0513","volume":"14","author":"S Pant","year":"2017","unstructured":"Pant S, Corsini C, Baker C, Hsia T-Y, Pennati G, Vignon-Clementel IE (2017) Inverse problems in reduced order models of cardiovascular haemodynamics: aspects of data assimilation and heart rate variability. J Royal Soc Interface 14(126):20160513","journal-title":"J Royal Soc Interface"},{"key":"1545_CR36","doi-asserted-by":"crossref","unstructured":"Pant S, Corsini C, Baker C, Hsia T-Y, Pennati G, Vignon-Clementel I, Modeling of\u00a0Congenital Hearts Alliance (MOCHA)\u00a0Investigators, et\u00a0al. Data assimilation and modelling of patient-specific single-ventricle physiology with and without valve regurgitation. J Biomech, 49(11):2162\u20132173, 2016","DOI":"10.1016\/j.jbiomech.2015.11.030"},{"key":"1545_CR37","doi-asserted-by":"crossref","unstructured":"Pant S, Fabr\u00e8ges B, Gerbeau J-F, Vignon-Clementel IE (2013). A multiscale filtering-based parameter estimation method for patient-specific coarctation simulations in rest and exercise. In: international workshop on statistical atlases and computational models of the heart, pages 102\u2013109. Springer","DOI":"10.1007\/978-3-642-54268-8_12"},{"issue":"11","key":"1545_CR38","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1001\/jama.1946.02870460017005","volume":"132","author":"Willis J Potts","year":"1946","unstructured":"Potts Willis J, Smith Sidney, Gibson Stanley (1946) Anastomosis of the aorta to a pulmonary artery: certain types in congenital heart disease. J Am Med Assoc 132(11):627\u2013631","journal-title":"J Am Med Assoc"},{"issue":"1","key":"1545_CR39","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1152\/jappl.1998.84.1.303","volume":"84","author":"RG Presson Jr","year":"1998","unstructured":"Presson RG Jr, Audi SH, Hanger CC, Zenk GM, Sidner RA, Linehan JH, Wagner WW Jr, Dawson CA (1998) Anatomic distribution of pulmonary vascular compliance. J Appl Physiol 84(1):303\u2013310","journal-title":"J Appl Physiol"},{"issue":"3","key":"1545_CR40","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1007\/s00366-008-0095-0","volume":"24","author":"O Sahni","year":"2008","unstructured":"Sahni O, Jansen KE, Shephard MS, Taylor CA, Beall MW (2008) Adaptive boundary layer meshing for viscous flow simulations. Eng Comput 24(3):267","journal-title":"Eng Comput"},{"issue":"6","key":"1545_CR41","doi-asserted-by":"publisher","first-page":"1800","DOI":"10.1002\/jmri.26554","volume":"49","author":"M Sch\u00e4fer","year":"2019","unstructured":"Sch\u00e4fer M, Frank BS, Ivy DD, Wilson N, Morgan GJ, Barker AJ, Browne LP, Mitchell MB, Truong U (2019) Close look at the potts shunt flow hemodynamics in a patient with severe pulmonary hypertension: 4d-flow mri evaluation. J Magnet Reson Imaging JMRI 49(6):1800\u20131802","journal-title":"J Magnet Reson Imaging JMRI"},{"issue":"1","key":"1545_CR42","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/1475-925X-10-33","volume":"10","author":"Y Shi","year":"2011","unstructured":"Shi Y, Lawford P, Hose R (2011) Review of zero-d and 1-d models of blood flow in the cardiovascular system. Biomed Eng Online 10(1):33","journal-title":"Biomed Eng Online"},{"key":"1545_CR43","doi-asserted-by":"publisher","first-page":"668902","DOI":"10.3389\/fphar.2021.668902","volume":"12","author":"T Shu","year":"2021","unstructured":"Shu T, Huaqiao Chen L, Wang WW, Feng P, Xiang R, Wen L, Huang W (2021) The efficacy and safety of pulmonary vasodilators in pediatric pulmonary hypertension (ph): a systematic review and meta-analysis. Frontiers Pharmacol 12:668902","journal-title":"Frontiers Pharmacol"},{"issue":"2","key":"1545_CR44","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1145\/2629697","volume":"41","author":"Hang Si","year":"2015","unstructured":"Si Hang (2015) Tetgen, a delaunay-based quality tetrahedral mesh generator. ACM Trans Math Softw (TOMS) 41(2):11","journal-title":"ACM Trans Math Softw (TOMS)"},{"issue":"21","key":"1545_CR45","doi-asserted-by":"publisher","first-page":"1735","DOI":"10.1136\/heartjnl-2016-309352","volume":"102","author":"A Sizarov","year":"2016","unstructured":"Sizarov A, Raimondi F, Bonnet D, Boudjemline Y (2016) Vascular anatomy in children with pulmonary hypertension regarding the transcatheter potts shunt. Heart 102(21):1735\u20131741","journal-title":"Heart"},{"issue":"8","key":"1545_CR46","doi-asserted-by":"publisher","first-page":"2635","DOI":"10.1007\/s10439-010-0011-9","volume":"38","author":"RL Spilker","year":"2010","unstructured":"Spilker RL, Taylor CA (2010) Tuning multidomain hemodynamic simulations to match physiological measurements. Ann Biomed Eng 38(8):2635\u20132648","journal-title":"Ann Biomed Eng"},{"issue":"4","key":"1545_CR47","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1007\/s10439-006-9240-3","volume":"35","author":"RL Spilker","year":"2007","unstructured":"Spilker RL, Feinstein JA, Parker DW, Reddy VM, Taylor CA (2007) Morphometry-based impedance boundary conditions for patient-specific modeling of blood flow in pulmonary arteries. Ann Biomed Eng 35(4):546\u2013559","journal-title":"Ann Biomed Eng"},{"key":"1545_CR48","doi-asserted-by":"crossref","unstructured":"Troianowski G, Taylor CA, Feinstein JA, Vignon-Clementel IE (2011) Three-dimensional simulations in glenn patients: clinically based boundary conditions, hemodynamic results and sensitivity to input data. J Biomech Eng, 133(11)","DOI":"10.1115\/1.4005377"},{"issue":"3","key":"1545_CR49","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1007\/s10439-016-1762-8","volume":"45","author":"Adam Updegrove","year":"2017","unstructured":"Updegrove Adam, Wilson Nathan M, Merkow Jameson, Lan Hongzhi, Marsden Alison L, Shadden Shawn C (2017) Simvascular: an open source pipeline for cardiovascular simulation. Ann Biomed Eng 45(3):525\u2013541","journal-title":"Ann Biomed Eng"},{"issue":"5","key":"1545_CR50","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1007\/s10237-016-0766-5","volume":"15","author":"W Yang","year":"2016","unstructured":"Yang W, Feinstein JA, Vignon-Clementel IE (2016) Adaptive outflow boundary conditions improve post-operative predictions after repair of peripheral pulmonary artery stenosis. Biomech Model Mechanobiol 15(5):1345\u20131353","journal-title":"Biomech Model Mechanobiol"}],"container-title":["Biomechanics and Modeling in Mechanobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10237-021-01545-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10237-021-01545-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10237-021-01545-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T19:17:20Z","timestamp":1666725440000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10237-021-01545-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,9]]},"references-count":50,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["1545"],"URL":"https:\/\/doi.org\/10.1007\/s10237-021-01545-2","relation":{},"ISSN":["1617-7959","1617-7940"],"issn-type":[{"value":"1617-7959","type":"print"},{"value":"1617-7940","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,9]]},"assertion":[{"value":"21 July 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 December 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 January 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 March 2022","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Update","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The missing funding information \u201cOpen Access funding enabled and organized by Projekt DEAL\u201d and \u201cEuropean Research Council (ERC) under the European Union\u2019s Horizon 2020 research and innovation programme (Grant agreement No. 864313)\u201d are included.","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}}]}}