{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T16:03:42Z","timestamp":1769270622141,"version":"3.49.0"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2022,1,29]],"date-time":"2022-01-29T00:00:00Z","timestamp":1643414400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,1,29]],"date-time":"2022-01-29T00:00:00Z","timestamp":1643414400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100000038","name":"natural sciences and engineering research council","doi-asserted-by":"crossref","award":["Discovery Grant"],"award-info":[{"award-number":["Discovery Grant"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biomech Model Mechanobiol"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1007\/s10237-021-01551-4","type":"journal-article","created":{"date-parts":[[2022,1,29]],"date-time":"2022-01-29T00:02:43Z","timestamp":1643414563000},"page":"605-614","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Lithium chloride-induced primary cilia recovery enhances biosynthetic response of chondrocytes to mechanical stimulation"],"prefix":"10.1007","volume":"21","author":[{"given":"Arianna","family":"Soave","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Loraine L. Y.","family":"Chiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aisha","family":"Momin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen D.","family":"Waldman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,1,29]]},"reference":[{"issue":"1","key":"1551_CR1","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1007\/s00018-002-8400-3","volume":"59","author":"T Aigner","year":"2002","unstructured":"Aigner T, McKenna L (2002) Molecular pathology and pathobiology of osteoarthritic cartilage. Cell Mol Life Sci 59(1):5\u201318. https:\/\/doi.org\/10.1007\/s00018-002-8400-3","journal-title":"Cell Mol Life Sci"},{"issue":"6","key":"1551_CR2","doi-asserted-by":"publisher","first-page":"724","DOI":"10.3109\/17453670903413111","volume":"80","author":"K Ando","year":"2009","unstructured":"Ando K, Imai S, Isoya E et al (2009) Effect of dynamic compressive loading and its combination with a growth factor on the chondrocytic phenotype of 3-dimensional scaffold-embedded chondrocytes. Acta Orthop 80(6):724\u2013733. https:\/\/doi.org\/10.3109\/17453670903413111","journal-title":"Acta Orthop"},{"issue":"6","key":"1551_CR3","doi-asserted-by":"publisher","first-page":"579","DOI":"10.3899\/jrheum.180147","volume":"46","author":"EM Badley","year":"2019","unstructured":"Badley EM, Goulart CM, Millstone DB, Perruccio AV (2019) An update on arthritis in Canada-National and provincial data regarding the past, present, and future. J Rheumatol 46(6):579\u2013586. https:\/\/doi.org\/10.3899\/jrheum.180147","journal-title":"J Rheumatol"},{"issue":"2","key":"1551_CR4","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1016\/s0021-9258(19)52382-1","volume":"196","author":"H Bostrom","year":"1952","unstructured":"Bostrom H, Mansson B (1952) On the enzymatic exchange of the sulfate group of chondroitinsulfuric acid in slices of cartilage. J Biol Chem 196(2):483\u2013488. https:\/\/doi.org\/10.1016\/s0021-9258(19)52382-1","journal-title":"J Biol Chem"},{"issue":"2","key":"1551_CR5","doi-asserted-by":"publisher","first-page":"E21","DOI":"10.1111\/aor.12199","volume":"38","author":"JM Brenner","year":"2014","unstructured":"Brenner JM, Ventura NM, Tse MY et al (2014) Implantation of scaffold-free engineered cartilage constructs in a rabbit model for chondral resurfacing. Artif Organs 38(2):E21-32. https:\/\/doi.org\/10.1111\/aor.12199","journal-title":"Artif Organs"},{"issue":"4","key":"1551_CR6","doi-asserted-by":"publisher","first-page":"1497","DOI":"10.1242\/jcs.108.4.1497","volume":"108","author":"MD Buschmann","year":"1995","unstructured":"Buschmann MD, Gluzband YA, Grodzinsky AJ, Hunziker EB (1995) Mechanical compression modulates matrix biosynthesis in chondrocyte\/agarose culture. J Cell Sci 108(4):1497\u20131508. https:\/\/doi.org\/10.1242\/jcs.108.4.1497","journal-title":"J Cell Sci"},{"issue":"10","key":"1551_CR7","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1016\/j.joca.2012.06.016","volume":"20","author":"MMJ Caron","year":"2012","unstructured":"Caron MMJ, Emans PJ, Coolsen MME et al (2012) Redifferentiation of dedifferentiated human articular chondrocytes: comparison of 2D and 3D cultures. Osteoarthr Cartil 20(10):1170\u20131178. https:\/\/doi.org\/10.1016\/j.joca.2012.06.016","journal-title":"Osteoarthr Cartil"},{"key":"1551_CR8","doi-asserted-by":"publisher","first-page":"58","DOI":"10.22203\/eCM.v009a08","volume":"9","author":"KH Chua","year":"2005","unstructured":"Chua KH, Aminuddin BS, Fuzina NH, Ruszymah BHI (2005) Insulin-transferrin-selenium prevent human chondrocyte dedifferentiation and promote the formation of high quality tissue engineered human hyaline cartilage. Eur Cell Mater 9:58\u201367","journal-title":"Eur Cell Mater"},{"issue":"3","key":"1551_CR9","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1007\/s12195-009-0077-3","volume":"2","author":"EM Darling","year":"2009","unstructured":"Darling EM, Pritchett PE, Evans BA, Superfine R, Zauscher S, Guilak F (2009) Mechanical properties and gene expression of chondrocytes on micropatterned substrates following dedifferentiation in monolayer. Cell Mol Bioeng 2(3):395\u2013404. https:\/\/doi.org\/10.1007\/s12195-009-0077-3","journal-title":"Cell Mol Bioeng"},{"issue":"3","key":"1551_CR10","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1016\/j.joca.2007.07.014","volume":"16","author":"RHJ Das","year":"2008","unstructured":"Das RHJ, Jahr H, Verhaar JAN, van der Linden JC, van Osch GJVM, Weinans H (2008) In vitro expansion affects the response of chondrocytes to mechanical stimulation. Osteoarthr Cartil 16(3):385\u2013391. https:\/\/doi.org\/10.1016\/j.joca.2007.07.014","journal-title":"Osteoarthr Cartil"},{"key":"1551_CR11","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17020188","author":"ME Deren","year":"2016","unstructured":"Deren ME, Yang X, Guan Y, Chen Q (2016) Biological and chemical removal of primary cilia affects mechanical activation of chondrogenesis markers in chondroprogenitors and hypertrophic chondrocytes. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms17020188","journal-title":"Int J Mol Sci."},{"issue":"4","key":"1551_CR12","doi-asserted-by":"publisher","first-page":"1672","DOI":"10.1007\/s10439-010-9917-5","volume":"38","author":"JCY Fan","year":"2010","unstructured":"Fan JCY, Waldman SD (2010) The effect of intermittent static biaxial tensile strains on tissue engineered cartilage. Ann Biomed Eng 38(4):1672\u20131682. https:\/\/doi.org\/10.1007\/s10439-010-9917-5","journal-title":"Ann Biomed Eng"},{"issue":"7","key":"1551_CR13","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.1016\/j.joca.2019.03.003","volume":"27","author":"S Fu","year":"2019","unstructured":"Fu S, Thompson CL, Ali A et al (2019) Mechanical loading inhibits cartilage inflammatory signalling via an HDAC6 and IFT-dependent mechanism regulating primary cilia elongation. Osteoarthr Cartil 27(7):1064\u20131074. https:\/\/doi.org\/10.1016\/j.joca.2019.03.003","journal-title":"Osteoarthr Cartil"},{"issue":"2","key":"1551_CR14","doi-asserted-by":"publisher","first-page":"301","DOI":"10.3892\/ijmm.17.2.301","volume":"17","author":"UR Goessler","year":"2006","unstructured":"Goessler UR, Bieback K, Bugert P et al (2006) In vitro analysis of integrin expression during chondrogenic differentiation of mesenchymal stem cells and chondrocytes upon dedifferentiation in cell culture. Int J Mol Med 17(2):301\u2013307. https:\/\/doi.org\/10.3892\/ijmm.17.2.301","journal-title":"Int J Mol Med"},{"issue":"s1","key":"1551_CR15","doi-asserted-by":"publisher","first-page":"S54","DOI":"10.1111\/j.1440-1614.1999.00669.x","volume":"33","author":"FK Goodwin","year":"1999","unstructured":"Goodwin FK, Ghaemi SN (1999) The impact of the discovery of lithium on psychiatric thought and practice in the USA and Europe. Aust N Z J Psychiatry 33(s1):S54\u2013S64. https:\/\/doi.org\/10.1111\/j.1440-1614.1999.00669.x","journal-title":"Aust N Z J Psychiatry"},{"issue":"11","key":"1551_CR16","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0143865","volume":"10","author":"S Guidotti","year":"2015","unstructured":"Guidotti S, Minguzzi M, Platano D et al (2015) Lithium chloride dependent glycogen synthase kinase 3 inactivation links oxidative DNA damage, hypertrophy and senescence in human articular chondrocytes and reproduces chondrocyte phenotype of obese osteoarthritis patients. PLoS ONE 10(11):e0143865. https:\/\/doi.org\/10.1371\/journal.pone.0143865","journal-title":"PLoS ONE"},{"key":"1551_CR17","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/S0070-2153(08)00811-9","volume":"85","author":"CJ Haycraft","year":"2008","unstructured":"Haycraft CJ, Serra R (2008) Chapter 11 Cilia involvement in patterning and maintenance of the skeleton. Curr Top Dev Biol. 85:303\u2013332. https:\/\/doi.org\/10.1016\/S0070-2153(08)00811-9","journal-title":"Curr Top Dev Biol."},{"issue":"2","key":"1551_CR18","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1002\/1097-4644(20010501)81:2<368::AID-JCB1051>3.0.CO;2-J","volume":"81","author":"M Jakob","year":"2001","unstructured":"Jakob M, D\u00e9marteau O, Sch\u00e4fer D et al (2001) Specific growth factors during the expansion and redifferentiation of adult human articular chondrocytes enhance chondrogenesis and cartilaginous tissue formation in vitro. J Cell Biochem 81(2):368\u2013377. https:\/\/doi.org\/10.1002\/1097-4644(20010501)81:2%3c368::AID-JCB1051%3e3.0.CO;2-J","journal-title":"J Cell Biochem"},{"key":"1551_CR19","first-page":"10","volume":"2","author":"JA Kaupp","year":"2012","unstructured":"Kaupp JA, Weber JF, Waldman SD (2012) Mechanical Stimulation of Chondrocyte-agarose Hydrogels. J Vis Exp 2:10","journal-title":"J Vis Exp"},{"issue":"7291","key":"1551_CR20","doi-asserted-by":"publisher","first-page":"1048","DOI":"10.1038\/nature08895","volume":"464","author":"J Kim","year":"2010","unstructured":"Kim J, Lee JE, Heynen-Genel S et al (2010) Functional genomic screen for modulators of ciliogenesis and cilium length. Nature 464(7291):1048\u20131051. https:\/\/doi.org\/10.1038\/nature08895","journal-title":"Nature"},{"issue":"10","key":"1551_CR21","doi-asserted-by":"publisher","first-page":"2817","DOI":"10.1089\/ten.tea.2008.0357","volume":"15","author":"JD Kisiday","year":"2009","unstructured":"Kisiday JD, Frisbie DD, McIlwraith CW, Grodzinsky AJ (2009) Dynamic compression stimulates proteoglycan synthesis by mesenchymal stem cells in the absence of chondrogenic cytokines. Tissue Eng Part A 15(10):2817\u20132824. https:\/\/doi.org\/10.1089\/ten.tea.2008.0357","journal-title":"Tissue Eng Part A"},{"issue":"9","key":"1551_CR22","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1016\/S1350-4533(98)00080-0","volume":"20","author":"MM Knight","year":"1998","unstructured":"Knight MM, Ghori SA, Lee DA, Bader DL (1998) Measurement of the deformation of isolated chondrocytes in agarose subjected to cyclic compression. Med Eng Phys 20(9):684\u2013688. https:\/\/doi.org\/10.1016\/S1350-4533(98)00080-0","journal-title":"Med Eng Phys"},{"issue":"8","key":"1551_CR23","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.1016\/j.jbiomech.2005.04.006","volume":"39","author":"MM Knight","year":"2006","unstructured":"Knight MM, Toyoda T, Lee DA, Bader DL (2006) Mechanical compression and hydrostatic pressure induce reversible changes in actin cytoskeletal organisation in chondrocytes in agarose. J Biomech 39(8):1547\u20131551. https:\/\/doi.org\/10.1016\/j.jbiomech.2005.04.006","journal-title":"J Biomech"},{"issue":"2","key":"1551_CR24","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1111\/j.1469-7580.2008.01021.x","volume":"214","author":"MM Knight","year":"2009","unstructured":"Knight MM, Mcglashan SR, Garcia M, Jensen CG, Poole CA (2009) Articular chondrocytes express connexin 43 hemichannels and P2 receptors-a putative mechanoreceptor complex involving the primary cilium? J Anat 214(2):275\u2013283. https:\/\/doi.org\/10.1111\/j.1469-7580.2008.01021.x","journal-title":"J Anat"},{"key":"1551_CR25","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1002\/0470867973.ch5","volume":"249","author":"JH Lee","year":"2003","unstructured":"Lee JH, Kisiday J, Grodzinsky AJ, Goldstein CK (2003) Tissue-engineered versus native cartilage: linkage between cellular mechano-transduction and biomechanical properties. Novartis Found Symp 249:52\u201369. https:\/\/doi.org\/10.1002\/0470867973.ch5","journal-title":"Novartis Found Symp"},{"issue":"2","key":"1551_CR26","first-page":"364","volume":"56","author":"F Mallein-Gerin","year":"1991","unstructured":"Mallein-Gerin F, Garrone R, Van der Rest M (1991) Proteoglycan and collagen synthesis are correlated with actin organization in dedifferentiating chondrocytes. Eur J Cell Biol 56(2):364\u2013373","journal-title":"Eur J Cell Biol"},{"issue":"3","key":"1551_CR27","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1115\/1.429656","volume":"122","author":"RL Mauck","year":"2000","unstructured":"Mauck RL, Soltz MA, Wang CCB et al (2000) Functional tissue engineering of articular cartilage through dynamic loading of chondrocyte-seeded agarose gels. J Biomech Eng 122(3):252\u2013260. https:\/\/doi.org\/10.1115\/1.429656","journal-title":"J Biomech Eng"},{"issue":"12","key":"1551_CR28","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1016\/j.joca.2003.08.006","volume":"11","author":"RL Mauck","year":"2003","unstructured":"Mauck RL, Wang CCB, Oswald ES, Ateshian GA, Hung CT (2003) The role of cell seeding density and nutrient supply for articular cartilage tissue engineering with deformational loading. Osteoarthr Cartil 11(12):879\u2013890. https:\/\/doi.org\/10.1016\/j.joca.2003.08.006","journal-title":"Osteoarthr Cartil"},{"issue":"8","key":"1551_CR29","doi-asserted-by":"publisher","first-page":"2013","DOI":"10.1002\/dvdy.21501","volume":"237","author":"SR McGlashan","year":"2008","unstructured":"McGlashan SR, Cluett EC, Jensen CG, Poole CA (2008) Primary Cilia in osteoarthritic chondrocytes: from chondrons to clusters. Dev Dyn 237(8):2013\u20132020. https:\/\/doi.org\/10.1002\/dvdy.21501","journal-title":"Dev Dyn"},{"issue":"5","key":"1551_CR30","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1042\/cbi20090094","volume":"34","author":"SR McGlashan","year":"2010","unstructured":"McGlashan SR, Knight MM, Chowdhury TT et al (2010) Mechanical loading modulates chondrocyte primary cilia incidence and length. Cell Biol Int 34(5):441\u2013446. https:\/\/doi.org\/10.1042\/cbi20090094","journal-title":"Cell Biol Int"},{"issue":"7","key":"1551_CR31","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1053\/joca.2002.0794","volume":"10","author":"KB McGowan","year":"2002","unstructured":"McGowan KB, Kurtis MS, Lottman LM, Watson D, Sah RL (2002) Biochemical quantification of DNA in human articular and septal cartilage using PicoGreen\u00ae and Hoechst 33258. Osteoarthr Cartil 10(7):580\u2013587. https:\/\/doi.org\/10.1053\/joca.2002.0794","journal-title":"Osteoarthr Cartil"},{"issue":"9","key":"1551_CR32","doi-asserted-by":"publisher","first-page":"2091","DOI":"10.1002\/1529-0131(200009)43:9<2091::AID-ANR21>3.0.CO;2-C","volume":"43","author":"SJ Millward-Sadler","year":"2000","unstructured":"Millward-Sadler SJ, Wright MO, Davies LW, Nuki G, Salter DM (2000) Mechanotransduction via integrins and interleukin-4 results in altered aggrecan and matrix metalloproteinase 3 gene expression in normal, but not osteoarthritic, human articular chondrocytes. Arthritis Rheum 43(9):2091\u20132099. https:\/\/doi.org\/10.1002\/1529-0131(200009)43:9%3c2091::AID-ANR21%3e3.0.CO;2-C","journal-title":"Arthritis Rheum"},{"issue":"4","key":"1551_CR33","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1016\/j.bbrc.2009.08.099","volume":"388","author":"K Miyoshi","year":"2009","unstructured":"Miyoshi K, Kasahara K, Miyazaki I, Asanuma M (2009) Lithium treatment elongates primary cilia in the mouse brain and in cultured cells. Biochem Biophys Res Commun 388(4):757\u2013762. https:\/\/doi.org\/10.1016\/j.bbrc.2009.08.099","journal-title":"Biochem Biophys Res Commun"},{"issue":"5","key":"1551_CR34","doi-asserted-by":"publisher","first-page":"279","DOI":"10.18926\/AMO\/47009","volume":"65","author":"K Miyoshi","year":"2011","unstructured":"Miyoshi K, Kasahara K, Miyazaki I, Asanuma M (2011) Factors that influence primary cilium length. Acta Med Okayama 65(5):279\u2013285. https:\/\/doi.org\/10.18926\/AMO\/47009","journal-title":"Acta Med Okayama"},{"issue":"1","key":"1551_CR35","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1007\/s00795-014-0076-x","volume":"48","author":"T Nakakura","year":"2015","unstructured":"Nakakura T, Asano-Hoshino A, Suzuki T et al (2015) The elongation of primary cilia via the acetylation of \u03b1-tubulin by the treatment with lithium chloride in human fibroblast KD cells. Med Mol Morphol 48(1):44\u201353. https:\/\/doi.org\/10.1007\/s00795-014-0076-x","journal-title":"Med Mol Morphol"},{"issue":"2","key":"1551_CR36","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/0014-4827(88)90391-6","volume":"178","author":"P Newman","year":"1988","unstructured":"Newman P, Watt FM (1988) Influence of cytochalasin d-induced changes in cell shape on proteoglycan synthesis by cultured articular chondrocytes. Exp Cell Res 178(2):199\u2013210. https:\/\/doi.org\/10.1016\/0014-4827(88)90391-6","journal-title":"Exp Cell Res"},{"issue":"1","key":"1551_CR37","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.orthres.2004.05.015","volume":"23","author":"KW Ng","year":"2005","unstructured":"Ng KW, Wang CCB, Mauck RL et al (2005) A layered agarose approach to fabricate depth-dependent inhomogeneity in chondrocyte-seeded constructs. J Orthop Res 23(1):134\u2013141. https:\/\/doi.org\/10.1016\/j.orthres.2004.05.015","journal-title":"J Orthop Res"},{"issue":"4","key":"1551_CR38","doi-asserted-by":"publisher","first-page":"1316","DOI":"10.1073\/pnas.1319569111","volume":"111","author":"CJ O\u2019Conor","year":"2014","unstructured":"O\u2019Conor CJ, Leddy HA, Benefield HC, Liedtke WB, Guilak F (2014) TRPV4-mediated mechanotransduction regulates the metabolic response of chondrocytes to dynamic loading. Proc Natl Acad Sci U S A 111(4):1316\u20131321. https:\/\/doi.org\/10.1073\/pnas.1319569111","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"16","key":"1551_CR39","doi-asserted-by":"publisher","first-page":"2802","DOI":"10.1016\/j.yexcr.2009.06.028","volume":"315","author":"Y Ou","year":"2009","unstructured":"Ou Y, Ruan Y, Cheng M, Moser JJ, Rattner JB, van der Hoorn FA (2009) Adenylate cyclase regulates elongation of mammalian primary cilia. Exp Cell Res 315(16):2802\u20132817. https:\/\/doi.org\/10.1016\/j.yexcr.2009.06.028","journal-title":"Exp Cell Res"},{"issue":"2","key":"1551_CR40","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1111\/joa.12554","volume":"230","author":"J Parreno","year":"2017","unstructured":"Parreno J, Nabavi Niaki M, Andrejevic K, Jiang A, Wu PH, Kandel RA (2017) Interplay between cytoskeletal polymerization and the chondrogenic phenotype in chondrocytes passaged in monolayer culture. J Anat 230(2):234\u2013248. https:\/\/doi.org\/10.1111\/joa.12554","journal-title":"J Anat"},{"issue":"6","key":"1551_CR41","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1021\/bi00782a009","volume":"10","author":"B Peterkofsky","year":"1971","unstructured":"Peterkofsky B, Diegelmann R (1971) Use of a mixture of proteinase-free collagenases for the specific assay of radioactive collagen in the presence of other proteins. Biochemistry 10(6):988\u2013994","journal-title":"Biochemistry"},{"issue":"10","key":"1551_CR42","doi-asserted-by":"publisher","first-page":"3028","DOI":"10.1002\/art.24799","volume":"60","author":"MN Phan","year":"2009","unstructured":"Phan MN, Leddy HA, Votta BJ et al (2009) Functional characterization of TRPV4 as an osmotically sensitive ion channel in porcine articular chondrocytes. Arthritis Rheum 60(10):3028\u20133037. https:\/\/doi.org\/10.1002\/art.24799","journal-title":"Arthritis Rheum"},{"issue":"1","key":"1551_CR43","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1017\/S0021878297002185","volume":"191","author":"CA Poole","year":"1997","unstructured":"Poole CA (1997) Articular cartilage chondrons: Form, function and failure. J Anat 191(1):1\u201313. https:\/\/doi.org\/10.1017\/S0021878297002185","journal-title":"J Anat"},{"issue":"8","key":"1551_CR44","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1006\/cbir.1997.0177","volume":"21","author":"CA Poole","year":"1997","unstructured":"Poole CA, Jensen CG, Snyder JA, Gray CG, Hermanutz VL, Wheatley DN (1997) Confocal analysis of primary cilia structure and colocalization with the Golgi apparatus in chondrocytes and aortic smooth muscle cells. Cell Biol Int 21(8):483\u2013494. https:\/\/doi.org\/10.1006\/cbir.1997.0177","journal-title":"Cell Biol Int"},{"issue":"6","key":"1551_CR45","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1023\/B:ABME.0000030261.38396.c0","volume":"32","author":"Y Sawae","year":"2004","unstructured":"Sawae Y, Shelton JC, Bader DL, Knight MM (2004) Confocal analysis of local and cellular strains in chondrocyte-agarose constructs subjected to mechanical shear. Ann Biomed Eng 32(6):860\u2013870. https:\/\/doi.org\/10.1023\/B:ABME.0000030261.38396.c0","journal-title":"Ann Biomed Eng"},{"issue":"1","key":"1551_CR46","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.berh.2009.08.006","volume":"24","author":"A Shane Anderson","year":"2010","unstructured":"Shane Anderson A, Loeser RF (2010) Why is osteoarthritis an age-related disease? Best Pract Res Clin Rheumatol 24(1):15\u201326. https:\/\/doi.org\/10.1016\/j.berh.2009.08.006","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"1551_CR47","doi-asserted-by":"publisher","first-page":"158","DOI":"10.22203\/eCM.v033a12","volume":"33","author":"M Spasic","year":"2017","unstructured":"Spasic M, Jacobs CR (2017) Lengthening primary cilia enhances cellular mechanosensitivity. Eur Cells Mater 33:158\u2013168. https:\/\/doi.org\/10.22203\/eCM.v033a12","journal-title":"Eur Cells Mater"},{"key":"1551_CR48","doi-asserted-by":"publisher","DOI":"10.1177\/1947603519841677","author":"OD Subedar","year":"2019","unstructured":"Subedar OD, Chiu LLY, Waldman SD (2019) Cell Cycle Synchronization of Primary Articular Chondrocytes Enhances Chondrogenesis. Cartilage. https:\/\/doi.org\/10.1177\/1947603519841677","journal-title":"Cartilage"},{"issue":"2","key":"1551_CR49","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1089\/ten.TEA.2009.0236","volume":"16","author":"DW Taylor","year":"2010","unstructured":"Taylor DW, Ahmed N, Gan L, Gross AE, Kandel RA (2010) Proteoglycan and collagen accumulation by passaged chondrocytes can be enhanced through side-by-side culture with primary chondrocytes. Tissue Eng Part A 16(2):643\u2013651. https:\/\/doi.org\/10.1089\/ten.TEA.2009.0236","journal-title":"Tissue Eng Part A"},{"key":"1551_CR50","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2013.12.016","author":"CL Thompson","year":"2014","unstructured":"Thompson CL, Chapple JP, Knight MM (2014) Primary cilia disassembly down-regulates mechanosensitive hedgehog signalling: A feedback mechanism controlling ADAMTS-5 expression in chondrocytes. Osteoarthr Cartil. https:\/\/doi.org\/10.1016\/j.joca.2013.12.016","journal-title":"Osteoarthr Cartil"},{"issue":"10","key":"1551_CR51","doi-asserted-by":"publisher","first-page":"1552","DOI":"10.1002\/jor.22913","volume":"33","author":"CL Thompson","year":"2015","unstructured":"Thompson CL, Yasmin H, Varone A, Wiles A, Poole CA, Knight MM (2015) Lithium chloride prevents interleukin-1\u03b2 induced cartilage degradation and loss of mechanical properties. J Orthop Res 33(10):1552\u20131559. https:\/\/doi.org\/10.1002\/jor.22913","journal-title":"J Orthop Res"},{"issue":"2","key":"1551_CR52","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1096\/fj.15-274944","volume":"30","author":"CL Thompson","year":"2016","unstructured":"Thompson CL, Wiles A, Poole CA, Knight MM (2016) Lithium chloride modulates chondrocyte primary cilia and inhibits Hedgehog signaling. FASEB J 30(2):716\u2013726. https:\/\/doi.org\/10.1096\/fj.15-274944","journal-title":"FASEB J"},{"key":"1551_CR53","doi-asserted-by":"publisher","first-page":"128","DOI":"10.22203\/eCM.v034a09","volume":"34","author":"CL Thompson","year":"2017","unstructured":"Thompson CL, Plant JCT, Wann AKT et al (2017) Chondrocyte expansion is associated with loss of primary cilia and disrupted hedgehog signalling. Eur Cells Mater 34:128\u2013141. https:\/\/doi.org\/10.22203\/eCM.v034a09","journal-title":"Eur Cells Mater"},{"issue":"4","key":"1551_CR54","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1016\/S0736-0266(03)00009-3","volume":"21","author":"SD Waldman","year":"2003","unstructured":"Waldman SD, Spiteri CG, Grynpas MD, Pilliar RM, Kandel RA (2003) Long-term intermittent shear deformation improves the quality of cartilaginous tissue formed in vitro. J Orthop Res 21(4):590\u2013596. https:\/\/doi.org\/10.1016\/S0736-0266(03)00009-3","journal-title":"J Orthop Res"},{"issue":"9\u201310","key":"1551_CR55","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1089\/ten.2004.10.1323","volume":"10","author":"SD Waldman","year":"2004","unstructured":"Waldman SD, Spiteri CG, Grynpas MD, Pilliar RM, Kandel RA (2004) Long-term intermittent compressive stimulation improves the composition and mechanical properties of tissue-engineered cartilage. Tissue Eng 10(9\u201310):1323\u20131331. https:\/\/doi.org\/10.1089\/ten.2004.10.1323","journal-title":"Tissue Eng"},{"issue":"2","key":"1551_CR56","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1002\/jor.23000","volume":"34","author":"JF Weber","year":"2016","unstructured":"Weber JF, Waldman SD (2016) Stochastic resonance is a method to improve the biosynthetic response of chondrocytes to mechanical stimulation. J Orthop Res 34(2):231\u2013239. https:\/\/doi.org\/10.1002\/jor.23000","journal-title":"J Orthop Res"},{"issue":"1","key":"1551_CR57","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1007\/s10439-018-02123-x","volume":"47","author":"JF Weber","year":"2019","unstructured":"Weber JF, Chiu LLY, Balko S, Waldman SD (2019) Stochastic resonance with dynamic compression improves the growth of adult chondrocytes in agarose gel constructs. Ann Biomed Eng 47(1):243\u2013256. https:\/\/doi.org\/10.1007\/s10439-018-02123-x","journal-title":"Ann Biomed Eng"},{"issue":"9","key":"1551_CR58","doi-asserted-by":"publisher","first-page":"2435","DOI":"10.1089\/ten.2006.12.2435","volume":"12","author":"KGA Yang","year":"2006","unstructured":"Yang KGA, Saris DBF, Geuze RE et al (2006) Impact of expansion and redifferentiation conditions on chondrogenic capacity of cultured chondrocytes. Tissue Eng 12(9):2435\u20132447. https:\/\/doi.org\/10.1089\/ten.2006.12.2435","journal-title":"Tissue Eng"},{"issue":"8","key":"1551_CR59","first-page":"2610","volume":"10","author":"R Yao","year":"2018","unstructured":"Yao R, Sun X, Xie Y et al (2018) Lithium chloride inhibits cell survival, overcomes drug resistance, and triggers apoptosis in multiple myeloma via activation of the Wnt\/\u03b2-catenin pathway. Am J Transl Res 10(8):2610\u20132618","journal-title":"Am J Transl Res"},{"key":"1551_CR60","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1146\/annurev-genet-111212-133243","volume":"47","author":"S Yuan","year":"2013","unstructured":"Yuan S, Sun Z (2013) Expanding horizons: Ciliary proteins reach beyond cilia. Annu Rev Genet 47:353\u2013376. https:\/\/doi.org\/10.1146\/annurev-genet-111212-133243","journal-title":"Annu Rev Genet"}],"container-title":["Biomechanics and Modeling in Mechanobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10237-021-01551-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10237-021-01551-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10237-021-01551-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T19:07:26Z","timestamp":1647976046000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10237-021-01551-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,29]]},"references-count":60,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["1551"],"URL":"https:\/\/doi.org\/10.1007\/s10237-021-01551-4","relation":{},"ISSN":["1617-7959","1617-7940"],"issn-type":[{"value":"1617-7959","type":"print"},{"value":"1617-7940","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,29]]},"assertion":[{"value":"8 July 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 December 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 January 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}