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To study these interactions, a computationally efficient, biophysically based mathematical model for the circulatory system is presented. In a four-chamber model of the heart, the LV is represented by a previously described low-order, wall volume-preserving model that includes torsion and base-to-apex and circumferential wall shortening and lengthening, and the other chambers are represented using spherical geometries. Active and passive myocardial mechanics of all four chambers are included. The cardiac model is coupled with a wave propagation model for the aorta and a closed lumped-parameter circulation model. Parameters for the normal heart and aorta are determined by fitting to experimental data. Changes in the timing and magnitude of pulse wave reflections by the aorta are demonstrated with changes in compliance and taper of the aorta as seen in aging (decreased compliance, increased diameter and length), and resulting effects on LV pressure\u2013volume loops and LV fiber stress and sarcomere shortening are predicted. Effects of aging of the aorta combined with reduced LV contractile force (failing heart) are examined. In the failing heart, changes in aortic properties with aging affect stroke volume and sarcomere shortening without appreciable augmentation of aortic pressure, and the reflected pressure wave contributes an increased proportion of aortic pressure.<\/jats:p>","DOI":"10.1007\/s10237-023-01690-w","type":"journal-article","created":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T14:02:26Z","timestamp":1673618546000},"page":"947-959","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["A fast computational model for circulatory dynamics: effects of left ventricle\u2013aorta coupling"],"prefix":"10.1007","volume":"22","author":[{"given":"Michael J.","family":"Moulton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0176-5502","authenticated-orcid":false,"given":"Timothy W.","family":"Secomb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,1,13]]},"reference":[{"key":"1690_CR1","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1007\/s10665-009-9275-1","volume":"64","author":"J Alastruey","year":"2009","unstructured":"Alastruey J, Parker KH, Peir\u00f3 J, Sherwin SJ (2009) Analysing the pattern of pulse waves in arterial networks: a time-domain study. 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