{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T12:07:22Z","timestamp":1786795642958,"version":"build-2736575974"},"reference-count":64,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2023,5,7]],"date-time":"2023-05-07T00:00:00Z","timestamp":1683417600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,5,7]],"date-time":"2023-05-07T00:00:00Z","timestamp":1683417600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HL105297"],"award-info":[{"award-number":["R01 HL105297"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biomech Model Mechanobiol"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1007\/s10237-023-01722-5","type":"journal-article","created":{"date-parts":[[2023,5,7]],"date-time":"2023-05-07T10:01:39Z","timestamp":1683453699000},"page":"1333-1347","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Biomechanical and transcriptional evidence that smooth muscle cell death drives an osteochondrogenic phenotype and severe proximal vascular disease in progeria"],"prefix":"10.1007","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6578-4585","authenticated-orcid":false,"given":"Sae-Il","family":"Murtada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2137-6464","authenticated-orcid":false,"given":"Yuki","family":"Kawamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Cavinato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Molly","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhay B.","family":"Ramachandra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart","family":"Spronck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Tellides","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1011-2025","authenticated-orcid":false,"given":"Jay D.","family":"Humphrey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,5,7]]},"reference":[{"key":"1722_CR1","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1161\/01.ATV.19.6.1499","volume":"19","author":"IM Bayer","year":"1999","unstructured":"Bayer IM, Adamson SL, Langille BL (1999) Atrophic remodeling of the artery-cuffed artery. Arterioscler Thromb Vasc Biol 19:1499\u20131505","journal-title":"ATVB"},{"key":"1722_CR2","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.3390\/cells10051157","volume":"10","author":"I Benedicto","year":"2021","unstructured":"Benedicto I, Dorado B, Andres V (2021) Molecular and cellular mechanisms driving cardiovascular disease in Hutchinson-Gilford progeria syndrome: lessons learned from animal models. Cells 10:1157","journal-title":"Cells"},{"key":"1722_CR4","doi-asserted-by":"crossref","first-page":"111697","DOI":"10.1016\/j.celrep.2022.111697","volume":"41","author":"JA Bibby","year":"2022","unstructured":"Bibby JA, Agarwal D, Freiwald T, Kunz N, Merle NS, West EE, Singh P, Larochelle A, Chinian F, Mukherjee S, Afzali B, Kemper C, Zhang NR (2022) Systematic single-cell pathway analysis to characterize early T cell activation. Cell Rep 41:111697","journal-title":"Cell Rep"},{"key":"1722_CR5","doi-asserted-by":"crossref","first-page":"2567","DOI":"10.1093\/hmg\/ddh295","volume":"13","author":"JLV Boers","year":"2004","unstructured":"Boers JLV, Peeters EAG, Kuijpers JHJ et al (2004) Decreased mechanical stiffness in LMNA\u2212\/\u2212 cells is caused by defective nucleo-cytoskeletal integrity: implications for the development of laminopathies. Hum Mol Genet 13:2567\u20132580","journal-title":"Hum Molc Genet"},{"key":"1722_CR1000","doi-asserted-by":"crossref","unstructured":"Boutouyrie P, Chowienczyk P, Humphrey JD, Mitchell GF (2021)  Arterial Stiffness and Cardiovascular Risk in Hypertension. Circ Res 128:864\u2013886","DOI":"10.1161\/CIRCRESAHA.121.318061"},{"key":"1722_CR6","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.devcel.2014.11.023","volume":"31","author":"A Briot","year":"2014","unstructured":"Briot A, Jaroszewicz A, Warren CM et al (2014) Repression of Sox9 by Jag1 is continuously required to suppress the default chondrogenic fate of vascular smooth muscle cells. Dev Cell 31:707\u2013721","journal-title":"Dev Cell"},{"key":"1722_CR7","doi-asserted-by":"crossref","first-page":"15902","DOI":"10.1073\/pnas.0807840105","volume":"105","author":"BC Capell","year":"2008","unstructured":"Capell BC, Olive M, Erdos MR, Cao K, Faddah DA, Tavarez UL, Chen X (2008) A farnesyltransferase inhibitor prevents both the onset and late progression of cardiovascular disease in a progeria mouse model. Proc Natl Acad Sci USA 105:15902\u201315907","journal-title":"Proc Natl Acad Sci USA"},{"key":"1722_CR8","doi-asserted-by":"crossref","first-page":"111471","DOI":"10.1016\/j.mad.2021.111471","volume":"196","author":"C Cavinato","year":"2021","unstructured":"Cavinato C, Murtada S-I, Rojas A, Humphrey JD (2021) Evolving structure-function relations during aortic maturation and aging revealed by multiphoton microscopy. Mechan Ageing Devel 196:111471","journal-title":"Mechanisms Ageing Develop"},{"key":"1722_CR9","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1038\/srep01087","volume":"3","author":"AB Chambliss","year":"2013","unstructured":"Chambliss AB, Khatau SB, Erdenberger N, Robinson DK, Hodzic D, Longmore GD, Wirtz D (2013) The LINC-anchored actin cap connects the extracellular milieus to the nucleus for ultrafast mechanotransduction. Sci Rept 3:1087","journal-title":"Sci Rept"},{"key":"1722_CR10","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1161\/CIRCRESAHA.108.175976","volume":"102","author":"MCH Clarke","year":"2008","unstructured":"Clarke MCH, Littlewood TD, Figg N, Maguire JJ, Davenport AP, Goddard M, Bennett MR (2008) Chronic apoptosis of vascular smooth muscle cells accelerates atherosclerosis and promotes calcification and medial degeneration. Circ Res 102:1529\u20131538","journal-title":"Circ Res"},{"key":"1722_CR11","doi-asserted-by":"publisher","DOI":"10.1126\/science.1084135","author":"A De Sandre-Giovannoli","year":"2003","unstructured":"De Sandre-Giovannoli A, Bernard R, Cau P et al (2003) Lamin A truncation in Hutchinson-Gilford Progeria. Science 300:2055","journal-title":"ScienceExpress"},{"key":"1722_CR12","doi-asserted-by":"crossref","first-page":"e12936","DOI":"10.1111\/acel.12936","volume":"18","author":"L Del Campo","year":"2019","unstructured":"Del Campo L, S\u00e1nchez-L\u00f3pez A, Salaices M, von Kleeck RA, Exp\u00f3sito E, Gonz\u00e1lez-G\u00f3mez C, Cuss\u00f3 L, Guzm\u00e1n-Mart\u00ednez G, Ruiz-Cabello J, Desco M, Assoian RK, Briones AM, Andr\u00e9s V (2019) Vascular smooth muscle cell-specific progerin expression in a mouse model of Hutchinson-Gilford progeria syndrome promotes arterial stiffness: therapeutic effect of dietary nitrite. Aging Cell 18:e12936","journal-title":"Aging Cell"},{"key":"1722_CR13","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.cardfail.2009.03.006","volume":"15","author":"AS Desai","year":"2009","unstructured":"Desai AS, Mitchell GF, Fang JC, Creager MA (2009) Central aortic stiffness is increased in patients with heart failure and preserved ejection fraction. J Card Fail 15:658\u2013664","journal-title":"J Cardiac Fail"},{"key":"1722_CR14","unstructured":"Dolgalev I (2022). msigdbr: MSigDB Gene sets for multiple organisms in a tidy data format. R package version 7.5.1, https:\/\/CRAN.R-project.org\/package=msigdbr"},{"key":"1722_CR15","doi-asserted-by":"crossref","first-page":"4206","DOI":"10.1073\/pnas.1802811115","volume":"115","author":"AJ DuBose","year":"2018","unstructured":"DuBose AJ, Lichtenstein ST, Petrash NM, Erdos MR, Gordon LB, Collins FS (2018) Everolimus rescues multiple cellular defects in laminopathy-patient fibroblasts. Proc Natl Acad Sci USA 115:4206\u20134211","journal-title":"Proc Natl Acad Sci"},{"key":"1722_CR16","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1093\/cvr\/cvy010","volume":"114","author":"AL Durham","year":"2018","unstructured":"Durham AL, Speer MY, Scatena M, Giachelli CM, Shanahan CM (2018) Role of smooth muscle cells in vascular calcification: implications in atherosclerosis and arterial stiffness. Cardiovasc Res 114:590\u2013600","journal-title":"Cardiovasc Res"},{"key":"1722_CR17","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/nature01629","volume":"423","author":"M Eriksson","year":"2003","unstructured":"Eriksson M, Brown WT, Gordon LB et al (2003) Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome. Nature 423:293\u2013298","journal-title":"Nature"},{"key":"1722_CR18","doi-asserted-by":"crossref","unstructured":"Estrada AC, Irons L, Rego BV, Li G, Tellides G, Humphrey JD (2021) Roles of mTOR in thoracic aortopathy understood by complex intracellular signaling interactions. PLoS Comput Biol 17:e1009683","DOI":"10.1371\/journal.pcbi.1009683"},{"key":"1722_CR20","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1007\/s10237-018-1026-7","volume":"17","author":"J Ferruzzi","year":"2018","unstructured":"Ferruzzi J, Madziva D, Caulk AW, Tellides G, Humphrey JD (2018) Compromised mechanical homeostasis in arterial aging and associated cardiovascular consequences. Biomech Model Mechanobiol 17:1281\u20131295","journal-title":"Biomech Model Mechanobiol"},{"key":"1722_CR21","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1161\/HYPERTENSIONAHA.111.180919","volume":"59","author":"M Gerhard-Herman","year":"2012","unstructured":"Gerhard-Herman M, Smoot LB, Wake N, Kieran MW, Kleinman ME, Miller DT, Schwartzman A, Giobbie-Hurder A, Neuberg D, Gordon LB (2012) Mechanisms of premature vascular aging in children with Hutchison-Gilford progeria syndrome. Hypertension 59:92\u201397","journal-title":"Hypertension"},{"key":"1722_CR22","doi-asserted-by":"crossref","first-page":"16666","DOI":"10.1073\/pnas.1202529109","volume":"109","author":"LB Gordon","year":"2012","unstructured":"Gordon LB, Kleinman ME, Miller DT et al (2012) Clinical trial of a farnesyltransferase inhibitor in children with Hutchinson-Gilford progeria syndrome. Proc Natl Acad Sci USA 109:16666\u201316671","journal-title":"PNAS"},{"key":"1722_CR23","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1161\/CIRCULATIONAHA.113.008285","volume":"130","author":"LB Gordon","year":"2014","unstructured":"Gordon LB, Massaro J, D\u2019Agostino RB et al (2014) Impact of farnesylation inhibitors on survival in Hutchinson-Gilford progeria syndrome. Circulation 130:27\u201334","journal-title":"Circulation"},{"key":"1722_CR24","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1001\/jama.2018.3264","volume":"319","author":"LB Gordon","year":"2018","unstructured":"Gordon LB, Shappell H, Massaro J, D\u2019Agostino RB, Brazier J, Kleinman ME, Kieran MW (2018) Association of lonafarnib treatment vs no treatment with mortality rates in patients with Hutchison-Gilford progeria syndrome. JAMA 319:1687\u20131695","journal-title":"JAMA"},{"key":"1722_CR25","doi-asserted-by":"crossref","unstructured":"Humphrey JD, Eberth JF, Dye WW, Gleason RL (2009) Fundamental role of axial stress in compensatory adaptations by arteries. J Biomech 42:1\u20138","DOI":"10.1016\/j.jbiomech.2008.11.011"},{"key":"1722_CR1001","doi-asserted-by":"crossref","unstructured":"Humphrey JD, Dufresne ER, Schwartz MA (2014) Mechanotransduction and extracellular matrix homeostasis. Nat Rev Mol Cell Biol 15:802\u2013812","DOI":"10.1038\/nrm3896"},{"key":"1722_CR26","first-page":"H169","volume":"316","author":"JD Humphrey","year":"2019","unstructured":"Humphrey JD, Tellides G (2019) Central artery stiffness and thoracic aortopathy. Am J Physiol 316:H169-182","journal-title":"Am J Physiol"},{"key":"1722_CR27","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1161\/01.RES.0000249379.55535.21","volume":"99","author":"RC Johnson","year":"2006","unstructured":"Johnson RC, Leopold JA, Loscalzo J (2006) Vascular calcification: pathobiological mechanisms and clinical implications. Circ Res 99:1044\u20131059","journal-title":"Circ Res"},{"key":"1722_CR28","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0070-2153(04)62006-0","volume":"62","author":"CM Kelleher","year":"2014","unstructured":"Kelleher CM, McLean SE, Mecham RP (2004) Vascular extracellular matrix and aortic development. Curr Trends Develop Biol 62:153\u2013188","journal-title":"Curr Trends Develop Biol"},{"key":"1722_CR29","doi-asserted-by":"crossref","unstructured":"Kim PH, Luu J, Heizer P, et al. (2018) Disrupting the LINC complex in smooth muscle cells reduces aortic disease in a mouse model of Hutchinson-Gilford progeria syndrome. Sci Transl Med 10:eaat7163","DOI":"10.1126\/scitranslmed.aat7163"},{"key":"1722_CR30","doi-asserted-by":"crossref","first-page":"e151515","DOI":"10.1172\/jci.insight.151515","volume":"6","author":"PH Kim","year":"2021","unstructured":"Kim PH, Chen NY, Heizer PJ et al (2021) Nuclear membrane ruptures underlie the vascular pathology in a mouse model of Hutchinson-Gilford progeria syndrome. JCI Insight 6:e151515","journal-title":"JCI Insight"},{"key":"1722_CR31","doi-asserted-by":"crossref","first-page":"e12852","DOI":"10.1111\/acel.12852","volume":"18","author":"R Kreienkamp","year":"2019","unstructured":"Kreienkamp R, Billon C, Bedia-Diaz G, Albert CJ, Toth Z, Butler AA, Gonzalo S (2019) Doubled lifespan and patient-like pathologies in progeria mice fed high-fat diet. Aging Cell 18:e12852","journal-title":"Aging Cell"},{"key":"1722_CR32","doi-asserted-by":"crossref","first-page":"20200622","DOI":"10.1098\/rspa.2020.0622","volume":"477","author":"M Latorre","year":"2021","unstructured":"Latorre M, Spronck B, Humphrey JD (2021) Complementary roles of mechanotransduction and inflammation in vascular homeostasis. Proc Math Phys Eng Sci 477:20200622","journal-title":"Proceed R Soc A"},{"key":"1722_CR33","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1161\/CIRCRESAHA.116.303596","volume":"116","author":"S Laurent","year":"2015","unstructured":"Laurent S, Boutouyrie P (2015) The structural factor of hypertension: large and small artery alterations. Circ Res 116:1007\u20131021","journal-title":"Circ Res"},{"key":"1722_CR34","doi-asserted-by":"crossref","first-page":"20141350","DOI":"10.1098\/rsif.2014.1350","volume":"12","author":"VP Le","year":"2015","unstructured":"Le VP, Cheng JK, Kim J et al (2015) Mechanical factors direct mouse aortic remodeling during early maturation. J R Soc Interface 12:20141350","journal-title":"J R Soc Interface"},{"key":"1722_CR35","doi-asserted-by":"crossref","unstructured":"Lemire JM, Patis C, Gordon LB, Sandy JD, Toole BPM, Weiss AS, (2006) Aggrecan expression is substantially and abnormally upregulated in Hutchinson-Gilford progeria syndrome dermal fibroblasts. Mech Ageing Develop 127:660\u2013669","DOI":"10.1016\/j.mad.2006.03.004"},{"key":"1722_CR37","doi-asserted-by":"crossref","unstructured":"Li G, Wang M, Caulk AW, Korneva A, Bersi MR, Wang G, Liu X, Mehta S, Geirsson A, Gulcher JR, Chittenden TW, Simons M, Humphrey JD, Tellides G (2020a) Chronic mTOR activation induces a degradative smooth muscle cell phenotype and aortopathy. J Clin Invest 130:1233\u20131251","DOI":"10.1172\/JCI131048"},{"key":"1722_CR38","doi-asserted-by":"crossref","first-page":"661","DOI":"10.3389\/fphar.2020.00661","volume":"11","author":"Y Li","year":"2020","unstructured":"Li Y, Sun Z, Zhang L, Yan J, Shao C, Jin L, Li L, Wang Z (2020b) Role of macrophages in the progression and regression of vascular calcification. Front Pharmacol 11:661","journal-title":"Front Pharmacol"},{"key":"1722_CR39","first-page":"e99","volume":"112","author":"Y Liu","year":"2013","unstructured":"Liu Y, Drozdov I, Shroff R, Beltran LE, Shanahan CM (2013) Prelamin A accelerates vascular calcification via activation of the DNA damage response and senescence-associated secretory phenotype in vascular smooth muscle cells. Circ Res 112:e99-109","journal-title":"Circ Res"},{"issue":"6","key":"1722_CR40","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.cels.2015.12.004","volume":"1","author":"A Liberzon","year":"2015","unstructured":"Liberzon A, Birger C, Thorvaldsd\u00f3ttir H, Ghandi M, Mesirov JP, Tamayo P (2015) The molecular signatures database (MSigDB) hallmark gene set collection. Cell Syst 1(6):417\u2013425","journal-title":"Cell Syst"},{"key":"1722_CR41","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.1161\/01.ATV.0000099882.52647.E4","volume":"23","author":"J-B Michel","year":"2003","unstructured":"Michel J-B (2003) Anoikis in the cardiovascular system: known and unknown extracellular mediators. Arterioscler Thromb Vasc Biol 23:2146\u20132154","journal-title":"ATVB"},{"key":"1722_CR42","doi-asserted-by":"crossref","first-page":"20200066","DOI":"10.1098\/rsif.2020.0066","volume":"17","author":"S-I Murtada","year":"2020","unstructured":"Murtada S-I, Kawamura Y, Caulk AW, Ahmadzadeh H, Mikush N, Zimmerman K, Kavanagh D, Weiss D, Latorre M, Zhuang ZW, Shadel GS, Braddock DT, Humphrey JD (2020) Paradoxical aortic stiffening and subsequent cardiac dysfunction in Hutchison-Gilford progeria. J R Soc Interface 17:20200066","journal-title":"J R Soc Interface"},{"key":"1722_CR43","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1002\/dvdy.283","volume":"250","author":"S-I Murtada","year":"2021","unstructured":"Murtada S-I, Kawamura Y, Li G, Schwartz MA, Tellides G, Humphrey JD (2021a) Developmental origins of mechanical homeostasis in the aorta. Dev Dyn 250:629\u2013639","journal-title":"Dev Dyn"},{"key":"1722_CR44","volume":"119","author":"S-I Murtada","year":"2021","unstructured":"Murtada S-I, Kawamura Y, Humphrey JD (2021b) Differential biomechanical responses of elastic and muscular arteries to angiotensin II-induced hypertension. J Biomech 119:110297","journal-title":"J Biomech"},{"key":"1722_CR45","doi-asserted-by":"crossref","unstructured":"Murtada S-I, Mikush N, Wang M, Ren P, Kawamura Y, Ramachandra AB, Braddock DT, Tellides G, Gordon LB, Humphrey JD (2023) Lonafarnib improves cardiovascular function and survival in a mouse model of Hutchinson-Gilford Progeria Syndrome. eLife 12:e82728.","DOI":"10.7554\/eLife.82728"},{"key":"1722_CR46","doi-asserted-by":"crossref","first-page":"174","DOI":"10.3389\/fcvm.2018.00174","volume":"5","author":"D Ngai","year":"2018","unstructured":"Ngai D, Lino M, Bendeck MP (2018) Cell-matrix interactions and mataricine signaling in the pathogenesis of vascular calcification. Front Cardiovasc Med 5:174","journal-title":"Front Cardiovasc Med"},{"key":"1722_CR47","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1161\/ATVBAHA.110.209460","volume":"30","author":"M Olive","year":"2010","unstructured":"Olive M, Harten I, Mitchell R et al (2010) Cardiovascular pathology in Hutchinson-Gilford Progeria: correlation with the vascular pathology of aging. Arterioscler Thromb Vasc Biol 30:2301\u20132309","journal-title":"ATVB"},{"key":"1722_CR48","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1172\/JCI121297","volume":"129","author":"S Osmanagic-Myers","year":"2019","unstructured":"Osmanagic-Myers S, Kiss A, Manakanatas C, Hamza O, Sedlmayer F, Szabo PL, Fischer I, Pichtinger P, Podesser BK, Eriksson M, Foisner R (2019) Endothelial progerin expression causes cardiovascular pathology through an impaired mechanoresponse. J Clin Invest 129:531\u2013545","journal-title":"J Clin Invest"},{"key":"1722_CR49","doi-asserted-by":"crossref","unstructured":"Osorio FG, Navarro CL, Cadinanos J, et al (2011) Splicing-directed therapy in a new mouse model of human accelerated aging. Sci Transl Med 3: 106ra107","DOI":"10.1126\/scitranslmed.3002847"},{"key":"1722_CR50","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1001\/jamacardio.2017.5235","volume":"3","author":"A Prakash","year":"2018","unstructured":"Prakash A, Gordon LB, Kleinman ME, Gurary EB, Massaro J, D\u2019Agostino R, Kieran MW, Gerhard-Herman M, Smoot L (2018) Cardiac abnormalities in patients with Hutchison-Gilford progeria syndrome. JAMA Cardiol 3:326\u2013334","journal-title":"JAMA Cardiol"},{"key":"1722_CR51","doi-asserted-by":"crossref","first-page":"e000405","DOI":"10.1161\/JAHA.113.000405","volume":"2","author":"E Purnomo","year":"2013","unstructured":"Purnomo E, Emoto N, Nugrahaningshi DAA et al (2013) Glycosaminoglycan overproduction in the aorta increases aortic calcification in murine chronic kidney disease. J Am Heart Assoc 2:e000405","journal-title":"J Am Heart Assoc"},{"key":"1722_CR52","doi-asserted-by":"crossref","first-page":"20140397","DOI":"10.1098\/rsif.2014.0397","volume":"11","author":"S Roccabianca","year":"2014","unstructured":"Roccabianca S, Bellini C, Humphrey JD (2014) Computational modeling suggests good, bad, and ugly roles of glycosaminoglycans in arterial mechanics and mechanobiology. J R Soc Interface 11:20140397","journal-title":"J R Soc Interface"},{"key":"1722_CR53","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1038\/nrcardio.2010.115","volume":"7","author":"AP Sage","year":"2010","unstructured":"Sage AP, Tintut Y, Demer LL (2010) Regulatory mechanisms in vascular calcification. Nat Rev Cardiol 7:528\u2013536","journal-title":"Nat Rev Cardiol"},{"key":"1722_CR54","doi-asserted-by":"crossref","unstructured":"Sanchez-Lopez A, Espinos-Estevez C, Gonzalez-Gomez C, et al. (2021) Cardiovascular progerin suppression and lamin A restoration rescues Hutchinson-Gilford progeria syndrome. Circulation 144:1777\u20131794","DOI":"10.1161\/CIRCULATIONAHA.121.055313"},{"key":"1722_CR55","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.matbio.2014.11.001","volume":"41","author":"OV Sazonova","year":"2015","unstructured":"Sazonova OV, Isenberg BC, Herrmann J et al (2015) Extracellular matrix presentation modulates vascular smooth muscle cell mechanotransduction. Matrix Biol 41:36\u201343","journal-title":"Matrix Biol"},{"key":"1722_CR56","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.jmbbm.2017.11.035","volume":"78","author":"F Schroeder","year":"2018","unstructured":"Schroeder F, Polzer S, Slazansky M, Man V, Skacel P (2018) Predictive capabilities of various constitutive models for arterial tissue. J Mech Behav Biomed Matl 78:369\u2013380","journal-title":"J Mech Behav Biomed Matl"},{"key":"1722_CR57","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S1054-8807(98)00023-4","volume":"8","author":"WE Stehbens","year":"1999","unstructured":"Stehbens WE, Wakefield SJ, Gilbert-Barness E, Olson RE, Ackerman J (1999) Histological and ultrastructural features of atherosclerosis in progeria. Cardiovasc Pathol 8:29\u201339","journal-title":"Cardiovasc Pathol"},{"key":"1722_CR58","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S1054-8807(01)00069-2","volume":"10","author":"WE Stehbens","year":"2001","unstructured":"Stehbens WE, Delahunt B, Shozawa T, Gilbert-Barness E (2001) Smooth muscle cell depletion and collagen types in progeric arteries. Cardiovasc Path 10:133\u2013136","journal-title":"Cardiovasc Path"},{"issue":"43","key":"1722_CR59","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","volume":"102","author":"A Subramanian","year":"2005","unstructured":"Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA, Paulovich A, Pomeroy SL, Golub TR, Lander ES, Mesirov JP (2005) Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci USA 102(43):15545\u201315550","journal-title":"Proc Natl Acad Sci USA"},{"key":"1722_CR60","doi-asserted-by":"crossref","first-page":"1240104","DOI":"10.1126\/science.1240104","volume":"341","author":"J Swift","year":"2013","unstructured":"Swift J, Ivanovska IL, Buxboim A, Harada T, Dingal PDP, Pinter J, Rehfeldt F (2013) Nuclear lamin-A scales with tissue stiffness and enhances matrix-directed differentiation. Science 341:1240104","journal-title":"Science"},{"key":"1722_CR61","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1161\/hc0502.102969","volume":"105","author":"Y Tintut","year":"2002","unstructured":"Tintut Y, Patel J, Territo M, Saini T, Parhami F, Demer LL (2002) Monocyte\/macrophage regulation of vascular calcification in vitro. Circulation 105:650\u2013655","journal-title":"Circulation"},{"key":"1722_CR62","doi-asserted-by":"crossref","unstructured":"Townsend RR, Wilkinson IB, Schiffrin EL, et al. on behalf of the American Heart Association Council on Hypertension (2015) Recommendations for improving and standardizing vascular research on arterial stiffness. Hypertension 66:698\u2013722","DOI":"10.1161\/HYP.0000000000000033"},{"key":"1722_CR63","doi-asserted-by":"crossref","first-page":"3250","DOI":"10.1073\/pnas.0600012103","volume":"103","author":"R Varga","year":"2006","unstructured":"Varga R, Eriksson M, Erdos MR et al (2006) Progressive vascular smooth muscle cell defects in a mouse model of Hutchinson-Gilford progeria syndrome. Proc Natl Acad Sci USA 103:3250\u20133255","journal-title":"PNAS"},{"key":"1722_CR64","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1111\/j.1474-9726.2008.00382.x","volume":"7","author":"VLRM Verstraeten","year":"2008","unstructured":"Verstraeten VLRM, Ji JY, Cummings KS, Lee RT, Lammerding J (2008) Increased mechanosensitivity and nuclear stiffness in Hutchinson-Gilford progeria cells: effects of farnesyltransferase inhibitors. Aging Cell 7:383\u2013393","journal-title":"Aging Cell"},{"key":"1722_CR65","doi-asserted-by":"crossref","first-page":"3442","DOI":"10.1161\/CIRCULATIONAHA.112.000571","volume":"127","author":"R Villa-Bellosta","year":"2013","unstructured":"Villa-Bellosta R, Rivera-Torres J, Osorio FG, Acin-Perez R, Enriquez JA, Lopez-Otin C, Andres V (2013) Defective extracellular pyrophosphate metabolism promotes vascular calcification in a mouse model of Hutchinson-Gilford progeria syndrome that is ameliorated on pyrophosphate treatment. Circulation 127:3442\u20133451","journal-title":"Circulation"}],"container-title":["Biomechanics and Modeling in Mechanobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10237-023-01722-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10237-023-01722-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10237-023-01722-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T14:15:11Z","timestamp":1690208111000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10237-023-01722-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,7]]},"references-count":64,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["1722"],"URL":"https:\/\/doi.org\/10.1007\/s10237-023-01722-5","relation":{},"ISSN":["1617-7959","1617-7940"],"issn-type":[{"value":"1617-7959","type":"print"},{"value":"1617-7940","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,7]]},"assertion":[{"value":"9 September 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 April 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 May 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"All live animal procedures were conducted in accordance with Federal Regulations and were approved by the Yale Institutional Animal Care and Use Committee prior to beginning the work.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics statement"}}]}}