{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T06:44:21Z","timestamp":1792651461475,"version":"4.5.0"},"reference-count":86,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T00:00:00Z","timestamp":1702425600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T00:00:00Z","timestamp":1702425600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["1919438."],"award-info":[{"award-number":["1919438."]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["1919438."],"award-info":[{"award-number":["1919438."]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["1919438."],"award-info":[{"award-number":["1919438."]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["1919438."],"award-info":[{"award-number":["1919438."]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biomech Model Mechanobiol"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1007\/s10237-023-01793-4","type":"journal-article","created":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T14:02:11Z","timestamp":1702476131000},"page":"581-599","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Multiscale computational modeling of aortic valve calcification"],"prefix":"10.1007","volume":"23","author":[{"given":"Javid","family":"Azimi-Boulali","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gretchen J.","family":"Mahler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce T.","family":"Murray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,12,13]]},"reference":[{"key":"1793_CR1","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1186\/1476-511X-10-191","volume":"10","author":"MAK Abdelhalim","year":"2011","unstructured":"Abdelhalim MAK (2011) The effects of size and period of administration of gold nanoparticles on rheological parameters of blood plasma of rats over a wide range of shear rates: in vivo. Lipids Health Dis 10:191. https:\/\/doi.org\/10.1186\/1476-511X-10-191","journal-title":"Lipids Health Dis"},{"key":"1793_CR2","doi-asserted-by":"publisher","unstructured":"Ahamed J, Burg N, Yoshinaga K, Janczak CA, Rifkin DB, Coller BS (2008) In vitro and in vivo evidence for shear-induced activation of latent transforming growth factor-$$\\beta 1$$. Blood 112:3650\u20133660. https:\/\/doi.org\/10.1182\/blood-2008-04-151753","DOI":"10.1182\/blood-2008-04-151753"},{"key":"1793_CR3","doi-asserted-by":"crossref","unstructured":"Aikawa E, Libby P (2017) A rock and a hard place: chiseling away at the multiple mechanisms of aortic stenosis. Am Heart Assoc 135(2)","DOI":"10.1161\/CIRCULATIONAHA.117.027776"},{"key":"1793_CR4","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.imu.2017.09.001","volume":"9","author":"A Amindari","year":"2017","unstructured":"Amindari A, Saltik L, Kirkkopru K, Yacoub M, Yalcin HC (2017) Assessment of calcified aortic valve leaflet deformations and blood flow dynamics using fluid\u2013structure interaction modeling. Inform Med Unlocked 9:191\u2013199","journal-title":"Inform Med Unlocked"},{"key":"1793_CR5","doi-asserted-by":"publisher","unstructured":"Anderson ARA (20056) A hybrid mathematical model of solid tumour invasion: the importance of cell adhesion. Math Med Biol A J IMA 22:163\u2013186. Retrieved from http:\/\/academic.oup.com\/imammb\/article\/22\/2\/163\/770979\/A-hybrid-mathematical-model-of-solid-tumour, https:\/\/doi.org\/10.1093\/imammb\/dqi005","DOI":"10.1093\/imammb\/dqi005"},{"issue":"6","key":"1793_CR6","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0020969","volume":"6","author":"RF Ankeny","year":"2011","unstructured":"Ankeny RF, Thourani VH, Weiss D, Vega JD, Taylor WR, Nerem RM, Jo H (2011) Preferential activation of smad1\/5\/8 on the fibrosa endothelium in calcified human aortic valves-association with low bmp antagonists and smad6. PLoS ONE 6(6):e20969","journal-title":"PLoS ONE"},{"issue":"11","key":"1793_CR7","doi-asserted-by":"crossref","first-page":"2922","DOI":"10.1021\/acsbiomaterials.7b00174","volume":"3","author":"A Arzani","year":"2017","unstructured":"Arzani A, Masters KS, Mofrad MR (2017) Multiscale systems biology model of calcific aortic valve disease progression. ACS Biomater Sci Eng 3(11):2922\u20132933","journal-title":"ACS Biomater Sci Eng"},{"key":"1793_CR8","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1007\/s10439-015-1348-x","volume":"43","author":"AA Bakhaty","year":"2015","unstructured":"Bakhaty AA, Mofrad MR (2015) Coupled simulation of heart valves: applications to clinical practice. Ann Biomed Eng 43:1626\u20131639","journal-title":"Ann Biomed Eng"},{"key":"1793_CR9","doi-asserted-by":"crossref","unstructured":"Balachandran K, Sucosky P, Yoganathan AP (2011) Hemodynamics and mechanobiology of aortic valve inflammation and calcification. Int J Inflamm 2011","DOI":"10.4061\/2011\/263870"},{"issue":"10","key":"1793_CR10","doi-asserted-by":"crossref","first-page":"e56","DOI":"10.1161\/CIR.0000000000000659","volume":"139","author":"EJ Benjamin","year":"2019","unstructured":"Benjamin EJ, Muntner P, Alonso A, Bittencourt MS, Callaway CW, Carson AP (2019) Heart disease and stroke statistics\u20132019 update: a report from the American heart association. Circulation 139(10):e56\u2013e528","journal-title":"Circulation"},{"key":"1793_CR11","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1161\/CIRCRESAHA.119.314813","volume":"124","author":"J Bischoff","year":"2019","unstructured":"Bischoff J (2019) Endothelial-to-mesenchymal transition. Circ Res 124:1163\u20131165. https:\/\/doi.org\/10.1161\/CIRCRESAHA.119.314813","journal-title":"Circ Res"},{"key":"1793_CR12","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.yjmcc.2013.04.001","volume":"60","author":"K Bosse","year":"2013","unstructured":"Bosse K, Hans CP, Zhao N, Koenig SN, Huang N, Guggilam A et al (2013) Endothelial nitric oxide signaling regulates Notch1 in aortic valve disease. J Mol Cell Cardiol 60:27\u201335. https:\/\/doi.org\/10.1016\/j.yjmcc.2013.04.001","journal-title":"J Mol Cell Cardiol"},{"issue":"3","key":"1793_CR13","doi-asserted-by":"crossref","DOI":"10.1088\/1758-5090\/abe025","volume":"13","author":"DJ Bustamante","year":"2021","unstructured":"Bustamante DJ, Basile EJ, Hildreth BM, Browning NW, Jensen SA, Moldovan L, Moldovan NI (2021) Biofabrication of spheroids fusion-based tumor models: computational simulation of glucose effects. Biofabrication 13(3):035010","journal-title":"Biofabrication"},{"issue":"1","key":"1793_CR16","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1161\/01.ATV.0000196624.70507.0d","volume":"26","author":"JT Butcher","year":"2006","unstructured":"Butcher JT, Tressel S, Johnson T, Turner D, Sorescu G, Jo H, Nerem RM (2006) Transcriptional profiles of valvular and vascular endothelial cells reveal phenotypic differences: influence of shear stress. Arterioscler Thromb Vasc Biol 26(1):69\u201377","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"1","key":"1793_CR15","first-page":"62","volume":"17","author":"JT Butcher","year":"2008","unstructured":"Butcher JT, Simmons CA, Warnock JN et al (2008) Mechanobiology of the aortic heart valve. J Heart Valve Dis 17(1):62","journal-title":"J Heart Valve Dis"},{"issue":"4\u20135","key":"1793_CR14","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.addr.2011.01.008","volume":"63","author":"JT Butcher","year":"2011","unstructured":"Butcher JT, Mahler GJ, Hockaday LA (2011) Aortic valve disease and treatment: the need for naturally engineered solutions. Adv Drug Deliv Rev 63(4\u20135):242\u2013268","journal-title":"Adv Drug Deliv Rev"},{"issue":"23","key":"1793_CR17","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1136\/heartjnl-2020-318556","volume":"107","author":"TR Cartlidge","year":"2021","unstructured":"Cartlidge TR, Bing R, Kwiecinski J, Guzzetti E, Pawade TA, Doris MK et al (2021) Contrast-enhanced computed tomography assessment of aortic stenosis. Heart 107(23):1905\u20131911","journal-title":"Heart"},{"key":"1793_CR18","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1007\/s10237-012-0375-x","volume":"11","author":"S Chandra","year":"2012","unstructured":"Chandra S, Rajamannan NM, Sucosky P (2012) Computational assessment of bicuspid aortic valve wall-shear stress: implications for calcific aortic valve disease. Biomech Model Mechanobiol 11:1085\u20131096","journal-title":"Biomech Model Mechanobiol"},{"issue":"11\u201312","key":"1793_CR19","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.cpc.2007.03.007","volume":"176","author":"N Chen","year":"2007","unstructured":"Chen N, Glazier JA, Izaguirre JA, Alber MS (2007) A parallel implementation of the Cellular Potts Model for simulation of cell-based morphogenesis. Comput Phys Commun 176(11\u201312):670\u2013681","journal-title":"Comput Phys Commun"},{"key":"1793_CR22","doi-asserted-by":"crossref","unstructured":"Chowkwale MS (2019) In silico multiscale modeling of endothelial cell mechanobiology in a tumor microenvironment","DOI":"10.1016\/j.jtbi.2019.08.012"},{"key":"1793_CR21","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.jtbi.2019.08.012","volume":"480","author":"M Chowkwale","year":"2019","unstructured":"Chowkwale M, Mahler GJ, Huang P, Murray BT (2019) A multiscale in silico model of endothelial to mesenchymal transformation in a tumor microenvironment. J Theor Biol 480:229\u2013240. https:\/\/doi.org\/10.1016\/j.jtbi.2019.08.012","journal-title":"J Theor Biol"},{"key":"1793_CR20","doi-asserted-by":"publisher","DOI":"10.1113\/JP283346","author":"M Chowkwale","year":"2022","unstructured":"Chowkwale M, Lindsey ML, Saucerman JJ (2022) Intercellular model predicts mechanisms of inflammation fibrosis coupling after myocardial infarction. J Physiol. https:\/\/doi.org\/10.1113\/JP283346","journal-title":"J Physiol"},{"key":"1793_CR23","doi-asserted-by":"crossref","unstructured":"Clark-Greuel JN, Connolly JM, Sorichillo E, Narula NR, Rapoport HS, Mohler ER III, Levy RJ (2007) Transforming growth factor-$$\\beta 1$$ mechanisms in aortic valve calcification: increased alkaline phosphatase and related events. Ann Thorac Surg 83(3):946\u2013953","DOI":"10.1016\/j.athoracsur.2006.10.026"},{"key":"1793_CR24","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0024029","author":"IE Collier","year":"2011","unstructured":"Collier IE, Legant W, Marmer B, Lubman O, Saffarian S, Wakatsuki T, Goldberg GI (2011) Diffusion of mmps on the surface of collagen fibrils: the mobile cell surface-collagen substratum interface. PLoS ONE. https:\/\/doi.org\/10.1371\/journal.pone.0024029","journal-title":"PLoS ONE"},{"key":"1793_CR25","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2022.783543","volume":"9","author":"NH Dayawansa","year":"2022","unstructured":"Dayawansa NH, Baratchi S, Peter K (2022) Uncoupling the vicious cycle of mechanical stress and inflammation in calcific aortic valve disease. Front Cardiovasc Med 9:783543","journal-title":"Front Cardiovasc Med"},{"key":"1793_CR26","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1038\/s41580-018-0080-4","volume":"20","author":"A Dongre","year":"2019","unstructured":"Dongre A, Weinberg RA (2019) New insights into the mechanisms of epithelial-mesenchymal transition and implications for cancer. Nat Rev Mol Cell Biol 20:69\u201384. https:\/\/doi.org\/10.1038\/s41580-018-0080-4","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"9","key":"1793_CR27","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1161\/CIRCRESAHA.121.318011","volume":"128","author":"K Driscoll","year":"2021","unstructured":"Driscoll K, Cruz AD, Butcher JT (2021) Inflammatory and biomechanical drivers of endothelial-interstitial interactions in calcific aortic valve disease. Circ Res 128(9):1344\u20131370","journal-title":"Circ Res"},{"key":"1793_CR28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11886-018-0968-9","volume":"20","author":"P Dutta","year":"2018","unstructured":"Dutta P, Lincoln J (2018) Calcific aortic valve disease: a developmental biology perspective. Curr Cardiol Rep 20:1\u201313","journal-title":"Curr Cardiol Rep"},{"issue":"11","key":"1793_CR29","doi-asserted-by":"crossref","first-page":"2801","DOI":"10.1016\/j.bpj.2020.04.024","volume":"118","author":"I Fortuna","year":"2020","unstructured":"Fortuna I, Perrone GC, Krug MS, Susin E, Belmonte JM, Thomas GL, de Almeida RM (2020) Compucell3d simulations reproduce mesenchymal cell migration on flat substrates. Biophys J 118(11):2801\u20132815","journal-title":"Biophys J"},{"key":"1793_CR30","doi-asserted-by":"publisher","first-page":"1965","DOI":"10.1007\/s11538-019-00597-x","volume":"81","author":"LC Franssen","year":"2019","unstructured":"Franssen LC, Lorenzi T, Burgess AEF, Chaplain MAJ (2019) A mathematical framework for modelling the metastatic spread of cancer. Bull Math Biol 81:1965\u20132010. https:\/\/doi.org\/10.1007\/s11538-019-00597-x","journal-title":"Bull Math Biol"},{"issue":"7056","key":"1793_CR31","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/nature03940","volume":"437","author":"V Garg","year":"2005","unstructured":"Garg V, Muth AN, Ransom JF, Schluterman MK, Barnes R, King IN, Srivastava D (2005) Mutations in notch1 cause aortic valve disease. Nature 437(7056):270\u2013274","journal-title":"Nature"},{"issue":"39","key":"1793_CR32","doi-asserted-by":"crossref","first-page":"33132","DOI":"10.1074\/jbc.M500608200","volume":"280","author":"T Gaur","year":"2005","unstructured":"Gaur T, Lengner CJ, Hovhannisyan H, Bhat RA, Bodine PV, Komm BS et al (2005) Canonical wnt signaling promotes osteogenesis by directly stimulating runx2 gene expression. J Biol Chem 280(39):33132\u201333140","journal-title":"J Biol Chem"},{"key":"1793_CR33","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00935-14","author":"S Gottesman","year":"2014","unstructured":"Gottesman S (2014) Coordinating bacterial cell division with nutrient availability: a role for glycolysis. mBio. https:\/\/doi.org\/10.1128\/mBio.00935-14","journal-title":"mBio"},{"issue":"13","key":"1793_CR34","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1103\/PhysRevLett.69.2013","volume":"69","author":"F Graner","year":"1992","unstructured":"Graner F, Glazier JA (1992) Simulation of biological cell sorting using a two-dimensional extended potts model. Phys Rev Lett 69(13):2013","journal-title":"Phys Rev Lett"},{"issue":"10","key":"1793_CR35","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1002\/bies.20636","volume":"29","author":"J Heino","year":"2007","unstructured":"Heino J (2007) The collagen family members as cell adhesion proteins. BioEssays 29(10):1001\u20131010","journal-title":"BioEssays"},{"key":"1793_CR36","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/j.atherosclerosis.2015.07.008","volume":"242","author":"J Hjortnaes","year":"2015","unstructured":"Hjortnaes J, Shapero K, Goettsch C, Hutcheson JD, Keegan J, Kluin J, Aikawa E (2015) Valvular interstitial cells suppress calcification of valvular endothelial cells. Atherosclerosis 242:251\u2013260. https:\/\/doi.org\/10.1016\/j.atherosclerosis.2015.07.008","journal-title":"Atherosclerosis"},{"key":"1793_CR37","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.yjmcc.2015.11.005","volume":"93","author":"MA Horn","year":"2016","unstructured":"Horn MA, Trafford AW (2016) Aging and the cardiac collagen matrix: Novel mediators of fibrotic remodelling. J Mol Cell Cardiol 93:175\u2013185. https:\/\/doi.org\/10.1016\/j.yjmcc.2015.11.005","journal-title":"J Mol Cell Cardiol"},{"issue":"1","key":"1793_CR38","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1161\/ATVBAHA.112.300278","volume":"33","author":"JD Hutcheson","year":"2013","unstructured":"Hutcheson JD, Chen J, Sewell-Loftin M, Ryzhova LM, Fisher CI, Su YR, Merryman WD (2013) Cadherin-11 regulates cell-cell tension necessary for calcific nodule formation by valvular myofibroblasts. Arterioscler Thromb Vasc Biol 33(1):114\u2013120","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"3","key":"1793_CR39","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.13187","volume":"55","author":"S Jafari Nivlouei","year":"2022","unstructured":"Jafari Nivlouei S, Soltani M, Shirani E, Salimpour MR, Travasso R, Carvalho J (2022) A multiscale cell-based model of tumor growth for chemotherapy assessment and tumor-targeted therapy through a 3d computational approach. Cell Prolif 55(3):e13187","journal-title":"Cell Prolif"},{"key":"1793_CR40","doi-asserted-by":"crossref","unstructured":"Jian B, Narula N, Li Q-Y, Mohler ER III, Levy RJ (2003) Progression of aortic valve stenosis: Tgf-$$\\beta 1$$ is present in calcified aortic valve cusps and promotes aortic valve interstitial cell calcification via apoptosis. Ann Thorac Surg 75(2):457\u2013465","DOI":"10.1016\/S0003-4975(02)04312-6"},{"issue":"77","key":"1793_CR41","doi-asserted-by":"crossref","first-page":"3268","DOI":"10.1098\/rsif.2012.0448","volume":"9","author":"AJ Kabla","year":"2012","unstructured":"Kabla AJ (2012) Collective cell migration: leadership, invasion and segregation. J R Soc Interface 9(77):3268\u20133278","journal-title":"J R Soc Interface"},{"key":"1793_CR42","doi-asserted-by":"crossref","unstructured":"Kawamoto M, Matsunami T, Ertl RF, Fukuda Y, Ogawa M, Spurzem JR, Rennard SI (1997) Selective migration of $$\\alpha$$-smooth muscle actin-positive myofibroblasts toward fibronectin in the Boyden\u2019s blindwell chamber. Clin Sci 93(4):355\u2013362","DOI":"10.1042\/cs0930355"},{"issue":"2","key":"1793_CR43","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/0022-5193(71)90050-6","volume":"30","author":"EF Keller","year":"1971","unstructured":"Keller EF, Segel LA (1971) Model for chemotaxis. J Theor Biol 30(2):225\u2013234","journal-title":"J Theor Biol"},{"key":"1793_CR44","doi-asserted-by":"publisher","first-page":"2346","DOI":"10.1161\/ATVBAHA.116.307870","volume":"36","author":"K Nekolla","year":"2016","unstructured":"Nekolla K, Rehberg M, Vollmar AM, Zahler S (2016) New view on endothelial cell migration. Arterioscler Thromb Vasc Biol 36:2346\u20132357. https:\/\/doi.org\/10.1161\/ATVBAHA.116.307870","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"12","key":"1793_CR45","doi-asserted-by":"crossref","first-page":"2346","DOI":"10.1161\/ATVBAHA.116.307870","volume":"36","author":"K Kick","year":"2016","unstructured":"Kick K, Nekolla K, Rehberg M, Vollmar AM, Zahler S (2016) New view on endothelial cell migration: switching modes of migration based on matrix composition. Arterioscler Thromb Vasc Biol 36(12):2346\u20132357","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"1793_CR46","doi-asserted-by":"publisher","first-page":"19905","DOI":"10.1038\/srep19905","volume":"6","author":"S Kumar","year":"2016","unstructured":"Kumar S, Kapoor A, Desai S, Inamdar MM, Sen S (2016) Proteolytic and non-proteolytic regulation of collective cell invasion: tuning by ECM density and organization. Sci Rep 6:19905. https:\/\/doi.org\/10.1038\/srep19905","journal-title":"Sci Rep"},{"key":"1793_CR47","doi-asserted-by":"publisher","unstructured":"Kumarswamy R, Volkmann I, Jazbutyte V, Dangwal S, Park D-H, Thum T (2012) Transforming growth factor-$$\\beta$$-induced endothelialto-mesenchymal transition is partly mediated by MicroRNA-21. Arterioscler Thromb Vasc Biol 32:361\u2013369. https:\/\/doi.org\/10.1161\/ATVBAHA.111.234286","DOI":"10.1161\/ATVBAHA.111.234286"},{"key":"1793_CR48","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0111896","volume":"9","author":"B Lee","year":"2014","unstructured":"Lee B, Zhou X, Riching K, Eliceiri KW, Keely PJ, Guelcher SA, Jiang Y (2014) A three-dimensional computational model of collagen network mechanics. PLoS ONE 9:e111896. https:\/\/doi.org\/10.1371\/journal.pone.0111896","journal-title":"PLoS ONE"},{"issue":"4","key":"1793_CR49","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1161\/CIRCINTERVENTIONS.112.971028","volume":"5","author":"JA Leopold","year":"2012","unstructured":"Leopold JA (2012) Cellular mechanisms of aortic valve calcification. Circ Cardiovasc Interv 5(4):605\u2013614","journal-title":"Circ Cardiovasc Interv"},{"key":"1793_CR50","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.jbiomech.2019.07.047","volume":"94","author":"G Luraghi","year":"2019","unstructured":"Luraghi G, Migliavacca F, Chiastra C, Rossi A, Reimers B, Stefanini GG, Matas JFR (2019) Does clinical data quality affect fluid-structure interaction simulations of patient-specific stenotic aortic valve models? J Biomech 94:202\u2013210","journal-title":"J Biomech"},{"issue":"3","key":"1793_CR51","first-page":"183","volume":"36","author":"X Ma","year":"2020","unstructured":"Ma X, Zhao D, Yuan P, Li J, Yun Y, Cui Y et al (2020) Endothelialto-mesenchymal transition in calcific aortic valve disease. Acta Cardiol Sin 36(3):183","journal-title":"Acta Cardiol Sin"},{"key":"1793_CR52","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1161\/ATVBAHA.112.300504","volume":"33","author":"GJ Mahler","year":"2013","unstructured":"Mahler GJ, Farrar EJ, Butcher JT (2013) Inflammatory cytokines promote mesenchymal transformation in embryonic and adult valve endothelial cells. Arterioscler Thromb Vasc Biol 33:121\u2013130. https:\/\/doi.org\/10.1161\/ATVBAHA.112.300504","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"1793_CR53","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11517-013-1113-y","volume":"52","author":"H Maleki","year":"2014","unstructured":"Maleki H, Shahriari S, Durand LG, Labrosse MR, Kadem L (2014) A metric for the stiffness of calcified aortic valves using a combined computational and experimental approach. Medical Biol Eng Comput 52:1\u20138","journal-title":"Medical Biol Eng Comput"},{"issue":"2","key":"1793_CR54","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1007\/s00380-016-0909-8","volume":"32","author":"S Masjedi","year":"2017","unstructured":"Masjedi S, Lei Y, Patel J, Ferdous Z (2017) Sex-related differences in matrix remodeling and early osteogenic markers in aortic valvular interstitial cells. Heart Vessels 32(2):217\u2013228. https:\/\/doi.org\/10.1007\/s00380-016-0909-8","journal-title":"Heart Vessels"},{"key":"1793_CR55","doi-asserted-by":"publisher","first-page":"4219","DOI":"10.1073\/pnas.93.9.4219","volume":"93","author":"SK Masur","year":"1996","unstructured":"Masur SK, Dewal HS, Dinh TT, Erenburg I, Petridou S (1996) Myofibroblasts differentiate from fibroblasts when plated at low density. Proc Natl Acad Sci 93:4219\u20134223. https:\/\/doi.org\/10.1073\/pnas.93.9.4219","journal-title":"Proc Natl Acad Sci"},{"key":"1793_CR56","doi-asserted-by":"crossref","unstructured":"Mathieu P, Bouchareb R, Boulanger M-C (2015) Innate and adaptive immunity in calcific aortic valve disease. J Immunol Res 2015","DOI":"10.1155\/2015\/851945"},{"key":"1793_CR57","doi-asserted-by":"publisher","first-page":"1374","DOI":"10.1039\/D1LC00931A","volume":"22","author":"M Mendoza","year":"2022","unstructured":"Mendoza M, Chen M-H, Huang P, Mahler GJ (2022) Shear and endothelial induced late-stage calcific aortic valve disease-on-achip develops calcium phosphate mineralizations. Lab Chip 22:1374\u20131385. https:\/\/doi.org\/10.1039\/D1LC00931A","journal-title":"Lab Chip"},{"key":"1793_CR58","doi-asserted-by":"publisher","unstructured":"ming Meng X, Nikolic-Paterson DJ, Lan HY (2016) TGF-$$\\beta$$: the master regulator of fibrosis. Nat Rev Nephrol 12:325\u2013338. https:\/\/doi.org\/10.1038\/nrneph.2016.48","DOI":"10.1038\/nrneph.2016.48"},{"issue":"11","key":"1793_CR59","doi-asserted-by":"crossref","DOI":"10.1115\/1.4054630","volume":"144","author":"A Mirza","year":"2022","unstructured":"Mirza A, Ramaswamy S (2022) Importance of non-newtonian computational fluid modeling on severely calcified aortic valve geometries\u2013insights from quasi-steady state simulations. J Biomech Eng 144(11):114501","journal-title":"J Biomech Eng"},{"issue":"1484","key":"1793_CR60","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1098\/rstb.2007.2125","volume":"362","author":"M Misfeld","year":"2007","unstructured":"Misfeld M, Sievers H-H (2007) Heart valve macro-and microstructure. Philos Trans Roy Soc B Biol Sci 362(1484):1421\u20131436","journal-title":"Philos Trans Roy Soc B Biol Sci"},{"issue":"9","key":"1793_CR61","doi-asserted-by":"crossref","DOI":"10.1002\/aic.16671","volume":"65","author":"YT Nguyen Edalgo","year":"2019","unstructured":"Nguyen Edalgo YT, Zornes AL, Ford Versypt AN (2019) A hybrid discrete-continuous model of metastatic cancer cell migration through a remodeling extracellular matrix. AIChE J 65(9):e16671","journal-title":"AIChE J"},{"issue":"9540","key":"1793_CR62","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/S0140-6736(06)69208-8","volume":"368","author":"VT Nkomo","year":"2006","unstructured":"Nkomo VT, Gardin JM, Skelton TN, Gottdiener JS, Scott CG, Enriquez-Sarano M (2006) Burden of valvular heart diseases: a population-based study. The Lancet 368(9540):1005\u20131011","journal-title":"The Lancet"},{"key":"1793_CR63","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/j.biomaterials.2004.02.052","volume":"26","author":"F O\u2019Brien","year":"2005","unstructured":"O\u2019Brien F, Harley B, Yannas I, Gibson L (2005) The effect of pore size on cell adhesion in collagengag scaffolds. Biomaterials 26:433\u2013441. https:\/\/doi.org\/10.1016\/j.biomaterials.2004.02.052","journal-title":"Biomaterials"},{"issue":"3","key":"1793_CR64","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.2353\/ajpath.2010.090735","volume":"176","author":"J O\u2019Brien","year":"2010","unstructured":"O\u2019Brien J, Lyons T, Monks J, Lucia MS, Wilson RS, Hines L, Schedin P (2010) Alternatively activated macrophages and collagen remodeling characterize the postpartum involuting mammary gland across species. Am J Pathol 176(3):1241\u20131255","journal-title":"Am J Pathol"},{"key":"1793_CR65","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1161\/CIRCULATIONAHA.105.001115","volume":"114","author":"L Osman","year":"2006","unstructured":"Osman L, Yacoub MH, Latif N, Amrani M, Chester AH (2006) Role of human valve interstitial cells in valve calcification and their response to atorvastatin. Circulation 114:547\u2013552. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.105.001115","journal-title":"Circulation"},{"issue":"3","key":"1793_CR66","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1513\/pats.200708-146DR","volume":"5","author":"SH Phan","year":"2008","unstructured":"Phan SH (2008) Biology of fibroblasts and myofibroblasts. Proc Am Thorac Soc 5(3):334\u2013337","journal-title":"Proc Am Thorac Soc"},{"key":"1793_CR67","doi-asserted-by":"publisher","first-page":"H1767","DOI":"10.1152\/ajpheart.01305.2007","volume":"294","author":"M Pho","year":"2008","unstructured":"Pho M, Lee W, Watt DR, Laschinger C, Simmons CA, McCulloch CA (2008) Cofilin is a marker of myofibroblast differentiation in cells from porcine aortic cardiac valves. Am J Physiol Heart Circ Physiol 294:H1767\u2013H1778. https:\/\/doi.org\/10.1152\/ajpheart.01305.2007","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"1793_CR68","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1007\/s10741-016-9536-9","volume":"21","author":"A Piek","year":"2016","unstructured":"Piek A, de Boer RA, Sillj\u00e9 HHW (2016) The fibrosis-cell death axis in heart failure. Heart Fail Rev 21:199\u2013211. https:\/\/doi.org\/10.1007\/s10741-016-9536-9","journal-title":"Heart Fail Rev"},{"issue":"16","key":"1793_CR69","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1161\/CIRCULATIONAHA.110.006767","volume":"124","author":"NM Rajamannan","year":"2011","unstructured":"Rajamannan NM, Evans FJ, Aikawa E, Grande-Allen KJ, Demer LL, Heistad DD et al (2011) Calcific aortic valve disease: not simply a degenerative process a review and agenda for research from the national heart and lung and blood institute aortic stenosis working group. Circulation 124(16):1783","journal-title":"Circulation"},{"key":"1793_CR70","doi-asserted-by":"crossref","unstructured":"Ramis-Conde I, Drasdo D, Anderson AR, Chaplain MA (2008) Modeling the influence of the E-cadherin-$$\\beta$$-catenin pathway in cancer cell invasion: a multiscale approach. Biophys J 95(1):155\u2013165","DOI":"10.1529\/biophysj.107.114678"},{"key":"1793_CR71","unstructured":"Rush MN (2018) Chemically modified monolayer surfaces influence valvular interstitial cell attachment and differentiation for heart valve tissue engineering (Unpublished doctoral dissertation)"},{"key":"1793_CR72","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbiomech.2021.110773","volume":"128","author":"MS Sadrabadi","year":"2021","unstructured":"Sadrabadi MS, Eskandari M, Feigenbaum HP, Arzani A (2021a) Local and global growth and remodeling in calcific aortic valve disease and aging. J Biomech 128:110773","journal-title":"J Biomech"},{"key":"1793_CR73","volume":"117","author":"MS Sadrabadi","year":"2021","unstructured":"Sadrabadi MS, Hedayat M, Borazjani I, Arzani A (2021b) Fluid-structure coupled biotransport processes in aortic valve disease. J Biomech 117:110239","journal-title":"J Biomech"},{"key":"1793_CR74","doi-asserted-by":"crossref","unstructured":"Sarper M, Cortes E, Lieberthal TJ, del R\u00edo Hern\u00e1ndez A (2016) Atra modulates mechanical activation of tgf-$$\\beta$$ by pancreatic stellate cells. Sci Rep 6(1):27639","DOI":"10.1038\/srep27639"},{"key":"1793_CR75","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1002\/dvdy.24589","volume":"247","author":"G S\u00e1nchez-Duffhues","year":"2018","unstructured":"S\u00e1nchez-Duffhues G, de Vinuesa AG, ten Dijke P (2018) Endothelial-to-mesenchymal transition in cardiovascular diseases: developmental signaling pathways gone awry. Dev Dyn 247:492\u2013508. https:\/\/doi.org\/10.1002\/dvdy.24589","journal-title":"Dev Dyn"},{"issue":"1","key":"1793_CR76","doi-asserted-by":"publisher","first-page":"17025","DOI":"10.1038\/micronano.2017.25","volume":"3","author":"KJ Son","year":"2017","unstructured":"Son KJ, Gheibi P, Stybayeva G, Rahimian A, Revzin A (2017) Detecting cell-secreted growth factors in microfluidic devices using bead-based biosensors. Microsyst Nanoeng 3(1):17025. https:\/\/doi.org\/10.1038\/micronano.2017.25","journal-title":"Microsyst Nanoeng"},{"issue":"6","key":"1793_CR77","doi-asserted-by":"publisher","first-page":"2035","DOI":"10.1016\/S0002-9440(10)64482-3","volume":"161","author":"SA Steitz","year":"2002","unstructured":"Steitz SA, Speer MY, McKee MD, Liaw L, Almeida M, Yang H, Giachelli CM (2002) Osteopontin inhibits mineral deposition and promotes regression of ectopic calcification. Am J Pathol 161(6):2035\u20132046. https:\/\/doi.org\/10.1016\/S0002-9440(10)64482-3","journal-title":"Am J Pathol"},{"issue":"6","key":"1793_CR78","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.carpath.2010.10.002","volume":"20","author":"EH Stephens","year":"2011","unstructured":"Stephens EH, Saltarrelli JG, Baggett LS, Nandi I, Kuo JJ, Davis AR, Grande-Allen KJ (2011) Differential proteoglycan and hyaluronan distribution in calcified aortic valves. Cardiovasc Pathol 20(6):334\u2013342","journal-title":"Cardiovasc Pathol"},{"key":"1793_CR79","doi-asserted-by":"crossref","unstructured":"Sucosky P, Balachandran K, Elhammali A, Jo H, Yoganathan AP (2009) Altered shear stress stimulates upregulation of endothelial vcam-1 and icam-1 in a bmp-4-and tgf-$$\\beta$$1-dependent pathway. Arterioscler Thromb Vasc Biol 29(2):254\u2013260","DOI":"10.1161\/ATVBAHA.108.176347"},{"key":"1793_CR80","doi-asserted-by":"crossref","unstructured":"Swat MH, Thomas GL, Belmonte JM, Shirinifard A, Hmeljak D, Glazier JA (2012) Multi-scale modeling of tissues using compucell3d. In: Methods in cell biology, vol 110. Elsevier, pp 325\u2013366","DOI":"10.1016\/B978-0-12-388403-9.00013-8"},{"issue":"1484","key":"1793_CR81","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1098\/rstb.2007.2117","volume":"362","author":"PM Taylor","year":"2007","unstructured":"Taylor PM (2007) Biological matrices and bionanotechnology. Philos Trans Roy Soc B Biol Sci 362(1484):1313\u20131320","journal-title":"Philos Trans Roy Soc B Biol Sci"},{"issue":"1","key":"1793_CR82","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/cm.20166","volume":"64","author":"BP Thampatty","year":"2007","unstructured":"Thampatty BP, Wang JH-C (2007) A new approach to study fibroblast migration. Cell Motil Cytoskelet 64(1):1\u20135","journal-title":"Cell Motil Cytoskelet"},{"key":"1793_CR83","doi-asserted-by":"publisher","first-page":"1976","DOI":"10.1172\/JCI114932","volume":"86","author":"LM Wakefield","year":"1990","unstructured":"Wakefield LM, Winokur TS, Hollands RS, Christopherson K, Levinson AD, Sporn MB (1990) Recombinant latent transforming growth factor beta 1 has a longer plasma half-life in rats than active transforming growth factor beta 1, and a different tissue distribution. J Clin Investig 86:1976\u20131984. https:\/\/doi.org\/10.1172\/JCI114932","journal-title":"J Clin Investig"},{"key":"1793_CR84","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1007\/s10558-007-9038-4","volume":"7","author":"EJ Weinberg","year":"2007","unstructured":"Weinberg EJ, Kaazempur Mofrad MR (2007) Transient, three-dimensional, multiscale simulations of the human aortic valve. Cardiovasc Eng 7:140\u2013155","journal-title":"Cardiovasc Eng"},{"key":"1793_CR85","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btac770","author":"C Welsh","year":"2023","unstructured":"Welsh C, Xu J, Smith L, K\u00f6nig M, Choi K, Sauro HM (2023) libRoadRunner 2.0: a high performance SBML simulation and analysis library. Bioinformatics. https:\/\/doi.org\/10.1093\/bioinformatics\/btac770","journal-title":"Bioinformatics"},{"issue":"11","key":"1793_CR86","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1161\/ATVBAHA.114.302523","volume":"34","author":"KE Yutzey","year":"2014","unstructured":"Yutzey KE, Demer LL, Body SC, Huggins GS, Towler DA, Giachelli CM et al (2014) Calcific aortic valve disease: a consensus summary from the alliance of investigators on calcific aortic valve disease. Arterioscler Thromb Vasc Biol 34(11):2387\u20132393","journal-title":"Arterioscler Thromb Vasc Biol"}],"container-title":["Biomechanics and Modeling in Mechanobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10237-023-01793-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10237-023-01793-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10237-023-01793-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T09:27:49Z","timestamp":1711358869000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10237-023-01793-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,13]]},"references-count":86,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["1793"],"URL":"https:\/\/doi.org\/10.1007\/s10237-023-01793-4","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-3101659\/v1","asserted-by":"object"}]},"ISSN":["1617-7959","1617-7940"],"issn-type":[{"value":"1617-7959","type":"print"},{"value":"1617-7940","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,13]]},"assertion":[{"value":"23 June 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 November 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 December 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no competing or financial interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}