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So far, extensions of these models have been proposed to include either intracellular signaling or chemo-mechanical coupling on the organ-scale. However, no version of constrained mixture models currently exists that includes both aspects. Here, we propose such a version that resolves cellular signal processing by a set of logic-gated ordinary differential equations and captures chemo-mechanical interactions between cells by coupling a reaction-diffusion equation with the equations of nonlinear continuum mechanics. To demonstrate the potential of the model, we present 2 case studies within vascular solid mechanics: (i) the influence of angiotensin II on aortic growth and remodeling and (ii) the effect of communication between endothelial and intramural arterial cells via nitric oxide and endothelin-1.<\/jats:p>","DOI":"10.1007\/s10237-024-01884-w","type":"journal-article","created":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T18:04:01Z","timestamp":1729188241000},"page":"2115-2136","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Multiscale homogenized constrained mixture model of the bio-chemo-mechanics of soft tissue growth and remodeling"],"prefix":"10.1007","volume":"23","author":[{"given":"Daniel","family":"Paukner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay D.","family":"Humphrey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian J.","family":"Cyron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,17]]},"reference":[{"key":"1884_CR1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1714377115","author":"M Adler","year":"2018","unstructured":"Adler M, Mayo A, Zhou X, Franklin RA, Jacox JB, Medzhitov R, Alon U (2018) Endocytosis as a stabilizing mechanism for tissue homeostasis. 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