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Identification and prediction of PE are of fundamental significance for disease diagnosis, prevention and treatment. In vivo optical coherence tomography (OCT) data of eight eroded plaques and eight non-eroded plaques were acquired to construct three-dimensional fluid\u2013structure interaction models and obtain plaque biomechanical conditions for investigation. Plaque stenosis severity, plaque burden, plaque wall stress (PWS) and strain (PWSn), flow shear stress (FSS), and \u0394FSS (FSS variation in time) were extracted for comparison and prediction. A logistic regression model was used to predict plaque erosion. Our results indicated that the combination of mean PWS and mean \u0394FSS gave best prediction (AUC\u2009=\u20090.866, 90% confidence interval (0.717, 1.0)). The best single predictor was max \u0394FSS (AUC\u2009=\u20090.819, 90% confidence interval (0.624, 1.0)). The average of maximum FSS values from eroded plaques was 76% higher than that from the non-eroded plaques (127.96 vs. 72.69 dyn\/cm<jats:sup>2<\/jats:sup>) while the average of mean FSS from erosion sites of the eight eroded plaques was 48.6% higher than that from sites without erosion (71.52 vs. 48.11 dyn\/cm<jats:sup>2<\/jats:sup>). The average of mean PWS from plaques with erosion was 22.83% lower than that for plaques without erosion (83.2\u00a0kPa vs. 107.8\u00a0kPa). This pilot study suggested that combining plaque stress, strain and flow shear stress could help better identify patients with potential plaque erosion, enabling possible early intervention therapy. Further studies are needed to validate our findings.<\/jats:p>","DOI":"10.1007\/s10237-024-01906-7","type":"journal-article","created":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T00:01:38Z","timestamp":1731369698000},"page":"213-231","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Comparison and identification of human coronary plaques with\/without erosion using patient-specific optical coherence tomography-based fluid\u2013structure interaction models: a pilot study"],"prefix":"10.1007","volume":"24","author":[{"given":"Yanwen","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheyang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Maehara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalin","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanqun","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yishuo","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengde","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoguo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibo","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minglong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary S.","family":"Mintz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,11,12]]},"reference":[{"key":"1906_CR1","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1007\/s13239-013-0165-3","volume":"4","author":"IC Campbell","year":"2013","unstructured":"Campbell IC, Timmins LH, Giddens DP, Virmani R, Veneziani A, Rab ST, Samady H, McDaniel MC, Finn AV, Taylor WR, Oshinski JN (2013) Computational Fluid Dynamics Simulations of Hemodynamics in Plaque Erosion. 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No ethical approval was needed.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}