{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:18:08Z","timestamp":1790194688678,"version":"4.1.0"},"reference-count":71,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T00:00:00Z","timestamp":1744761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T00:00:00Z","timestamp":1744761600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biomech Model Mechanobiol"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1007\/s10237-025-01952-9","type":"journal-article","created":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T13:15:26Z","timestamp":1744809326000},"page":"1043-1056","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A computational and experimental study of veno-arterial extracorporeal membrane oxygenation in cardiogenic shock: defining the trade-off between perfusion and afterload"],"prefix":"10.1007","volume":"24","author":[{"given":"Emanuele","family":"Gasparotti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Vignali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Scolaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorela","family":"Haxhiademi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Celi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,16]]},"reference":[{"issue":"11","key":"1952_CR1","doi-asserted-by":"publisher","first-page":"e179","DOI":"10.1097\/MAT.0000000000001819","volume":"68","author":"Y Ahmed","year":"2022","unstructured":"Ahmed Y, Lynch SR, Haft JW, Moll FL, van Herwaarden JA, Burris NS, Patel HJ, Figueroa CA (2022) Patient-specific computational modeling of different cannulation strategies for extracorporeal membrane oxygenation. ASAIO J 68(11):e179\u2013e187","journal-title":"ASAIO J"},{"key":"1952_CR2","doi-asserted-by":"crossref","unstructured":"Anatol J, Vignali E, Gasparotti E, Castro-Ruiz F, Rubio M, Barrios-Collado C, Sierra-Pallares J, Celi S (2025) A novel valveless pulsatile flow pump for extracorporeal blood circulation. Ann Biomed Eng 1\u201314","DOI":"10.1007\/s10439-024-03672-0"},{"issue":"12","key":"1952_CR3","doi-asserted-by":"publisher","first-page":"3494","DOI":"10.1007\/s10439-021-02841-9","volume":"49","author":"MN Antonuccio","year":"2021","unstructured":"Antonuccio MN, Mariotti A, Fanni BM, Capellini K, Capelli C, Sauvage E, Celi S (2021) Effects of uncertainty of outlet boundary conditions in a patient-specific case of aortic coarctation. Ann Biomed Eng 49(12):3494\u20133507","journal-title":"Ann Biomed Eng"},{"key":"1952_CR4","doi-asserted-by":"publisher","DOI":"10.1016\/j.medengphy.2022.103873","volume":"107","author":"MN Antonuccio","year":"2022","unstructured":"Antonuccio MN, Morales HG, This A, Capellini K, Avril S, Celi S, Rouet L (2022) Towards the 2d velocity reconstruction in abdominal aorta from color-doppler ultrasound. Med Eng Phys 107:103873","journal-title":"Med Eng Phys"},{"key":"1952_CR5","doi-asserted-by":"publisher","first-page":"1141623","DOI":"10.3389\/fcvm.2023.1141623","volume":"10","author":"MN Antonuccio","year":"2023","unstructured":"Antonuccio MN, Gasparotti E, Bardi F, Monteleone A, This A, Rouet L, Avril S, Celi S (2023) Fabrication of deformable patient-specific aaa models by material casting techniques. Front Cardiovascu Med 10:1141623","journal-title":"Front Cardiovascu Med"},{"issue":"3","key":"1952_CR6","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1097\/CRD.0000000000000223","volume":"27","author":"EE Argueta","year":"2019","unstructured":"Argueta EE, Paniagua D (2019) Thermodilution cardiac output: a concept over 250 years in the making. Cardiol Rev 27(3):138\u2013144","journal-title":"Cardiol Rev"},{"key":"1952_CR7","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1007\/s40472-017-0158-5","volume":"4","author":"DA Baran","year":"2017","unstructured":"Baran DA (2017) Extracorporeal membrane oxygenation (ecmo) and the critical cardiac patient. Curr Transplant Rep 4:218\u2013225","journal-title":"Curr Transplant Rep"},{"issue":"5","key":"1952_CR8","doi-asserted-by":"publisher","first-page":"1651","DOI":"10.1109\/TBME.2022.3224581","volume":"70","author":"F Bardi","year":"2022","unstructured":"Bardi F, Gasparotti E, Vignali E, Avril S, Celi S (2022) A hybrid mock circulatory loop for fluid dynamic characterization of 3d anatomical phantoms. IEEE Trans Biomed Eng 70(5):1651\u20131661","journal-title":"IEEE Trans Biomed Eng"},{"key":"1952_CR9","doi-asserted-by":"publisher","first-page":"1452278","DOI":"10.3389\/fbioe.2024.1452278","volume":"12","author":"F Bardi","year":"2024","unstructured":"Bardi F, Gasparotti E, Vignali E, Antonuccio MN, Storto E, AVRIL S, Celi S (2024) A hybrid mock circulatory loop integrated with a led-piv system for the investigation of aaa compliant phantoms. Front Bioeng Biotechnol 12:1452278","journal-title":"Front Bioeng Biotechnol"},{"key":"1952_CR10","doi-asserted-by":"crossref","unstructured":"Bennett VA, Aya HD, Cecconi M (2018) Evaluation of cardiac function using heart-lung interactions. Ann Translat Med 6(18)","DOI":"10.21037\/atm.2018.08.10"},{"key":"1952_CR11","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1007\/s13239-018-00387-x","volume":"9","author":"A Boccadifuoco","year":"2018","unstructured":"Boccadifuoco A, Mariotti A, Capellini K, Celi S, Salvetti MV (2018) Validation of numerical simulations of thoracic aorta hemodynamics: comparison with in vivo measurements and stochastic sensitivity analysis. Cardiovasc Eng Technol 9:688\u2013706","journal-title":"Cardiovasc Eng Technol"},{"issue":"1\u2013Supp 1","key":"1952_CR12","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1177\/0267659119830521","volume":"34","author":"LM Broman","year":"2019","unstructured":"Broman LM, Prahl Wittberg L, Westlund CJ, Gilbers M, Perry da C\u00e2mara L, Swol J, Taccone FS, Malfertheiner MV, Di Nardo M, Vercaemst L et al (2019) Pressure and flow properties of cannulae for extracorporeal membrane oxygenation i: return (arterial) cannulae. Perfusion 34(1\u2013Supp 1):58\u201364","journal-title":"Perfusion"},{"issue":"11","key":"1952_CR13","doi-asserted-by":"publisher","first-page":"1200","DOI":"10.1080\/10255842.2014.887698","volume":"18","author":"A Caballero","year":"2015","unstructured":"Caballero A, La\u00edn S (2015) Numerical simulation of non-newtonian blood flow dynamics in human thoracic aorta. Comput Methods Biomech Biomed Eng 18(11):1200\u20131216","journal-title":"Comput Methods Biomech Biomed Eng"},{"issue":"11","key":"1952_CR14","doi-asserted-by":"publisher","DOI":"10.1115\/1.4040940","volume":"140","author":"K Capellini","year":"2018","unstructured":"Capellini K, Vignali E, Costa E, Gasparotti E, Biancolini ME, Landini L, Positano V, Celi S (2018) Computational fluid dynamic study for ataa hemodynamics: an integrated image-based and radial basis functions mesh morphing approach. J Biomech Eng 140(11):111007","journal-title":"J Biomech Eng"},{"key":"1952_CR15","first-page":"68","volume":"91","author":"K Capellini","year":"2021","unstructured":"Capellini K, Gasparotti E, Cella U, Costa E, Fanni BM, Groth C, Porziani S, Biancolini ME, Celi S (2021) A novel formulation for the study of the ascending aortic fluid dynamics with in vivo data. Med Eng Phys 91:68\u201378","journal-title":"Med Eng Phys"},{"key":"1952_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1532-429X-14-51","volume":"14","author":"M Carlsson","year":"2012","unstructured":"Carlsson M, Andersson R, Markenroth Bloch K, Steding-Ehrenborg K, Mos\u00e9n H, Stahlberg F, Ekmehag B, Arheden H (2012) Cardiac output and cardiac index measured with cardiovascular magnetic resonance in healthy subjects, elite athletes and patients with congestive heart failure. J Cardiovasc Magn Reson 14:1\u20137","journal-title":"J Cardiovasc Magn Reson"},{"key":"1952_CR17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2020.104294","volume":"115","author":"A Cavallo","year":"2021","unstructured":"Cavallo A, Gasparotti E, Losi P, Foffa I, Al Kayal T, Vignali E, Celi S, Soldani G (2021) Fabrication and in-vitro characterization of a polymeric aortic valve for minimally invasive valve replacement. J Mech Behav Biomed Mater 115:104294","journal-title":"J Mech Behav Biomed Mater"},{"key":"1952_CR18","doi-asserted-by":"publisher","DOI":"10.3389\/fmedt.2021.748908","volume":"3","author":"S Celi","year":"2021","unstructured":"Celi S, Vignali E, Capellini K, Gasparotti E (2021) On the role and effects of uncertainties in cardiovascular in silico analyses. Front Med Technol 3:748908","journal-title":"Front Med Technol"},{"key":"1952_CR19","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/393258","volume-title":"Monitoring of the adult patient on venoarterial extracorporeal membrane oxygenation","author":"M Chung","year":"2014","unstructured":"Chung M, Shiloh AL, Carlese A (2014) Monitoring of the adult patient on venoarterial extracorporeal membrane oxygenation. The Scientific World Journal, Singapore"},{"issue":"1","key":"1952_CR20","first-page":"9","volume":"21","author":"L Cioccari","year":"2019","unstructured":"Cioccari L, Luethi N, Glassford NJ, Bellomo R (2019) The normal cardiac index in older healthy individuals: a scoping review. Crit Care Resusc 21(1):9\u201317","journal-title":"Crit Care Resusc"},{"issue":"2","key":"1952_CR21","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1177\/0267659118794112","volume":"34","author":"DW Donker","year":"2019","unstructured":"Donker DW, Brodie D, Henriques JP, Broom\u00e9 M (2019) Left ventricular unloading during veno-arterial ecmo: a review of percutaneous and surgical unloading interventions. Perfusion 34(2):98\u2013105","journal-title":"Perfusion"},{"issue":"16","key":"1952_CR22","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.1161\/CIRCULATIONAHA.122.062371","volume":"147","author":"SM Ezad","year":"2023","unstructured":"Ezad SM, Ryan M, Donker DW, Pappalardo F, Barrett N, Camporota L, Price S, Kapur NK, Perera D (2023) Unloading the left ventricle in venoarterial ecmo: in whom, when, and how? Circulation 147(16):1237\u20131250","journal-title":"Circulation"},{"key":"1952_CR23","doi-asserted-by":"publisher","DOI":"10.1016\/j.compfluid.2023.105912","volume":"260","author":"BM Fanni","year":"2023","unstructured":"Fanni BM, Gasparotti E, Vignali E, Capelli C, Positano V, Celi S (2023) An integrated in-vitro and in-silico workflow to study the pulmonary bifurcation hemodynamics. Comput Fluids 260:105912","journal-title":"Comput Fluids"},{"issue":"5","key":"1952_CR24","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1097\/MAT.0000000000001547","volume":"68","author":"J Farag","year":"2022","unstructured":"Farag J, Stephens AF, Chong WJ, Gregory SD, Marasco SF (2022) Intra-aortic balloon pump use with extra corporeal membrane oxygenation-a mock circulation loop study. ASAIO J 68(5):669\u2013675","journal-title":"ASAIO J"},{"key":"1952_CR25","doi-asserted-by":"crossref","unstructured":"Fiusco F, Lem\u00e9tayer J, Broman LM, Prahl Wittberg L (2023a) Effect of flow rate ratio and positioning on a lighthouse tip ecmo return cannula. Biomech Model Mechanobiol 1\u20139","DOI":"10.1007\/s10237-023-01741-2"},{"issue":"2","key":"1952_CR26","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1111\/aor.14421","volume":"47","author":"F Fiusco","year":"2023","unstructured":"Fiusco F, Rorro F, Broman LM, Prahl Wittberg L (2023b) Numerical and experimental investigation of a lighthouse tip drainage cannula used in extracorporeal membrane oxygenation. Artif Organs 47(2):330\u2013341","journal-title":"Artif Organs"},{"issue":"2","key":"1952_CR27","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1097\/MAT.0000000000001630","volume":"68","author":"EF Gajkowski","year":"2022","unstructured":"Gajkowski EF, Herrera G, Hatton L, Antonini MV, Vercaemst L, Cooley E (2022) Elso guidelines for adult and pediatric extracorporeal membrane oxygenation circuits. ASAIO J 68(2):133\u2013152","journal-title":"ASAIO J"},{"key":"1952_CR28","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmpb.2019.105041","volume":"182","author":"K Gu","year":"2019","unstructured":"Gu K, Guan Z, Lin X, Feng Y, Feng J, Yang Y, Zhang Z, Chang Y, Ling Y, Wan F (2019) Numerical analysis of aortic hemodynamics under the support of venoarterial extracorporeal membrane oxygenation and intra-aortic balloon pump. Comput Methods Prog Biomed 182:105041","journal-title":"Comput Methods Prog Biomed"},{"key":"1952_CR29","doi-asserted-by":"crossref","unstructured":"Haymet AB, Boone A, Vallely MP, Malfertheiner MV, Pauls JP, Suen JY, Fraser JF (2021) Assessing potential for aortoiliac vascular injury from venoarterial extracorporeal membrane oxygenation cannulae: an in vitro particle image velocimetry study. Artif Organs 45(2)","DOI":"10.1111\/aor.13807"},{"issue":"Suppl 1","key":"1952_CR30","doi-asserted-by":"publisher","first-page":"S11","DOI":"10.4103\/0971-9784.197791","volume":"20","author":"AL Jayaraman","year":"2017","unstructured":"Jayaraman AL, Cormican D, Shah P, Ramakrishna H (2017) Cannulation strategies in adult veno-arterial and veno-venous extracorporeal membrane oxygenation: techniques, limitations, and special considerations. Ann Card Anaesth 20(Suppl 1):S11\u2013S18","journal-title":"Ann Card Anaesth"},{"issue":"4","key":"1952_CR31","doi-asserted-by":"publisher","first-page":"S320","DOI":"10.1016\/j.healun.2023.02.738","volume":"42","author":"J Jiang","year":"2023","unstructured":"Jiang J, Jain P, Adji A, Barua S, Hayward C (2023) (724) determinants of lv filling pressure during ecpr with va-ecmo: a mock circulatory loop study. J Heart Lung Transpl 42(4):S320","journal-title":"J Heart Lung Transpl"},{"issue":"5","key":"1952_CR32","doi-asserted-by":"publisher","first-page":"839","DOI":"10.3390\/diagnostics13050839","volume":"13","author":"M Keller","year":"2023","unstructured":"Keller M, Magunia H, Rosenberger P, Koeppen M (2023) Echocardiography as a tool to assess cardiac function in critical care-a review. Diagnostics 13(5):839","journal-title":"Diagnostics"},{"key":"1952_CR33","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2024.108263","volume":"172","author":"M Khamooshi","year":"2024","unstructured":"Khamooshi M, Wickramarachchi A, Byrne T, Seman M, Fletcher DF, Burrell A, Gregory SD (2024) Blood flow and emboli transport patterns during venoarterial extracorporeal membrane oxygenation: a computational fluid dynamics study. Comput Biol Med 172:108263","journal-title":"Comput Biol Med"},{"key":"1952_CR34","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2021.630568","volume":"9","author":"J Lem\u00e9tayer","year":"2021","unstructured":"Lem\u00e9tayer J, Broman LM, Prahl Wittberg L (2021) Flow dynamics and mixing in extracorporeal support: a study of the return cannula. Front Bioeng Biotechnol 9:630568","journal-title":"Front Bioeng Biotechnol"},{"key":"1952_CR35","doi-asserted-by":"crossref","unstructured":"Li D, Li X, Xia Y, Weng C, Liang F (2024) Impact of peripheral venoarterial extracorporeal membrane oxygenation support for heart failure on systemic hemodynamics and aortic blood flow. Phys Fluids 36(10)","DOI":"10.1063\/5.0232133"},{"issue":"8","key":"1952_CR36","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1097\/MAT.0000000000001510","volume":"67","author":"R Lorusso","year":"2021","unstructured":"Lorusso R, Shekar K, MacLaren G, Schmidt M, Pellegrino V, Meyns B, Haft J, Vercaemst L, Pappalardo F, Bermudez C et al (2021) Elso interim guidelines for venoarterial extracorporeal membrane oxygenation in adult cardiac patients. ASAIO J 67(8):827\u2013844","journal-title":"ASAIO J"},{"key":"1952_CR37","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.xjtc.2022.02.039","volume":"13","author":"R Lorusso","year":"2022","unstructured":"Lorusso R, Meani P, Raffa GM, Kowalewski M (2022) Extracorporeal membrane oxygenation and left ventricular unloading: What is the evidence? JTCVS Tech 13:101\u2013114","journal-title":"JTCVS Tech"},{"key":"1952_CR38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12938-018-0497-1","volume":"17","author":"S Madhavan","year":"2018","unstructured":"Madhavan S, Kemmerling E (2018) The effect of inlet and outlet boundary conditions in image-based cfd modeling of aortic flow. Biomed Eng Online 17:1\u201320","journal-title":"Biomed Eng Online"},{"issue":"3","key":"1952_CR39","doi-asserted-by":"publisher","first-page":"208","DOI":"10.21037\/cdt.2016.03.08","volume":"6","author":"A Mahalingam","year":"2016","unstructured":"Mahalingam A, Gawandalkar UU, Kini G, Buradi A, Araki T, Ikeda N, Nicolaides A, Laird JR, Saba L, Suri JS (2016) Numerical analysis of the effect of turbulence transition on the hemodynamic parameters in human coronary arteries. Cardiovascu Diagnosis Therapy 6(3):208","journal-title":"Cardiovascu Diagnosis Therapy"},{"key":"1952_CR40","doi-asserted-by":"crossref","unstructured":"Malinowski D, Fournier Y, Horbach A, Frick M, Magliani M, Kalverkamp S, Hildinger M, Spillner J, Behbahani M, Hima F (2022) Computational fluid dynamics analysis of endoluminal aortic perfusion. Perfusion 2676591221099809","DOI":"10.1177\/02676591221099809"},{"issue":"8","key":"1952_CR41","doi-asserted-by":"publisher","first-page":"5095","DOI":"10.3390\/app13085095","volume":"13","author":"A Mariotti","year":"2023","unstructured":"Mariotti A, Vignali E, Gasparotti E, Morello M, Singh J, Salvetti MV, Celi S (2023) In vitro analysis of hemodynamics in the ascending thoracic aorta: sensitivity to the experimental setup. Appl Sci 13(8):5095","journal-title":"Appl Sci"},{"key":"1952_CR42","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1002\/ejhf.850","volume":"19","author":"P Meani","year":"2017","unstructured":"Meani P, Gelsomino S, Natour E, Johnson DM, Rocca H, Pappalardo F, Bidar E, Makhoul M, Raffa G, Heuts S et al (2017) Modalities and effects of left ventricle unloading on extracorporeal life support: a review of the current literature. Eur J Heart Fail 19:84\u201391","journal-title":"Eur J Heart Fail"},{"key":"1952_CR43","unstructured":"Mohrman DE, Heller LJ (2018) Cardiovascular physiology, 9th edn. McGraw-Hill Education LLC, New York, ISBN 9781260026115; 1260026116"},{"key":"1952_CR44","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2024.109124","volume":"182","author":"H Moradi","year":"2024","unstructured":"Moradi H, Seethala RR, Edelman ER, Keller SP, Nezami FR (2024) Effect of upper body venoarterial ecmo on systemic hemodynamics and oxygenation: a computational study. Comput Biol Med 182:109124","journal-title":"Comput Biol Med"},{"key":"1952_CR45","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/j.ijcard.2015.03.311","volume":"187","author":"LC Napp","year":"2015","unstructured":"Napp LC, Brehm M, K\u00fchn C, Sch\u00e4fer A, Bauersachs J (2015) Heart against veno-arterial ecmo: competition visualized. Int J Cardiol 187:164\u2013165","journal-title":"Int J Cardiol"},{"issue":"5","key":"1952_CR46","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1007\/s13239-024-00739-w","volume":"15","author":"M Neidlin","year":"2024","unstructured":"Neidlin M, Amiri A, Hugenroth K, Steinseifer U (2024) Investigations of differential hypoxemia during venoarterial membrane oxygenation with and without impella support. Cardiovasc Eng Technol 15(5):623\u2013632","journal-title":"Cardiovasc Eng Technol"},{"issue":"3","key":"1952_CR47","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1097\/MAT.0000000000001221","volume":"67","author":"FR Nezami","year":"2021","unstructured":"Nezami FR, Khodaee F, Edelman ER, Keller SP (2021) A computational fluid dynamics study of the extracorporeal membrane oxygenation-failing heart circulation. ASAIO J (Am Soc Artif Internal Organs: 1992) 67(3):276","journal-title":"ASAIO J (Am Soc Artif Internal Organs: 1992)"},{"issue":"6","key":"1952_CR48","doi-asserted-by":"publisher","first-page":"1578","DOI":"10.1093\/ejcts\/ezv459","volume":"49","author":"S Numata","year":"2016","unstructured":"Numata S, Itatani K, Kanda K, Doi K, Yamazaki S, Morimoto K, Manabe K, Ikemoto K, Yaku H (2016) Blood flow analysis of the aortic arch using computational fluid dynamics. Eur J Cardiothorac Surg 49(6):1578\u20131585","journal-title":"Eur J Cardiothorac Surg"},{"key":"1952_CR49","doi-asserted-by":"crossref","unstructured":"Prisco AR, Aguado-Sierra J, Butakoff C, Vazquez M, Houzeaux G, Eguzkitza B, Bartos JA, Yannopoulos D, Raveendran G, Holm M, et al (2021) Concomitant respiratory failure can impair myocardial oxygenation in patients with acute cardiogenic shock supported by va-ecmo. J Cardiovascu Translat Res 1\u201310","DOI":"10.1007\/s12265-021-10110-2"},{"issue":"9","key":"1952_CR50","doi-asserted-by":"publisher","first-page":"e004905","DOI":"10.1161\/CIRCHEARTFAILURE.118.004905","volume":"11","author":"P Rao","year":"2018","unstructured":"Rao P, Khalpey Z, Smith R, Burkhoff D, Kociol RD (2018) Venoarterial extracorporeal membrane oxygenation for cardiogenic shock and cardiac arrest: cardinal considerations for initiation and management. Circ Heart Fail 11(9):e004905","journal-title":"Circ Heart Fail"},{"issue":"Suppl 4","key":"1952_CR51","doi-asserted-by":"publisher","first-page":"S353","DOI":"10.21037\/jtd.2016.04.42","volume":"8","author":"J Reeb","year":"2016","unstructured":"Reeb J, Olland A, Renaud S, Lejay A, Santelmo N, Massard G, Falcoz P-E (2016) Vascular access for extracorporeal life support: tips and tricks. J Thorac Dis 8(Suppl 4):S353","journal-title":"J Thorac Dis"},{"issue":"1","key":"1952_CR52","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1177\/02676591211056567","volume":"39","author":"S Rozencwajg","year":"2024","unstructured":"Rozencwajg S, Wu EL, Heinsar S, Stevens M, Chinchilla J, Fraser JF, Pauls JP (2024) A mock circulation loop to evaluate differential hypoxemia during peripheral venoarterial extracorporeal membrane oxygenation. Perfusion 39(1):66\u201375","journal-title":"Perfusion"},{"issue":"2","key":"1952_CR53","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1161\/01.CIR.77.2.478","volume":"77","author":"K Sagar","year":"1988","unstructured":"Sagar K, Pelc L, Rhyne T, Wann L, Waltier D (1988) Influence of heart rate, preload, afterload, and inotropic state on myocardial ultrasonic backscatter. Circulation 77(2):478\u2013483","journal-title":"Circulation"},{"key":"1952_CR54","doi-asserted-by":"publisher","first-page":"1211461","DOI":"10.3389\/fphys.2023.1211461","volume":"14","author":"MA Scarpolini","year":"2023","unstructured":"Scarpolini MA, Mazzoli M, Celi S (2023) Enabling supra-aortic vessels inclusion in statistical shape models of the aorta: a novel non-rigid registration method. Front Physiol 14:1211461","journal-title":"Front Physiol"},{"issue":"12","key":"1952_CR55","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1016\/j.jchf.2018.09.009","volume":"6","author":"B Schrage","year":"2018","unstructured":"Schrage B, Burkhoff D, R\u00fcbsamen N, Becher PM, Schwarzl M, Bernhardt A, Grahn H, Lubos E, S\u00f6ffker G, Clemmensen P et al (2018) Unloading of the left ventricle during venoarterial extracorporeal membrane oxygenation therapy in cardiogenic shock. JACC Heart Failure 6(12):1035\u20131043","journal-title":"JACC Heart Failure"},{"issue":"6","key":"1952_CR56","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1097\/MAT.0000000000001268","volume":"67","author":"AF Stephens","year":"2021","unstructured":"Stephens AF, Wanigasekara D, Pellegrino VA, Burrell AJ, Marasco SF, Kaye DM, Steinseifer U, Gregory SD (2021) Comparison of circulatory unloading techniques for venoarterial extracorporeal membrane oxygenation. ASAIO J 67(6):623\u2013631","journal-title":"ASAIO J"},{"issue":"6","key":"1952_CR57","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.1111\/aor.14179","volume":"46","author":"AF Stephens","year":"2022","unstructured":"Stephens AF, Wickramarachchi A, Burrell AJ, Bellomo R, Raman J, Gregory SD (2022) Hemodynamics of small arterial return cannulae for venoarterial extracorporeal membrane oxygenation. Artif Organs 46(6):1068\u20131076","journal-title":"Artif Organs"},{"key":"1952_CR58","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.jbiomech.2017.02.009","volume":"55","author":"M Stevens","year":"2017","unstructured":"Stevens M, Callaghan F, Forrest P, Bannon P, Grieve S (2017) Flow mixing during peripheral veno-arterial extra corporeal membrane oxygenation\u2014a simulation study. J Biomech 55:64\u201370","journal-title":"J Biomech"},{"issue":"20","key":"1952_CR59","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1093\/eurheartj\/ehv051","volume":"36","author":"H Thiele","year":"2015","unstructured":"Thiele H, Ohman EM, Desch S, Eitel I, de Waha S (2015) Management of cardiogenic shock. Eur Heart J 36(20):1223\u20131230","journal-title":"Eur Heart J"},{"key":"1952_CR60","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.ymeth.2020.01.011","volume":"185","author":"M Viceconti","year":"2021","unstructured":"Viceconti M, Pappalardo F, Rodriguez B, Horner M, Bischoff J, Tshinanu FM (2021) In silico trials: verification, validation and uncertainty quantification of predictive models used in the regulatory evaluation of biomedical products. Methods 185:120\u2013127","journal-title":"Methods"},{"key":"1952_CR61","doi-asserted-by":"crossref","unstructured":"Vignali E, Gasparotti E, Fanni BM, Ait-Ali L, Positano V, Landini L, Celi S (2020) Development of a fully controllable real-time pump to reproduce left ventricle physiological flow. In: Proceedings of XXIV AIMETA conference 2019 24. Springer, pp 908\u2013919","DOI":"10.1007\/978-3-030-41057-5_74"},{"key":"1952_CR62","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.732561","volume":"12","author":"E Vignali","year":"2021","unstructured":"Vignali E, Gasparotti E, Celi S, Avril S (2021) Fully-coupled fsi computational analyses in the ascending thoracic aorta using patient-specific conditions and anisotropic material properties. Front Physiol 12:732561","journal-title":"Front Physiol"},{"issue":"10","key":"1952_CR63","doi-asserted-by":"publisher","first-page":"1272","DOI":"10.1097\/MAT.0000000000001651","volume":"68","author":"E Vignali","year":"2022","unstructured":"Vignali E, Gasparotti E, Mariotti A, Haxhiademi D, Ait-Ali L, Celi S (2022) High-versatility left ventricle pump and aortic mock circulatory loop development for patient-specific hemodynamic in vitro analysis. ASAIO J 68(10):1272\u20131281","journal-title":"ASAIO J"},{"key":"1952_CR64","doi-asserted-by":"crossref","unstructured":"Vignali E, Gasparotti E, Haxhiademi D, Celi S (2023) Fluid dynamic model for extracorporeal membrane oxygenation support and perfusion in cardiogenic shock. Phys Fluids 35(11)","DOI":"10.1063\/5.0174259"},{"key":"1952_CR65","unstructured":"Vrints C, Andreotti F, Koskinas KC, Rossello X, Adamo M, Ainslie J, Banning AP, Budaj A, Buechel RR, Chiariello GA, et al (2024) 2024 esc guidelines for the management of chronic coronary syndromes: Developed by the task force for the management of chronic coronary syndromes of the european society of cardiology (esc) endorsed by the european association for cardio-thoracic surgery (eacts). Eur Heart J ehae177"},{"key":"1952_CR66","unstructured":"V A, &V40 (2018) Assessing credibility of computational modeling through verification and validation: application to medical devices. Am Soc Mech Eng"},{"issue":"1","key":"1952_CR67","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1007\/s13246-022-01203-6","volume":"46","author":"A Wickramarachchi","year":"2023","unstructured":"Wickramarachchi A, Burrell AJ, Stephens AF, \u0160eman M, Vatani A, Khamooshi M, Raman J, Bellomo R, Gregory SD (2023) The effect of arterial cannula tip position on differential hypoxemia during venoarterial extracorporeal membrane oxygenation. Phys Eng Sci Med 46(1):119\u2013129","journal-title":"Phys Eng Sci Med"},{"key":"1952_CR68","doi-asserted-by":"publisher","DOI":"10.1016\/j.medntd.2022.100183","volume":"16","author":"Y Xi","year":"2022","unstructured":"Xi Y, Li Y, Wang H, Sun A, Deng X, Chen Z, Fan Y (2022) The impact of ecmo lower limb cannulation on the aortic flow features under differential blood perfusion conditions. Med Novel Technol Devices 16:100183","journal-title":"Med Novel Technol Devices"},{"issue":"2","key":"1952_CR69","first-page":"509","volume":"124","author":"L Xu","year":"2020","unstructured":"Xu L, Yang T, Yin L, Kong Y, Vassilevski Y, Liang F (2020) Numerical simulation of blood flow in aorta with dilation: a comparison between laminar and LES modeling methods. CMES Comput Model Eng Sci 124(2):509\u2013526","journal-title":"CMES Comput Model Eng Sci"},{"issue":"1","key":"1952_CR70","doi-asserted-by":"publisher","first-page":"14125","DOI":"10.1038\/s41598-024-64721-1","volume":"14","author":"K Yahagi","year":"2024","unstructured":"Yahagi K, Nishimura G, Kuramoto K, Tsuboko Y, Iwasaki K (2024) Hemodynamics with mechanical circulatory support devices using a cardiogenic shock model. Sci Rep 14(1):14125","journal-title":"Sci Rep"},{"issue":"1","key":"1952_CR71","doi-asserted-by":"publisher","DOI":"10.1115\/1.4037857","volume":"140","author":"P Youssefi","year":"2018","unstructured":"Youssefi P, Gomez A, Arthurs C, Sharma R, Jahangiri M, Alberto Figueroa C (2018) Impact of patient-specific inflow velocity profile on hemodynamics of the thoracic aorta. J Biomech Eng 140(1):011002","journal-title":"J Biomech Eng"}],"container-title":["Biomechanics and Modeling in Mechanobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10237-025-01952-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10237-025-01952-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10237-025-01952-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T13:05:40Z","timestamp":1749733540000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10237-025-01952-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,16]]},"references-count":71,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["1952"],"URL":"https:\/\/doi.org\/10.1007\/s10237-025-01952-9","relation":{},"ISSN":["1617-7959","1617-7940"],"issn-type":[{"value":"1617-7959","type":"print"},{"value":"1617-7940","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,16]]},"assertion":[{"value":"24 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 March 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 April 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Local Ethical Committee of the Tuscany Region (No. 95\/2024).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The authors have no competing interests or declarations to declare.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}