{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T12:56:29Z","timestamp":1776257789087,"version":"3.50.1"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2025,5,25]],"date-time":"2025-05-25T00:00:00Z","timestamp":1748131200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,5,25]],"date-time":"2025-05-25T00:00:00Z","timestamp":1748131200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","award":["EP\/T517793\/1\u20142592407"],"award-info":[{"award-number":["EP\/T517793\/1\u20142592407"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","award":["EP\/W008092\/1"],"award-info":[{"award-number":["EP\/W008092\/1"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","award":["EP\/W008092\/1"],"award-info":[{"award-number":["EP\/W008092\/1"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","award":["EP\/W008092\/1"],"award-info":[{"award-number":["EP\/W008092\/1"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","award":["EP\/T517793\/1\u20142592407"],"award-info":[{"award-number":["EP\/T517793\/1\u20142592407"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biomech Model Mechanobiol"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>Craniosynostosis (CS) is the premature closure of craniofacial joints known as sutures. Typically, this condition is treated by numerous invasive surgical interventions. Previously we investigated the level of mechanical strain induced due to frontal bone loading on a mouse model of this condition in light of a minimally invasive cyclic bone loading, showing success in retaining coronal suture patency in the Crouzon mouse model. Here we expanded on the previous investigations and characterised the response to external loading on the anterior part of the parietal bone, posterior part of the parietal bone and interparietal bone in addition to the previously investigated frontal bone loading. The results highlighted the significantly higher deformation of the skull and cranial joints during loading of the posterior skull compared to anterior skull loading. These results suggest that loading-based treatment requires different loading regimes depending on location. Additionally, the response of the coronal suture was investigated directly at postnatal day 7 (P7) in both mutant and wild-type animals. The wild-type mice exhibited significant deformation of the coronal suture across all loading locations, whereas no significant deformation was observed in the mutants. Finally, the experimental results were utilised to develop and analyse computational models of WT mice at three ages: P7, P14, and P21. This underscored the challenges in accurately capturing the highly variable response of the mouse craniofacial system to external loading. In summary, this work provided more details on the mechanics of the mouse craniofacial system and its variable overall stiffness across the different anatomical regions of the skull.<\/jats:p>","DOI":"10.1007\/s10237-025-01962-7","type":"journal-article","created":{"date-parts":[[2025,5,25]],"date-time":"2025-05-25T07:35:40Z","timestamp":1748158540000},"page":"1207-1222","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Regional variability in craniofacial stiffness: a study in normal and Crouzon mice during postnatal development"],"prefix":"10.1007","volume":"24","author":[{"given":"Marius","family":"Didziokas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miranda","family":"Steacy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tengyang","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arsalan","family":"Marghoub","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Alazmani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erwin","family":"Pauws","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehran","family":"Moazen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,5,25]]},"reference":[{"key":"1962_CR1","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1111\/joa.14121","volume":"245","author":"S Ajami","year":"2024","unstructured":"Ajami S, Van den Dam Z, Hut J et al (2024) Cranial bone microarchitecture in a mouse model for syndromic craniosynostosis. J Anat. https:\/\/doi.org\/10.1111\/joa.14121","journal-title":"J Anat"},{"key":"1962_CR2","doi-asserted-by":"publisher","first-page":"3189","DOI":"10.1007\/s00381-021-05330-5","volume":"37","author":"RWF Breakey","year":"2021","unstructured":"Breakey RWF, van de Lande LS, Sidpra J et al (2021) Spring-assisted posterior vault expansion-a single-centre experience of 200 cases. Childs Nerv Syst 37:3189\u20133197. https:\/\/doi.org\/10.1007\/s00381-021-05330-5","journal-title":"Childs Nerv Syst"},{"key":"1962_CR3","doi-asserted-by":"publisher","first-page":"1172","DOI":"10.1111\/joa.13843","volume":"242","author":"C Buzi","year":"2023","unstructured":"Buzi C, Profico A, Liang C et al (2023) Icex\u202f: Advances in the automatic extraction and volume calculation of cranial cavities. J Anat 242:1172\u20131183. https:\/\/doi.org\/10.1111\/joa.13843","journal-title":"J Anat"},{"key":"1962_CR4","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1111\/j.1475-1305.2007.00385.x","volume":"44","author":"CH Chien","year":"2008","unstructured":"Chien CH, Wu YD, Chao YJ et al (2008) The effects of different cranial modules on mechanical properties of cranial suture in Lewis rats and same-aged C57BL\/6 mice. Strain 44:272\u2013277. https:\/\/doi.org\/10.1111\/j.1475-1305.2007.00385.x","journal-title":"Strain"},{"key":"1962_CR5","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.1016\/j.jcms.2016.07.007","volume":"44","author":"M Cornelissen","year":"2016","unstructured":"Cornelissen M, den Ottelander B, Rizopoulos D et al (2016) Increase of prevalence of craniosynostosis. J Cranio-Maxillofac Surg 44:1273\u20131279. https:\/\/doi.org\/10.1016\/j.jcms.2016.07.007","journal-title":"J Cranio-Maxillofac Surg"},{"key":"1962_CR6","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1097\/00006534-199003000-00002","volume":"85","author":"DJ David","year":"1990","unstructured":"David DJ, Sheen R (1990) Surgical correction of Crouzon syndrome. Plast Reconstr Surg 85:344\u2013354. https:\/\/doi.org\/10.1097\/00006534-199003000-00002","journal-title":"Plast Reconstr Surg"},{"key":"1962_CR7","doi-asserted-by":"publisher","first-page":"59","DOI":"10.4103\/sni.sni_17_18","volume":"9","author":"HHK Delye","year":"2018","unstructured":"Delye HHK, Borstlap WA, van Lindert EJ (2018) Endoscopy-assisted craniosynostosis surgery followed by helmet therapy. Surg Neurol Int 9:59. https:\/\/doi.org\/10.4103\/sni.sni_17_18","journal-title":"Surg Neurol Int"},{"key":"1962_CR8","doi-asserted-by":"publisher","DOI":"10.1007\/s10237-023-01799-y","author":"M Didziokas","year":"2024","unstructured":"Didziokas M, Jones D, Alazmani A et al (2024a) Multiscale mechanical characterisation of the craniofacial system under external forces. Biomech Model Mechanobiol. https:\/\/doi.org\/10.1007\/s10237-023-01799-y","journal-title":"Biomech Model Mechanobiol"},{"key":"1962_CR9","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1111\/joa.14063","volume":"245","author":"M Didziokas","year":"2024","unstructured":"Didziokas M, Pauws E, K\u00f6lby L et al (2024b) BounTI (boundary-preserving threshold iteration): a user-friendly tool for automatic hard tissue segmentation. J Anat. https:\/\/doi.org\/10.1111\/joa.14063","journal-title":"J Anat"},{"key":"1962_CR10","doi-asserted-by":"publisher","first-page":"12555","DOI":"10.1073\/pnas.0405031101","volume":"101","author":"VP Eswarakumar","year":"2004","unstructured":"Eswarakumar VP, Horowitz MC, Locklin R et al (2004) A gain-of-function mutation of Fgfr2c demonstrates the roles of this receptor variant in osteogenesis. Proc Natl Acad Sci USA 101:12555\u201312560. https:\/\/doi.org\/10.1073\/pnas.0405031101","journal-title":"Proc Natl Acad Sci USA"},{"key":"1962_CR11","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1002\/wdev.227","volume":"5","author":"K Flaherty","year":"2016","unstructured":"Flaherty K, Singh N, Richtsmeier JT (2016) Understanding craniosynostosis as a growth disorder. Wiley Interdiscip Rev Dev Biol 5:429\u2013459. https:\/\/doi.org\/10.1002\/wdev.227","journal-title":"Wiley Interdiscip Rev Dev Biol"},{"key":"1962_CR12","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1159\/000143860","volume":"83","author":"SW Herring","year":"1972","unstructured":"Herring SW (1972) Sutures\u2013a tool in functional cranial analysis. Acta Anat (Basel) 83:222\u2013247. https:\/\/doi.org\/10.1159\/000143860","journal-title":"Acta Anat (Basel)"},{"key":"1962_CR13","doi-asserted-by":"publisher","DOI":"10.1111\/joa.14043","author":"SW Herring","year":"2024","unstructured":"Herring SW, Rafferty KL, Shin DU et al (2024) Cyclic loading failed to promote growth in a pig model of midfacial hypoplasia. J Anat. https:\/\/doi.org\/10.1111\/joa.14043","journal-title":"J Anat"},{"key":"1962_CR14","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/bs.ctdb.2015.07.004","volume":"115","author":"M Ishii","year":"2015","unstructured":"Ishii M, Sun J, Ting M-C, Maxson RE (2015) The development of the calvarial bones and sutures and the pathophysiology of craniosynostosis. Curr Top Dev Biol 115:131\u2013156. https:\/\/doi.org\/10.1016\/bs.ctdb.2015.07.004","journal-title":"Curr Top Dev Biol"},{"key":"1962_CR15","doi-asserted-by":"publisher","first-page":"77","DOI":"10.3171\/jns.1998.88.1.0077","volume":"88","author":"DF Jimenez","year":"1998","unstructured":"Jimenez DF, Barone CM (1998) Endoscopic craniectomy for early surgical correction of sagittal craniosynostosis. J Neurosurg 88:77\u201381. https:\/\/doi.org\/10.3171\/jns.1998.88.1.0077","journal-title":"J Neurosurg"},{"key":"1962_CR16","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1038\/ejhg.2010.235","volume":"19","author":"D Johnson","year":"2011","unstructured":"Johnson D, Wilkie AOM (2011) Craniosynostosis. Eur J Hum Genet 19:369\u2013376. https:\/\/doi.org\/10.1038\/ejhg.2010.235","journal-title":"Eur J Hum Genet"},{"key":"1962_CR17","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.1016\/j.jbiomech.2011.01.019","volume":"44","author":"T Kaster","year":"2011","unstructured":"Kaster T, Sack I, Samani A (2011) Measurement of the hyperelastic properties of ex vivo brain tissue slices. J Biomech 44:1158\u20131163. https:\/\/doi.org\/10.1016\/j.jbiomech.2011.01.019","journal-title":"J Biomech"},{"key":"1962_CR18","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.bbacli.2016.04.006","volume":"6","author":"MA Katsianou","year":"2016","unstructured":"Katsianou MA, Adamopoulos C, Vastardis H, Basdra EK (2016) Signaling mechanisms implicated in cranial sutures pathophysiology: Craniosynostosis. BBA Clin 6:165\u2013176. https:\/\/doi.org\/10.1016\/j.bbacli.2016.04.006","journal-title":"BBA Clin"},{"key":"1962_CR19","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1359\/jbmr.2003.18.3.521","volume":"18","author":"RA Kopher","year":"2003","unstructured":"Kopher RA, Mao JJ (2003) Suture growth modulated by the oscillatory component of micromechanical strain. J Bone Miner Res 18:521\u2013528. https:\/\/doi.org\/10.1359\/jbmr.2003.18.3.521","journal-title":"J Bone Miner Res"},{"key":"1962_CR20","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1114\/1.1603259","volume":"31","author":"RA Kopher","year":"2003","unstructured":"Kopher RA, Nudera JA, Wang X et al (2003) Expression of in vivo mechanical strain upon different wave forms of exogenous forces in rabbit craniofacial sutures. Ann Biomed Eng 31:1125\u20131131. https:\/\/doi.org\/10.1114\/1.1603259","journal-title":"Ann Biomed Eng"},{"key":"1962_CR21","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1159\/000491004","volume":"10","author":"KKL Lee","year":"2019","unstructured":"Lee KKL, Stanier P, Pauws E (2019) Mouse models of syndromic craniosynostosis. Mol Syndromol 10:58\u201373. https:\/\/doi.org\/10.1159\/000491004","journal-title":"Mol Syndromol"},{"key":"1962_CR22","unstructured":"Li Y, Harada T (2022) Non-rigid point cloud registration with neural deformation pyramid"},{"key":"1962_CR23","doi-asserted-by":"publisher","first-page":"110617","DOI":"10.1016\/j.isci.2024.110617","volume":"27","author":"C Liang","year":"2024","unstructured":"Liang C, Marghoub A, Profico A et al (2024) A physico-mechanical model of postnatal craniofacial growth in human. iScience 27:110617. https:\/\/doi.org\/10.1016\/j.isci.2024.110617","journal-title":"iScience"},{"key":"1962_CR24","doi-asserted-by":"publisher","first-page":"9641","DOI":"10.1038\/s41598-023-36646-8","volume":"13","author":"C Liang","year":"2023","unstructured":"Liang C, Profico A, Buzi C et al (2023) Normal human craniofacial growth and development from 0 to 4 years. Sci Rep 13:9641. https:\/\/doi.org\/10.1038\/s41598-023-36646-8","journal-title":"Sci Rep"},{"key":"1962_CR25","doi-asserted-by":"publisher","first-page":"255","DOI":"10.2307\/2532051","volume":"45","author":"LI-K Lin","year":"1989","unstructured":"Lin LI-K (1989) A concordance correlation coefficient to evaluate reproducibility. Biometrics 45:255. https:\/\/doi.org\/10.2307\/2532051","journal-title":"Biometrics"},{"key":"1962_CR26","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1007\/s00223-013-9701-2","volume":"92","author":"J Liu","year":"2013","unstructured":"Liu J, Nam HK, Wang E, Hatch NE (2013) Further analysis of the Crouzon mouse: effects of the FGFR2(C342Y) mutation are cranial bone-dependent. Calcif Tissue Int 92:451\u2013466. https:\/\/doi.org\/10.1007\/s00223-013-9701-2","journal-title":"Calcif Tissue Int"},{"key":"1962_CR27","doi-asserted-by":"publisher","first-page":"21569","DOI":"10.1038\/srep21569","volume":"6","author":"DB MacManus","year":"2016","unstructured":"MacManus DB, Pierrat B, Murphy JG, Gilchrist MD (2016) Mechanical characterization of the P56 mouse brain under large-deformation dynamic indentation. Sci Rep 6:21569. https:\/\/doi.org\/10.1038\/srep21569","journal-title":"Sci Rep"},{"key":"1962_CR28","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1177\/154405910208101203","volume":"81","author":"JJ Mao","year":"2002","unstructured":"Mao JJ (2002) Mechanobiology of craniofacial sutures. J Dent Res 81:810\u2013816. https:\/\/doi.org\/10.1177\/154405910208101203","journal-title":"J Dent Res"},{"key":"1962_CR29","doi-asserted-by":"publisher","first-page":"917","DOI":"10.2741\/917","volume":"8","author":"JJ Mao","year":"2003","unstructured":"Mao JJ (2003) Strain induced osteogenesis of the craniofacial suture upon controlled delivery of low-frequency cyclic forces. Front Biosci 8:917. https:\/\/doi.org\/10.2741\/917","journal-title":"Front Biosci"},{"key":"1962_CR30","doi-asserted-by":"publisher","first-page":"048103","DOI":"10.1103\/PhysRevLett.122.048103","volume":"122","author":"A Marghoub","year":"2019","unstructured":"Marghoub A, Libby J, Babbs C et al (2019) Characterizing and modeling bone formation during mouse calvarial development. Phys Rev Lett 122:048103. https:\/\/doi.org\/10.1103\/PhysRevLett.122.048103","journal-title":"Phys Rev Lett"},{"key":"1962_CR31","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1002\/dvdy.23903","volume":"242","author":"N Mart\u00ednez-Abad\u00edas","year":"2013","unstructured":"Mart\u00ednez-Abad\u00edas N, Motch SM, Pankratz TL et al (2013) Tissue-specific responses to aberrant FGF signaling in complex head phenotypes. Dev Dyn 242:80\u201394. https:\/\/doi.org\/10.1002\/dvdy.23903","journal-title":"Dev Dyn"},{"key":"1962_CR32","doi-asserted-by":"publisher","first-page":"e23249","DOI":"10.1002\/dvg.23249","volume":"57","author":"F Merkuri","year":"2019","unstructured":"Merkuri F, Fish JL (2019) Developmental processes regulate craniofacial variation in disease and evolution. Genesis 57:e23249. https:\/\/doi.org\/10.1002\/dvg.23249","journal-title":"Genesis"},{"key":"1962_CR33","doi-asserted-by":"publisher","first-page":"20150486","DOI":"10.1098\/rsif.2015.0486","volume":"12","author":"LA Mihai","year":"2015","unstructured":"Mihai LA, Chin L, Janmey PA, Goriely A (2015) A comparison of hyperelastic constitutive models applicable to brain and fat tissues. J R Soc Interface 12:20150486. https:\/\/doi.org\/10.1098\/rsif.2015.0486","journal-title":"J R Soc Interface"},{"key":"1962_CR34","doi-asserted-by":"publisher","first-page":"9693","DOI":"10.1038\/s41598-022-13807-9","volume":"12","author":"M Moazen","year":"2022","unstructured":"Moazen M, Hejazi M, Savery D et al (2022) Mechanical loading of cranial joints minimizes the craniofacial phenotype in Crouzon syndrome. Sci Rep 12:9693. https:\/\/doi.org\/10.1038\/s41598-022-13807-9","journal-title":"Sci Rep"},{"key":"1962_CR35","doi-asserted-by":"publisher","first-page":"e0125757","DOI":"10.1371\/journal.pone.0125757","volume":"10","author":"M Moazen","year":"2015","unstructured":"Moazen M, Peskett E, Babbs C et al (2015) Mechanical properties of calvarial bones in a mouse model for craniosynostosis. PLoS ONE 10:e0125757. https:\/\/doi.org\/10.1371\/journal.pone.0125757","journal-title":"PLoS ONE"},{"key":"1962_CR36","doi-asserted-by":"publisher","first-page":"2381","DOI":"10.1002\/nme.6943","volume":"123","author":"A Odot","year":"2022","unstructured":"Odot A, Haferssas R, Cotin S (2022) DeepPhysics: a physics aware deep learning framework for real-time simulation. Int J Numer Methods Eng 123:2381\u20132398. https:\/\/doi.org\/10.1002\/nme.6943","journal-title":"Int J Numer Methods Eng"},{"key":"1962_CR37","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1093\/hmg\/4.6.1077","volume":"4","author":"M Oldridge","year":"1995","unstructured":"Oldridge M, Wilkie AO, Slaney SF et al (1995) Mutations in the third immunoglobulin domain of the fibroblast growth factor receptor-2 gene in Crouzon syndrome. Hum Mol Genet 4:1077\u20131082. https:\/\/doi.org\/10.1093\/hmg\/4.6.1077","journal-title":"Hum Mol Genet"},{"key":"1962_CR38","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1097\/SCS.0b013e318241db3e","volume":"23","author":"AJ Oppenheimer","year":"2012","unstructured":"Oppenheimer AJ, Rhee ST, Goldstein SA, Buchman SR (2012) Force-induced craniosynostosis via paracrine signaling in the murine sagittal suture. J Craniofac Surg 23:573\u2013577. https:\/\/doi.org\/10.1097\/SCS.0b013e318241db3e","journal-title":"J Craniofac Surg"},{"key":"1962_CR39","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1002\/1097-0177(2000)9999:9999<::AID-DVDY1073>3.0.CO;2-F","volume":"219","author":"LA Opperman","year":"2000","unstructured":"Opperman LA (2000) Cranial sutures as intramembranous bone growth sites. Dev Dyn 219:472\u2013485. https:\/\/doi.org\/10.1002\/1097-0177(2000)9999:9999%3c::AID-DVDY1073%3e3.0.CO;2-F","journal-title":"Dev Dyn"},{"key":"1962_CR40","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1016\/j.bone.2007.05.014","volume":"42","author":"AI Peptan","year":"2008","unstructured":"Peptan AI, Lopez A, Kopher RA, Mao JJ (2008) Responses of intramembranous bone and sutures upon in vivo cyclic tensile and compressive loading. Bone 42:432\u2013438. https:\/\/doi.org\/10.1016\/j.bone.2007.05.014","journal-title":"Bone"},{"key":"1962_CR41","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1597\/05-212","volume":"43","author":"CA Perlyn","year":"2006","unstructured":"Perlyn CA, DeLeon VB, Babbs C et al (2006) The craniofacial phenotype of the Crouzon mouse: analysis of a model for syndromic craniosynostosis using three-dimensional MicroCT. Cleft Palate Craniofac J 43:740\u2013748. https:\/\/doi.org\/10.1597\/05-212","journal-title":"Cleft Palate Craniofac J"},{"key":"1962_CR42","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1242\/bio.022178","volume":"6","author":"E Peskett","year":"2017","unstructured":"Peskett E, Kumar S, Baird W et al (2017) Analysis of the Fgfr2C342Y mouse model shows condensation defects due to misregulation of Sox9 expression in prechondrocytic mesenchyme. Biol Open 6:223\u2013231. https:\/\/doi.org\/10.1242\/bio.022178","journal-title":"Biol Open"},{"key":"1962_CR43","doi-asserted-by":"publisher","first-page":"135","DOI":"10.4103\/2231-0746.186144","volume":"6","author":"C Rahimov","year":"2016","unstructured":"Rahimov C, Asadov R, Hajiyeva G et al (2016) Crouzon syndrome: virtual planning of surgical treatment by application of internal distractors. Ann Maxillofac Surg 6:135\u2013140. https:\/\/doi.org\/10.4103\/2231-0746.186144","journal-title":"Ann Maxillofac Surg"},{"key":"1962_CR44","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1093\/ejo\/25.2.139","volume":"25","author":"DPC Rice","year":"2003","unstructured":"Rice DPC, Rice R, Thesleff I (2003) Molecular mechanisms in calvarial bone and suture development, and their relation to craniosynostosis. Eur J Orthod 25:139\u2013148. https:\/\/doi.org\/10.1093\/ejo\/25.2.139","journal-title":"Eur J Orthod"},{"key":"1962_CR45","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1007\/s00401-013-1104-y","volume":"125","author":"JT Richtsmeier","year":"2013","unstructured":"Richtsmeier JT, Flaherty K (2013) Hand in glove: brain and skull in development and dysmorphogenesis. Acta Neuropathol 125:469\u2013489. https:\/\/doi.org\/10.1007\/s00401-013-1104-y","journal-title":"Acta Neuropathol"},{"key":"1962_CR46","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1007\/s00774-016-0737-z","volume":"35","author":"N Takeshita","year":"2017","unstructured":"Takeshita N, Hasegawa M, Sasaki K et al (2017) In vivo expression and regulation of genes associated with vascularization during early response of sutures to tensile force. J Bone Miner Metab 35:40\u201351. https:\/\/doi.org\/10.1007\/s00774-016-0737-z","journal-title":"J Bone Miner Metab"},{"key":"1962_CR47","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1016\/s0003-9969(00)00082-0","volume":"45","author":"E Tanaka","year":"2000","unstructured":"Tanaka E, Miyawaki Y, del Pozo R, Tanne K (2000) Changes in the biomechanical properties of the rat interparietal suture incident to continuous tensile force application. Arch Oral Biol 45:1059\u20131064. https:\/\/doi.org\/10.1016\/s0003-9969(00)00082-0","journal-title":"Arch Oral Biol"},{"key":"1962_CR48","doi-asserted-by":"publisher","first-page":"68","DOI":"10.3171\/2020.1.PEDS2051","volume":"26","author":"E T\u00f8nne","year":"2020","unstructured":"T\u00f8nne E, Due-T\u00f8nnessen BJ, Wiig U et al (2020) Epidemiology of craniosynostosis in Norway. J Neurosurg Pediatr 26:68\u201375. https:\/\/doi.org\/10.3171\/2020.1.PEDS2051","journal-title":"J Neurosurg Pediatr"},{"key":"1962_CR49","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1097\/scs.0b013e31818436be","volume":"20","author":"J van der Meulen","year":"2009","unstructured":"van der Meulen J, van der Hulst R, van Adrichem L et al (2009) The increase of metopic synostosis: a pan-European observation. J Craniofac Surg 20:283\u2013286. https:\/\/doi.org\/10.1097\/scs.0b013e31818436be","journal-title":"J Craniofac Surg"},{"key":"1962_CR50","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.jmbbm.2018.04.011","volume":"83","author":"GZ Voyiadjis","year":"2018","unstructured":"Voyiadjis GZ, Samadi-Dooki A (2018) Hyperelastic modeling of the human brain tissue: Effects of no-slip boundary condition and compressibility on the uniaxial deformation. J Mech Behav Biomed Mater 83:63\u201378. https:\/\/doi.org\/10.1016\/j.jmbbm.2018.04.011","journal-title":"J Mech Behav Biomed Mater"},{"key":"1962_CR51","doi-asserted-by":"publisher","first-page":"1843","DOI":"10.1359\/jbmr.2002.17.10.1843","volume":"17","author":"X Wang","year":"2002","unstructured":"Wang X, Mao JJ (2002) Accelerated chondrogenesis of the rabbit cranial base growth plate by oscillatory mechanical stimuli. J Bone Miner Res 17:1843\u20131850. https:\/\/doi.org\/10.1359\/jbmr.2002.17.10.1843","journal-title":"J Bone Miner Res"}],"container-title":["Biomechanics and Modeling in Mechanobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10237-025-01962-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10237-025-01962-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10237-025-01962-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T13:13:19Z","timestamp":1752153199000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10237-025-01962-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,25]]},"references-count":51,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["1962"],"URL":"https:\/\/doi.org\/10.1007\/s10237-025-01962-7","relation":{},"ISSN":["1617-7959","1617-7940"],"issn-type":[{"value":"1617-7959","type":"print"},{"value":"1617-7940","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,25]]},"assertion":[{"value":"31 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 May 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}