{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T18:34:40Z","timestamp":1789583680063,"version":"build-2803163510"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2025,8,9]],"date-time":"2025-08-09T00:00:00Z","timestamp":1754697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,8,9]],"date-time":"2025-08-09T00:00:00Z","timestamp":1754697600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"European Unions Horizon 2020","award":["101017578"],"award-info":[{"award-number":["101017578"]}]},{"name":"European Unions Horizon 2020","award":["101017578"],"award-info":[{"award-number":["101017578"]}]},{"name":"European Unions Horizon 2020","award":["101017578"],"award-info":[{"award-number":["101017578"]}]},{"name":"European Unions Horizon 2020","award":["101017578"],"award-info":[{"award-number":["101017578"]}]},{"name":"European Unions Horizon 2020","award":["101017578"],"award-info":[{"award-number":["101017578"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biomech Model Mechanobiol"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1007\/s10237-025-01984-1","type":"journal-article","created":{"date-parts":[[2025,8,9]],"date-time":"2025-08-09T07:45:19Z","timestamp":1754725519000},"page":"1605-1618","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Impact of calcifications on paravalvular leakage by transcatheter aortic valve prostheses: findings from a new in silico clinical trial framework"],"prefix":"10.1007","volume":"24","author":[{"given":"Laura","family":"Supp","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Oldenburg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Leuchter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Br\u00fcning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Capelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alper","family":"\u00d6ner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus-Peter","family":"Schmitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Stiehm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Finja","family":"Borowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,9]]},"reference":[{"issue":"2","key":"1984_CR1","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1007\/s10237-018-1094-8","volume":"18","author":"M Bianchi","year":"2019","unstructured":"Bianchi M, Marom G, Ghosh RP et al (2019) Patient-specific simulation of transcatheter aortic valve replacement: impact of deployment options on paravalvular leakage. Biomech Model Mechanobiol 18(2):435\u2013451. https:\/\/doi.org\/10.1007\/s10237-018-1094-8","journal-title":"Biomech Model Mechanobiol"},{"key":"1984_CR2","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/j.jbiomech.2018.02.017","volume":"71","author":"GM Bosi","year":"2018","unstructured":"Bosi GM, Capelli C, Cheang MH et al (2018) Population-specific material properties of the implantation site for transcatheter aortic valve replacement finite element simulations. J Biomech 71:236\u2013244. https:\/\/doi.org\/10.1016\/j.jbiomech.2018.02.017","journal-title":"J Biomech"},{"issue":"13","key":"1984_CR3","doi-asserted-by":"publisher","first-page":"2824","DOI":"10.1016\/j.jbiomech.2016.06.024","volume":"49","author":"B Bosmans","year":"2016","unstructured":"Bosmans B, Famaey N, Verhoelst E et al (2016) A validated methodology for patient specific computational modeling of self-expandable transcatheter aortic valve implantation. J Biomech 49(13):2824\u20132830. https:\/\/doi.org\/10.1016\/j.jbiomech.2016.06.024","journal-title":"J Biomech"},{"key":"1984_CR4","doi-asserted-by":"crossref","unstructured":"Chambers J, Hastie T (2017) Statistical models. In: Statistical models in S. Routledge, pp 13\u201344","DOI":"10.1201\/9780203738535-2"},{"key":"1984_CR5","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.neuroimage.2014.06.043","volume":"101","author":"S Durrleman","year":"2014","unstructured":"Durrleman S, Prastawa M, Charon N et al (2014) Morphometry of anatomical shape complexes with dense deformations and sparse parameters. Neuroimage 101:35\u201349. https:\/\/doi.org\/10.1016\/j.neuroimage.2014.06.043","journal-title":"Neuroimage"},{"issue":"9","key":"1984_CR6","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1016\/j.rec.2017.10.025","volume":"71","author":"E Enr\u00edquez-Rodr\u00edguez","year":"2018","unstructured":"Enr\u00edquez-Rodr\u00edguez E, Amat-Santos IJ, Jim\u00e9nez-Quevedo P et al (2018) Comparison of the hemodynamic performance of the balloon-expandable sapien 3 versus self-expandable evolut r transcatheter valve: A case-matched study. Revista espanola de cardiologia (English ed) 71(9):735\u2013742. https:\/\/doi.org\/10.1016\/j.rec.2017.10.025","journal-title":"Revista espanola de cardiologia (English ed)"},{"issue":"9","key":"1984_CR7","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1016\/j.mri.2012.05.001","volume":"30","author":"A Fedorov","year":"2012","unstructured":"Fedorov A, Beichel R, Kalpathy-Cramer J et al (2012) 3d slicer as an image computing platform for the quantitative imaging network. Magn Reson Imag 30(9):1323\u20131341. https:\/\/doi.org\/10.1016\/j.mri.2012.05.001","journal-title":"Magn Reson Imag"},{"key":"1984_CR8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2021.104772","volume":"123","author":"A Finotello","year":"2021","unstructured":"Finotello A, Gorla R, Brambilla N et al (2021) Finite element analysis of transcatheter aortic valve implantation: Insights on the modelling of self-expandable devices. J Mech Behav Biomed Mater 123:104772. https:\/\/doi.org\/10.1016\/j.jmbbm.2021.104772","journal-title":"J Mech Behav Biomed Mater"},{"key":"1984_CR9","unstructured":"Fox J, Weisberg S (2019) An R companion to applied regression, 3rd edn. SAGE, Thousand Oaks, CA"},{"issue":"16","key":"1984_CR10","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1136\/heartjnl-2012-301998","volume":"98","author":"P Gripari","year":"2012","unstructured":"Gripari P, Ewe SH, Fusini L et al (2012) Intraoperative 2d and 3d transoesophageal echocardiographic predictors of aortic regurgitation after transcatheter aortic valve implantation. Heart (British Cardiac Society) 98(16):1229\u20131236. https:\/\/doi.org\/10.1136\/heartjnl-2012-301998","journal-title":"Heart (British Cardiac Society)"},{"key":"1984_CR11","doi-asserted-by":"publisher","first-page":"8249497","DOI":"10.1155\/2020\/8249497","volume":"2020","author":"A Hagar","year":"2020","unstructured":"Hagar A, Li Y, Wei X et al (2020) Incidence, predictors, and outcome of paravalvular leak after transcatheter aortic valve implantation. J Interv Cardiol 2020:8249497. https:\/\/doi.org\/10.1155\/2020\/8249497","journal-title":"J Interv Cardiol"},{"issue":"3","key":"1984_CR12","doi-asserted-by":"publisher","first-page":"e298","DOI":"10.4244\/EIJ-D-18-00137","volume":"14","author":"A Harnath","year":"2018","unstructured":"Harnath A, Gomes B, Herwig V et al (2018) First experience with the 34 mm self-expanding evolut r in a multicentre registry. EuroInterventionjournal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology 14(3):e298\u2013e300. https:\/\/doi.org\/10.4244\/EIJ-D-18-00137","journal-title":"EuroInterventionjournal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology"},{"issue":"6","key":"1984_CR13","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.1002\/ccd.30816","volume":"102","author":"TW Hokken","year":"2023","unstructured":"Hokken TW, Wienemann H, Dargan J et al (2023) Clinical value of ct-derived simulations of transcatheter-aortic-valve-implantation in challenging anatomies the precise-tavi trial. Catheter Cardiovasc Interventions J Soc Cardiac Angiogr Intervent 102(6):1140\u20131148. https:\/\/doi.org\/10.1002\/ccd.30816","journal-title":"Catheter Cardiovasc Interventions J Soc Cardiac Angiogr Intervent"},{"issue":"5","key":"1984_CR14","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1115\/1.1800557","volume":"126","author":"GA Holzapfel","year":"2004","unstructured":"Holzapfel GA, Sommer G, Regitnig P (2004) Anisotropic mechanical properties of tissue components in human atherosclerotic plaques. J Biomech Eng 126(5):657\u2013665. https:\/\/doi.org\/10.1115\/1.1800557","journal-title":"J Biomech Eng"},{"issue":"19","key":"1984_CR15","doi-asserted-by":"publisher","first-page":"2403","DOI":"10.1093\/eurheartj\/ehs255","volume":"33","author":"AP Kappetein","year":"2012","unstructured":"Kappetein AP, Head SJ, G\u00e9n\u00e9reux P et al (2012) Updated standardized endpoint definitions for transcatheter aortic valve implantation: the valve academic research consortium-2 consensus document. Eur Heart J 33(19):2403\u20132418. https:\/\/doi.org\/10.1093\/eurheartj\/ehs255","journal-title":"Eur Heart J"},{"issue":"6","key":"1984_CR16","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1093\/ejcts\/ezaa254","volume":"58","author":"T Laakso","year":"2020","unstructured":"Laakso T, Laine M, Moriyama N et al (2020) Impact of paravalvular regurgitation on the mid-term outcome after transcatheter and surgical aortic valve replacement. Eur J Cardiothorac Surg 58(6):1145\u20131152. https:\/\/doi.org\/10.1093\/ejcts\/ezaa254","journal-title":"Eur J Cardiothorac Surg"},{"issue":"4","key":"1984_CR17","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1080\/10255842.2020.1817409","volume":"24","author":"G Luraghi","year":"2021","unstructured":"Luraghi G, Matas J, Beretta M et al (2021) The impact of calcification patterns in transcatheter aortic valve performance: a fluid-structure interaction analysis. Comput Methods Biomech Biomed Engin 24(4):375\u2013383. https:\/\/doi.org\/10.1080\/10255842.2020.1817409","journal-title":"Comput Methods Biomech Biomed Engin"},{"key":"1984_CR18","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmpb.2022.107244","volume":"228","author":"C Miller","year":"2023","unstructured":"Miller C, Konduri P, Bridio S et al (2023) In silico thrombectomy trials for acute ischemic stroke. Comput Methods Programs Biomed 228:107244. https:\/\/doi.org\/10.1016\/j.cmpb.2022.107244","journal-title":"Comput Methods Programs Biomed"},{"key":"1984_CR19","doi-asserted-by":"publisher","unstructured":"Moerman KM (2018) Gibbon: The geometry and image-based bioengineering add-on. J Open Source Softw 3(22):506. https:\/\/doi.org\/10.21105\/joss.00506","DOI":"10.21105\/joss.00506"},{"issue":"12","key":"1984_CR20","doi-asserted-by":"publisher","first-page":"2513","DOI":"10.1016\/j.jbiomech.2015.10.048","volume":"49","author":"S Morganti","year":"2016","unstructured":"Morganti S, Brambilla N, Petronio AS et al (2016) Prediction of patient-specific post-operative outcomes of tavi procedure: The impact of the positioning strategy on valve performance. J Biomech 49(12):2513\u20132519. https:\/\/doi.org\/10.1016\/j.jbiomech.2015.10.048","journal-title":"J Biomech"},{"key":"1984_CR21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.carrev.2021.07.010","volume":"35","author":"A Musallam","year":"2022","unstructured":"Musallam A, Buchanan KD, Yerasi C et al (2022) Impact of left ventricular outflow tract calcification on outcomes following transcatheter aortic valve replacement. Cardiovasc Revasculariz Medicineinclud Mol Interventions 35:1\u20137. https:\/\/doi.org\/10.1016\/j.carrev.2021.07.010","journal-title":"Cardiovasc Revasculariz Medicineinclud Mol Interventions"},{"issue":"4","key":"1984_CR22","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1515\/cdbme-2024-2115","volume":"10","author":"J Oldenburg","year":"2024","unstructured":"Oldenburg J, Borowski F, Supp L et al (2024) Generation of shape models of calcified tavr populations for solid mechanics simulations by means of deep learning. Current Direct Biomed Eng 10(4):469\u2013472. https:\/\/doi.org\/10.1515\/cdbme-2024-2115","journal-title":"Current Direct Biomed Eng"},{"issue":"1","key":"1984_CR23","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1109\/TMI.2023.3294128","volume":"43","author":"DH Pak","year":"2024","unstructured":"Pak DH, Liu M, Kim T et al (2024) Patient-specific heart geometry modeling for solid biomechanics using deep learning. IEEE Trans Med Imag 43(1):203\u2013215. https:\/\/doi.org\/10.1109\/TMI.2023.3294128","journal-title":"IEEE Trans Med Imag"},{"issue":"5","key":"1984_CR24","doi-asserted-by":"publisher","first-page":"1699","DOI":"10.1093\/bib\/bby043","volume":"20","author":"F Pappalardo","year":"2019","unstructured":"Pappalardo F, Russo G, Tshinanu FM et al (2019) In silico clinical trials: concepts and early adoptions. Brief Bioinform 20(5):1699\u20131708. https:\/\/doi.org\/10.1093\/bib\/bby043","journal-title":"Brief Bioinform"},{"issue":"1","key":"1984_CR25","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1161\/CIRCINTERVENTIONS.108.780858","volume":"1","author":"N Piazza","year":"2008","unstructured":"Piazza N, de Jaegere P, Schultz C et al (2008) Anatomy of the aortic valvar complex and its implications for transcatheter implantation of the aortic valve. Circ Cardiovasc Interv 1(1):74\u201381. https:\/\/doi.org\/10.1161\/CIRCINTERVENTIONS.108.780858","journal-title":"Circ Cardiovasc Interv"},{"issue":"4","key":"1984_CR26","doi-asserted-by":"publisher","first-page":"1406","DOI":"10.1016\/j.jtcvs.2018.08.085","volume":"157","author":"F Pollari","year":"2019","unstructured":"Pollari F, Dell\u2019Aquila AM, S\u00f6hn C et al (2019) Risk factors for paravalvular leak after transcatheter aortic valve replacement. J Thorac Cardiovasc Surg 157(4):1406-1415.e3. https:\/\/doi.org\/10.1016\/j.jtcvs.2018.08.085","journal-title":"J Thorac Cardiovasc Surg"},{"key":"1984_CR27","unstructured":"Precise Simulation (2024) FEATool Multiphysics\u2014MATLAB FEA and CFD Toolbox. https:\/\/github.com\/precise-simulation\/featool-multiphysics\/releases\/tag\/1.17.2, GitHub, accessed December 12, 2024"},{"issue":"3","key":"1984_CR28","doi-asserted-by":"publisher","DOI":"10.1088\/2516-1091\/acdc71","volume":"5","author":"C Rodero","year":"2023","unstructured":"Rodero C, Baptiste T, Barrows RK et al (2023) A systematic review of cardiac in-silico clinical trials. Prog Biomed Eng (Bristol England) 5(3):032004. https:\/\/doi.org\/10.1088\/2516-1091\/acdc71","journal-title":"Prog Biomed Eng (Bristol England)"},{"issue":"5","key":"1984_CR29","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1093\/ehjci\/jev174","volume":"17","author":"M Seiffert","year":"2016","unstructured":"Seiffert M, Fujita B, Avanesov M et al (2016) Device landing zone calcification and its impact on residual regurgitation after transcatheter aortic valve implantation with different devices. Eur Heart J Cardiovasc Imag 17(5):576\u2013584. https:\/\/doi.org\/10.1093\/ehjci\/jev174","journal-title":"Eur Heart J Cardiovasc Imag"},{"issue":"3","key":"1984_CR30","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1007\/s10237-024-01816-8","volume":"23","author":"M Spanjaards","year":"2024","unstructured":"Spanjaards M, Borowski F, Supp L et al (2024) A fast in silico model for preoperative risk assessment of paravalvular leakage. Biomech Model Mechanobiol 23(3):959\u2013985. https:\/\/doi.org\/10.1007\/s10237-024-01816-8","journal-title":"Biomech Model Mechanobiol"},{"issue":"1","key":"1984_CR31","doi-asserted-by":"publisher","DOI":"10.1002\/cnm.3778","volume":"40","author":"S Verstraeten","year":"2024","unstructured":"Verstraeten S, Hoeijmakers M, Tonino P et al (2024) Generation of synthetic aortic valve stenosis geometries for in silico trials. Int J Numer Methods Biomed Eng 40(1):e3778. https:\/\/doi.org\/10.1002\/cnm.3778","journal-title":"Int J Numer Methods Biomed Eng"},{"issue":"6","key":"1984_CR32","doi-asserted-by":"publisher","first-page":"2281","DOI":"10.1002\/mp.12203","volume":"44","author":"J Weese","year":"2017","unstructured":"Weese J, Lungu A, Peters J et al (2017) Cfd- and bernoulli-based pressure drop estimates: A comparison using patient anatomies from heart and aortic valve segmentation of ct images. Med Phys 44(6):2281\u20132292. https:\/\/doi.org\/10.1002\/mp.12203","journal-title":"Med Phys"},{"key":"1984_CR33","doi-asserted-by":"publisher","unstructured":"Wilczek K, Bujak K, Regu\u0142a R, et\u00a0al (2015) Risk factors for paravalvular leak after transcatheter aortic valve implantation. Kardiochirurgia i torakochirurgia polska = Polish journal of cardio-thoracic surgery 12(2):89\u201394. https:\/\/doi.org\/10.5114\/kitp.2015.52848","DOI":"10.5114\/kitp.2015.52848"},{"issue":"14","key":"1984_CR34","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1016\/j.jacc.2011.12.015","volume":"59","author":"AB Willson","year":"2012","unstructured":"Willson AB, Webb JG, Labounty TM et al (2012) 3-dimensional aortic annular assessment by multidetector computed tomography predicts moderate or severe paravalvular regurgitation after transcatheter aortic valve replacement: a multicenter retrospective analysis. J Am Coll Cardiol 59(14):1287\u20131294. https:\/\/doi.org\/10.1016\/j.jacc.2011.12.015","journal-title":"J Am Coll Cardiol"},{"issue":"4","key":"1984_CR35","first-page":"190","volume":"25","author":"D Wong","year":"2013","unstructured":"Wong D, Bertaso AG, Liew G et al (2013) Relationship of aortic annular eccentricity and paravalvular regurgitation post transcatheter aortic valve implantation with corevalve. J Invasive Cardiol 25(4):190\u2013195","journal-title":"J Invasive Cardiol"}],"container-title":["Biomechanics and Modeling in Mechanobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10237-025-01984-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10237-025-01984-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10237-025-01984-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T13:04:36Z","timestamp":1758546276000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10237-025-01984-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,9]]},"references-count":35,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["1984"],"URL":"https:\/\/doi.org\/10.1007\/s10237-025-01984-1","relation":{},"ISSN":["1617-7959","1617-7940"],"issn-type":[{"value":"1617-7959","type":"print"},{"value":"1617-7940","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,9]]},"assertion":[{"value":"13 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 August 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no Conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"University Medical Center Rostock: Registration number of ethics application A 2020-0250. Bart\u2019s Heart Centre at University College London: upon application and approval by the NHS Digital Data Access Request Service. Ethical approval for data access and research protocol was granted by the Barts Health NHS Trust Research Ethics Committee under reference number 296325. Charit\u00e9 University Medical Center Berlin: Ethical approval was granted by Ethikkommission der Charit\u00e8-Universitatsmedizin Berlin. Number of the ethics vote: EA2\/174\/19.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}