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Previous studies have indicated an association between pediatric intussusception and inflammation as well as intestinal motility. However, the underlying mechanisms remain unclear, particularly with regard to the mechanics. We hypothesized that invagination occurs when longitudinal and circular smooth muscles are not coordinated during peristalsis. To test the hypothesis from a mechanical perspective, we developed a computational model of the terminal ileum, where the terminal ileum is modeled as a hyperelastic tube. We showed that circumferential contraction with longitudinal relaxation of the hyperelastic tube wall caused invagination in the contracting region of the tube. We also found that invagination occurred when a square-shaped contracting region emerged in the hyperelastic tube. These results indicate that uncoordinated motion of the circular and longitudinal muscles can lead to invagination of the intestinal wall. In addition, the configuration of peristalsis may serve as an indicator of the risk of pediatric intussusception.<\/jats:p>","DOI":"10.1007\/s10237-025-02010-0","type":"journal-article","created":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T07:35:58Z","timestamp":1756884958000},"page":"2117-2126","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Intestinal invagination caused by circumferential contraction with longitudinal relaxation of the wall"],"prefix":"10.1007","volume":"24","author":[{"given":"Hitomi","family":"Okino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hironori","family":"Takeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunichi","family":"Ishida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohsuke","family":"Imai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,3]]},"reference":[{"issue":"4","key":"2010_CR1","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1016\/j.jpeds.2006.04.010","volume":"149","author":"JE Bines","year":"2006","unstructured":"Bines JE, Liem NT, Justice FA et al (2006) Risk factors for intussusception in infants in Vietnam and Australia: adenovirus implicated, but not rotavirus. 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